Cited by 2,085Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.

Fat and Beyond: The Diverse Biology of PPARγ

Tontonoz, Peter, Spiegelman, Bruce M.·2008·Annual Review of Biochemistry

DOI 10.1146/annurev.biochem.77.061307.091829

Open this paper in CoChat — free account

Abstract

The nuclear receptor PPARgamma is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of physiological processes. PPARgamma was initially characterized as the master regulator for the development of adipose cells. Ligands for PPARgamma include naturally occurring fatty acids and the thiazolidinedione (TZD) class of antidiabetic drugs. Activation of PPARgamma improves insulin sensitivity in rodents and humans through a combination of metabolic actions, including partitioning of lipid stores and the regulation of metabolic and inflammatory mediators termed adipokines. PPARgamma signaling has also been implicated in the control of cell proliferation, atherosclerosis, macrophage function, and immunity. Here, we review recent advances in our understanding of the diverse biological actions of PPARgamma with an eye toward the expanding therapeutic potential of PPARgamma agonist drugs.

Integrity signals

Registry

Crossref · 10.1146/annurev.biochem.77.061307.091829

Cites

174 of 174 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Self-citation
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Nissen, S. E., & Wolski, K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072761 · Cited by 4,675
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Self-citation
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645

Show all 173 references

Research works printed but not linked: 7

Kletzien R, 1992, Mol. Pharmacol., 42, 558
Harris P, 1994, Mol. Pharmacol., 45, 439
10.1210/me.11.6.779 · DOI
10.1172/JCI200525102 · DOI · Paper page
10.1016/j.expneurol.2006.04.006 · DOI
10.1210/en.142.7.3125 · DOI
Suh N, 1999, Cancer Res., 59, 5671

