Cited by 2,085Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.

Fat and Beyond: The Diverse Biology of PPARγ

Tontonoz, Peter, Spiegelman, Bruce M.·2008·Annual Review of Biochemistry

DOI 10.1146/annurev.biochem.77.061307.091829

Open this paper in CoChat — free account

Abstract

The nuclear receptor PPARgamma is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of physiological processes. PPARgamma was initially characterized as the master regulator for the development of adipose cells. Ligands for PPARgamma include naturally occurring fatty acids and the thiazolidinedione (TZD) class of antidiabetic drugs. Activation of PPARgamma improves insulin sensitivity in rodents and humans through a combination of metabolic actions, including partitioning of lipid stores and the regulation of metabolic and inflammatory mediators termed adipokines. PPARgamma signaling has also been implicated in the control of cell proliferation, atherosclerosis, macrophage function, and immunity. Here, we review recent advances in our understanding of the diverse biological actions of PPARgamma with an eye toward the expanding therapeutic potential of PPARgamma agonist drugs.

Integrity signals

Registry

Crossref · 10.1146/annurev.biochem.77.061307.091829

Cites

174 of 174 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Self-citation
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Nissen, S. E., & Wolski, K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072761 · Cited by 4,675
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Self-citation
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645

Show all 173 references

Research works printed but not linked: 7

Kletzien R, 1992, Mol. Pharmacol., 42, 558
Harris P, 1994, Mol. Pharmacol., 45, 439
10.1210/me.11.6.779 · DOI
10.1172/JCI200525102 · DOI · Paper page
10.1016/j.expneurol.2006.04.006 · DOI
10.1210/en.142.7.3125 · DOI
Suh N, 1999, Cancer Res., 59, 5671

