Cited by 1,231Heat shock proteins researchGenomics and Chromatin DynamicsBacterial Genetics and Biotechnology

The DOI matches its Crossref record.

Heat Shock Transcription Factors: Structure and Regulation

Wu, Carl·1995·Annual Review of Cell and Developmental Biology

Open this paper in CoChat — free account

Abstract

Organisms respond to elevated temperatures and to chemical and physiological stresses by an increase in the synthesis of heat shock proteins. The regulation of heat shock gene expression in eukaryotes is mediated by the conserved heat shock transcription factor (HSF). HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerization and high-affinity binding to DNA and by exposure of domains for transcriptional activity. Analysis of HSF cDNA clones from many species has defined structural and regulatory regions responsible for the inducible activities. The heat stress signal is thought to be transduced to HSF by changes in the physical environment, in the activity of HSF-modifying enzymes. or by changes in the intracellular level of heat shock proteins.

Integrity signals

Registry

Crossref · 10.1146/annurev.cb.11.110195.002301

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 901–1,000 of 1,000

The Effect of Structure and Mechanism of the Hsp70 Chaperone on the Ability to Identify Chemical Modulators and Therapeutics
Manos‐Turvey, A., Brodsky, J. L., & Wipf, P. (2015) · Topics in medicinal chemistry · doi:10.1007/7355_2015_90 · Cited by 8
“HSF1 forms an active trimer only when a cell is stressed and binds to the promoter region of HSPA1A/B, causing upregulation of mRNA synthesis [99, 100].”
Background
AtHSBP functions in seed development and the motif is required for subcellular localization and interaction with AtHSFs
Hsu, S.-F., & Jinn, T.-L. (2010) · Plant Signaling & Behavior · doi:10.4161/psb.5.8.12404 · Cited by 8
Imaging Transcriptional Regulation of Eukaryotic mRNA Genes: Advances and Outlook
Yao, J. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.11.007 · Cited by 8
Molecular Characterization of Heat-Induced HSP11.0 and Master-Regulator HSF from Cotesia chilonis and Their Consistent Response to Heat Stress
He, F.-J., Zhu, F., Lu, M., & Du, Y. (2021) · Insects · doi:10.3390/insects12040322 · Cited by 8
“0, perhaps because the regulation involves a conversion that affects its activity, such as its conversion from a monomer to a multimeric form or phosphorylation [41,44].”
Background
Basal level transcription of the human hsp86 gene is directed by intron‐based elements
Lange, P., Victor, M., & Benecke, B. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.d01-309.x · Cited by 8
“This element is in turn specifically recognized by the heat shock transcription factor (HSF), a conserved regulatory protein that is activated upon heat stress by the induction of trimerization, and multiple forms of which have been identified in a variety of species (reviewed by Wu 1995 ).”
Background
Refined methods for propagating vesicular stomatitis virus vectors that are defective for G protein expression
Witko, S. E., Johnson, J. E., Kalyan, N. K., Felber, B. K., Pavlakis, G. N., Sidhu, M. K., Hendry, R. M., Udem, S. A., & Parks, C. L. (2009) · Journal of Virological Methods · doi:10.1016/j.jviromet.2009.11.023 · Cited by 8
“and promote an increased magnitude of response, multiple copies of the sequence 5′NGAAN-3′ and its complement (5′-NTTCN-3′) were inserted 5′ of the minimal promoter generating multiple bindings sites (nGAAnnTTCnnGAAn) for heat shock factor 1 (HSF-1) (Wang and Morgan, 1994), which binds DNA as a trimer (Wu, 1995).”