Sorted by citations

Items 701–800 of 1,001

Cloning and Characterization of Lxr and Srebp1, and Their Potential Roles in Regulation of LC‐PUFA Biosynthesis in Rabbitfish Siganus canaliculatus
Zhang, Q., You, C., Liu, F., Zhu, W., Wang, S., Xie, D., Monroig, Ó., Tocher, D. R., & Li, Y. (2016) · Lipids · doi:10.1007/s11745-016-4176-3 · Cited by 39
Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF- β 1/Smad2-Mediated Endothelial-to-Mesenchymal Transition
Jin, Y., Yuan, Y., Wu, Q., Zhang, N., Fan, D., Che, Y., Wang, Z., Xiao, Y., Wang, S., & Tang, Q. (2017) · PPAR Research · doi:10.1155/2017/2647129 · Cited by 40
Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids
Qi, Y., Sun, L., & Yang, H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.06.016 · Cited by 41
Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
Korman, B. D., Marangoni, R. G., Lord, G., Olefsky, J. M., Tourtellotte, W. G., & Varga, J. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1630-z · Cited by 40
Degradation of selenoprotein S and selenoprotein K through PPARγ-mediated ubiquitination is required for adipocyte differentiation
Lee, J. H., Jang, J. K., Ko, K. Y., Jin, Y., Ham, M., Kang, H., & Kim, I. Y. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0180-x · Cited by 41
A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors
Goto, T. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1559025 · Cited by 39
Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects
Tilekar, K. N., Hess, J. D., Upadhyay, N., Bianco, A. L., Schweipert, M., Laghezza, A., Loiodice, F., Meyer‐Almes, F., Aguilera, R. J., Lavecchia, A., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00491 · Cited by 40
Examination of nuclear receptor expression in osteoblasts reveals rorβ as an important regulator of osteogenesis
Roforth, M. M., Liu, G., Khosla, S., & Monroe, D. G. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1502 · Cited by 40
STAT6 Signaling Mediates PPARγ Activation and Resolution of Acute Sterile Inflammation in Mice
Lee, Y.-J., Kim, B.-M., Ahn, Y.-H., Choi, J. H., Choi, Y.-H., & Kang, J. L. (2021) · Cells · doi:10.3390/cells10030501 · Cited by 39
Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation
Paciello, F., Pisani, A., Rolesi, R., Escarrat, V., Galli, J., Paludetti, G., Grassi, C., Troiani, D., & Fetoni, A. R. (2021) · Antioxidants · doi:10.3390/antiox10081188 · Cited by 40
Current status of systemic sclerosis biomarkers: applications for diagnosis, management and drug development
Castelino, F. V., & Varga, J. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.848792 · Cited by 39
Scutellarin from Scutellaria baicalensis Suppresses Adipogenesis by Upregulating PPARα in 3T3-L1 Cells
Lu, K., Han, M., Ting, H. L., Liu, Z., & Zhang, D. (2013) · Journal of Natural Products · doi:10.1021/np300889y · Cited by 39
Crosstalk between the Androgen Receptor and PPAR Gamma Signaling Pathways in the Prostate
Olokpa, E., Moss, P. E., & Stewart, L. V. (2017) · PPAR Research · doi:10.1155/2017/9456020 · Cited by 37
Pioglitazone Represents an Effective Therapeutic Target in Preventing Oxidative/Inflammatory Cochlear Damage Induced by Noise Exposure
Paciello, F., Fetoni, A. R., Rolesi, R., Wright, M. B., Grassi, C., Troiani, D., & Paludetti, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01103 · Cited by 39
The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity
Hung, T., Chu, F.-L., Wu, D., Wu, S., & Huang, C. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1457-2 · Cited by 40
Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder
Barone, R. M. E., Rizzo, R., Tabbı̀, G., Malaguarnera, M., Frye, R. E., & Bastin, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081878 · Cited by 40
The ZEB1 Transcription Factor Is a Novel Repressor of Adiposity in Female Mice
Saykally, J. N., Doğan, S., Cleary, M. P., & Sanders, M. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008460 · Cited by 39
Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes
Chen, Y., Xue, P., Hou, Y., Zhang, H., Zheng, H., Zhou, T., Qu, W., Teng, W., Zhang, Q., Andersen, M. E., et al. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.005 · Cited by 39
Adiponectin, Adiponectin Receptors, and Epigenetic Regulation of AdipogenesisPreprint
Kadowaki, T., Yamauchi, T., Waki, H., Iwabu, M., Okada‐Iwabu, M., & Nakamura, M. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2012.76.010587 · Cited by 39
Thinking inside the box: Current insights into targeting orbital tissue remodeling and inflammation in thyroid eye disease
Gupta, V., Hammond, C. L., Roztocil, E., Gonzalez, M. O., Feldon, S. E., & Woeller, C. F. (2021) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2021.08.010 · Cited by 39
2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors
Ren, X., Chang, R. C.-A., Huang, Y., Amato, A. A., Carivenc, C., Grimaldi, M., Kuo, Y., Balaguer, P., Bourguet, W., & Blumberg, B. (2023) · Endocrinology · doi:10.1210/endocr/bqad021 · Cited by 38