Sorted by citations

Items 801–900 of 1,001

Recent Progress in Metabolic Syndrome Research and Therapeutics
Kao, T., & Huang, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136862 · Cited by 35
Modulatory role of the endocannabinoidome in the pathophysiology of the gastrointestinal tract
Lian, J., Casari, I., & Falasca, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106025 · Cited by 37
Phenotypic Differences Among Familial Partial Lipodystrophy Due to LMNA or PPARG Variants
Vasandani, C., Li, X., Sekizkardes, H., Brown, R. J., & Garg, A. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac155 · Cited by 34
β-Arrestin-1 Protein Represses Adipogenesis and Inflammatory Responses through Its Interaction with Peroxisome Proliferator-activated Receptor-γ (PPARγ)
Zhuang, L.-N., Hu, W.-X., Xin, S.-M., Zhao, J., & Pei, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.256099 · Cited by 34
c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2
Keshet, R., Kraitshtein, Z. B., Shanzer, M., Adler, J., Reuven, N. B., & Shaul, Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411086111 · Cited by 34
13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells
Chow, Y., Sogame, M., & Sato, F. (2016) · Scientific Reports · doi:10.1038/srep38129 · Cited by 34
A flavonoid-rich fraction of Euphorbia peplus attenuates hyperglycemia, insulin resistance, and oxidative stress in a type 2 diabetes rat model
Alruhaimi, R. S., Mostafa‐Hedeab, G., Abduh, M. S., Bin‐Ammar, A., Hassanein, E. H. M., Kamel, E. M., & Mahmoud, A. M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1204641 · Cited by 33
ApoE−/− PGC-1α−/− Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis
Stein, S., Lohmann, C., Handschin, C., Stenfeldt, E., Borén, J., Lüscher, T. F., & Matter, C. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013539 · Cited by 32
RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation
Fabre, O., Salehzada, T., Lambert, K., Seok, Y. B., Zhou, A., Mercier, J. G., & Bisbal, C. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.23 · Cited by 33
Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity
Choi, S., Jung, J., Yang, Y. R., Kim, E. S., Jang, H., Kim, E., Kim, I. S., Lee, J.-Y., Kim, J. K., Seo, J. K., et al. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.09.009 · Cited by 39
Mitochondria and diabetes mellitus: untangling a conflictive relationship?
Schiff, M., Loublier, S., Coulibaly, A., Bénit, P., de Baulny, H. O., & Rustin, P. (2009) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-009-1263-0 · Cited by 31
Abdominal Obesity and Brain Atrophy in Type 2 Diabetes Mellitus
Climie, R. E., Moran, C., Callisaya, M. L., Blizzard, L., Sharman, J. E., Venn, A., Phan, T. G., Beare, R. J., Forbes, J. M., Blackburn, N. B., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142589 · Cited by 33
Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease
Wang, N., Kong, R., Luo, H., Xu, X., & Lu, J. (2017) · PPAR Research · doi:10.1155/2017/6561701 · Cited by 33
The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPARγ
Lee, J. M., Choi, S. S., Lee, Y. H., Khim, K. W., Yoon, S., Kim, B.-G., Nam, D., Suh, P., Myung, K., & Choi, J. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0162-6 · Cited by 33
Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease
O’Neill, L. M., Guo, C., Ding, F., Phang, Y. X., Liu, Z., Shamsuzzaman, S., & Ntambi, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228619 · Cited by 33
The manifold roles of protein S-nitrosylation in the life of insulin
Zhou, H., Premont, R. T., & Stamler, J. S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00583-1 · Cited by 36
Impacts of the apoptosis inhibitor of macrophage (AIM) on obesity-associated inflammatory diseases
Arai, S., & Miyazaki, T. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0405-5 · Cited by 33
Dichloromethane extracts of Sophora japonica L. stimulate osteoblast differentiation in mesenchymal stem cells
Yoon, H.-J., Seo, C., Kim, M., Kim, Y. J., Song, N., Jang, W.-S., Kim, B.-J., Lee, J., Hong, J., Nho, C. W., et al. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.08.004 · Cited by 33
Differential Expression of PPARγ, FASN, and ACADM Genes in Various Adipose Tissues and Longissimus dorsi Muscle from Yanbian Yellow Cattle and Yan Yellow Cattle
Ji, S., Yang, R., Lu, C., Qiu, Z., Yan, C., & Zhao, Z. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2013.13422 · Cited by 33
Promising link between selenium and peroxisome proliferator activated receptor gamma in the treatment protocols of obesity as well as depression
Donma, M. M., & Donma, O. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.02.008 · Cited by 35
Anatomy and physiology of the nutritional system
Cinti, S. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.04.001 · Cited by 37
The immune cell transcription factor T-bet: A novel metabolic regulator
Stolarczyk, E., Lord, G. M., & Howard, J. K. (2014) · Adipocyte · doi:10.4161/adip.26220 · Cited by 32
A novel peroxisome proliferator-activated receptor gamma ligand improves insulin sensitivity and promotes browning of white adipose tissue in obese mice
Wu, D., Eeda, V., Undi, R. B., Mann, S. N., Stout, M., Lim, H., & Wang, W. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101363 · Cited by 34
Transcriptomic evaluation of bovine blastocysts obtained from peri-pubertal oocyte donors
Morin-Doré, L., Blondin, P., Vigneault, C., Grand, F., Labrecque, R., & Sirard, M. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.01.005 · Cited by 33
Withaferin A inhibits adipogenesis in 3T3-F442A cell line, improves insulin sensitivity and promotes weight loss in high fat diet-induced obese mice
Khalilpourfarshbafi, M., Murugan, D. D., Sattar, M. Z. A., Sucedaram, Y., & Abdullah, N. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218792 · Cited by 33
An interaction between MKL1, BRG1, and C/EBPβ mediates palmitate induced CRP transcription in hepatocytes
Fan, Z., Li, N., Xu, Z., Wu, J., Fan, X., & Xu, Y. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194412 · Cited by 33
Arctigenin promotes bone formation involving PI3K/Akt/PPARγ signaling pathway
Li, H., Yang, C., Lan, M., Liao, X., & Tang, Z. (2019) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13659 · Cited by 32
Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes
Furuhata, R., Kabe, Y., Kanai, A., Sugiura, Y., Tsugawa, H., Sugiyama, E., Hirai, M., Yamamoto, T., Koike, I., Yoshikawa, N., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01202-x · Cited by 46
Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARγ by inducing lipogenesis but not lipolysis
Chang, R. C.-A., Thangavelu, C. S., Joloya, E. M., Kuo, Y., Li, Z., & Blumberg, B. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114910 · Cited by 34
Pharmacological induction of mitochondrial biogenesis as a therapeutic strategy for the treatment of type 2 diabetes
Zamora, M., Pardo, R., & Villena, J. A. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.032 · Cited by 32
A Peroxisome Proliferator-activated Receptor γ (PPARγ)/PPARγ Coactivator 1β Autoregulatory Loop in Adipocyte Mitochondrial Function
Deng, T., Sieglaff, D. H., Zhang, A., Lyon, C. J., Ayers, S. D., Čvoro, A., Gupte, A. A., Xia, X., Baxter, J. D., Webb, P., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.251926 · Cited by 32
Virtual Screening as a Technique for PPAR Modulator Discovery
Lewis, S. N., Bassaganya-Riera, J., & Bevan, D. R. (2009) · PPAR Research · doi:10.1155/2010/861238 · Cited by 33
Constitutively active Stat5A and Stat5B promote adipogenesis
Wakao, H., Wakao, R., Oda, A., & Fujita, H. (2010) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-010-0193-7 · Cited by 32
Adipocyte reporter assays: Application for identification of anti‐inflammatory and antioxidant properties of mangosteen xanthones
Shen, Q., Chitchumroonchokchai, C., Thomas, J. L., Gushchina, L. V., DiSilvestro, D. J., Failla, M. L., & Ziouzenkova, O. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300181 · Cited by 32
Peroxisome Proliferator-Activated Receptor γ Antagonists Decrease Na+ Transport via the Epithelial Na+ Channel
Pavlov, T. S., Levchenko, V., Karpushev, A. V., Vandewalle, A., & Staruschenko, A. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056911 · Cited by 31
Epigenetic DNA methylation in the promoters of Peroxisome Proliferator-Activated Receptor γ in chicken lines divergently selected for fatness1
Sun, Y., Gao, Y., Qiao, S., Wang, S. Z., Duan, K., Wang, Y. X., Li, H., & Wang, N. (2013) · Journal of Animal Science · doi:10.2527/jas.2013-6962 · Cited by 32
PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ
Zhong, Y., Wang, Y., Li, X., Qin, H., Yan, S. W., Rao, C., Fan, D., Liu, D., Deng, F., Miao, Y., et al. (2023) · Diabetes · doi:10.2337/db22-1016 · Cited by 36
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Collins, K. H., Lenz, K. L., Welhaven, H. D., Ely, E. V., Springer, L. E., Paradi, S. G., Tang, R., Braxton, L. A., Akk, A. M., Yan, H., et al. (2025) · Science Advances · doi:10.1126/sciadv.adt5915 · Cited by 33
The Epigenome and Its Role in Diabetes
Waki, H., Yamauchi, T., & Kadowaki, T. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0328-x · Cited by 31
Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPARγand IKK/NF-κB signaling
Li, Q., Chen, L., Yan, M., Shi, X., & Zhong, M. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2014.993038 · Cited by 31
Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle
Ding, Y., Fang, H., Shang, W. H., Xiao, Y., Sun, T., Hou, N., Pan, L., Sun, X., Ma, Q., Zhou, J., et al. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1278-y · Cited by 31
Investigations on Binding Pattern of Kinase Inhibitors with PPARγ: Molecular Docking, Molecular Dynamic Simulations, and Free Energy Calculation Studies
Mazumder, M., Ponnan, P., Das, U., Gourinath, S., Khan, H. A., Yang, J. P., & Sakharkar, M. K. (2017) · PPAR Research · doi:10.1155/2017/6397836 · Cited by 31
Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
Ebrahimi, M. M., Rajion, M. A., Jafari, S., Jahromi, M. F., Oskoueian, E., Sazili, A. Q., Goh, Y. M., & Ghaffari, M. H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0188369 · Cited by 31
Agaricus bisporus-derived β-glucan prevents obesity through PPAR γ downregulation and autophagy induction in zebrafish fed by chicken egg yolk
Li, X.-M., Xue, Y., Pang, L., Len, B., Lin, Z., Huang, J., Shangguan, Z., & Pan, Y. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.12.122 · Cited by 31
Protective Function of Mitogen‐Activated Protein Kinase Phosphatase 5 in Aging‐ and Diet‐Induced Hepatic Steatosis and Steatohepatitis
Tang, P., Low, H. B., Png, C. W., Torta, F. T., Kumar, J. K., Lim, H. Y., Zhou, Y., Yang, H. H., Angeli, V., Shabbir, A., et al. (2019) · Hepatology Communications · doi:10.1002/hep4.1324 · Cited by 31
Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders
Reguero, M., de Cedrón, M. G., Wagner, S., Reglero, G., Quintela, J. C., & de Molina, A. R. (2021) · Cancers · doi:10.3390/cancers13040866 · Cited by 32
Insights into Dynamic Mechanism of Ligand Binding to Peroxisome Proliferator-Activated Receptor γ toward Potential Pharmacological Applications
Miyamae, Y. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00263 · Cited by 33
Exposure, toxicological mechanism of endocrine disrupting compounds and future direction of identification using nano-architectonics
Priyadarshini, E., Parambil, A. M., Rajamani, P., Ponnusamy, V. K., & Chen, Y. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115577 · Cited by 31
miR-128-3p regulates chicken granulosa cell function via 14-3-3β/FoxO and PPAR-γ/LPL signaling pathways
Ning, Z., Deng, X., Li, L., Feng, J. Q., Du, X., Amevor, F. K., Tian, Y., Li, L., Rao, Y., Yi, Z., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124654 · Cited by 31
Peroxisome Proliferator-activated Receptor γ (PPARγ) and Its Target Genes Are Downstream Effectors of FoxO1 Protein in Islet β-Cells
Gupta, D., Leahy, A. A., Monga, N., Peshavaria, M., Jetton, T. L., & Leahy, J. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.486852 · Cited by 30
Antidiabetic Property of Symplocos cochinchinensis Is Mediated by Inhibition of Alpha Glucosidase and Enhanced Insulin Sensitivity
Antu, K. A., Riya, M. P., Mishra, A., Anilkumar, K. S., Chandrakanth, C. K., Tamrakar, A. K., Srivastava, A. K., & Raghu, K. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105829 · Cited by 31
PPARγ as a therapeutic target in cystic fibrosis
Dekkers, J. F., van der Ent, C. K., Kalkhoven, E., & Beekman, J. M. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.03.004 · Cited by 32
White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies
Pagano, E. S., Spinedi, E., & Gagliardino, J. J. (2016) · Neuroendocrinology · doi:10.1159/000453317 · Cited by 31
EPA and DHA Inhibit Myogenesis and Downregulate the Expression of Muscle-related Genes in C2C12 Myoblasts
Zhang, J., Xu, X., Liu, Y., Zhang, L., Odle, J., Lin, X., Zhu, H., Wang, X., & Liu, Y. (2019) · Genes · doi:10.3390/genes10010064 · Cited by 35
Cell density-dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells
Ghosh, S., Dean, A. K., Walter, M., Bao, Y., Hu, Y., Ruan, J., & Li, R. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.015 · Cited by 31
PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism
Zhang, G., Yu, X., Guo, H., Sun, J., Liu, Z., Zhu, J., Liu, T., Dong, L., Shen, X., & Yin, J. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2156 · Cited by 30
Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome
Chen, Y., Wang, G., Chen, J., Wang, C., Dong, X., Chang, H., Yuan, S., Zhao, Y., & Mu, L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae002 · Cited by 33
Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity
Apalasamy, Y. D., & Mohamed, Z. (2015) · Human Genetics · doi:10.1007/s00439-015-1533-x · Cited by 35
PPARγ agonists: Potential treatments for exudative age-related macular degeneration
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.09.008 · Cited by 29
Epigenetic Regulation of Adipogenic Differentiation by Histone Lysine Demethylation
Nic-Can, G. I., Rodas-Junco, B. A., Carrillo‐Cocom, L. M., Zepeda, A., Peñaloza-Cuevas, R., Aguilar-Ayala, F. J., & Rojas-Herrera, R. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163918 · Cited by 32
Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3 T3-L1 cells
Shen, H., Yang, C., Kung, C.-W., Chen, S., Wu, H., Cheng, P., Lam, K., & Lee, Y. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0556-3 · Cited by 30
Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue
Caputo, T., Tran, V. D. T., Bararpour, N., Winkler, C., Aguileta, G., Trang, B. K., Attianese, G. M. P. G., Wilson, A., Thomas, A., Pagni, M., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03485-z · Cited by 31
Heritability of fat accumulation in white adipocytes
Katz, L. S., Geras‐Raaka, E., & Gershengorn, M. C. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00075.2014 · Cited by 30
