Myonectin deletion promotes adipose fat storage and reduces liver steatosis

Little, Hannah C.; Rodriguez, Susana; Lei, Xia; Tan, Stefanie Y.; Stewart, Ashley N.; Sahagun, Ageline; Sarver, Dylan C.; William Wong, G.

doi:10.1096/fj.201900520r

Cited by 78Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismLipid metabolism and disorders

Myonectin deletion promotes adipose fat storage and reduces liver steatosis

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Little, Hannah C., Rodriguez, Susana, Lei, Xia, Tan, Stefanie Y., Stewart, Ashley N., Sahagun, Ageline, Sarver, Dylan C., William Wong, G.·2019·The FASEB Journal

DOI 10.1096/fj.201900520rPMC PMC6593887

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Abstract

We recently described myonectin (also known as erythroferrone) as a novel skeletal muscle‐derived myokine with metabolic functions. Here, we use a genetic mouse model to determine myonectin's requirement for metabolic homeostasis. Female myonectin‐deficient mice had larger gonadal fat pads and developed mild insulin resistance when fed a high‐fat diet (HFD) and had reduced food intake during refeeding after an unfed period but were otherwise indistinguishable from wild‐type littermates. Male mice lacking myonectin, however, had reduced physical activity when fed ad libitum and in the postprandial state but not during the unfed period. When stressed with an HFD, myonectin‐knockout male mice had significantly elevated VLDL‐triglyceride (TG) and strikingly impaired lipid clearance from circulation following an oral lipid load. Fat distribution between adipose and liver was also altered in myonectin‐deficient male mice fed an HFD. Greater fat storage resulted in significantly enlarged adipocytes and was associated with increased postprandial lipoprotein lipase activity in adipose tissue. Parallel to this was a striking reduction in liver steatosis due to significantly reduced TG accumulation. Liver metabolite profiling revealed additional significant changes in bile acids and 1‐carbon metabolism pathways. Combined, our data affirm the physiologic importance of myonectin in regulating local and systemic lipid metabolism.—Little, H. C., Rodriguez, S., Lei, X., Tan, S. Y., Stewart, A. N., Sahagun, A., Sarver, D. C., Wong, G. W. Myonectindeletion promotes adipose fat storage and reduces liver steatosis. FASEB J. 33, 8666–8687 (2019). www.fasebj.org

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In myonectin knockout mice, WAT lipolysis is unaffected, but dietary lipid clearance is impaired versus wild-type, leading to increased WAT mass and decreased liver steatosis.
“in myonectin knockout mice, WAT lipolysis is unaffected; however, dietary lipid clearance is impaired compared with lipid clearance in wild-type mice, resulting in increased WAT mass and decreased liver steatosis82.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [82]

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Dietary conjugated linoleic acid increases endurance capacity and fat oxidation in mice during exercise
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Multiplex Quantification Identifies Novel Exercise-regulated Myokines/Cytokines in Plasma and in Glycolytic and Oxidative Skeletal Muscle
Little, H. C., Tan, S. Y., Cali, F. M., Rodriguez, S., Lei, X., Wolfe, A., Hug, C., & Wong, G. W. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000794 · Cited by 33 · see citing works
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Partial deficiency of CTRP12 alters hepatic lipid metabolism
Tan, S. Y., Little, H. C., Lei, X., Li, S., Rodriguez, S., & Wong, G. W. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00111.2016 · Cited by 32 · see citing works
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Erythroferrone is not required for the glucoregulatory and hematologic effects of chronic erythropoietin treatment in mice
Coffey, R., Sardo, U., Kautz, L., Gabayan, V. R., Nemeth, E., & Ganz, T. (2018) · Physiological Reports · doi:10.14814/phy2.13890 · Cited by 29 · see citing works

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Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works
Erythroferrone structure, function, and physiology: Iron homeostasis and beyond
Srole, D. N., & Ganz, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30247 · Cited by 155 · see citing works
Exercise-Released Myokines in the Control of Energy Metabolism
Laurens, C., Bergouignan, A., & Moro, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00091 · Cited by 159 · see citing works
Iron Deficiency in Obesity and after Bariatric Surgery
Bjørklund, G., Peana, M., Pivina, L., Dosa, A., Aaseth, J., Semenova, Y., Chirumbolo, S., Medici, S., Dadar, M., & Costea, D.-O. (2021) · Biomolecules · doi:10.3390/biom11050613 · Cited by 99 · see citing works
Myokines and Heart Failure: Challenging Role in Adverse Cardiac Remodeling, Myopathy, and Clinical Outcomes
Berezin, A. Е., Berezin, A. A., & Lichtenauer, M. (2021) · Disease Markers · doi:10.1155/2021/6644631 · Cited by 93 · see citing works
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works
The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations
Leuchtmann, A. B., Adak, V., Dilbaz, S., & Handschin, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.709807 · Cited by 84 · see citing works
Exploring the Role of Skeletal Muscle in Insulin Resistance: Lessons from Cultured Cells to Animal Models
Feraco, A., Gorini, S., Armani, A., Camajani, E., Rizzo, M., & Caprio, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179327 · Cited by 76 · see citing works
Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway
Ozaki, Y., Ohashi, K., Otaka, N., Kawanishi, H., Takikawa, T., Fang, L., Takahara, K., Tatsumi, M., Ishihama, S., Takefuji, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40435-2 · Cited by 63 · see citing works
Myokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance
Yi, J., Chen, J., Yao, X., Zhao, Z., Niu, X., Li, X., Sun, J., Ji, Y., Shang, T., Gong, L., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117326 · Cited by 59 · see citing works
Cytokines and exosomal miRNAs in skeletal muscle–adipose crosstalk
Guo, L., Quan, M., Pang, W., Yin, Y., & Li, F. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.07.006 · Cited by 48 · see citing works
C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue lipolysis and hepatic triglyceride secretion
Lei, X., & Wong, G. W. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009230 · Cited by 39 · see citing works
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Loss of CTRP4 alters adiposity and food intake behaviors in obese mice
Sarver, D. C., Stewart, A. N., Rodriguez, S., Little, H. C., Aja, S. M., & Wong, G. W. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00448.2020 · Cited by 38 · see citing works
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Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice
Coffey, R., Jung, G., Olivera, J. D., Karin, G., Pereira, R. C., Nemeth, E., & Ganz, T. (2021) · Blood · doi:10.1182/blood.2021014054 · Cited by 37 · see citing works
Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients—The Debate Is Still Open
Kruszewska, J., Laudy-Wiaderny, H., & Kunicki, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19042099 · Cited by 36 · see citing works
Effects of Intermittent Hypoxia on Cytokine Expression Involved in Insulin Resistance
Uchiyama, T., Ota, H., Ohbayashi, C., & Takasawa, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312898 · Cited by 29 · see citing works
Sarcopenic obesity: epidemiology, pathogenesis and diagnostic criteria
Berns, S. A., Sheptulina, A. F., Мамутовна, М. Э., Kiselev, A. R., & Drapkina, O. M. (2023) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2023-3576 · Cited by 28 · see citing works
A comparison of CrossFit and concurrent training on myonectin, insulin resistance and physical performance in healthy young women
Bahremand, M., Dokht, E. H., & Moazzami, M. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1853173 · Cited by 23 · see citing works
CTRP12 ablation differentially affects energy expenditure, body weight, and insulin sensitivity in male and female mice
Tan, S. Y., Lei, X., Little, H. C., Rodriguez, S., Sarver, D. C., Cao, X., & Wong, G. W. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00533.2019 · Cited by 22 · see citing works
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The Pan-liver Network Theory
Zhang, Y., & Fang, X.-M. (2023) · The Chinese Journal of Physiology · doi:10.4103/cjop.cjop-d-22-00131 · Cited by 22 · see citing works
Myokines: Novel therapeutic targets for diabetic nephropathy
Yang, M., Luo, S., Yang, J., Chen, W., He, L., Liu, D., Zhao, L., & Wang, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1014581 · Cited by 18 · see citing works
Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling
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Epidemiological, mechanistic, and practical bases for assessment of cardiorespiratory fitness and muscle status in adults in healthcare settings
Gallo‐Villegas, J., & Calderón, J. C. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-022-05114-y · Cited by 20 · see citing works
Serum Levels of Myonectin Are Lower in Adults with Metabolic Syndrome and Are Negatively Correlated with Android Fat Mass
Petro, J. L., Fragozo-Ramos, M. C., Milán, A. F., Aristizábal, J. C., Gallo‐Villegas, J., & Calderón, J. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086874 · Cited by 17 · see citing works
Association of decreased myonectin levels with metabolic and hormonal disturbance in polycystic ovary syndrome
Demir, İ., & Güler, A. (2020) · Gynecological Endocrinology · doi:10.1080/09513590.2020.1751109 · Cited by 17 · see citing works
Erythroferrone in focus: emerging perspectives in iron metabolism and hematopathologies
Babar, S., & Saboor, M. (2024) · Blood Science · doi:10.1097/bs9.0000000000000198 · Cited by 17 · see citing works
CTRP4 ablation impairs associative learning and memory
Sarver, D. C., Xu, C., Cheng, Y., Terrillion, C. E., & Wong, G. W. (2021) · The FASEB Journal · doi:10.1096/fj.202100733rr · Cited by 16 · see citing works
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CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF‐4α and DGAT2 expression
Tan, S. Y., Little, H. C., Sarver, D. C., Watkins, P. A., & Wong, G. W. (2020) · FEBS Letters · doi:10.1002/1873-3468.13895 · Cited by 16 · see citing works
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Serum myonectin is increased after laparoscopic sleeve gastrectomy
Li, L., Wang, Q., & Qin, C. (2020) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563220942263 · Cited by 15 · see citing works
Upregulation of IL ‐8, osteonectin, and myonectin mRNAs by intermittent hypoxia via OCT1 ‐ and NRF2 ‐mediated mechanisms in skeletal muscle cells
Takasawa, S., Shobatake, R., Itaya‐Hironaka, A., Makino, M., Uchiyama, T., Sakuramoto‐Tsuchida, S., Takeda, Y., Ota, H., & Yamauchi, A. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17618 · Cited by 15 · see citing works
CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding
Sarver, D. C., Xu, C., Aja, S. M., & Wong, G. W. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00002.2022 · Cited by 14 · see citing works
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CTRP11 contributes modestly to systemic metabolism and energy balance
Sarver, D. C., Xu, C., Carreno, D., Arking, A., Terrillion, C. E., Aja, S. M., & Wong, G. W. (2022) · The FASEB Journal · doi:10.1096/fj.202200189rr · Cited by 14 · see citing works
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Protein Modifications Critical for Myonectin/Erythroferrone Secretion and Oligomer Assembly
Stewart, A. N., Little, H. C., Clark, D. J., Zhang, H., & Wong, G. W. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00461 · Cited by 14 · see citing works
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Myokines as potential mediators of changes in glucose homeostasis and muscle mass after bariatric surgery
Orioli, L., & Thissen, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1554617 · Cited by 13 · see citing works
Decreased serum myonectin concentrations in diabetic nephropathy patients
Zhang, J., Hu, W., Lin, P., & Wang, R. (2020) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00654-z · Cited by 13 · see citing works
Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus – A Case-control Study
Onat, T., & İnandıklıoğlu, N. (2021) · Zeitschrift für Geburtshilfe und Neonatologie · doi:10.1055/a-1404-4323 · Cited by 12 · see citing works
Myonectin and metabolic health: a systematic review
Petro, J. L., Gallo‐Villegas, J., & Calderón, J. C. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1557142 · Cited by 11 · see citing works
Correlation analysis of myonectin levels with metabolic and hormonal disorders in patients with polycystic ovary syndrome
Zhang, J., Chen, L., & Ye, J. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-458 · Cited by 10 · see citing works
Male-specific Association between Iron and Lipid Metabolism Changes and Erythroferrone after Hepatitis C Virus Eradication
Inomata, S., Morihara, D., Anan, A., Yamauchi, E., Yamauchi, R., Takata, K., Tanaka, T., Yokoyama, K., Takeyama, Y., Irie, M., et al. (2021) · Internal Medicine · doi:10.2169/internalmedicine.7172-21 · Cited by 9 · see citing works
Characterization of erythroferrone oligomerization and its impact on BMP antagonism
Mast, E. M., Leach, E. A. E., & Thompson, T. B. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105452 · Cited by 9 · see citing works
The Molecular Mechanisms of Muscle–Adipose Crosstalk: Myokines, Adipokines, Lipokines and the Mediating Role of Exosomes
Li, A., Zhou, Z., Li, D., Sha, P.-R., Hu, H., Lin, Y.-Q., Yue, B.-L., Li, J., & Xiong, Y. (2025) · Cells · doi:10.3390/cells14241954 · Cited by 10 · see citing works
Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron‐deficient mouse pregnancies
Sangkhae, V., Yu, V., Coffey, R., O'Brien, K. O., Ganz, T., & Nemeth, E. (2022) · American Journal of Hematology · doi:10.1002/ajh.26680 · Cited by 9 · see citing works
CTRP13 ablation improves systemic glucose and lipid metabolism
Chen, F., Sarver, D. C., Saqib, M., Zhou, M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101824 · Cited by 9 · see citing works
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Plasma Complement C1q/tumor necrosis factor-related protein 15 concentration is associated with polycystic ovary syndrome
Vatannejad, A., Fadaei, R., Salimi, F., Fouani, F. Z., Habibi, B., Shapourizadeh, S., Eivazi, S., Eivazi, S., Sadeghi, A., & Moradi, N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263658 · Cited by 8 · see citing works
Genomic Prediction and Genome-Wide Association Study for Boar Taint Compounds
Faggion, S., Boschi, E., Veroneze, R., Carnier, P., & Bonfatti, V. (2023) · Animals · doi:10.3390/ani13152450 · Cited by 8 · see citing works
The Significance of Selected Myokines in Predicting the Length of Rehabilitation of Patients after COVID-19 Infection
Mińko, A., Turoń-Skrzypińska, A., Rył, A., Mańkowska, K., Cymbaluk‐Płoska, A., & Rotter, I. (2024) · Biomedicines · doi:10.3390/biomedicines12040836 · Cited by 7 · see citing works
Clinical improvement may not reflect metabolic homeostasis normalization in subjects with and without Roux-En-Y bariatric surgery after 12 years: comparison of surgical subjects to a lean cohort
Butler, A. E., Ramanjaneya, M., Moin, A. S. M., Hunt, S. C., & Atkin, S. L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1228853 · Cited by 6 · see citing works
Loss of CTRP10 results in female obesity with preserved metabolic healthPreprint
Chen, F., Sarver, D. C., Saqib, M., Vélez, L. M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2024) · eLife · doi:10.7554/elife.93373.3 · Cited by 7 · see citing works
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Liquiritigenin Alleviates Hepatic Metabolic Inflammation Through Regulation of Muscle–Liver Crosstalk Signal of Myonectin
Qin, H., Chen, J.-M., Xu, Z.-Y., Chen, J.-F., Fu, Y., Wang, Z., Liu, X., & Zheng, W. (2025) · Phytotherapy Research · doi:10.1002/ptr.70014 · Cited by 5 · see citing works
Myonectin in grass carp (Ctenopharyngodon idella): Molecular cloning and effect of nutrition state, insulin and glucagon on myonectin expression
Yang, G., Liang, X., Jiang, Y., Li, C., Hu, J., Zhang, Y., Zhang, X., Chang, X., Hu, W., Li, K., et al. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101306 · Cited by 6 · see citing works
Exercise, myonectin response, and insulin resistance among overweight, obese and healthy individuals: a systematic review and narrative synthesis
Muthukrishnan, R., Alzaabi, A. M. M. A., Ismail, M., Kandakurthi, P. K., Durairaj, S., Sukumar, S., & Gopal, K. (2025) · Journal of Medicine and Life · doi:10.25122/jml-2024-0277 · Cited by 4 · see citing works
Exercise-Induced Exerkines Modulate Autophagy: Implications for Interorgan Crosstalk in the Hallmarks of Ageing
Qi, D. E. N. G., Huang, J., Wang, C., & Liang, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062746 · Cited by 4 · see citing works
Effects of an energy drink on myonectin in the liver, kidney and skeletal muscle of exercised rats
Avcu, E. Ç., Çınar, V., Yasul, Y., Akbulut, T., Pancar, Z., Aydemir, İ., Aydın, S., Yalçın, M. H., & Aydın, S. (2024) · Biotechnic & Histochemistry · doi:10.1080/10520295.2024.2305113 · Cited by 4 · see citing works
Combined serum CTRP7 and CTRP15 levels as a novel biomarker for insulin resistance and type 2 diabetes mellitus
Xue, S., Ling, J., Tian, M., Li, K., Li, S., Liu, D., Li, L., Yang, M., & Yang, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30029 · Cited by 4 · see citing works
Correlation of serum myonectin concentrations with the presence and severity of obstructive sleep apnoea syndrome
Zou, H.-L., Yang, W., & Liu, Y. (2020) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563220978680 · Cited by 4 · see citing works
Short-term periods of strenuous physical activity lower iron absorption
Brittenham, G. M. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa365 · Cited by 4 · see citing works
Impact of moderate dietary protein restriction on glucose homeostasis in a model of estrogen deficiency
Fournier, C., Karagounis, L. G., Sacco, S. M., Horcajada, M.-N., Decaens, T., Offord, E., Bouzakri, K., & Ammann, P. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108952 · Cited by 3 · see citing works
Enhancement of Serum Myonectin Levels by Progressive Resistance Training in Rats Fed with High-Fat Diet and Sucrose Solution
Safarzade, A., & Safarpour, H. (2021) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms.108209 · Cited by 3 · see citing works
Effects of myonectin on porcine intramuscular adipocyte differentiation and exogenous free fatty acid utilization
Sun, Z., Liu, Z., Xi, J., Liu, Y., Zheng, Z., Li, N., Li, Z., Liang, S., Li, Q., Zhang, H., et al. (2023) · Animal Biotechnology · doi:10.1080/10495398.2023.2224838 · Cited by 3 · see citing works
Increased circulating level of CTRP15 in patients with type 2 diabetes mellitus and its relation with inflammation and insulin resistance
Azadi, S. M., Shateri, H., Mohammadi, M. R., Fadaei, R., Sajedi, F., & Ziamajidi, N. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00892-2 · Cited by 3 · see citing works
Codon-optimized FAM132b gene therapy prevents dietary obesity by blockading adrenergic response and insulin action
Qi, Z., Xia, J., Xue, X., Liu, W., Huang, Z., Zhang, X., Zou, Y., Liu, J., Li, X., Li, X., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01189-x · Cited by 3 · see citing works
How Exercise Affects Exerkines in Metabolic Syndrome
Babaei, P., & Yadegari, F. (2025) · Hormone and Metabolic Research · doi:10.1055/a-2720-5398 · Cited by 2 · see citing works
Role of CTRP14/C1QL1 in motor coordination and learning across the lifespan
Chen, F., Saqib, M., Terrillion, C. E., Miranda, C., Sarver, D. C., Scafidi, J., & Wong, G. W. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114799 · Cited by 2 · see citing works
Self-citation
Effect of Recombinant Human Erythroferrone Protein on Hepcidin Gene (Hamp1) Expression in HepG2 and HuH7 Cells
Than, M. M., Koonyosying, P., Ruangsuriya, J., Junrungsee, S., Uthaipibull, C., & Srichairatanakool, S. (2021) · Materials · doi:10.3390/ma14216480 · Cited by 2 · see citing works
Muscle mass as a resilence factor for endothelial health in obesity
Stepp, D. W., & Fulton, D. J. (2026) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00096-9 · Cited by 1 · see citing works
Circulating Myonectin and Oxytocin Levels in Pediatric Obesity: A Comparative Study
Büyükinan, M., Can, Ü., Bağcı, Z., & Akdu, S. (2026) · Children · doi:10.3390/children13030401 · Cited by 1 · see citing works
Leveraging genetic correlation structure to target discrete signaling mechanisms across metabolic tissuesPreprint
Zhou, M., Van, C., Molendijk, J., Chang, I. Y.-Y., Johnson, C., Vélez, L. M., Yeo, R. X., Bae, H., Le, J., Larson, N., et al. (2023) · eLife · doi:10.7554/elife.88863.1 · Cited by 1 · see citing works
Codon-Optimized FAM132b Prevents Diet-Induced Obesity by Modulating Adrenergic Response and Insulin ActionPreprint
Qi, Z., Xia, J., Xue, X., Liu, W., Huang, Z., Zhang, X., Zou, Y., Liu, J., Liu, J., Li, X., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3708518
Loss of CTRP10 results in female obesity with preserved metabolic healthPreprint
Chen, F., Sarver, D. C., Saqib, M., Vélez, L. M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2024) · eLife · doi:10.7554/elife.93373.1
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Physiological regulation of moderate-intensity exercise in improving the biomarkers visfatin and myonectin as a modulator of increasing metabolic performance in obese
Sugiharto, S., Pranoto, A., Ihsan, N., Goenawan, H., Merawati, D., Rejeki, P. S., Siantoro, G., Widyatama, F. S., & Angga, P. D. (2025) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2024-0207
Loss of CTRP10 results in female obesity with preserved metabolic healthPreprint
Chen, F., Sarver, D. C., Saqib, M., Vélez, L. M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2025) · eLife · doi:10.7554/elife.93373.2
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Gestational fish oil supplementation in a high-fat diet induces sex-specific myokine changes in weanling offspring
Woyames, J., Martins, I., de Souza, M. S., Saggioro, B. B., Silva, C. B. R. D., Tatagiba, M. C. A., Sousa, R., de Andrade, C. B. V., Neto, J. G. O., de Almeida, M. M., et al. (2025) · Journal of Endocrinology · doi:10.1530/joe-25-0033
Pretransplant and posttransplant erythroferrone levels and outcomes after heart transplantationPreprint
Gros, B. P., Rocca, A., Laptseva, N., Martinelli, M., Flammer, A. J., Lu, H. Y., Meyer, P., Leuenberger, N., Müller, M., & Hullin, R. (2026) · medRxiv · doi:10.64898/2026.02.20.26346755
CTRP10 is required for optimal motor function
Chen, F., Saqib, M., Terrillion, C. E., Wright, N., Sarver, D. C., Scafidi, J., & Wong, G. W. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111420
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Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study
Kono, K., Moriyama, Y., Ohashi, K., Otaka, N., Tatsumi, M., Murohara, T., Ouchi, N., & Oshima, S. (2026) · Therapeutic Apheresis and Dialysis · doi:10.1002/1744-9987.70177
Exerkines in precision management of metabolic diseases
Jin, L., Lin, Y., Zheng, Y., Wang, A., Liao, P., Luo, Y., Sui, Z., Ni, X., Zhang, J., Shen, Q., et al. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004200
Myokines and mitochondrial function in cardiometabolic diseases
Saavedra, J. E., Gallo-Villegas, J., & Calderón, J. C. (2026) · Journal of physiology and biochemistry · doi:10.1007/s13105-026-01233-8

Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
Seldin, M. M., Peterson, J. M., Byerly, M. S., Wei, Z., & Wong, G. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336834 · Cited by 406 · see citing works
Effects of myonectin on porcine intramuscular adipocyte differentiation and exogenous free fatty acid utilization
Sun, Z., Liu, Z., Xi, J., Liu, Y., Zheng, Z., Li, N., Li, Z., Liang, S., Li, Q., Zhang, H., et al. (2023) · Animal Biotechnology · doi:10.1080/10495398.2023.2224838 · Cited by 3 · see citing works
Myonectin and metabolic health: a systematic review
Petro, J. L., Gallo‐Villegas, J., & Calderón, J. C. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1557142 · Cited by 11 · see citing works
AdipoRon prevents myostatin‐induced upregulation of fatty acid synthesis and downregulation of insulin activity in a mouse hepatocyte line
Liu, X., Pan, J. P., Bauman, W. A., & Cardozo, C. P. (2019) · Physiological Reports · doi:10.14814/phy2.14152 · Cited by 18 · see citing works
Serum Myonectin Correlates With Abdominal Adiposity But Not With Serum Or Intramuscular Lipids In Adults
Petro, J. L., Fragozo-Ramos, M. C., Milán, A. F., Gallo‐Villegas, J., & Calderón, J. C. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000981788.43618.23

Authors: Little, H. C., Rodriguez, S., Lei, X., Tan, S. Y., Stewart, A. N., Sahagun, A., Sarver, D. C., & William Wong, G.
Affiliations: Johns Hopkins University (US)
Department of Physiology Johns Hopkins University School of Medicine Baltimore Maryland USA
ORCID: Rodriguez, Susana
Lei, Xia
Sarver, Dylan C.
Venue: The FASEB Journal
Publisher: Wiley
Published: 2019-04-19
Volume: 33
Issue: 7
Pages: 8666-8687
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.201900520r
PMC: PMC6593887
OpenAlex: W2940313036
Cited by: 78
References: 78
Citations by year: 2026: 8 · 2025: 12 · 2024: 6 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 1
FWCI: 7.42
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK084171)
National Institute of General Medical Sciences (T32 GM007445)
American Diabetes Association (1-18-PMF-022)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: myonectin, erythroferrone, myokines, skeletal muscle, hepatic steatosis, insulin resistance, high-fat diet, lipid metabolism, VLDL triglycerides, lipoprotein lipase, bile acids, one-carbon metabolism, sex differences, adipocyte size, lipid clearance
MeSH terms: Adipose Tissue, Animals, Fatty Liver, Female, Homeostasis, Insulin, Insulin Resistance, Lipoproteins, VLDL, Liver, Male, Mice, Inbred C57BL, Muscle Proteins, Obesity, Triglycerides, Cytokines, Adipocytes, Mice, Knockout, Muscle, Skeletal, Adiposity, Lipid Metabolism, Mice, Diet, High-Fat

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Myonectin deletion promotes adipose fat storage and reduces liver steatosis

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