Safety of Antidiabetic Therapies on Bone
Lecka‐Czernik, B. (2012) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-012-9129-7 · Cited by 38
Coregulator Cell Cycle and Apoptosis Regulator 1 (CCAR1) Positively Regulates Adipocyte Differentiation through the Glucocorticoid Signaling Pathway
Ou, C. Y., Chen, T.-C., Lee, J. V., Wang, J.-C., & Stallcup, M. R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.548081 · Cited by 38
Fish oil supplementation induces expression of genes related to cell cycle, endoplasmic reticulum stress and apoptosis in peripheral blood mononuclear cells: a transcriptomic approach
Myhrstad, M. C. W., Ulven, S. M., Günther, C., Ottestad, I. O., Holden, M. T. G., Ryeng, E., Borge, G. I. A., Köhler, A., Brønner, K. W., Thoresen, M., et al. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12217 · Cited by 38
Disruption of Endothelial Peroxisome Proliferator-Activated Receptor γ Accelerates Diet-Induced Atherogenesis in LDL Receptor-Null Mice
Qu, A., Shah, Y. M., Manna, S. K., & Gonzalez, F. J. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.239137 · Cited by 38
Fisetin Up-regulates the Expression of Adiponectin in 3T3-L1 Adipocytes via the Activation of Silent Mating Type Information Regulation 2 Homologue 1 (SIRT1)-Deacetylase and Peroxisome Proliferator-Activated Receptors (PPARs)
Jin, T., Kim, O. Y., Shin, M., Choi, E. Y., Lee, S. S., Han, Y. S., & Chung, J. H. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf502849j · Cited by 38
Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors
Iida, M., Katsuno, M., Nakatsuji, H., Adachi, H., Kondo, N., Miyazaki, Y., Tohnai, G., Ikenaka, K., Watanabe, H., Yamamoto, M., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu445 · Cited by 36
Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy
Cui, X., Wang, Y., Meng, L., Fei, W., Deng, J., Xu, G., Peng, X., Ju, S., Zhang, L., Liu, C., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00237.2011 · Cited by 38
Panax ginseng Leaf Extracts Exert Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats
Lee, S. G., Lee, Y. J., Jang, M.-H., Kwon, T. R., & Nam, J. (2017) · Nutrients · doi:10.3390/nu9090999 · Cited by 40
Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view
Ferreira, V., Grajales, D., & Valverde, Á. M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158534 · Cited by 41
Endocrine-Disrupting Chemicals and Insulin Resistance in Children
Rotondo, E., & Chiarelli, F. (2020) · Biomedicines · doi:10.3390/biomedicines8060137 · Cited by 43
The forgotten type 2 diabetes mellitus medicine: rosiglitazone
Xu, B., Xing, A., & Li, S. (2021) · Diabetology International · doi:10.1007/s13340-021-00519-0 · Cited by 38
18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis.
Moon, M., Jeong, J.-K., Lee, Y.-J., Seol, J., Ahn, D., Kim, I.-S., & Park, S.-Y. (2012) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2012.03.078 · Cited by 37
The interplay between regulatory T cells and metabolism in immune regulation
Zeng, H., & Chi, H. (2013) · OncoImmunology · doi:10.4161/onci.26586 · Cited by 38
The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity
Taşdelen, I., van Beekum, O., Gorbenko, O., Fleskens, V., van den Broek, N. J. F., Koppen, A., Hamers, N., Berger, R., Coffer, P. J., Brenkman, A. B., et al. (2013) · Biochemical Journal · doi:10.1042/bj20121113 · Cited by 38
Peroxisome Proliferator-Activated Receptor-γ Inhibits Transformed Growth of Non-Small Cell Lung Cancer Cells through Selective Suppression of Snail
Choudhary, R., Li, H. Y., Winn, R. A., Sorenson, A. L., Weiser‐Evans, M. C. M., & Nemenoff, R. A. (2010) · Neoplasia · doi:10.1593/neo.91638 · Cited by 39
Oxidative Stress in Metabolic Disorders and Drug‐Induced Injury: The Potential Role of Nrf2 and PPARs Activators
Mahmoud, A. M., Alexander, M. Y., Tutar, Y., Wilkinson, F. L., & Venditti, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2508909 · Cited by 38
Glycolysis and beyond in glucose metabolism: exploring pulmonary fibrosis at the metabolic crossroads
Wang, Y., Wang, X., Du, C., Wang, Z., Wang, J., Zhou, N., Wang, B., Tan, K., Fan, Y., & Cao, P. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1379521 · Cited by 39
What the Genetics of Lipodystrophy Can Teach Us About Insulin Resistance and Diabetes
Vatier, C., Bidault, G., Briand, N., Guénantin, A.-C., Salle-Teyssières, L., Lascols, O., Capeau, J., & Vigouroux, C. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0431-7 · Cited by 37
Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men
Enzenbach, C., Kröger, J., Zietemann, V., Jansen, E. H. J. M., Fritsche, A., Döring, F., Boeing, H., & Schulze, M. B. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0169-4 · Cited by 37
Structure Basis of Bigelovin as a Selective RXR Agonist with a Distinct Binding Mode
Zhang, H., Li, L., Chen, L., Hu, L., Jiang, H., & Shen, X. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.01.032 · Cited by 37
Differential expression of lipid metabolism-related genes and myosin heavy chain isoform genes in pig muscle tissue leading to different meat quality
Zhang, C., Luo, J., Zheng, P., Yu, B., Huang, Z., Mao, X., He, J., Yu, J., Chen, J., & Chen, D. W. (2015) · animal · doi:10.1017/s1751731115000324 · Cited by 37
Homology modeling and molecular docking studies on Type II diabetes complications reduced PPARγ receptor with various ligand molecules
Prabhu, S., Vijayakumar, S., Manogar, P., Maniam, G. P., & Govindan, N. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.077 · Cited by 37
Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
Duszka, K., & Wahli, W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082210 · Cited by 37
Mesenteric Adipose Tissue Alterations in Crohn’s Disease Are Associated With the Lymphatic System
Shen, W., Li, Y., Zou, Y., Cao, L., Cai, X., Gong, J., Xu, Y., & Zhu, W. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy306 · Cited by 37
Phytochemical drug candidates for the modulation of peroxisome proliferator‐activated receptor γ in inflammatory bowel diseases
Venkataraman, B., Ojha, S. K., Belur, P. D., Bhongade, B. A., Raj, V., Collin, P. D., Adrian, T. E., & Subramanya, S. B. (2020) · Phytotherapy Research · doi:10.1002/ptr.6625 · Cited by 37
Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm
Duszka, K., & Wahli, W. (2020) · Nutrients · doi:10.3390/nu12113476 · Cited by 37
Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure
Mohajer, N., Joloya, E. M., Seo, J., Shioda, T., & Blumberg, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.787580 · Cited by 37
Further understanding of fat biology: Lessons from a fat fly
Hong, J., & Park, K. W. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.1.007 · Cited by 37
Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy
Ronkainen, P. H. A., Pöllänen, E., Alén, M., Pitkänen, R., Puolakka, J. O., Kujala, U. M., Kaprio, J. A., Sipilä, S., & Kovanen, V. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00636.x · Cited by 37
Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight
Viera, J. T., El‐Merahbi, R., Nieswandt, B., Stegner, D., & Sumara, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157607 · Cited by 37
Activation of PPARγ2 by PPARγ1 through a functional PPRE in transdifferentiation of myoblasts to adipocytes induced by EPA
Luo, H., Zhou, Y., Hu, X., Peng, X., Wei, H., Peng, J., & Jiang, S. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1033594 · Cited by 36
Novel thiazolidin-4-one benzenesulfonamide hybrids as PPARγ agonists: Design, synthesis and in vivo anti-diabetic evaluation
Ali, I. H., Hassan, R. M., Kerdawy, A. M. E., Abo-Elfadl, M. T., Abdallah, H. M. I., Sciandra, F., & Ghannam, I. A. Y. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116279 · Cited by 37
Relaxin signaling activates peroxisome proliferator-activated receptor gamma
Singh, S., & Bennett, R. G. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.014 · Cited by 36
Peroxisome proliferator‐activated receptor‐γ activation inhibits hepatocellular carcinoma cell invasion by upregulating plasminogen activator inhibitor‐1
Pang, X., Wei, Y., Zhang, Y., Zhang, M., Lu, Y. Z., & Shen, P. (2013) · Cancer Science · doi:10.1111/cas.12143 · Cited by 36
PPARγ Activation Inhibits Growth and Survival of Human Endometriotic Cells by Suppressing Estrogen Biosynthesis and PGE2 Signaling.
Lebovic, D. I., Kavoussi, S. K., Lee, J., Banu, S. K., & Arosh, J. A. (2013) · Endocrinology · doi:10.1210/en.2013-1168 · Cited by 36
Metabolic map of osthole and its effect on lipids
Zhao, Q., Li, X., Liu, H., Gonzalez, F. J., & Li, F. (2017) · Xenobiotica · doi:10.1080/00498254.2017.1306660 · Cited by 35
Pioglitazone reduces cold-induced brown fat glucose uptake despite induction of browning in cultured human adipocytes: a randomised, controlled trial in humans
Loh, R. K. C., Formosa, M. F., Eikelis, N., Bertovic, D. A., Anderson, M. J., Barwood, S. A., Nanayakkara, S., Cohen, N. D., Gerche, A. L., Reutens, A. T., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4479-9 · Cited by 36
CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
Jang, M. J., Park, U., Kim, J. W., Choi, H., Um, S., & Kim, E.-J. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0070-z · Cited by 36
Grape Seed Proanthocyanidins Improve White Adipose Tissue Expansion during Diet-Induced Obesity Development in Rats
Pascual‐Serrano, A., Bladé, C., Suárez, M., & Arola‐Arnal, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092632 · Cited by 36
PPARG rs3856806 C>T Polymorphism Increased the Risk of Colorectal Cancer: A Case-Control Study in Eastern Chinese Han Population
Lin, J., Chen, Y., Tang, W., Liu, C., Zhang, S., Guo, Z., Chen, G., & Zheng, X. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00063 · Cited by 36