Background
Delivery of HSF1(+) protein using HIV-1 TAT protein transduction domain
Hou, Y., & Zou, J. (2009) · Molecular Biology Reports · doi:10.1007/s11033-008-9444-8 · Cited by 8
Regulation of Genes Encoding Chloroplast Antioxidant Enzymes in Comparison to Regulation of the Extra-plastidic Antioxidant Defense System
Baier, M., Pitsch, N. T., Mellenthin, M., et al. (2010) · Springer eBooks · doi:10.1007/978-90-481-9404-9_13 · Cited by 8
Effect of the C.–1 388 A>G polymorphism in chicken heat shock transcription factor 3 gene on heat tolerance
ZHANG, W.-W., Kong, L. N., Zhang, D., et al. (2015) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(14)60943-6 · Cited by 8
Differing patterns of hsp70 gene expression in invasive and native kelp species: evidence for acclimation-induced variation
Henkel, S. K., & Hofmann, G. E. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9619-8_56 · Cited by 8
The Heat Shock Response and the Stress of Misfolded Proteins
Morimoto, R. I., & Westerheide, S. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00268-0 · Cited by 9
Analysis of cell surface and relative gene expression of heat shock protein 70 in human leukemia cell lines
Hromadníková, I., & Sedláčková, L. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190701851372 · Cited by 8
“HSE serves as a binding site for heat shock transcription factor (HSF), whose activation is essential for the transcriptional regulation of heat shock genes [27,28].”
Background
Regulation of the Activity of Eukaryotic Initiation Factors in Stressed Cells
Scheper, G. C., van Wijk, R., & Thomas, A. A. M. (2001) · Progress in molecular and subcellular biology · doi:10.1007/978-3-662-09889-9_2 · Cited by 8
Hsp30, the integral plasma membrane heat shock protein of Saccharmyces cerevisiae, is a stress-inducible regulator of plasma membrane H+-ATPase
Piper, P. W., Ortiz-Calderon, C., Holyoak, C. D., Coote, P. J., & Cole, M. (1997) · Cell Stress and Chaperones · doi:10.1379/1466-1268(1997)002 · Cited by 192
Heat Shock Proteins and Cancer: Plant Based Therapy
Uçar, E. Ö. (2015) · Heat shock proteins · doi:10.1007/978-3-319-17211-8_3 · Cited by 7
“This HSF1 monomers are hyperphosphorilated by ERK1, JNK/SAPK and p38 protein kinase [110] and they form a homotrimer approximately 700 kDa [105].”
Background
Artificial recruitment of certain Mediator components affects requirement of basal transcription factor IIE
Sakurai, H., & Fukasawa, T. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00613.x · Cited by 7
“Heat-induced transcription of heat shock genes is mediated by heat shock factor Hsf1, which binds to an enhancer element called heat shock element (HSE) in the promoter region (reviewed in Wu 1995).”
Background
Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease
Tovar, C., Patchett, A. L., Kim, V., Wilson, R., Darby, J. M., Lyons, A. B., & Woods, G. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196469 · Cited by 7
“In eukaryotes, this rapid and classical stress response occurs via transcriptional induction of the heat shock genes via the heat shock transcription factor (HSF1), which binds highly conserved regulatory sequences (heat shock elements, HSEs) located within heat shock gene promoters [52].”
Background
Neuroprotective Effects of Asparagus officinalis Stem Extract in Transgenic Mice Overexpressing Amyloid Precursor Protein
Peng, Z., Bedi, S. S., Mann, V., Sundaresan, A., Homma, K., Gaskey, G., Kowada, M., Umar, S., Kulkarni, A. D., Eltzschig, H. K., et al. (2021) · Journal of Immunology Research · doi:10.1155/2021/8121407 · Cited by 7
“It is also well established that HSPs are molecular chaperones that play a protective role against various stressors by preserving protein ’ s homeostasis [32].”
Background
Heat shock proteins: a history of study in Russia
Евгеньев, М. Б. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01219-z · Cited by 7
“Subsequently, it turned out that our logic was generally correct, and later, the American scientist Carl Wu described the desired Drosophila heat shock factor (HSF1) that regulates all hs genes at once (Wu 1995) using our logic, as he later communicated in a private conversation.”
Background
Knockdown of heat shock transcription factor 1 decreases temperature stress tolerance in Bemisia tabaci MED
Bai, J., Liu, Y.-C., Wei, R., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-19788-z · Cited by 7
Comparative Transcriptomic Analysis of Inarching Invigorating Rootstock onto Incompatible Grafts in Citrus
He, W., Xie, R., Luo, L., Chai, J., Wang, H. E., Wang, Y., Chen, Q., Wu, Z., Yang, S., Li, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314523 · Cited by 8
“The Hsf (Heat stress factor) was able to connect ABA signaling and ABA-mediated stress responses [16,26].”
