Fat and Beyond: The Diverse Biology of PPARγ

Obesity is associated with macrophage accumulation in adipose tissue

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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The hormone resistin links obesity to diabetes

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

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Inflammation, stress, and diabetes

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

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Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

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The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

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Atherosclerosis

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15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

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Adipocyte differentiation from the inside out

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AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint

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Adipocytes as regulators of energy balance and glucose homeostasis

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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

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Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

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PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

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A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

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PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

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Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

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Transcriptional control of adipocyte formation

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

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IKK-β links inflammation to obesity-induced insulin resistance

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

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C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint

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Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

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Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

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Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

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PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

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A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

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PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

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A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

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Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

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ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

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PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

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Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity

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PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

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Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

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Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

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15-Deoxy-Δ 12,14 -prostaglandin J 2 inhibits multiple steps in the NF-κB signaling pathway

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Differentiation and reversal of malignant changes in colon cancer through PPARγ

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Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

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Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

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Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

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Effect of Rosiglitazone Treatment on Nontraditional Markers of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus

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Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

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Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice

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PPAR and human metabolic disease

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Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

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Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome

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PAX8-PPAR γ 1 Fusion in Oncogene Human Thyroid Carcinoma

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A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response

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Regulation of Fasted Blood Glucose by Resistin

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Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

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A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis

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The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

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Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

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Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass

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Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

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Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists

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Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

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The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

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Adipose Tissue-Derived Factors: Impact on Health and Disease

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Adipocyte-specific Gene Expression and Adipogenic Steatosis in the Mouse Liver Due to Peroxisome Proliferator-activated Receptor γ1 (PPARγ1) Overexpression

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Induction of Peroxisome Proliferator-Activated Receptor γ during the Conversion of 3T3 Fibroblasts into Adipocytes Is Mediated by C/EBPβ, C/EBPδ, and Glucocorticoids

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Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

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Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activationPreprint

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p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

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PPARα Activators Inhibit Cytokine-Induced Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells

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Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease

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Activators of the nuclear receptor PPARγ enhance colon polyp formation

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Peroxisome Proliferator-Activated Receptor Gamma Activators Inhibit Gene Expression and Migration in Human Vascular Smooth Muscle Cells

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Nuclear Receptor Cofactors in PPAR γ -Mediated Adipogenesis and Adipocyte Energy Metabolism

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PPARγ agonists as new therapeutic agents for the treatment of Alzheimer's disease

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Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

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Peroxisome Proliferator-activated Receptor-γ-independent Inhibition of Macrophage Activation by the Non-thiazolidinedione Agonist L-796,449

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A PPARγ mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus

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Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ

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Substitution of Pyridoxal 5′-Phosphate in the O-Acetylserine Sulfhydrylase from Salmonella typhimurium by Cofactor Analogs Provides a Test of the Mechanism Proposed for Formation of the α-Aminoacrylate Intermediate

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The Paired Box-8/Peroxisome Proliferator-Activated Receptor-γ Oncogene in Thyroid Tumorigenesis

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Genetic deficiency in Pparg does not alter development of experimental prostate cancer

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Antineoplastic and anti–inflammatory effects of PPAR ligands in colitis

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Mechanisms underlying inflammation in neurodegeneration

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Pathophysiology of human visceral obesity: an update

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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals

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What we talk about when we talk about fat

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PPARγ signaling and metabolism: the good, the bad and the future

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Peroxisome proliferator-activated receptor-γ: a versatile metabolic regulator

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Peroxisome proliferator-activated receptor γ, the ultimate liaison between fat and transcription

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The clinical significance of PPARα and γ agonism

Staels, B. (2002) · The British Journal of Diabetes · doi:10.1177/1474651402002001s0701 · Cited by 19

PPARγ in human and mouse physiology

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Contrôle du métabolisme par des ligands de PPARγ

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