miR-27a is an important adipogenesis regulator associated with differential lipid accumulation between intramuscular and subcutaneous adipose tissues of sheep
Deng, K., Ren, C., Fan, Y. X., Liu, Z., Zhang, G., Zhang, Y., You, P., & Wang, F. (2019) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2019.106393 · Cited by 35
Creeping fat formation and interaction with intestinal disease in Crohn's disease
Yin, Y. B., Xie, Y., Ge, W., & Li, Y. (2022) · United European Gastroenterology Journal · doi:10.1002/ueg2.12349 · Cited by 40
Thiazolidinedione treatment and constitutive‐PPARγ activation induces ectopic adipogenesis and promotes age‐related thymic involution
Youm, Y., Yang, H., Amin, R., Smith, S. R., Leff, T., & Dixit, V. D. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00574.x · Cited by 37
Beneficial Effects of Red Yeast Rice on High-Fat Diet-Induced Obesity, Hyperlipidemia, and Fatty Liver in Mice
Lee, H. S., Lee, Y. J., Chung, Y. H., Nam, Y., Kim, S. T., Park, E. S., Hong, S. M., Yang, Y. K., Kim, H., & Jeong, J. H. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3259 · Cited by 36
Hypoxia induces peroxisome proliferator-activated receptor γ expression via HIF-1-dependent mechanisms in HepG2 cell line
Zhao, Y., Liu, X., Shen, G., Ma, Y., Zhang, F., Chen, M., Zhao, H.-L., Yu, J., & Zhang, J. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.12.010 · Cited by 35
The Peroxisome Proliferator–Activated Receptor (PPAR)-γ Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPARδ and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages
Schubert, M., Becher, S., Wallert, M., Maeß, M. B., Abhari, M., Rennert, K., Mosig, A. S., Große, S., Heller, R., Grün, M., et al. (2020) · Molecular Pharmacology · doi:10.1124/mol.119.117887 · Cited by 35
Engaging plasticity: Differentiation therapy in solid tumors
Bar-Hai, N., & Ishay-Ronen, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.944773 · Cited by 35
Hepatic Lipid Metabolism
Huang, J., Borensztajn, J., & Reddy, J. K. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_10 · Cited by 40
Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia
Nakamura, Y., Hinoi, E., Iezaki, T., Takada, S., Hashizume, S., Takahata, Y., Tsuruta, E., Takahashi, S., & Yoneda, Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.010 · Cited by 35
Peroxisome Proliferator-Activated Receptor (PPAR): Balance for Survival in Parasitic Infections
Chan, M. M.-Y., Evans, K. W., Moore, A. R., & Fong, D. (2010) · BioMed Research International · doi:10.1155/2010/828951 · Cited by 35
Role of fibroblast growth factors in elicitation of cell responses
Laestander, C., & Engström, W. (2013) · Cell Proliferation · doi:10.1111/cpr.12084 · Cited by 35
Antiadipogenic Effects ofAster glehniExtract: In Vivo and In Vitro Effects
Lee, H.-M., Yang, G., Ahn, T.-G., Kim, M.-D., Nugroho, A., Park, H.-J., Lee, K., Park, W., & An, H. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/859624 · Cited by 35
SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism
van Marrewijk, L. M., Polyak, S. W., Hijnen, M., Kuruvilla, D. S., Chang, M. R., Shin, Y., Kamenecka, T. M., Griffin, P. R., & Bruning, J. B. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00580 · Cited by 36
Effects of combined PPAR-γ and PPAR-α agonist therapy on fructose induced NASH in rats: Modulation of gene expression
El-Haleim, E. A. A., Bahgat, A. K., & Saleh, S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.01.011 · Cited by 35
Obesogens, stem cells and the maternal programming of obesity
Blumberg, B. (2010) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174410000589 · Cited by 35
Extraction of Flavonoids from the Flowers of Abelmoschus manihot (L.) Medic by Modified Supercritical CO2 Extraction and Determination of Antioxidant and Anti-Adipogenic Activity
Li, J., Zhang, J., & Wang, M. (2016) · Molecules · doi:10.3390/molecules21070810 · Cited by 35
Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expression
González, F. B., Villar, S. R., Toneatto, J., Pacini, M. F., Márquez, J., D’Attilio, L., Bottasso, O. A., Piwien‐Pilipuk, G., & Pérez, A. R. (2018) · Medical Microbiology and Immunology · doi:10.1007/s00430-018-0572-z · Cited by 36
Increased marrow adipogenesis does not contribute to age‐dependent appendicular bone loss in female mice
Almeida, M., Kim, H., Li, H., Zhou, D., Thostenson, J., Porter, R. M., Ambrogini, E., Manolagas, S. C., & Jilka, R. L. (2020) · Aging Cell · doi:10.1111/acel.13247 · Cited by 35
Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease
Lee, J., Kim, D., & Min, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.865593 · Cited by 38
Chapter 10 Roles of Histone H3‐Lysine 4 Methyltransferase Complexes in NR‐Mediated Gene Transcription
Lee, S., Roeder, R. G., & Lee, J. W. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)87010-5 · Cited by 36
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice
Gao, X., van der Veen, J. N., Hermansson, M., Ordoñez, M., Gómez‐Muñoz, A., Vance, D. E., & Jacobs, R. L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.11.006 · Cited by 34
15‐Deoxy‐Δ12,14‐prostaglandin J2 (15d‐ PGJ 2) protects neurons from oxidative death via an Nrf2 astrocyte‐specific mechanism independent of PPAR γ
Haskew-Layton, R. E., Payappilly, J. B., Xu, H., Bennett, S. A. L., & Ratan, R. R. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12107 · Cited by 35
Crosstalk between peroxisome proliferator-activated receptor-γ and angiotensin II in renal tubular epithelial cells in IgA nephropathy
Xiao, J., Leung, J. C. K., Chan, L. Y. Y., Tang, S. C. W., & Lai, K. N. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.04.004 · Cited by 35
Nuclear Receptors Reverse McGarry's Vicious Cycle to Insulin Resistance
Moore, D. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.016 · Cited by 37
Why do anti-inflammatory therapies fail to improve insulin sensitivity?
Gao, Z., & Ye, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.131 · Cited by 35
Peroxisome proliferator‐activated receptor‐γ agonists attenuate biofilm formation by Pseudomonas aeruginosa
Bedi, B., Maurice, N. M., Ciavatta, V. T., Lynn, K. S., Yuan, Z., Molina, S. A., Joo, M., Tyor, W. R., Goldberg, J. B., Koval, M. H., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700075r · Cited by 35
Antibiotics disrupt lipid metabolism in zebrafish (Danio rerio) larvae and 3T3-L1 preadipocytes
Lei, Y., Li, F., Mortimer, M., Li, Z., Peng, B.-X., Li, M., Guo, L., & Zhuang, G. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159755 · Cited by 34
Galectin-9 in cancer therapy: from immune checkpoint ligand to promising therapeutic target
Zhang, M., Liu, C., Ye, L., Li, H., Zhang, W., Liu, J., Wang, L., & Sun, C. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1332205 · Cited by 34
Translational potential of mouse models of human metabolic disease
Farooqi, I. S., & Xu, Y. (2024) · Cell · doi:10.1016/j.cell.2024.07.011 · Cited by 37
Insulin Sensitizing and Anti-Inflammatory Effects of Thiazolidinediones Are Heightened in Obese Patients
Esterson, Y. B., Zhang, K., Koppaka, S., Kehlenbrink, S., Kishore, P., Raghavan, P., Maginley, S. R., Carey, M., & Hawkins, M. (2013) · Journal of Investigative Medicine · doi:10.2310/jim.0000000000000017 · Cited by 34
Bmp4 expressed in preadipocytes is required for the onset of adipocyte differentiation
Suenaga, M., Kurosawa, N., Asano, H., Kanamori, Y., Umemoto, T., Yoshida, H., Murakami, M., Kawachi, H., Matsui, T., & Funaba, M. (2013) · Cytokine · doi:10.1016/j.cyto.2013.07.011 · Cited by 34
Nuclear receptors and metabolism: from feast to famine
Hong, S.-H., Ahmadian, M., Yu, R. T., Atkins, A. R., Downes, M., & Evans, R. M. (2014) · Diabetologia · doi:10.1007/s00125-014-3209-9 · Cited by 34
Adipocyte NCoR Knockout Decreases PPARg Phosphorylation and Enhances PPARg Activity and Insulin Sensitivity
Li, P., Fan, W., Xu, J., Lu, M. M., Yamamoto, H., Auwerx, J. H., Sears, D. D., Talukdar, S., Oh, D., Chen, A., et al. (2011) · Cited by 34
Pioglitazone increases the glycolytic efficiency of human Sertoli cells with possible implications for spermatogenesis
Meneses, M. J., Bernardino, R. L., Sá, R., Silva, J., Barros, A., Sousa, M., Silva, B. M., Oliveira, P. F., & Alves, M. G. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.08.011 · Cited by 36
Structure–Activity Relationship of 2,4-Dichloro- N -(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics
Frkic, R. L., He, Y., Rodriguez, B. B., Chang, M. R., Kuruvilla, D. S., Ciesla, A., Abell, A. D., Kamenecka, T. M., Griffin, P. R., & Bruning, J. B. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01727 · Cited by 34
IDH1-dependent α-KG regulates brown fat differentiation and function by modulating histone methylation
Kang, H. S., Lee, J. H., Oh, K., Lee, E., Han, B., Park, K.-Y., Suh, J. M., Min, J., Chi, S., Lee, S. C., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154173 · Cited by 33
Therapeutic application of nutraceuticals in diabetic nephropathy: Current evidence and future implications
Dehdashtian, E., Pourhanifeh, M. H., Hemati, K., Mehrzadi, S., & Hosseinzadeh, A. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3336 · Cited by 35
Decreased ANGPTL4 impairs endometrial angiogenesis during peri‐implantation period in patients with recurrent implantation failure
Li, M., Hu, J., Yao, L., & Gao, M. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15696 · Cited by 34
IL‐17‐induced inflammation modulates the mPGES‐1/PPAR‐γ pathway in monocytes/macrophages
Raucci, F., Saviano, A., Casillo, G. M., Guerra-Rodríguez, M., Mansour, A. A., Piccolo, M., Ferraro, M. G., Panza, E., Vellecco, V., Irace, C., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15413 · Cited by 34

Authors: Tontonoz, P., & Spiegelman, B. M.
Affiliations: Howard Hughes Medical Institute (US)
Harvard University (US)
ORCID: Tontonoz, Peter
Spiegelman, Bruce M.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2008-06-01
Volume: 77
Issue: 1
Pages: 289-312
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.biochem.77.061307.091829
OpenAlex: W2097511872
Cited by: 2,085
References: 173
Citations by year: 2026: 79 · 2025: 100 · 2024: 104 · 2023: 103 · 2022: 111 · 2021: 106 · 2020: 105 · 2019: 108 · 2018: 110 · 2017: 112 · 2016: 135 · 2015: 125 · 2014: 154 · 2013: 160 · 2012: 149
FWCI: 8.02
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Heart, Lung, and Blood Institute (R01HL066088, HL66088)
National Institute of Diabetes and Digestive and Kidney Diseases (R37 DK 3140)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: PPARγ, nuclear receptors, transcriptional regulation, adipose tissue development, thiazolidinediones, insulin sensitivity, adipokines, lipid partitioning, atherosclerosis, macrophage function, immunity, cell proliferation, PPARγ agonists, antidiabetic drugs
MeSH terms: Animals, Cell Nucleus, Humans, Inflammation, Insulin Resistance, Macrophages, Models, Biological, Models, Molecular, Neoplasms, Protein Conformation, Protein Structure, Tertiary, Adipocytes, Thiazolidinediones, PPAR gamma, Adipogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fat and Beyond: The Diverse Biology of PPARγ

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks