The DOI matches its Crossref record; 233 of the 233 references it cites were found in a registry or an index.
Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation
Abstract
The Per-Arnt-Sim (PAS) domain is conserved across the kingdoms of life and found in an ever-growing list of proteins. This domain can bind to and sense endogenous or xenobiotic small molecules such as molecular oxygen, cellular metabolites, or polyaromatic hydrocarbons. Members of this family are often found in pathways that regulate responses to environmental change; in mammals these include the hypoxia, circadian, and dioxin response pathways. These pathways function in development and throughout life to regulate cellular, organ, and whole-organism adaptive responses. Remarkably, in the case of the clock, this adaptation includes anticipation of environmental change. In this review, we summarize the roles of PAS domain-containing proteins in mammals. We provide structural evidence that functionally classifies both known and unknown biological roles. Finally, we discuss the role of PAS proteins in anticipation of and adaptation to environmental change.
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“Finally, it is important to note that mice homozygous for this allele are a phenocopy of null mice for the DV endpoint and may be useful in identifying other ARNT dependent signaling events mediated by partners such as hypoxia inducible factors (HIFs) (Chan et al., 1999; Gradin et al., 1996; McIntosh et al., 2010).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as McIntosh et al., 2010
In the citing paper
“Notably, ARNT is now known to dimerize with HIFs, and through these interactions is essential in biological processes including the hypoxia response, glucose metabolism, blood cell development, and angiogenesis (Gradin et al., 1996; McIntosh et al., 2010).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as McIntosh et al., 2010
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Metadata
- Authors
- McIntosh, B. E., Hogenesch, J. B., & Bradfield, C. A.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Pennsylvania (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2010-03-17
- Volume
- 72
- Issue
- 1
- Pages
- 625-645
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2143654291
- Cited by
- 352
- References
- 233
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 24 · 2023: 21 · 2022: 26 · 2021: 30 · 2020: 18 · 2019: 14 · 2018: 15 · 2017: 14 · 2016: 28 · 2015: 18 · 2014: 25 · 2013: 36 · 2012: 32
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (R37ES005703)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- environmental adaptation, hypoxia response, circadian clock, metabolite sensing, polycyclic aromatic hydrocarbons, protein structure, mammalian physiology
- MeSH terms
- Adaptation, Physiological, Amino Acid Sequence, Animals, Hypoxia, Circadian Rhythm, Dioxins, Environment, Humans, Mammals, Terminology as Topic, Polycyclic Aromatic Hydrocarbons, Signal Transduction, Aryl Hydrocarbon Receptor Nuclear Translocator, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Period Circadian Proteins
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