Synergistic Suppression of Early Phase of Adipogenesis by Microsomal PGE Synthase-1 (PTGES1)-Produced PGE2 and Aldo-Keto Reductase 1B3-Produced PGF2α
Fujimori, K., Yano, M., & Ueno, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044698 · Cited by 30
Structural design and synthesis of arylalkynyl amide-type peroxisome proliferator-activated receptor γ (PPARγ)-selective antagonists based on the helix12-folding inhibition hypothesis
Ōhashi, M., Gamo, K., Tanaka, Y., Waki, M., Beniyama, Y., Matsuno, K., Wada, J., Tenta, M., Eguchi, J., Makishima, M., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.11.017 · Cited by 30
PKA regulatory subunit R2B is required for murine and human adipocyte differentiation
Peverelli, E., Ermetici, F., Corbetta, S., Gozzini, E., Avagliano, L., Zappa, M. A., Bulfamante, G., Beck‐Peccoz, P., Spada, A., & Mantovani, G. (2013) · Endocrine Connections · doi:10.1530/ec-13-0049 · Cited by 30
Human macrophage differentiation induces OCTN2–mediated L-carnitine transport through stimulation of mTOR–STAT3 axis
Ingoglia, F., Visigalli, R., Rotoli, B. M., Barilli, A., Riccardi, B., Puccini, P., Milioli, M., Lascia, M. D., Bernuzzi, G., & Dall’Asta, V. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0616-254r · Cited by 31
Impact of arsenic exposure on clinical biomarkers indicative of cardiovascular disease risk in Mexican women
Ochoa‐Martínez, Á. C., Ruíz-Vera, T., Almendarez‐Reyna, C. I., Zarazúa, S., Carrizales, L., & Pérez‐Maldonado, I. N. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.088 · Cited by 30
The new therapeutic frontier--nuclear receptors and the liver
Karpen, S. J., & Trauner, M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.002 · Cited by 29
Exercise‐Induced cytokines, diet, and inflammation and their role in adipose tissue metabolism
Al‐Ibraheem, A. M. T., Hameed, A. A. Z., Marsool, M. D. M., Jain, H., Prajjwal, P., Khazmi, I., Nazzal, R., Al-Najati, H. M. H., Al‐Zuhairi, B. H. Y. K., Razzaq, M., et al. (2024) · Health Science Reports · doi:10.1002/hsr2.70034 · Cited by 33
New life for antidiabetic drugs
Houtkooper, R. H., & Auwerx, J. H. (2010) · Nature · doi:10.1038/466443a · Cited by 29
Excess fructose intake‐induced hypertrophic visceral adipose tissue results from unbalanced precursor cell adipogenic signals
Zubiría, M. G., Fariña, J. P., Moreno, G., Gagliardino, J. J., Spinedi, E., & Giovambattista, A. (2013) · FEBS Journal · doi:10.1111/febs.12511 · Cited by 31
β-Catenin Directly Sequesters Adipocytic and Insulin Sensitizing Activities but Not Osteoblastic Activity of PPARγ2 in Marrow Mesenchymal Stem Cells
Rahman, S., Czernik, P. J., Lu, Y., & Lecka‐Czernik, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051746 · Cited by 33
Stimulators of adipogenesis from the marine sponge Xestospongia testudinaria
Akiyama, T., Takada, K., Oikawa, T., Matsuura, N., Ise, Y., Okada, S., & Matsunaga, S. (2013) · Tetrahedron · doi:10.1016/j.tet.2013.06.007 · Cited by 29
Impacts of peroxisome proliferator-activated receptor-γ activation on cigarette smoke-induced exacerbated response to bacteria
Morissette, M. C., Shen, P., Thayaparan, D., & Stämpfli, M. R. (2014) · European Respiratory Journal · doi:10.1183/09031936.00004314 · Cited by 29
Pu’erh tea extract-mediated protection against hepatosteatosis and insulin resistance in mice with diet-induced obesity is associated with the induction of de novo lipogenesis in visceral adipose tissue
Cai, X., Hayashi, S., Fang, C., Hao, S., Wang, X., Nishiguchi, S., Tsutsui, H., & Sheng, J. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1332-3 · Cited by 29
PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment
Liu, L., Fan, L., Chan, M., Kraakman, M. J., Yang, J. L., Fan, Y., Aaron, N., Wan, Q., Carrillo-Sepúlveda, M. A., Tall, A. R., et al. (2020) · Diabetes · doi:10.2337/db20-0217 · Cited by 29
Th2A cells: The pathogenic players in allergic diseases
Huang, Z., Chu, M., Chen, X., Wang, Z., Lin, J., Ma, Y., & Wang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.916778 · Cited by 31
Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes
Lasrich, D., Bartelt, A., Grewal, T., & Heeren, J. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.07.015 · Cited by 29
Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance
Weismann, D., Erion, D. M., Ignatova-Todorava, I., Nagai, Y., Stark, R., Hsiao, J. J., Flannery, C. A., Birkenfeld, A. L., May, T., Kahn, M., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1984-5 · Cited by 30
The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP–protein kinase A signalling pathway in white adipose tissue
Xiong, Y., Qu, Z., Chen, N., Gong, H., Song, M., Chen, X., Du, J.-Z., & Xu, C. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.05.012 · Cited by 29
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option
Willems, S. M., Schrage, Y. M., Bruijn, I. H. B., Szuhai, K., Hogendoorn, P. C. W., & Bovée, J. V. M. G. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-257 · Cited by 30
Role for PPARγ in IL-2 inhibition in T cells by Echinacea-derived undeca-2E-ene-8,10-diynoic acid isobutylamide
Spelman, K., Iiams-Hauser, K., Cech, N. B., Taylor, E. W., Smirnoff, N., & Wenner, C. A. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.08.009 · Cited by 29
Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning
Shomonov-Wagner, L., Raz, A., & Leikin-Frenkel, A. I. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0012-7 · Cited by 29
Adipose tissue RNASeq reveals novel gene–nutrient interactions following n-3 PUFA supplementation and evoked inflammation in humans
Ferguson, J. F., Xue, C., Hu, Y., Li, M., & Reilly, M. P. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.12.010 · Cited by 28
Dietary intervention in obese dams protects male offspring from WAT induction of TRPV4, adiposity, and hyperinsulinemia
Janoschek, R., Bae‐Gartz, I., Vohlen, C., Alcazar, M. A. A., Dinger, K., Appel, S., Dötsch, J., & Hucklenbruch‐Rother, E. (2016) · Obesity · doi:10.1002/oby.21486 · Cited by 29
Effects of early intervention with sodium butyrate on lipid metabolism-related gene expression and liver metabolite profiles in neonatal piglets
Yu, S., Ren, E., Xu, J., Su, Y., & Zhu, W. (2016) · Livestock Science · doi:10.1016/j.livsci.2016.11.013 · Cited by 29
PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice
Song, N.-J., Chang, S.-H., Kim, S., Panic, V., Jang, B., Yun, U. J., Choi, J.-H., Li, Z., Park, K.-M., Yoon, J., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0904-3 · Cited by 26
Peroxisome Proliferator Activated Receptor Gamma Sensitizes Non-small Cell Lung Carcinoma to Gamma Irradiation Induced Apoptosis
Kaur, S. P., Nag, A., Gangenahalli, G. U., & Sharma, K. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00554 · Cited by 30
Structural Biology Inspired Development of a Series of Human Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Ligands: From Agonist to Antagonist
Miyachi, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043940 · Cited by 29
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance
Nishio, N., & Isobe, K. (2015) · Scientific Reports · doi:10.1038/srep13519 · Cited by 28
Editor’s Highlight: Thy1 (CD90) Expression is Reduced by the Environmental Chemical Tetrabromobisphenol-A to Promote Adipogenesis Through Induction of microRNA-103
Woeller, C. F., Flores, E. M., Pollock, S. J., & Phipps, R. P. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx046 · Cited by 28
TLR-2-mediated metabolic reprogramming participates in polyene phosphatidylcholine-mediated inhibition of M1 macrophage polarization
Feng, T., Yang, X., Hao, S., Sun, F., Huang, Y., Lin, Q., & Pan, W. X. (2020) · Immunologic Research · doi:10.1007/s12026-020-09125-9 · Cited by 28
Cooperation of ATF4 and CTCF promotes adipogenesis through transcriptional regulation
Chen, Y., He, R., Han, Z., Wu, Y., Wang, Q., Zhu, X., Huang, Z., Ye, J., Tang, Y., Huang, H., et al. (2021) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09608-x · Cited by 28
Preventive Effects of β-Cryptoxanthin, a Potent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases—A Central Focus on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD)
Nishino, A., Maoka, T., & Yasui, H. (2021) · Antioxidants · doi:10.3390/antiox11010043 · Cited by 29
Arbutin ameliorates hyperglycemia, dyslipidemia and oxidative stress and modulates adipocytokines and PPARγ in high-fat diet/streptozotocin-induced diabetic rats
Abduh, M. S., Alzoghaibi, M. A., Alzoghaibi, A. M., Bin‐Ammar, A., Alotaibi, M., Kamel, E. M., & Mahmoud, A. M. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121612 · Cited by 29
Peroxisome-proliferator-activated receptor gamma (PPARγ) is required for modulating endothelial inflammatory response through a nongenomic mechanism
Cantini, G., Lombardi, A., Borgogni, E., Francalanci, M., Ceni, E., Degl’Innocenti, S., Gelmini, S., Poli, G., Galli, A., Serio, M., et al. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.04.002 · Cited by 28
Improved Insulin Sensitivity after Long-Term Treatment with AT1 Blockers Is Not Associated with PPARγ Target Gene Regulation
Müller‐Fielitz, H., Landolt, J., Heidbreder, M., Werth, S., VOGT, F. M., Jöhren, O., & Raasch, W. (2012) · Endocrinology · doi:10.1210/en.2011-0183 · Cited by 28
Dominant Processes during Human Dendritic Cell Maturation Revealed by Integration of Proteome and Transcriptome at the Pathway Level
Buschow, S. I., Lasonder, E., van Deutekom, H. W. M., Oud, M. M., Beltrame, L., Huynen, M. A., de Vries, I. J. M., Figdor, C. G., & Cavalieri, D. (2010) · Journal of Proteome Research · doi:10.1021/pr9008546 · Cited by 28
Fat-enriched rather than high-fructose diets promote whitening of adipose tissue in a sex-dependent manner
Dobner, J., Ress, C., Rufinatscha, K., Salzmann, K., Salvenmoser, W., Folie, S., Wieser, V. E., Moser, P. L., Weiß, G., Goebel, G., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.07.009 · Cited by 28

Authors: Tontonoz, P., & Spiegelman, B. M.
Affiliations: Howard Hughes Medical Institute (US)
Harvard University (US)
ORCID: Tontonoz, Peter
Spiegelman, Bruce M.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2008-06-01
Volume: 77
Issue: 1
Pages: 289-312
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.biochem.77.061307.091829
OpenAlex: W2097511872
Cited by: 2,085
References: 173
Citations by year: 2026: 79 · 2025: 100 · 2024: 104 · 2023: 103 · 2022: 111 · 2021: 106 · 2020: 105 · 2019: 108 · 2018: 110 · 2017: 112 · 2016: 135 · 2015: 125 · 2014: 154 · 2013: 160 · 2012: 149
FWCI: 8.02
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Heart, Lung, and Blood Institute (R01HL066088, HL66088)
National Institute of Diabetes and Digestive and Kidney Diseases (R37 DK 3140)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: PPARγ, nuclear receptors, transcriptional regulation, adipose tissue development, thiazolidinediones, insulin sensitivity, adipokines, lipid partitioning, atherosclerosis, macrophage function, immunity, cell proliferation, PPARγ agonists, antidiabetic drugs
MeSH terms: Animals, Cell Nucleus, Humans, Inflammation, Insulin Resistance, Macrophages, Models, Biological, Models, Molecular, Neoplasms, Protein Conformation, Protein Structure, Tertiary, Adipocytes, Thiazolidinediones, PPAR gamma, Adipogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fat and Beyond: The Diverse Biology of PPARγ

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks