Mechanisms of Alternative Pre-Messenger RNA Splicing

Identification of Novel Genes Coding for Small Expressed RNAs

Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 3,345

Listening to silence and understanding nonsense: exonic mutations that affect splicing

Cartegni, L., Chew, S. L., & Krainer, A. R. (2002) · Nature Reviews Genetics · doi:10.1038/nrg775 · Cited by 2,209

microRNAs

Ambros, V. (2001) · Cell · doi:10.1016/s0092-8674(01)00616-x · Cited by 1,705

A genomic view of alternative splicing

Modrek, B., & Lee, C. J. (2002) · Nature Genetics · doi:10.1038/ng0102-13 · Cited by 1,320

RNA-Binding Proteins Tia-1 and Tiar Link the Phosphorylation of Eif-2α to the Assembly of Mammalian Stress Granules

Kedersha, N., Gupta, M., Li, W., Miller, I. J., & Anderson, P. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.7.1431 · Cited by 1,260

Alternative splicing: increasing diversity in the proteomic world

Graveley, B. R. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(00)02176-4 · Cited by 1,228

An extensive network of coupling among gene expression machines

Maniatis, T., & Reed, R. (2002) · Nature · doi:10.1038/416499a · Cited by 1,148

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

Staley, J. P., & Guthrie, C. (1998) · Cell · doi:10.1016/s0092-8674(00)80925-3 · Cited by 1,133

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109

Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity

Schmucker, D., Clemens, J. C., Shu, H., Worby, C. A., Xiao, J. Y., Muda, M., Dixon, J. E., & Zipursky, S. L. (2000) · Cell · doi:10.1016/s0092-8674(00)80878-8 · Cited by 1,105

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., & Dreyfuss, G. (2002) · Genes & Development · doi:10.1101/gad.974702 · Cited by 1,105

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcriptionPreprint

Komarnitsky, P. B., Cho, E., & Buratowski, S. (2000) · Genes & Development · doi:10.1101/gad.824700 · Cited by 1,098

Exon Recognition in Vertebrate Splicing

Berget, S. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2411 · Cited by 1,090

Integrating mRNA Processing with Transcription

Proudfoot, N. J., Furger, A., & Dye, M. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00617-7 · Cited by 1,084

Sorting out the complexity of SR protein functions

Graveley, B. R. (2000) · RNA · doi:10.1017/s1355838200000960 · Cited by 1,080

Predictive Identification of Exonic Splicing Enhancers in Human Genes

Fairbrother, W. G., Yeh, R., Sharp, P. A., & Burge, C. B. (2002) · Science · doi:10.1126/science.1073774 · Cited by 1,020

The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions

Hir, H. L., Izaurralde, E., Maquat, L. E., & Moore, M. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6860 · Cited by 970

Large-Scale Proteomic Analysis of the Human SpliceosomePreprint

Rappsilber, J., Ryder, U., Lamond, A. I., & Mann, M. (2002) · Genome Research · doi:10.1101/gr.473902 · Cited by 945

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

McCracken, S. A., Fong, N., Yankulov, K., Ballantyne, S. M., Pan, G., Greenblatt, J., Patterson, S. D., Wickens, M., & Bentley, D. L. (1997) · Nature · doi:10.1038/385357a0 · Cited by 925

Alternative pre-mRNA splicing: the logic of combinatorial control

Smith, C. W. J., & Valcárcel, J. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01604-2 · Cited by 901

Comprehensive proteomic analysis of the human spliceosome

Zhou, Z., Licklider, L. J., Gygi, S. P., & Reed, R. (2002) · Nature · doi:10.1038/nature01031 · Cited by 884

AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

Chen, C.-Y., Gherzi, R., Ong, S.-E., Chan, E. L., Raijmakers, R., Pruijn, G. J. M., Stoecklin, G., Moroni, C., Mann, M., & Karin, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00578-5 · Cited by 865

The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense‐mediated mRNA decay

Hir, H. L., Gatfield, D., Izaurralde, E., & Moore, M. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4987 · Cited by 842

hnRNP complexes: composition, structure, and function

Krecic, A. M., & Swanson, M. S. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80051-9 · Cited by 813

SR proteins: a conserved family of pre-mRNA splicing factors.Preprint

Zahler, A. M., Lane, W. S., Stolk, J. A., & Roth, M. (1992) · Genes & Development · doi:10.1101/gad.6.5.837 · Cited by 798

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

Savkur, R. S., Philips, A. V., & Cooper, T. A. (2001) · Nature Genetics · doi:10.1038/ng704 · Cited by 795