Background
Analysis of Saccharomyces cerevisiae Genome for the Distributions of Stress-Response Elements Potentially Affecting Gene Expression by Transcriptional Interference
Liu, Y., Ye, S., & Erkine, A. M. (2009) · In Silico Biology · doi:10.3233/isb-2009-0412 · Cited by 7
“The structure and function of the HSE as well as HSF are highly conserved among eukaryotes [12].”
ATP Analog Enhances the Actions of a Heat Shock Protein 90 Inhibitor in Multiple Myeloma Cells
Cervantes-Gomez, F., Nimmanapalli, R., & Gandhi, V. V. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.184903 · Cited by 7
“HSF-1 is a transcription activator of all HSP genes (Wu, 1995).”
Background
Atypical heat shock response and acquisition of thermotolerance in P388D1 cells
Oommen, D., Giricz, Z., Srinivas, U. K., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.124 · Cited by 7
HSF1 Regulation in Aging and Its Role in Longevity
Shemesh, N., & Ben‐Zvi, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55852-1_5 · Cited by 7
Regulation of the heat shock response by heat shock transcription factors
Hietakangas, V., & Sistonen, L. (2006) · Springer eBooks · doi:10.1007/4735_109 · Cited by 8
“The eukaryotic transcription factors that bind to HSEs and activate transcription are called heat shock transcription factors or HSFs (for review see Wu 1995; Pirkkala et al. 2001).”
Background
Heat shock-induced interactions among nuclear HSFs detected by fluorescence cross-correlation spectroscopy
Pack, C., & Ahn, S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.056 · Cited by 7
Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats
Pu, J., Shi, W., Wang, Z., et al. (2011) · Journal of Biomedical Research · doi:10.1016/s1674-8301(11)60040-7 · Cited by 7
“HSPs are found in virtually all living organisms, from bacteria to humans in response to environmental challenges, including hyperthermia, excitotoxic exposure, and other stresses([25]).”
Background
Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin‐treated 9L rat gliosarcoma cells
Chao, C., Sun, F., Wang, C., et al. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21705 · Cited by 7
“In response to various inducers, most HSFs undergo trimerization, become phosphorylated, and acquire DNA-binding activity to HSE, leading to transactivation of the heat-shock genes [Morimoto, 1993; Wu, 1995; Pirkkala et al., 2001].”
Background
Innate immune system gene polymorphisms in women with vulvovaginal infections
Genç, M., Onderdonk, A. B., & Witkin, S. S. (2004) · Current Infectious Disease Reports · doi:10.1007/s11908-004-0066-6 · Cited by 7
“Induction of hsp70 gene transcription inhibits expression of the genes coding for the proinflammatory cytokines, IL-1β and TNF-α [ 47 ,48].”
Background
Paradoxical increase of heat-shock response with age in a substrain of F344 rats: comparison between F344/DuCrj and F344/Jcl
Takahashi, R., Toyoda, E., Aoki, Y., et al. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00096-9 · Cited by 7
Improvement in Sensitivity of Live Cell-Based Sensor Cells by Co-Transfection of a Reporter Gene Driven by a Modified HSP70B' and HSF1 Expression Vector
Wada, K., Okuda‐Shimazaki, J., & Taniguchi, A. (2007) · The Open Biotechnology Journal · doi:10.2174/1874070700701010021 · Cited by 7
“Keywords: HSF, HSP70B' promoter, luciferase assay, sensor cell.”
