Cited by 2,704RNA Research and SplicingRNA regulation and diseaseRNA and protein synthesis mechanisms

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Mechanisms of Alternative Pre-Messenger RNA Splicing

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Black, Douglas L.·2003·Annual Review of Biochemistry

DOI 10.1146/annurev.biochem.72.121801.161720

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Abstract

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher eukaryotes. Variability in splicing patterns is a major source of protein diversity from the genome. In this review, I describe what is currently known of the molecular mechanisms that control changes in splice site choice. I start with the best-characterized systems from the Drosophila sex determination pathway, and then describe the regulators of other systems about whose mechanisms there is some data. How these regulators are combined into complex systems of tissue-specific splicing is discussed. In conclusion, very recent studies are presented that point to new directions for understanding alternative splicing and its mechanisms.

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Items 201–377 of 377

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Sacco-Bubulya, P. A., & Spector, D. L. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200107017 · Cited by 154
The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.Preprint
Siebel, C. W., Fresco, L. D., & Rio, D. C. (1992) · Genes & Development · doi:10.1101/gad.6.8.1386 · Cited by 152
The role of U2AF35 and U2AF65 in enhancer-dependent splicing
Graveley, B. R., Hertel, K. J., & Maniatis, T. (2001) · RNA · doi:10.1017/s1355838201010317 · Cited by 151
Conserved Sr Protein Kinase Functions in Nuclear Import and Its Action Is Counteracted by Arginine Methylation inSaccharomyces cerevisiae
Yun, C. Y., & Fu, X. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.4.707 · Cited by 151
Substrate Specificities of SR Proteins in Constitutive Splicing Are Determined by Their RNA Recognition Motifs and Composite Pre-mRNA Exonic Elements
Mayeda, A., Screaton, G. R., Chandler, S. D., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1853 · Cited by 151
Antagonistic effects of T‐Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing
Kadener, S., Cramer, P., Nogués, G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.20.5759 · Cited by 150
A Model System for Activation-Induced Alternative Splicing of CD45 Pre-mRNA in T Cells Implicates Protein Kinase C and Ras
Lynch, K. W., & Weiss, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.70-80.2000 · Cited by 149
Tissue-Specific Splicing in Vivo of the β-Tropomyosin Gene: Dependence on an RNA Secondary Structure
Libri, D., Piseri, A., & Fiszman, M. Y. (1991) · Science · doi:10.1126/science.2063196 · Cited by 148
Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?Preprint
Black, D. L. (1991) · Genes & Development · doi:10.1101/gad.5.3.389 · Cited by 147
Self-citation
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Yeakley, J. M., Tronchère, H., Olesen, J., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.447 · Cited by 146
RNAi-Mediated PTB Depletion Leads to Enhanced Exon Definition
Wagner, E. J., & García-Blanco, M. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00645-7 · Cited by 144
Common themes in the function of transcription and splicing enhancers
Hertel, K. J., Lynch, K. W., & Maniatis, T. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80007-5 · Cited by 143
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Jacquenet, S., Méreau, A., Bilodeau, P. S., Damier-Piolle, L., Stoltzfus, C. M., & Branlant, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104070200 · Cited by 142
A splicing enhancer exhibits both constitutive and regulated activities.Preprint
Tian, M., & Maniatis, T. (1994) · Genes & Development · doi:10.1101/gad.8.14.1703 · Cited by 142
Alternative splicing: combinatorial output from the genome
Roberts, G. C., & Smith, C. W. J. (2002) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(02)00320-4 · Cited by 141
Control of retroviral RNA splicing through maintenance of suboptimal processing signals.
Katz, R. A., & Skalka, A. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.696 · Cited by 139
Polypyrimidine Tract Binding Protein Functions as a Repressor To Regulate Alternative Splicing of α-Actinin Mutally Exclusive Exons
Southby, J., Gooding, C., & Smith, C. W. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2699 · Cited by 139
Conservation in budding yeast of a kinase specific for SR splicing factors
Siebel, C. W., Feng, L. L., Guthrie, C., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5440 · Cited by 138
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation
Ford, L. P., Wright, W. E., & Shay, J. W. (2002) · Oncogene · doi:10.1038/sj.onc.1205086 · Cited by 138
Presence of Negative and Positive cis -Acting RNA Splicing Elements within and Flanking the First tat Coding Exon of Human Immunodeficiency Virus Type 1
Amendt, B. A., Hesslein, D. G. T., Chang, L., & Stoltzfus, C. M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3960-3970.1994 · Cited by 137
A Family of Human RNA-binding Proteins Related to theDrosophila Bruno Translational Regulator
Good, P. J., Chen, Q., Warner, S. J., & Herring, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003083200 · Cited by 136
Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells
Vallano, M. L., Lambolez, B., Audinat, É., & Rossier, J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00631.1996 · Cited by 135
The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.
Levy, J. B., Dorai, T., Wang, L. H., et al. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.11.4142 · Cited by 135
ASESORÍAS INNOVADORAS EN RECURSOS HUMANOS PARA LAS PYMES MEDIANTE EL USO DE LA RED DE INTERNET
ARTAVIA, N. I. V. (1969) · Revista Nacional de Administración · doi:10.22458/rna.v4i1.535 · Cited by 135
Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.
Wang, Z., Hoffmann, H. M., & Grabowski, P. J. (1995) · PubMed · Cited by 135
RNA processing and human disease
Philips, A. V., & Cooper*, T. A. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000687 · Cited by 134
A Complex Intronic Splicing Enhancer from the c- src Pre-mRNA Activates Inclusion of a Heterologous Exon
Modafferi, E. F., & Black, D. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6537 · Cited by 132
Self-citation
Alternative Splicing and Programmed Cell Death
Jiang, Z., & Wu, J. Y. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-11.x · Cited by 132
Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB)
Wollerton, M., Gooding, C., Robinson, F., Brown, E. C., Jackson, R. J., & Smith, C. W. J. (2001) · RNA · doi:10.1017/s1355838201010214 · Cited by 132
Eukaryotic mRNA Processing
Krainer, A. R. (1997) · doi:10.1093/oso/9780199634187.001.0001 · Cited by 131
The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute
Kaminski, A., & Jackson, R. J. (1998) · RNA · doi:10.1017/s1355838298971898 · Cited by 131
Regulation of Alternative Splicing by the ATP-Dependent DEAD-Box RNA Helicase p72
Hönig, A., Auboeuf, D., Parker, M. M., O’Malley, B. W., & Berget, S. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5698-5707.2002 · Cited by 130
Functional Recognition of the 5′ Splice Site by U4/U6.U5 tri-snRNP Defines a Novel ATP-Dependent Step in Early Spliceosome Assembly
Maroney, P. A., ROMFO, C. M., & Nilsen, T. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00032-0 · Cited by 127
SR proteins and hnRNP H regulate the splicing of the HIV‐1 tev‐specific exon 6D
Caputi, M., & Zahler, A. M. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.845 · Cited by 127
Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selectionPreprint
Puig, Ó., GOTTSCHALK, A. R., Fabrizio, P., & Séraphin, B. (1999) · Genes & Development · doi:10.1101/gad.13.5.569 · Cited by 127
Retroviruses as Model Systems for the Study of Nuclear RNA Export Pathways
Cullen, B. R. (1998) · Virology · doi:10.1006/viro.1998.9331 · Cited by 126
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
Kadener, S., Fededa, J. P., Rosbash, M., & Kornblihtt, A. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122246099 · Cited by 126
The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer‐dependent splicing of the β‐tropomyosin alternative exon 6A
Gallego, M. E., Gattoni, R., Stévenin, J., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1772 · Cited by 126
Generation of Alternative Ultrabithorax Isoforms and Stepwise Removal of a Large Intron by Resplicing at Exon–Exon Junctions
Hatton, A. R., Subramaniam, V., & Lopez, A. J. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80293-2 · Cited by 123
Heterogeneous Nuclear Ribonucleoprotein (hnRNP) K Is a Component of an Intronic Splicing Enhancer Complex That Activates the Splicing of the Alternative Exon 6A from Chicken β-Tropomyosin Pre-mRNA
Expert-Bezançon, A., Caer, J. P. L., & Marie, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201083200 · Cited by 122
Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI.Preprint
Siebel, C. W., Kanaar, R., & Rio, D. C. (1994) · Genes & Development · doi:10.1101/gad.8.14.1713 · Cited by 122
Alternatively spliced forms of cyclin D1 modulate entry into the cell cycle in an inverse manner
Sawa, H., Ohshima, T. A., Ukita, H., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1201691 · Cited by 121
Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing.Preprint
Siebel, C. W., Admon, A., & Rio, D. C. (1995) · Genes & Development · doi:10.1101/gad.9.3.269 · Cited by 120
Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing
Brudno, M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.2338 · Cited by 119
Protein Phosphorylation Plays an Essential Role in the Regulation of Alternative Splicing and Sex Determination in Drosophila
Du, C., McGuffin, M. E., Dauwalder, B., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80289-0 · Cited by 118
Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus
Robertson, K. D., & Jones, P. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202737 · Cited by 115
Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB
ZHANG, L., Liu, W., & Grabowski, P. J. (1999) · RNA · doi:10.1017/s1355838299981530 · Cited by 115
Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs
Xu, R.-M., Jokhan, L., Cheng, X., et al. (1997) · Structure · doi:10.1016/s0969-2126(97)00211-6 · Cited by 113
The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA.Preprint
Fu, X., Katz, R. A., Skalka, A. M., et al. (1991) · Genes & Development · doi:10.1101/gad.5.2.211 · Cited by 113
Avian retroviral RNA element promotes unspliced RNA accumulation in the cytoplasm
Ogert, R. A., Lee, L. H., & BEEMON, K. L. (1996) · Journal of Virology · doi:10.1128/jvi.70.6.3834-3843.1996 · Cited by 113
Two Closely Related Human Nuclear Export Factors Utilize Entirely Distinct Export Pathways
Yang, J., Bogerd, H. P., Wang, P. J., Page, D. C., & Cullen, B. R. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00303-3 · Cited by 112
Conserved Intron Elements Repress Splicing of a Neuron-Specific c-src Exon In Vitro
Chan, R. C., & Black, D. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2970 · Cited by 111
Self-citation
The SR protein B52/SRp55 is essential for Drosophila development.
Ring, H. Z., & Lis, J. T. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.11.7499 · Cited by 111
Regulation of pre-mRNA splicing in metazoa
Wang, J., & Manley, J. L. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80130-x · Cited by 110
X-chromosome-counting mechanisms that determine nematode sex
Nicoll, M., Akerib, C. C., & Meyer, B. J. (1997) · Nature · doi:10.1038/40669 · Cited by 108
Alternative Splicing of the Fibronectin EIIIB Exon Depends on Specific TGCATG Repeats
Lim, L. P., & Sharp, P. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3900 · Cited by 107
Regulation of Drosophila P element transposition
Rio, D. C. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90309-e · Cited by 105
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins
Chandler, S. D., Mayeda, A., Yeakley, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3596 · Cited by 105
A Human Papillomavirus E2 Transcriptional Activator
Lai, M., Teh, B.-H., & Tarn, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11832 · Cited by 104
Control ofDrosophila Sex-lethalpre-mRNA splicing by its own female-specific product
Sakamoto, H., Inoue, K., Higuchi, I., Ono, Y., & Shimura, Y. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.21.5533 · Cited by 102
Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicingPreprint
Wang, J., Xiao, S.-H., & Manley, J. L. (1998) · Genes & Development · doi:10.1101/gad.12.14.2222 · Cited by 101
Smooth muscle‐specific switching of alpha‐tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon.
Gooding, C., Roberts, G. C., Moreau, G., Nadal‐Ginard, B., & Smith, C. W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06697.x · Cited by 100
Heterogeneous Ribonucleoprotein A1 Is Part of an Exon-specific Splice-silencing Complex Controlled by Oncogenic Signaling Pathways
Matter, N., Marx, M., Weg‐Remers, S., Ponta, H., Herrlich, P. A., & König, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004692200 · Cited by 100
Serine-Arginine (SR) Protein-like Factors That Antagonize Authentic SR Proteins and Regulate Alternative Splicing
Cowper, A. E., Cáceres, J. F., Mayeda, A., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103967200 · Cited by 99
The STAR/GSG Family Protein rSLM-2 Regulates the Selection of Alternative Splice Sites
Stoß, O., Olbrich, M., Hartmann, A. M., König, H., Memmott, J. E., Andreadis, A., & Stamm, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006851200 · Cited by 99
The SRm160/300 splicing coactivator is required for exon-enhancer function
Eldridge, A. G., Li, Y., Sharp, P. A., & Blencowe, B. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6125 · Cited by 98
Dopamine and Glutamate Induce Distinct Striatal Splice Forms of Ania-6, an RNA Polymerase II-Associated Cyclin
Berke, J. D., Sgambato, V., Zhu, P.-P., Lavoie, B. A., Vincent, M., Krause, M., & Hyman, S. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00465-2 · Cited by 97
Muscle-Specific Splicing Enhancers Regulate Inclusion of the Cardiac Troponin T Alternative Exon in Embryonic Skeletal Muscle
Ryan, K. J., & Cooper, T. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4014 · Cited by 97
The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNAPreprint
Lisbin, M. J., Qiu, J., & White, K. (2001) · Genes & Development · doi:10.1101/gad.903101 · Cited by 97
Activity‐dependent regulation of alternative splicing patterns in the rat brain
Daoud, R., Berzaghi, M. D. P., Siedler, F., Hübener, M., & Stamm, S. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00486.x · Cited by 96
Region-specific alternative splicing in the nervous system: Implications for regulation by the RNA-binding protein NAPOR
Zhang, W., Liu, H., Han, K., & Grabowski, P. J. (2002) · RNA · doi:10.1017/s1355838202027036 · Cited by 93
Regulation of Alternative Splicing of Protein Kinase Cβ by Insulin
Chalfant, C. E., Mischak, H., Watson, J. E., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13326 · Cited by 92
The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA.
Gebauer, F., Merendino, L., Hentze, M. W., & Valcárcel, J. (1998) · Europe PMC (PubMed Central) · Cited by 92
Roles for SR Proteins and hnRNP A1 in the Regulation of c -src Exon N1
Rooke, N., Markovtsov, V. V., Çağavi, E., & Black, D. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.6.1874-1884.2003 · Cited by 92
Self-citation
half pint Regulates Alternative Splice Site Selection in Drosophila
Buskirk, C. V., & Schüpbach, T. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00128-4 · Cited by 91
Determination of functional domains in polypyrimidine-tract-binding protein
Oh, Y. L., Hahm, B., Kim, Y. K., Lee, H. K., Lee, J. W., Ok.-K., S. O. N. G., Tsukiyama–Kohara, K., Kohara, M., Nomoto, A., & Jang, S. K. (1998) · Biochemical Journal · doi:10.1042/bj3310169 · Cited by 90
Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein.
Buvoli, M., Cobianchi, F., Bestagno, M., et al. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08230.x · Cited by 89
Ischemia Induces a Translocation of the Splicing Factor tra2-β1 and Changes Alternative Splicing Patterns in the Brain
Daoud, R., Mies, G., Smialowska, A., Oláh, L., Hossmann, K.-A., & Stamm, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05889.2002 · Cited by 89
Splicing in the Inner Ear: a Familiar Tune, but What Are the Instruments?
Black, D. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80444-4 · Cited by 87
Self-citation
Heterogeneous Nuclear Ribonucleoprotein A1 and UP1 Protect Mammalian Telomeric Repeats and Modulate Telomere Replication in Vitro
Dallaire, F., Dupuis, S., Fiset, S., & Chabot, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14509 · Cited by 86
Selection of Novel Exon Recognition Elements from a Pool of Random Sequences
Tian, H., & Kole, R. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6291 · Cited by 84
Conserved Intron Elements Repress Splicing of a Neuron-Specific c- src Exon In Vitro
Chan, R. C., & Black, D. L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6377 · Cited by 83
Self-citation
Conserved stem-loop structures in the HIV-1 RNA region containing the A3 3' splice site and its cis-regulatory element: possible involvement in RNA splicing
Jacquenet, S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.2.464 · Cited by 81
Identification of a Bidirectional Splicing Enhancer: Differential Involvement of SR Proteins in 5′ or 3′ Splice Site Activation
Bourgeois, C. F., Popielarz, M., Hildwein, G., & Stévenin, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7347 · Cited by 81
The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts
Lundquist, E. A., Herman, R. K., Rogalski, T. M., Mullen, G. P., Moerman, D. G., & Shaw, J. E. (1996) · Development · doi:10.1242/dev.122.5.1601 · Cited by 81
The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation.Preprint
Wang, J., & Bell, L. R. (1994) · Genes & Development · doi:10.1101/gad.8.17.2072 · Cited by 80
The Function of Multisite Splicing Enhancers
Hertel, K. J., & Maniatis, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80045-3 · Cited by 80
The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila
Hilfiker, A., Amrein, H., Dübendorfer, A., Schneiter, R., & Nöthiger, R. (1995) · Development · doi:10.1242/dev.121.12.4017 · Cited by 80
A Yeast Intronic Splicing Enhancer and Nam8p Are Required for Mer1p-Activated Splicing
Spingola, M., & Ares, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00033-2 · Cited by 79
Participation of the C-Terminal Domain of RNA Polymerase II in Exon Definition during Pre-mRNA Splicing
Zeng, C., & Berget, S. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8290-8301.2000 · Cited by 78
Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing.Preprint
Gontarek, R. R., McNally, M. T., & BEEMON, K. L. (1993) · Genes & Development · doi:10.1101/gad.7.10.1926 · Cited by 75
Modulation of P-Element Pre-mRNA Splicing by a Direct Interaction between PSI and U1 snRNP 70K Protein
Labourier, E., Adams, M. D., & Rio, D. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00311-2 · Cited by 74
A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA
Hastings, M. L., WILSON, C. M., & Munroe, S. H. (2001) · RNA · doi:10.1017/s1355838201002084 · Cited by 74
The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element.
Xu, R., Teng, J., & Cooper, T. A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3660 · Cited by 74
The Neuron-Enriched Splicing Pattern of Drosophila erect wing Is Dependent on the Presence of ELAV Protein
Koushika, S. P., Soller, M., & White, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1836-1845.2000 · Cited by 73
Intronic sequences and 3' splice sites control Rous sarcoma virus RNA splicing
McNally, M. T., & BEEMON, K. L. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.6-11.1992 · Cited by 72
SRp30c Is a Repressor of 3′ Splice Site Utilization
Simard, M. J., & Chabot, B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4001-4010.2002 · Cited by 71
Combinatorial control of a neuron-specific exon
Modafferi, E. F., & Black, D. L. (1999) · RNA · doi:10.1017/s1355838299990155 · Cited by 71
Self-citation
The intranuclear site of excision of each intron in Balbiani ring 3 pre-mRNA is influenced by the time remaining to transcription termination and different excision efficiencies for the various introns.
Wetterberg, I., Baurén, G., & Wieslander, L. (1996) · PubMed · Cited by 68
U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in Caenorhabditis elegans
Zorio, D. A. R., & Blumenthal, T. (1999) · RNA · doi:10.1017/s1355838299982225 · Cited by 68
The alternative splicing factor PSI regulates P-element third intron splicing in vivo.Preprint
Adams, M. D., Tarng, R. S., & Rio, D. C. (1997) · Genes & Development · doi:10.1101/gad.11.1.129 · Cited by 67
Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain
Lilleväli, K., Kulla, A., & Örd, T. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00566-9 · Cited by 66
Single stranded RNA binding proteins
Antson, A. A. (2000) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)00054-8 · Cited by 64
Change in plasma membrane Ca2+-ATPase splice-variant expression in response to a rise in intracellular Ca2+
Zacharias, D. A., & Strehler, E. E. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70788-4 · Cited by 63
Developmental regulation of SR protein phosphorylation and activityPreprint
Sanford, J. R., & Bruzik, J. P. (1999) · Genes & Development · doi:10.1101/gad.13.12.1513 · Cited by 63
Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor
Wang, A., Cohen, D. S., Palmer, E., & Sheppard, D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98447-4 · Cited by 62
Alternative splicing, muscle contraction and intraspecific variation: associations between troponin T transcripts, Ca2+ sensitivity and the force and power output of dragonfly flight muscles during oscillatory contraction
Marden, J. H., Fitzhugh, G. H., Girgenrath, M., et al. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.20.3457 · Cited by 62
Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal
Crowder, S. M., Kanaar, R., Rio, D. C., & Alber, T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4892 · Cited by 61
SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain
Tange, T. Ø., & Kjems, J. K. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4971 · Cited by 61
The genetic analysis of snf: a Drosophila sex determination gene required for activation of Sex-lethal in both the germline and the soma.
Salz, H. K. (1992) · Genetics · doi:10.1093/genetics/130.3.547 · Cited by 61
Elements regulating an alternatively spliced exon of the rat fibronectin gene.
Huh, G. S., & Hynes, R. O. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5301 · Cited by 61
The Spliceosome
Nilsen, T. W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00430-6 · Cited by 59
RNA Processing: Splicing and the Cytoplasmic Localisation of mRNA
Palacios, I. M. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00671-6 · Cited by 59
Coupled in vitro synthesis and splicing of RNA polymerase II transcripts
Ghosh, S., & García-Blanco, M. A. (2000) · RNA · doi:10.1017/s1355838200992537 · Cited by 59
A Cellular Protein, hnRNP H, Binds to the Negative Regulator of Splicing Element from Rous Sarcoma Virus
Fogel, B. L., & McNally, M. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005000200 · Cited by 59
Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro.
Bennett, M., Piñol-Roma, S., Staknis, D., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.7.3165 · Cited by 59
Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila developmentPreprint
Labourier, E., Bourbon, H.-M., Gallouzi, I., et al. (1999) · Genes & Development · doi:10.1101/gad.13.6.740 · Cited by 58
Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein
Liu, H., Zhang, W., Reed, R., Liu, W., & Grabowski, P. J. (2002) · RNA · doi:10.1017/s1355838202015029 · Cited by 58
RNA structural patterns and splicing: molecular basis for an RNA-based enhancer.
Libri, D., Stutz, F., McCarthy, T., & Rosbash, M. (1995) · Europe PMC (PubMed Central) · Cited by 57
Control of alternative pre-mRNA splicing by distributed pentameric repeats
Hedjran, F., Yeakley, J. M., Huh, G. S., Hynes, R. O., & Rosenfeld, M. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12343 · Cited by 55
Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA.
Shifrin, V. I., & Neel, B. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74402-0 · Cited by 54
A Human RNA Polymerase II-containing Complex Associated with Factors Necessary for Spliceosome Assembly
Robert, F., Blanchette, M., Maes, O. C., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110516200 · Cited by 54
Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivoPreprint
Rudner, D. Z., Breger, K. S., & Rio, D. C. (1998) · Genes & Development · doi:10.1101/gad.12.7.1010 · Cited by 54
Mammalian pre-mRNA splicing factors
Cáceres, J. F., & Krainer, A. R. (1997) · doi:10.1093/oso/9780199634187.003.0006 · Cited by 53
Muscle-Specific Splicing of a Heterologous Exon Mediated by a Single Muscle-Specific Splicing Enhancer from the Cardiac Troponin T Gene
Cooper, T. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4519 · Cited by 53
Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to depend largely on controlling the use of the male exon 5' splice site.
Horabin, J. I., & Schedl, P. D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7734 · Cited by 50
Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle
Fischer, U., Pollard, V. W., Lührmann, R., Teufel, M., Michael, M. W., Dreyfuss, G., & Malim, M. H. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.21.4128 · Cited by 49
Regulation of transcription factor localization: fine-tuning of gene expression
Vandromme, M. (1996) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(96)80867-x · Cited by 49
U1 Small Nuclear Ribonucleoprotein and Splicing Inhibition by the Rous Sarcoma Virus Negative Regulator of Splicing Element
McNally, L. M., & McNally, M. T. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.2385-2393.1999 · Cited by 47
An RNA Splicing Enhancer-Like Sequence Is a Component of a Splicing Inhibitor Element from Rous Sarcoma Virus
McNally, L. M., & McNally, M. T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3103 · Cited by 47
Mechanisms of Transcriptional Timing in Drosophila
Thummel, C. S. (1992) · Science · doi:10.1126/science.1553530 · Cited by 45
Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein
Choi, D., Ito, T., Tsukahara, F., et al. (1999) · Gene · doi:10.1016/s0378-1119(99)00312-1 · Cited by 45
Distinct Factor Requirements for Exonic Splicing Enhancer Function and Binding of U2AF to the Polypyrimidine Tract
Li, Y., & Blencowe, B. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35074 · Cited by 45
Novel Exonic Elements That Modulate Splicing of the Human Fibronectin EDA Exon
Staffa, A., Acheson, N. H., & Cochrane, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.33394 · Cited by 42
Cooperation of pre-mRNA sequence elements in splice site selection.
Dominski, Z., & Kole, R. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.2108 · Cited by 40
Exonic splicing enhancers contribute to the use of both 3′ and 5′ splice site usage of rat β-tropomyosin pre-mRNA
Selvakumar, M., & Helfman, D. M. (1999) · RNA · doi:10.1017/s1355838299981050 · Cited by 39
The gene fl(2)d is needed for the sex-specific splicing of transformer pre-mRNA but not for double-sex pre-mRNA in Drosophila melanogaster
Granadino, B., Penalva, L. O. F., & Sánchez, L. (1996) · Molecular and General Genetics MGG · doi:10.1007/s004380050292 · Cited by 37
Selective Regulation of Agrin mRNA Induction and Alternative Splicing in PC12 Cells by Ras-dependent Actions of Nerve Growth Factor
Smith, M. A., Fanger, G. R., O’Connor, L. T., Bridle, P., & Maue, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15675 · Cited by 37
The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processingPreprint
Labourier, E., Blanchette, M., Feiger, J. W., et al. (2002) · Genes & Development · doi:10.1101/gad.948602 · Cited by 37
Structural and functional analysis of the avian leukemia virus constitutive transport element
Yang, J., & Cullen, B. R. (1999) · RNA · doi:10.1017/s1355838299991616 · Cited by 37
The role of overlapping U1 and U11 5′ splice site sequences in a negative regulator of splicing
HIBBERT, C. S., Gontarek, R. R., & BEEMON, K. L. (1999) · RNA · doi:10.1017/s1355838299981347 · Cited by 37
Modulation of msl-2 5′ splice site recognition by Sex-lethal
Förch, P., Merendino, L., Martínez, C., et al. (2001) · RNA · doi:10.1017/s1355838201010536 · Cited by 36
Positive and Negative Modulation of Human Immunodeficiency Virus Type 1 Rev Function by cis and trans Regulators of Viral RNA Splicing
Pongoski, J., Asai, K., & Cochrane, A. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.5108-5120.2002 · Cited by 36
Distinct mechanisms of splicing regulation in vivo by the Drosophila protein Sex-lethal
Granadino, B., Penalva, L. O. F., Green, M. R., Valcárcel, J., & Sánchez, L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7343 · Cited by 35
Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements.
Hertel, K. J., Lynch, K. W., Hsiao, E. C., Liu, E. H., & Maniatis, T. (1996) · PubMed Central · Cited by 35
Both Loss-of-Function and Gain-of-Function Mutations in snf Define a Role for snRNP Proteins in Regulating Sex-lethal Pre-mRNA Splicing in Drosophila Development
Salz, H. K., & Flickinger, T. W. (1996) · Genetics · doi:10.1093/genetics/144.1.95 · Cited by 34
Regulation of alternative pre-mRNA splicing
Woodley, L. (2002) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/1.3.266 · Cited by 33
Alternative Splicing and the Control of Flowering Time
Eckardt, N. A. (2002) · The Plant Cell · doi:10.1105/tpc.140410 · Cited by 32
Retroviral RNA elements integrate components of post-transcriptional gene expression
Boris‐Lawrie, K., Roberts, T. M., & Hull, S. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01360-1 · Cited by 32
Regulation of SR protein localization during development
Sanford, J. R., & Bruzik, J. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181340498 · Cited by 31
Strong RNA Splicing Enhancers Identified by a Modified Method of Cycled Selection Interact with SR Protein
Tian, H., & Kole, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102957200 · Cited by 31
Sex, AGility, and the Regulation of Alternative Splicing
Graveley, B. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00750-x · Cited by 30
An Intronic Downstream Enhancer Promotes 3′ Splice Site Usage of a Neural Cell-specific Exon
Guo, N.-H., & Kawamoto, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005597200 · Cited by 30
Analysis of autoregulation at the level of pre-mRNA splicing of the suppressor-of-white-apricot gene in Drosophila.
Zachar, Z., Chou, T.-B., Kramer, J., et al. (1994) · Genetics · doi:10.1093/genetics/137.1.139 · Cited by 28
Alternative Splicing of a Neural-Specific Src mRNA (Src+) Is a Rapid and Protein Synthesis-Independent Response to Neural Induction in Xenopus laevis
Collett, J. W., & Steele, R. E. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1206 · Cited by 28
Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins
Barnard, D. C., Li, J., Peng, R., et al. (2002) · RNA · doi:10.1017/s1355838202029928 · Cited by 28
Analysis of the functional specificity of RS domains in vivo
Dauwalder, B., & Mattox, W. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.6049 · Cited by 28
“Cross-Talk” between Cell Division Cycle and Development in Plants
Boniotti, M. B., & Griffith, M. E. (2002) · The Plant Cell · doi:10.1105/tpc.000000 · Cited by 28
An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection
Côté, J. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.12.2529 · Cited by 27
Induction of Long‐Term Potentiation In Vivo Regulates Alternate Splicing to Alter Syntaxin 3 Isoform Expression in Rat Dentate Gyrus
Rodger, J., Davis, S., Laroche, S., Mallet, J. J., & Hicks, A. A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71020666.x · Cited by 26
Localization of Serine Kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), Specific for the SR Family of Splicing Factors in Mouse and Human Chromosomes
Wang, H.-Y., Arden, K. C., Bermingham, J. R., et al. (1999) · Genomics · doi:10.1006/geno.1999.5770 · Cited by 25
Switch in 3′ Splice Site Recognition between Exon Definition and Splicing Catalysis Is Important for Sex-lethal Autoregulation
Penalva, L. O. F., Lallena, M. J., & Valcárcel, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.1986-1996.2001 · Cited by 25
Ca2+ and pH modulate alternative splicing of exon 5 in NMDA receptor subunit 1
Vallano, M. L., Beaman‐Hall, C. M., & Benmansour, S. (1999) · Neuroreport · doi:10.1097/00001756-199911260-00036 · Cited by 24
Pararetro- and retrovirus RNA: splicing and the control of nuclear export
Kiss-László, Z., & Höhn, T. (1996) · Trends in Microbiology · doi:10.1016/s0966-842x(97)82909-5 · Cited by 21
Splicing of the drosophila Sex-lethal early transcripts involves exon skipping that is independent of Sex-lethal protein.
Horabin, J. I., & Schedl, P. D. (1996) · PubMed · Cited by 19
A Parallel Spliceosome
Nilsen, T. W. (1996) · Science · doi:10.1126/science.273.5283.1813 · Cited by 19
Chapter 9 Alternative mRNA splicing in the nervous system
Burke, J. F., Bright, K. E., Kellett, E., et al. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61168-1 · Cited by 17
RNA splicing: More clues from spinal muscular atrophy
Matera, A. G. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80083-9 · Cited by 17
Role of the Constitutive Splicing Factors U2AF65 and SAP49 in Suboptimal RNA Splicing of Novel Retroviral Mutants
Bouck, J. B., Fu, X., Skalka, A. M., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15169 · Cited by 16
In vitro selection of exonic splicing enhancer sequences: identification of novel CD44 enhancers
Woerfel, G. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.15.3204 · Cited by 16
The Sex-lethal Early Splicing Pattern Uses a Default Mechanism Dependent on the Alternative 5′ Splice Sites
Zhu, C., Urano, J., & Bell, L. R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1674 · Cited by 15
Novel functions for `nuclear factors' in the cytoplasm: theSex-lethalparadigm
Gebauer, F., Merendino, L., Hentze, M. W., et al. (1997) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1997.0181 · Cited by 14
Doublesex in the Middle
Burtis, K. C. (2002) · Science · doi:10.1126/science.1074492 · Cited by 13
Alternative splicing in parallel
Grabowski, P. J. (2002) · Nature Biotechnology · doi:10.1038/nbt0402-346 · Cited by 8
Presence of Exon Splicing Silencers within Human Immunodeficiency Virus Type 1 tat Exon 2 and tat-rev Exon 3: Evidence for Inhibition Mediated by Cellular Factors
Amendt, B. A., Si, Z. H., & Stoltzfus, C. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6480 · Cited by 8
Two domains and one RNA: a molecular threesome.
Hughson, F. M., & Schedl, P. D. (1999) · Nature Structural Biology · doi:10.1038/9264 · Cited by 5
Untitled work
Greber (1999) · doi:10.1002/(sici)1522-2683(19990101)20:4/5

Research works printed but not linked: 14

Burge CB, Tuschl T, Sharp PA. 1999. In The RNA World , ed. RF Gesteland, TR Cech, JF Atkins, pp. 525–60. Cold Spring Harbor, NY: Cold Spring Harb. Lab. 2nd ed.
Black DL, 1995, RNA, 1, 763
Libri D, 1995, RNA, 1, 425
Gebauer F, 1998, RNA, 4, 142
Horabin JI, 1996, RNA, 2, 1
Hertel KJ, 1996, RNA, 2, 969
Roscigno RF, 1995, RNA, 1, 692
Wang Z, 1995, RNA, 1, 21
Hanamura A, 1998, RNA, 4, 430
10.1128/MCB.14.6.3960 · DOI
Pérez I, 1997, RNA, 3, 764
Gooding C, 1998, RNA, 4, 85
Ashiya M, 1997, RNA, 3, 996
Wetterberg I, 1996, RNA, 2, 641

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Authors: Black, D. L.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Black, Douglas L.
ORCID: Black, Douglas L.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2003-06
Volume: 72
Issue: 1
Pages: 291-336
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.biochem.72.121801.161720
OpenAlex: W2109936378
Cited by: 2,704
References: 377
Citations by year: 2026: 69 · 2025: 76 · 2024: 92 · 2023: 83 · 2022: 79 · 2021: 91 · 2020: 90 · 2019: 103 · 2018: 103 · 2017: 99 · 2016: 108 · 2015: 130 · 2014: 121 · 2013: 153 · 2012: 139
FWCI: 10.39
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: alternative splicing, splicing regulation, tissue-specific splicing, protein diversity, splicing regulators, genetic control
MeSH terms: Animals, Drosophila, Exons, Introns, Organ Specificity, RNA Precursors, RNA, Messenger, Transcription Factors, RNA-Binding Proteins, Spliceosomes, Alternative Splicing, Sex Determination Processes

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Mechanisms of Alternative Pre-Messenger RNA Splicing

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