Mechanism and regulation of mRNA polyadenylation

Colgan, D. F., & Manley, J. L. (1997) · Genes & Development · doi:10.1101/gad.11.21.2755 · Cited by 784

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

Wu, J. Y., & Maniatis, T. (1993) · Cell · doi:10.1016/0092-8674(93)90316-i · Cited by 755

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

Mayeda, A., & Krainer, A. R. (1992) · Cell · doi:10.1016/0092-8674(92)90477-t · Cited by 735

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1

Cartegni, L., & Krainer, A. R. (2002) · Nature Genetics · doi:10.1038/ng854 · Cited by 730

THE HIV-1 REV PROTEIN

Pollard, V. W., & Malim, M. H. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.491 · Cited by 715

Exon definition may facilitate splice site selection in RNAs with multiple exons.

Robberson, B. L., Cote, G. J., & Berget, S. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.1.84 · Cited by 710

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

Blencowe, B. J. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01549-8 · Cited by 687

SR proteins and splicing control.Preprint

Manley, J. L., & Tacke, R. (1996) · Genes & Development · doi:10.1101/gad.10.13.1569 · Cited by 673

Alternative splicing: multiple control mechanisms and involvement in human disease

Cáceres, J. F., & Kornblihtt, A. R. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(01)02626-9 · Cited by 666

ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation

Lopez, A. J. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.279 · Cited by 641

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

Kohtz, J. D., Jamison, S. F., Will, C. L., et al. (1994) · Nature · doi:10.1038/368119a0 · Cited by 626

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

Cáceres, J. F., Stamm, S., Helfman, D. M., & Krainer, A. R. (1994) · Science · doi:10.1126/science.8085156 · Cited by 619

Loss of the Muscle-Specific Chloride Channel in Type 1 Myotonic Dystrophy Due to Misregulated Alternative Splicing

Charlet‐Berguerand, N., Savkur, R. S., Singh, G., Philips, A. V., Grice, E. A., & Cooper, T. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00572-5 · Cited by 619

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

Colwill, K., Pawson, T. J., Andrews, B., Prasad, J., Manley, J. L., Bell, J. C., & Duncan, P. I. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00357.x · Cited by 583

RNA polymerase II and the integration of nuclear eventsPreprint

Hirose, Y., & Manley, J. L. (2000) · Genes & Development · doi:10.1101/gad.14.12.1415 · Cited by 577

Protein Diversity from Alternative Splicing

Black, D. L. (2000) · Cell · doi:10.1016/s0092-8674(00)00128-8 · Cited by 565

TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus

Grüter, P., Tabernero, C., von Kobbe, C., Schmitt, C., Saavedra, C., Bachi, A., Wilm, M., Felber, B. K., & Izaurralde, E. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80065-9 · Cited by 560

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

Gui, J., Lane, W. S., & Fu, X. (1994) · Nature · doi:10.1038/369678a0 · Cited by 543

Distinct Binding Specificities and Functions of Higher Eukaryotic Polypyrimidine Tract-Binding Proteins

Singh, R., Valcárcel, J., & Green, M. R. (1995) · Science · doi:10.1126/science.7761834 · Cited by 539

Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene

Ryner, L. C., Goodwin, S. F., Castrillón, D. H., Anand, A., Villella, A., Baker, B. S., Hall, J. C., Taylor, B. J., & Wasserman, S. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81802-4 · Cited by 524

Identification of functional exonic splicing enhancer motifs recognized by individual SR proteinsPreprint

Liu, H., Zhang, M. Q., & Krainer, A. R. (1998) · Genes & Development · doi:10.1101/gad.12.13.1998 · Cited by 513

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

Larsson, S., Charlieu, J.-P., Miyagawa, K., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90392-5 · Cited by 510

RNA binding specificity of hnRNP A1: significance of hnRNP A1 high‐affinity binding sites in pre‐mRNA splicing.

Burd, C. G., & Dreyfuss, G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06369.x · Cited by 488

Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex

Neubauer, G., King, A., Rappsilber, J., Calvio, C., Watson, M. A., Ajuh, P., Sleeman, J., Lamond, A. I., & Mann, M. (1998) · Nature Genetics · doi:10.1038/1700 · Cited by 478

Sex in flies: the splice of life

Baker, B. S. (1989) · Nature · doi:10.1038/340521a0 · Cited by 468

Identification of a (CUG)n Triplet Repeat RNA-Binding Protein and Its Expression in Myotonic Dystrophy

Timchenko, L., Miller, J. W., Timchenko, N. A., DeVore, D. R., Datar, K. V., Lin, L., Roberts, R., Caskey, C. T., & Swanson, M. S. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.22.4407 · Cited by 465

The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing

Ladd, A. N., Charlet‐Berguerand, N., & Cooper, T. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1285-1296.2001 · Cited by 464

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila developmentPreprint

Chen, G., Fernandez, J., Mische, S. M., & Courey, A. J. (1999) · Genes & Development · doi:10.1101/gad.13.17.2218 · Cited by 444

Experimental annotation of the human genome using microarray technology

Shoemaker, D. D., Schadt, E. E., Armour, C. D., He, Y. D., Garrett-Engele, P. W., MCDONAGH, P. D., Loerch, P., Leonardson, A. S., Lum, P. Y., Cavet, G., et al. (2001) · Nature · doi:10.1038/35057141 · Cited by 440

Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability

Jensen, K. B., Dredge, B. K., Stefani, G., Zhong, R., Buckanovich, R. J., Okano, H. J., Yang, Y. Y. L., & Darnell, R. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)80900-9 · Cited by 426

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

Clark, T. A., Sugnet, C. W., & Ares, M. (2002) · Science · doi:10.1126/science.1069415 · Cited by 411

Exon Identity Established through Differential Antagonism between Exonic Splicing Silencer-Bound hnRNP A1 and Enhancer-Bound SR Proteins

Zhu, J., Mayeda, A., & Krainer, A. R. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00409-9 · Cited by 409

Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

Luo, M., Zhou, Z., Magni, K., Christoforides, C., Rappsilber, J., Mann, M., & Reed, R. (2001) · Nature · doi:10.1038/35098106 · Cited by 403

A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

Reed, R., & Hurt, E. (2002) · Cell · doi:10.1016/s0092-8674(02)00627-x · Cited by 400

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.Preprint

Xiao, S.-H., & Manley, J. L. (1997) · Genes & Development · doi:10.1101/gad.11.3.334 · Cited by 397

Direct Coupling of Transcription and mRNA Processing through the Thermogenic Coactivator PGC-1

Monsalve, M., Wu, Z., Adelmant, G., Puigserver, P., Fan, M., & Spiegelman, B. M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00031-9 · Cited by 395

Splicing is required for rapid and efficient mRNA export in metazoans

Luo, M., & Reed, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14937 · Cited by 379

Polypyrimidine Tract Binding Protein Antagonizes Exon Definition

Wagner, E. J., & García-Blanco, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3281-3288.2001 · Cited by 376

The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.

Tacke, R., & Manley, J. L. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07360.x · Cited by 373

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein

Handa, N., Nureki, O., Kurimoto, K., Kim, I., Sakamoto, H., Shimura, Y., Muto, Y., & Yokoyama, S. (1999) · Nature · doi:10.1038/19242 · Cited by 372

Allosteric Cascade of Spliceosome Activation

Brow, D. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.043002.091635 · Cited by 372

Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript

Inoue, K., Hoshijima, K., Sakamoto, H., et al. (1990) · Nature · doi:10.1038/344461a0 · Cited by 352

Structure, function and evolution of sex-determining systems in Dipteran insects

Schütt, C., & Nöthiger, R. (2000) · Development · doi:10.1242/dev.127.4.667 · Cited by 352

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.Preprint

García-Blanco, M. A., Jamison, S. F., & Sharp, P. A. (1989) · Genes & Development · doi:10.1101/gad.3.12a.1874 · Cited by 346

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

Tian, M., & Maniatis, T. (1993) · Cell · doi:10.1016/0092-8674(93)90298-5 · Cited by 345

The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation

van Oordt, C. W. M. D. H., Díaz-Meco, M. T., Lozano, J., Krainer, A. R., Moscat, J., & Cáceres, J. F. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.2.307 · Cited by 345

Stimulatory effect of splicing factors on transcriptional elongation

Fong, Y. W., & Zhou, Q. (2001) · Nature · doi:10.1038/414929a · Cited by 341

Differential SMN2 expression associated with SMA severity

Gavrilov, D. K., Shi, X., Das, K., Gilliam, T. C., & Wang, C. H. (1998) · Nature Genetics · doi:10.1038/3030 · Cited by 337

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctionsPreprint

Hir, H. L., Moore, M. J., & Maquat, L. E. (2000) · Genes & Development · doi:10.1101/gad.14.9.1098 · Cited by 337

Alternative RNA splicing in the nervous system

Grabowski, P. J., & Black, D. L. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00007-7 · Cited by 336

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.Preprint

Patton, J. G., Mayer, S. A., Tempst, P., & Nadal‐Ginard, B. (1991) · Genes & Development · doi:10.1101/gad.5.7.1237 · Cited by 334

SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells

Wang, H., Lin, W., Dyck, J. A., Yeakley, J. M., Songyang, Z., Cantley, L. C., & Fu, X. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.4.737 · Cited by 332

A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.Preprint

Min, H., Turck, C. W., Nikolic, J. M., & Black, D. L. (1997) · Genes & Development · doi:10.1101/gad.11.8.1023 · Cited by 330

Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism.

Mermoud, J. E., Cohen, P. T., & Lamond, A. I. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06906.x · Cited by 330

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

Mayeda, A., Munroe, S. H., Cáceres, J. F., & Krainer, A. R. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06883.x · Cited by 329

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

Hanamura, A., Cáceres, J. F., Mayeda, A., Franza, B. R., & Krainer, A. R. (1998) · PubMed Central · Cited by 329

Expression of Msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila

Kelley, R. L., Solovyeva, I., Lyman, L. M., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90007-1 · Cited by 326

RNA Polymerase II Targets Pre-mRNA Splicing Factors to Transcription Sites In Vivo

Misteli, T., & Spector, D. L. (1999) · Molecular Cell · doi:10.1016/s1097-2765(01)80002-2 · Cited by 326

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.Preprint

DUNCAN, R. C., Bazar, L. S., Michelotti, G. A., Tomonaga, T., Krutzsch, H. C., Avigan, M., & Levens, D. (1994) · Genes & Development · doi:10.1101/gad.8.4.465 · Cited by 326

Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNAPreprint

Ding, J., Hayashi, M. K., Zhang, Y., Manche, L., Krainer, A. R., & Xu, R.-M. (1999) · Genes & Development · doi:10.1101/gad.13.9.1102 · Cited by 322

Coupling of Transcription with Alternative Splicing

Cramer, P., Cáceres, J. F., Cazalla, D., Kadener, S., Muro, A. F., Baralle, F. E., & Kornblihtt, A. R. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80372-x · Cited by 319

Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system

Buckanovich, R. J., Posner, J. B., & Darnell, R. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90077-5 · Cited by 318

Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein

Markovtsov, V. V., Nikolic, J. M., Goldman, J. A., Turck, C. W., Chou, M., & Black, D. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7463-7479.2000 · Cited by 311

hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

Ghetti, A., Piñol-Roma, S., Michael, W. M., Morandi, C., & Dreyfuss, G. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.14.3671 · Cited by 311

The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA

Valcárcel, J., Singh, R., Zamore, P. D., & Green, M. R. (1993) · Nature · doi:10.1038/362171a0 · Cited by 309

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.Preprint

Lavigueur, A., Branche, H. L., Kornblihtt, A. R., et al. (1993) · Genes & Development · doi:10.1101/gad.7.12a.2405 · Cited by 307

RNA RECOGNITION BY RNP PROTEINS DURING RNA PROCESSING

Varani, G., & Nagai, K. (1998) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.27.1.407 · Cited by 306

Neuronal pp60 c- src Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

Martinez, R., Mathey-Prévôt, B., Bernards, A., & Baltimore, D. (1987) · Science · doi:10.1126/science.2440106 · Cited by 305

A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

Cooper, T. A., & Ordahl, C. P. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39158-5 · Cited by 304

Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage

Sosnowski, B. A., Belote, J. M., & McKeown, M. (1989) · Cell · doi:10.1016/0092-8674(89)90426-1 · Cited by 292

Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG

Merendino, L., Guth, S., Bilbao, D., Martínez, C., & Valcárcel, J. (1999) · Nature · doi:10.1038/45602 · Cited by 290

The Apoptosis-Promoting Factor TIA-1 Is a Regulator of Alternative Pre-mRNA Splicing

Förch, P., Puig, Ó., Kedersha, N., Martínez, C., Granneman, S., Séraphin, B., Anderson, P., & Valcárcel, J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00107-6 · Cited by 288

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.Preprint

Zuo, P., & Maniatis, T. (1996) · Genes & Development · doi:10.1101/gad.10.11.1356 · Cited by 287

Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase

Branche, H. L., Dupuis, S., Ben‐David, Y., Bani, M. R., Wellinger, R. J., & Chabot, B. (1998) · Nature Genetics · doi:10.1038/575 · Cited by 286

Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

Eperon, L. P., Graham, I. R., Griffiths, A. D., & Eperon, I. C. (1988) · Cell · doi:10.1016/0092-8674(88)90202-4 · Cited by 275

Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP

Stevens, S. W., Ryan, D. E., Ge, H. Y., Moore, R. E., Young, M. K., Lee, T. D., & Abelson, J. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00436-7 · Cited by 273

The Regulation of Splice-Site Selection, and Its Role in Human Disease

Cooper, T. A., & Mattox, W. (1997) · The American Journal of Human Genetics · doi:10.1086/514856 · Cited by 272

Protein functions in pre-mRNA splicing

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The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway

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Identification of a New Class of Exonic Splicing Enhancers by In Vivo Selection

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Oncoprotein TLS Interacts with Serine-Arginine Proteins Involved in RNA Splicing

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Selection of splice sites in pre-mRNAs with short internal exons.

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Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

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The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia

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Arginine/Serine-Rich Domains of SR Proteins Can Function as Activators of Pre-mRNA Splicing

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The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo

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The Polypyrimidine Tract Binding Protein Binds Upstream of Neural Cell-Specific c- src Exon N1 To Repress the Splicing of the Intron Downstream

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Molecular basis of sequence‐specific recognition of pre‐ribosomal RNA by nucleolin

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Mutually exclusive splicing of α-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing

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The Regulation of the Drosophila Gene Reveals a Function for in Translational Control

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The SR Protein SRp38 Represses Splicing in M Phase Cells

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Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors.

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Post-transcriptional regulation: The dawn of PTB

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The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site

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Positive Control of Pre-mRNA Splicing in Vitro

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The Splicing Factor, Prp40, Binds the Phosphorylated Carboxyl-terminal Domain of RNA Polymerase II

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Functional Association of U2 snRNP with the ATP-Independent Spliceosomal Complex E

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Function of quaking in myelination: Regulation of alternative splicing

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Multiple Distinct Splicing Enhancers in the Protein-Coding Sequences of a Constitutively Spliced Pre-mRNA

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Co-transcriptional commitment to alternative splice site selection

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Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.Preprint

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The RNA binding protein YB‐1 binds A/C‐rich exon enhancers and stimulates splicing of the CD44 alternative exon v4

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RNP particles at splice junction sequences on Drosophila chorion transcripts

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Phosphorylation–dephosphorylation differentially affects activities of splicing factor ASF/SF2

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Dynamic Antagonism between ETR-3 and PTB Regulates Cell Type-Specific Alternative Splicing

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Finding splice sites within a wilderness of RNA.

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Regulation of Sex-Specific Selection of fruitless 5′ Splice Sites by transformer and transformer-2

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Regulation of alternative pre‐mRNA splicing by the ERK MAP‐kinase pathway

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A Subset of SR Proteins Activates Splicing of the Cardiac Troponin T Alternative Exon by Direct Interactions with an Exonic Enhancer

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Male‐specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex‐specific regulation and encodes a protein with a RING finger and a metallothionein‐like cysteine cluster.

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The hnRNP A1 protein regulates HIV‐1 tat splicing via a novel intron silencer element

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Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis

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Multiple RRMs Contribute to RNA Binding Specificity and Affinity for Polypyrimidine Tract Binding Protein

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Functional characterization of SR and SR‐related genes in Caenorhabditis elegans

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The splicing factor‐associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation

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Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6·U5] tri‐snRNP

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Regulation of Nuclear Localization during Signaling

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The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export

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SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.

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CD44 Acts Both as a Growth‐ and Invasiveness‐Promoting Molecule and as a Tumor‐Suppressing Cofactor

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The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal

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A predominantly nuclear protein affecting cytoplasmic localization of β-actin mRNA in fibroblasts and neurons

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Splicing Regulation at the Second Catalytic Step by Sex-lethal Involves 3′ Splice Site Recognition by SPF45

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SC35 Plays a Role in T Cell Development and Alternative Splicing of CD45

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Coupling of signal transduction to alternative pre‐mRNA splicing by a composite splice regulator

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A CTD function linking transcription to splicing

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Molecular Genetic Dissection of the Sex-Specific and Vital Functions of the Drosophila melanogaster Sex Determination Gene fruitless

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An Intronic Splicing Silencer Causes Skipping of the IIIb Exon of Fibroblast Growth Factor Receptor 2 through Involvement of Polypyrimidine Tract Binding Protein

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Complementary Sequence-Mediated Exon Circularization

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TAPAS: tools to assist the targeted protein quantification of human alternative splice variants

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