Heat stress and recovery induce transcriptomic changes in lactogenic-like bovine mammary epithelial (MAC-T) cells
Yu, X., Harman, R. M., Danev, N., Li, G., Fang, Y., de Walle, G. R. V., & Duan, J. E. (2025) · Physiological Genomics · doi:10.1152/physiolgenomics.00127.2024 · Cited by 6
Omics for Elucidating Heat Stress Tolerance Mechanisms in Wheat: A Review Update
Chatterjee, A., Sen, P., Chattopadhyay, T., Maji, A., Gorai, S., Sarkar, A., & Ali, M. N. (2023) · Current Agriculture Research Journal · doi:10.12944/carj.11.2.02 · Cited by 6
Screening and Structural Characterization of Heat Shock Response Elements (HSEs) in Entamoeba histolytica Promoters
Dorantes-Palma, D., Pérez-Mora, S., Azuara-Liceaga, E. I., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021319 · Cited by 6
Transcriptomic Profile of Tef (Eragrostis tef) in Response to Drought
Gonzales, L. R., Cannarozzi, G. M., Rindisbacher, A., Jäggi, L., Schneider, R., Weichert, A., Plaza‐Wüthrich, S., Chanyalew, S., Assefa, K., & Tadele, Z. (2024) · Plants · doi:10.3390/plants13213086 · Cited by 6
HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms
Ghai, S., Shrestha, R., & Su, K. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1500880 · Cited by 7
Manganese alleviates heat stress of primary cultured chick embryonic myocardial cells via enhancing manganese superoxide dismutase expression and attenuating heat shock response
Qin, S., Huang, L., Lü, L., et al. (2022) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2022.103440 · Cited by 6
Heat-related biomarkers: Focus on the correlation of troponin I and 70 kDa heat shock protein
Dervišević, E., Hasić, S., Katica, M., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14565 · Cited by 6
Functional analysis of the Hsf4(lop11) allele responsible for cataracts in lop11 mice.
Liang, L., Liegel, R. P., Endres, B., et al. (2011) · PubMed · Cited by 6
How Cells Protect Themselves against Stress?
Khlebodarova, T. M. (2002) · Russian Journal of Genetics · doi:10.1023/a:1015284032526 · Cited by 6
High‐Throughput Tag‐Sequencing Analysis of Early Events Induced by Ochratoxin A in HepG‐2 Cells
Zhang, Y., Qi, X., Zheng, J., et al. (2015) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21739 · Cited by 6
“The dramatic upregulation of the HSPs is a key part of the heat shock response and is induced primarily by HSF [35].”
Background
Complex regulation of Hsf1-Skn7 activities by the catalytic subunits of PKA in Saccharomyces cerevisiae: experimental and computational evidences
Pérez-Landero, S., Sandoval‐Motta, S., Martínez‐Anaya, C., Yang, R. Y., Folch‐Mallol, J. L., Martínez, L. M., Ventura, L., Guillén‐Navarro, K., Aldana, M., & Nieto‐Sotelo, J. (2015) · BMC Systems Biology · doi:10.1186/s12918-015-0185-8 · Cited by 6
“To thoroughly understand the implications of our observations we constructed a discrete dynamical model of the PKA-RN based both on our results and in the literature [4, 10, 19, 20, 23, 26, 60, 61, 66, 68, 69, 76, 78, 84, 89, 94].”
Background
Targeted Deletion of Hsf1, 2, and 4 Genes in Mice
Jin, X., Eroglu, B., Moskophidis, D., et al. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-295-3_1 · Cited by 6
“The intramolecular interactions between the amino- and carboxyl-terminal domains keep Hsf1 in an inactive state under nonstress conditions (1).”
Chilo suppressalis heat shock proteins are regulated by heat shock factor 1 during heat stress
Dong, C., Zhu, F., Lu, M., & Du, Y. (2022) · Insect Molecular Biology · doi:10.1111/imb.12814 · Cited by 7
“Several studies have demonstrated that overproduced HSPs, especially HSP70 and HSP90, bind the transactivation domain and block the transactivation activity of HSF1 (Morimoto, 1998; Wu, 1995).”
BackgroundResultInfluential
Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human
Zanotto‐Filho, A., Ravi, D., Loranc, E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153970 · Cited by 6
Heat, Salinity, and Acidity, Commonly Upregulate A1aB1b Proglycinin in Soybean Embryonic Axes
Arce‐Paredes, P., Mora‐Escobedo, R., Pedro, J., et al. (2011) · InTech eBooks · doi:10.5772/14227 · Cited by 6
“They are activated upon heat stress by induction of oligomerization and high-affinity binding to DNA and by exposure of domains for transcriptional activity (Wu, 1995).”
Background
Effects of calmodulin on DNA-binding activity of heat shock transcription factorin vitro
Li, B., Liu, H., Mu, R., et al. (2003) · Chinese Science Bulletin · doi:10.1007/bf03183293 · Cited by 6
Two types of heat shock factors in cultured tobacco cells
Shoji, T., Kato, K., Sekine, M., et al. (2000) · Plant Cell Reports · doi:10.1007/s002990050749 · Cited by 6
“The genes for HSFs have been isolated and characterized from yeast, Drosophila, chicken, mice, humans ( Wu 1995 ), tomato (Scharf et al. 1990), Arabidopsis (Hubel et al. 1994), maize (Gagliardi et al. 1995), and soybean (Czarnecka-Verner et al. 1995).”
Background
Les protéines de stress
David, J. C., & Grongnet, J. (2001) · INRAE Productions Animales · doi:10.20870/productions-animales.2001.14.1.3723 · Cited by 6
“Il faut noter ici que la localisation de HSF est nucléaire et cytoplasmique pour HSF1 (Sarge et al 1993) et, pour HSF2, cytoplasmique dans les cellules non stressées et nucléaire après activation (Wu 1995).”
BackgroundInfluential
Proteolytic mapping of heat shock transcription factor domains
Zhong, M., & Wu, C. (1996) · Protein Science · doi:10.1002/pro.5560051222 · Cited by 6
“Boxes show conserved domains from HSF sequence alignments (Wu, 1995).”
BackgroundResultInfluentialSelf-citation
Hyperthermia classic article commentary: ‘Re-induction of hsp70 synthesis: An assay for thermotolerance’ by Gloria C. Li and Johnson Y. Mak,International Journal of Hyperthermia1989;5:389-403
Li, G. C., & Calderwood, S. K. (2009) · International Journal of Hyperthermia · doi:10.1080/02656730902862106 · Cited by 6
“These studies showed that heat-induced hsp70 expression in mouse tissues is entirely controlled by HSF1 and that cells derived from hsf1 / mice lack the ability to develop thermotolerance [39].”
BackgroundInfluential
HIGH HYDROSTATIC PRESSURE INDUCES SYNTHESIS OF HEAT‐SHOCK PROTEINS AND TREHALOSE‐6‐PHOSPHATE SYNTHASE IN Anastrepha ludens LARVAE
Vargas-Ortiz, M. A., Quintana‐Castro, R., Oliart‐Ros, R. M., Medina, J. D. L. C., Ramírez, J. A., & Garcia, H. S. (2013) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.21085 · Cited by 5
“These SPs are inactive in cells under nonstress environmental conditions; however, they become activated in the cell as a response to a stress stimulus (Wu, 1995).”
Background
Studies on the Mechanism of the DNA Nicking Property of Amyloid-β 40 : Implications in Alzheimer's Disease
Gupta, V. B., Monica, F. S., Berrocal, R., Rao, K. S., & Rao, K. S. J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121249 · Cited by 5
Association of heat shock proteins with all-cause mortality
Broer, L., Demerath, E. W., Garcia, M., Homuth, G., Kaplan, R. C., Lunetta, K. L., Tanaka, T., Tranah, G. J., Walter, S., Arnold, A. M., et al. (2012) · AGE · doi:10.1007/s11357-012-9417-7 · Cited by 5
“The role of HSF2 in later life has remained unknown for a long time (Wu 1995).”
Background
Lessons Learned from Two Decades of Modeling the Heat-Shock Response
Ranawade, A., SHARMA, R. R., & Levine, E. (2022) · Biomolecules · doi:10.3390/biom12111645 · Cited by 5
Role of Heat Shock Factors in Stress-Induced Transcription: An Update
Bunch, H., & Calderwood, S. K. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3342-7_3 · Cited by 5
Heat Shock Proteins
Richter‐Landsberg, C. (2009) · Springer eBooks · doi:10.1007/978-0-387-39954-6_1 · Cited by 5
Biology of Extracellular HSP60
Nativel, B., Planesse, C., Gasque, P., Silva, C. R. D., Meihac, O., & Viranaïcken, W. (2019) · Heat shock proteins · doi:10.1007/978-3-030-02254-9_3 · Cited by 5
The novel EhHSTF7 transcription factor displays an oligomer state and recognizes a heat shock element in the Entamoeba histolytica parasite
Bello, F., Orozco, E., Benítez‐Cardoza, C. G., et al. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105349 · Cited by 5
Antibiotic-Induced Treatments Reveal Stress-Responsive Gene Expression in the Endangered Lichen Lobaria pulmonaria
Pizarro, T. C., Resl, P., Kuhl-Nagel, T., et al. (2022) · Journal of Fungi · doi:10.3390/jof8060625 · Cited by 5
Evaluation of the genotoxic or mutagenic effects of thermal stress oncultured human lymphocytes
İla, H. B., Topaktaş, M., Arslan, M., et al. (2015) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1404-55 · Cited by 5
“As a result of thermal stress, transcriptional discrepancies and extraordinary RNA processing merge, synthesis of mRNAs is stimulated, and various molecular responses like heat shock protein accumulation occur (Wu, 1995).”
Background
Heat Induced Oxidative Stress and Aberrations in Liver Function Leading to Hepatic Injury in Rats
Gupta, A., Chauhan, N. R., Singh, A., et al. (2018) · Defence Life Science Journal · doi:10.14429/dlsj.4.13174 · Cited by 5
Expression and characterisation of a Plasmodium falciparum protein containing domains homologous to sarcalumenin and a tyrosine kinase substrate, eps151The nucleotide sequence has been submitted to the GenBank™ with the accession number: U84395.1
McDaniel, J. P., Syin, C., Lin, D. T. S., et al. (1999) · International Journal for Parasitology · doi:10.1016/s0020-7519(99)00024-7 · Cited by 5
Stress response and apoptosis in zebrafish embryos
Yamashita, M., Uchino, K., Taguchi, Y., et al. (2003) · Springer eBooks · doi:10.1007/978-4-431-65938-9_17 · Cited by 5
Potential alterations in gene expression associated with carcinogen exposure inMya arenaria
R. J. Van Beneden, L. D. R. (1999) · Biomarkers · doi:10.1080/135475099230642 · Cited by 5
Heat‐Shock Response
Morimoto, R. I. (2002) · Encyclopedia of Molecular Biology · doi:10.1002/047120918x.emb0639 · Cited by 5
Redox Regulation of Gene Expression and Transcription Factors in Response to Environmental Oxidants
Masutani, H., Nishiyama, A., Kwon, Y.-W., et al. (2001) · CRC Press eBooks · doi:10.1201/9780203904787.ch6 · Cited by 5
Identification and characterization of a heat shock transcription factor in the marine red alga Pyropia yezoensis (Rhodophyta)
Wi, J., & Choi, D. (2024) · Journal of Applied Phycology · doi:10.1007/s10811-024-03402-y · Cited by 4
Regulation of HSF Activation and Repression
Takaki, E., & Nakai, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55852-1_3 · Cited by 4
HSF1 is required for cellular adaptation to daily temperature fluctuations
Takii, R., Fujimoto, M., Pandey, A., Jaiswal, K., Shearwin‐Whyatt, L., Grützner, F., & Nakai, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-72415-x · Cited by 4
Heat stress induces oxidative stress and activates the KEAP1‐NFE2L2‐ARE pathway in reproduction‐related cells
Bai, H., Kawahara, M., Kusama, K., Sakurai, T., Pfarrer, C. D., & Takahashi, M. (2025) · Animal Science Journal · doi:10.1111/asj.70023 · Cited by 4
Activation of the heat shock response by human milk-derived extracellular vesicles in neonates with perinatal high-fat diet exposure
Storm, J. A., Lu, J., Obtial, M. F., & Wijenayake, S. (2025) · Journal of Developmental Origins of Health and Disease · doi:10.1016/j.cstres.2025.100088 · Cited by 7
“49,50 Following trimerization, HSF1 becomes hyperphosphorylated, translocates to the nucleus, and binds to the 5′-nGAAn-3′ sequence (also referred to as the AGAAN heat shock element) of target genes.”
Protonation Behavior of Histidine during HSF1 Activation by Physiological Acidification
Lu, M., & Park, J. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25051 · Cited by 4
“In all known HSFs, the histidine at the position of 63 in hHSF1 is the most highly conserved one, which located in the “turn” region of a helix-turn-helix motif [Wu, 1995].”
BackgroundInfluential
A comparative study of the timecourse of the expression of the thermo-inducible HSP70 gene in clinical and environmental isolates of Aspergillus fumigatus
Sharafi, G., Khosravi, A., Vahedi, G., Yahyaraeyat, R., & Abbasi, T. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5058 · Cited by 4
“Indeed, in eukaryotes, HSP (HSP90 and HSP70) expression is governed by HSF1 (31), which is highly conserved from yeast to human (42).”
Elevation of major constitutive heat shock proteins is heat shock factor independent and essential for establishment and growth of Lgl loss and Yorkie gain-mediated tumors in Drosophila
Singh, G., Chakraborty, S., & Lakhotia, S. C. (2022) · Cell Stress and Chaperones · doi:10.1007/s12192-022-01283-z · Cited by 3
“Activation of heat shock genes following cell stress is majorly regulated by the HSF (Masser et al., 2020; Sarge et al., 1993; Wu, 1995), which unlike in mammals is encoded by a single gene in Drosophila (Jedlicka et al.”
Background
Cellular HSF1 expression is induced during HIV-1 infection by activation of its promoter mediated through the cooperative interaction of HSF1 and viral Nef protein
Mitra, A., Mitra, A., Dasgupta, A., et al. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109947 · Cited by 4
HSF1-mediated oxidative stress response to menadione in Saccharomyces cerevisiae KNU5377Y3 by using proteomic approach
Kim, I.-S., Kim, H., Kim, Y.-S., Jin, I., & Yoon, H. (2013) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2013.41007 · Cited by 4
“the transcriptional level have been reported to date [4-7].”
Background
Adaptive epibiochemistry and epigenetics
Buryanov, Y. I. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915090059 · Cited by 4
“The activated tran scriptional factors bind with specific sequences of regula tory promoter regions of genes and trigger their tran scription [8, 9].”
Background
Biochemical events in the activation and attenuation of the heat shock transcriptional response
Satyal, S. H., & Morimoto, R. I. (1998) · Journal of Biosciences · doi:10.1007/bf02936123 · Cited by 4
“In eukaryotes, heat shock gene expression is controlled by a conserved regulator called heat shock transcription factor (HSF) (Morimoto 1993; Wu 1995 ).”
Background
Heat stress induced apoptosis in BC-8 cells derived from AK-5 tumor involves downregulation of Bcl-2 and generation of reactive oxygen species.
Khar, A., Kumari, A. L., Pardhasaradhi, B. V. V., Varalakshmi, C., & Rangaraj, N. (2006) · PubMed · Cited by 4
The Heat-Shock Response: Sensing the Stress of Misfolded Proteins
Morimoto, R. I., & Nollen, E. A. A. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50672-0 · Cited by 4
Small Heat Shock Proteins, a Key Player in Grass Plant Thermotolerance
Wang, K., Zhang, X., & Ervin, E. H. (2016) · Heat shock proteins · doi:10.1007/978-3-319-46340-7_3 · Cited by 4
Structural and biochemical studies on Vibrio cholerae Hsp31 reveals a novel dimeric form and Glutathione-independent Glyoxalase activity
Das, S., Chowdhury, S. R., Dey, S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172629 · Cited by 4
Possible Strategies for the Diagnosis of Fatal Excited Delirium Syndrome
Karch, S. B. (2012) · Academic Forensic Pathology · doi:10.23907/2012.040 · Cited by 4
Suppression of miR-26a attenuates physiological disturbances arising from exposure of Nile tilapia (Oreochromis niloticus) to ammonia
Zhao, Y., Zhou, H., Ayisi, C. L., Wang, Y., Wang, J., Chen, X., & Zhao, J. (2018) · Biology Open · doi:10.1242/bio.029082 · Cited by 4
“HSP70 is a member of the important stress-protein families and its expression is remarkably induced in response to various stresses including extreme temperature, UV irradiation, infection, and toxic chemicals (Wu, 1995).”
Background
Plant Temperature Stress
Hayashi, H. (2001) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0001320 · Cited by 4
Heat-Shocked A20 Lymphoma Cells Fail to Induce Degranulation of Cytotoxic T Lymphocytes: Possible Mechanism of Resistance
Jackson, K. M. P., DeLeon, M., Sistonen, L., et al. (2000) · Cellular Immunology · doi:10.1006/cimm.2000.1669 · Cited by 4
Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activationPreprint
Duarte, F. M., Fuda, N. J., Mahat, D. B., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/055921 · Cited by 4
Heat Shock Protein (HSP)
Karademir-Yilmaz, B., & Sari-Kaplan, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101809 · Cited by 4
Root morphology and transcriptomic analyses of the response to heat stress in Paspalum wettsteinii hack
Zhou, J., Huang, L., Wang, P., & Zhao, L. (2024) · Genetic Resources and Crop Evolution · doi:10.1007/s10722-023-01828-w · Cited by 3
“The activation of the heat-induced HSP90A gene exhibits evolutionary conservation in eukaryotes, and its homologue in prokaryotes, HTPG , also shows heat inducibility (Wu 1995; Leach et al. 2012).”
Kinetics of heat-shock response upon dysfunction of general transcription factor (HSF)
Funikov, S. Y., Garbuz, D. G., & Zatsepina, O. G. (2014) · Molecular Biology · doi:10.1134/s0026893314020058 · Cited by 3
The wonderous chaperones: A highlight on therapeutics of cancer and potentially malignant disorders
Tyagi, N., & Tyagi, R. (2015) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/0973-029x.164535 · Cited by 3
“HSF1 trimers subsequently bind with high affinity to the previously mentioned HSEs.”
Background
Physiological Role of Heat Shock Proteins, Molecular Function and Stress Removal in Fishes
Sen, S. S., & Giri, S. S. (2017) · Heat shock proteins · doi:10.1007/978-3-319-73377-7_8 · Cited by 4
Screening of genes coupled to heat response in Mongolian and Dorper sheep breeds
Wang, S., Zhang, D., Zhou, H., Pan, J., Zhang, Y., & Cao, Y. (2020) · Biologia · doi:10.2478/s11756-020-00616-6 · Cited by 5
“As molecular chaperone, HSPs are mostly induced by heat shock factor, and instrumental in folding of polypeptides and resolubilization of denatured proteins under stress (Wu 1995; De Maio 1999).”
Background
Yeni Bir Hücre Ölüm Şekli Olarak Ferroptozis
Çelenk, A. (2021) · Arşiv Kaynak Tarama Dergisi · doi:10.17827/aktd.980659 · Cited by 3
Regulation of Heat Shock Genes Expression
Evgen’ev, M. B., Garbuz, D. G., & Zatsepina, O. G. (2014) · Springer eBooks · doi:10.1007/978-94-017-9235-6_3 · Cited by 3
Dynamics of Heat Shock Proteins in Immunity and Aging
Prithika, U., & Balamurugan, K. (2019) · Heat shock proteins · doi:10.1007/978-3-030-03952-3_5 · Cited by 3
The Role of Heat Shock Protein 70, IgE and MMP-9 in Detecting Early Minor Myocardial Damage and Evaluating the Efficacy of Coronary Artery Bypass Grafting (CABG)
Baalash, A., Baalash, Hāla, Hamouda, Ghada, Ismail, I., İbrahim, Yassein, & Bedir (2012) · JoLS Journal of Life Sciences · Cited by 3
Untitled work
Sánchez (2002) · doi:10.1379/1466-1268(2002)007

Authors: Wu, C.
Affiliations: National Institutes of Health (US)
Corresponding author: Wu, Carl
ORCID: Wu, Carl
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1995-11
Volume: 11
Issue: 1
Pages: 441-469
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cb.11.110195.002301
OpenAlex: W2145760315
Cited by: 1,231
References: 0
Citations by year: 2026: 13 · 2025: 23 · 2024: 29 · 2023: 20 · 2022: 32 · 2021: 33 · 2020: 23 · 2019: 35 · 2018: 35 · 2017: 31 · 2016: 40 · 2015: 48 · 2014: 44 · 2013: 49 · 2012: 57
FWCI: 11.93
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: heat shock transcription factor, heat shock proteins, heat shock gene expression, DNA binding, transcriptional activation
MeSH terms: Heat Shock Transcription Factors, Amino Acid Sequence, Animals, Bacteria, Binding Sites, Cloning, Molecular, DNA-Binding Proteins, Heat-Shock Proteins, Humans, Models, Structural, Molecular Sequence Data, Transcription Factors, Conserved Sequence, Sequence Homology, Amino Acid, Protein Structure, Secondary, Helix-Turn-Helix Motifs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Heat Shock Transcription Factors: Structure and Regulation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks