Cited by 1,231Heat shock proteins researchGenomics and Chromatin DynamicsBacterial Genetics and Biotechnology

The DOI matches its Crossref record.

Heat Shock Transcription Factors: Structure and Regulation

Wu, Carl·1995·Annual Review of Cell and Developmental Biology

Open this paper in CoChat — free account

Abstract

Organisms respond to elevated temperatures and to chemical and physiological stresses by an increase in the synthesis of heat shock proteins. The regulation of heat shock gene expression in eukaryotes is mediated by the conserved heat shock transcription factor (HSF). HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerization and high-affinity binding to DNA and by exposure of domains for transcriptional activity. Analysis of HSF cDNA clones from many species has defined structural and regulatory regions responsible for the inducible activities. The heat stress signal is thought to be transduced to HSF by changes in the physical environment, in the activity of HSF-modifying enzymes. or by changes in the intracellular level of heat shock proteins.

Integrity signals

Registry

Crossref · 10.1146/annurev.cb.11.110195.002301

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 401–500 of 1,000

Modelling the Regulation of Thermal Adaptation in Candida albicans, a Major Fungal Pathogen of Humans
Leach, M. D., Tyc, K. M., Brown, A. J. P., & Klipp, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032467 · Cited by 61
“Strain Genotype Source THE1 ade2::hisG/ade2::hisG, ura3::l imm434/ura3::l imm434, ENO1/eno1::ENO1-tetR-ScHAP4AD-3XHA-ADE2 [86] ML250 ade2::hisG/ade2::hisG, ura3::l imm434/ura3::l imm434, ENO1/eno1::ENO1-tetR-ScHAP4AD-3XHA-ADE2 HSF1/HSF1, pACT1-FLAG-HSF1 this study doi:10.1371/journal.pone.0032467.t005 PLoS ONE | www.p…”
BackgroundInfluential
Molecular approaches for designing heat tolerant wheat
Kumar, S., Kumari, P., Kumar, U., Grover, M., Singh, A. K., SINGH, R. D., & Sengar, R. S. (2013) · Journal of Plant Biochemistry and Biotechnology · doi:10.1007/s13562-013-0229-3 · Cited by 62
ATF1 Modulates the Heat Shock Response by Regulating the Stress-Inducible Heat Shock Factor 1 Transcription Complex
Takii, R., Fujimoto, M., Tan, K., Takaki, E., Hayashida, N., Nakato, R., Shirahige, K., & Nakai, A. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00754-14 · Cited by 65
“As a master regulator of this response in all eukaryotes, HSF should be one of the ancient factors that regulate primitive response mechanisms (6, 17).”
Background
Heat shock proteins as biomarkers of lung cancer
Mittal, S., & Rajala, M. S. (2020) · Cancer Biology & Therapy · doi:10.1080/15384047.2020.1736482 · Cited by 62
“Activated HSF1 binds to 5′ promoter sequences of HSP genes and initiates transcription.(8) Hsps are overexpressed in various cancers including lung cancer and their increased expression is generally associated”
Background
Isolation and characterization of tomato Hsa32 encoding a novel heat-shock protein
Liu, N.-Y., Ko, S., Yeh, K., et al. (2006) · Plant Science · doi:10.1016/j.plantsci.2006.01.008 · Cited by 61
Are polyamines involved in the synthesis of heat-shock proteins in cell suspension cultures of tobacco and alfalfa in response to high-temperature stress?
Königshofer, H., & Lechner, S. (2002) · Plant Physiology and Biochemistry · doi:10.1016/s0981-9428(01)01347-x · Cited by 63
Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis
Tran, S. E. F., Meinander, A., Holmström, T., Rivero-Müller, A., Heiskanen, K., Linnau, E. K., Courtney, M., Mosser, D., Sistonen, L., & Eriksson, J. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401278 · Cited by 63
Implication of a Small GTPase Rac1 in the Activation of c-Jun N-terminal Kinase and Heat Shock Factor in Response to Heat Shock
Han, S. I., Oh, S. Y., Woo, S. H., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006042200 · Cited by 61
Different thermal tolerance and hsp gene expression in invasive and indigenous sibling species of Bemisia tabaci
Yu, H., Wan, F. H., & Guo, J. Y. (2012) · Biological Invasions · doi:10.1007/s10530-012-0171-7 · Cited by 60
“In particular, heat shock proteins (Hsps) are thought to play an ecologically and evolutionarily important role in the thermal adaptation of insects (Parsell and Lindquist 1993; Feder and Hofmann 1999).”
BackgroundInfluential
Recovery from heat, salt and osmotic stress in Physcomitrella patens requires a functional small heat shock protein PpHsp16.4
Ruibal, C., Castro, A., Carballo, V., et al. (2013) · BMC Plant Biology · doi:10.1186/1471-2229-13-174 · Cited by 60
“Stress-induced expression of sHsps is controlled by heat shock transcription factors (Hsfs) which bind to highly conserved palindromic motifs, so-called heat stress- elements (HSEs) [24-26].”
Background
Surface architecture of Histoplasma capsulatum
Guimaraes, A. J., & Nosanchuk, J. D. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00225 · Cited by 66
Heat‐shock tagging: a simple method for expression and isolation of plant genome DNA flanked by T‐DNA insertions
Matsuhara, S., Jingu, F., Takahashi, T., et al. (2000) · The Plant Journal · doi:10.1046/j.1365-313x.2000.00716.x · Cited by 60
Pathogenetic and Clinical Implications of Non-Immunoglobulin; BCL6 Translocations in B-Cell Non-Hodgkin's Lymphoma
Ohno, H. (2006) · Journal of the Japan Society of the Reticuloendothelial System · doi:10.3960/jslrt.46.43 · Cited by 58
Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes
Storz, G., & Polla, B. S. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9088-5_16 · Cited by 58
Turtle anoxia tolerance: Biochemistry and gene regulation
Krivoruchko, A., & Storey, K. B. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.02.001 · Cited by 58
Regulation of heat shock gene expression in response to stress
Garbuz, D. G. (2017) · Molecular Biology · doi:10.1134/s0026893317020108 · Cited by 57
Differing patterns of hsp70 gene expression in invasive and native kelp species: evidence for acclimation-induced variation
Henkel, S. K., & Hofmann, G. E. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9275-3 · Cited by 59
“From a mechanistic standpoint, inducible Hsp expression in all organisms is regulated by heat shock transcription factors (HSFs), which are complexed with Hsp70 in the cytoplasm and dissociate from the protein during stressful conditions when chaperoning is necessary (Wu 1995; Shi et al. 1998).”
Background
Larvae of related Diptera species from thermally contrasting habitats exhibit continuous up‐regulation of heat shock proteins and high thermotolerance
Garbuz, D. G., Zatsepina, O. G., Przhiboro, A. A., et al. (2008) · Molecular Ecology · doi:10.1111/j.1365-294x.2008.03947.x · Cited by 58
“In response to temperature elevation, HSF as expected (Wu 1995) binds specifically to heat-shock element (correspondent high molecular weight band is shown by an arrow in Fig.”
Background
Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise
West, J. D., Wang, Y., & Morano, K. A. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300264x · Cited by 59
Surviving the Heat of the Moment: A Fungal Pathogens Perspective
Leach, M. D., & Cowen, L. E. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003163 · Cited by 57
“All living organisms respond by inducing a set of proteins important for high-temperature growth called heat-shock proteins, which, in eukaryotes, are dependent on the heat-shock transcription factor (Hsf1) (Figure 1) [9–11].”
EGLN1 variants influence expression and Sa O 2 levels to associate with high-altitude pulmonary oedema and adaptation
Mishra, A., Mohammad, G., Thinlas, T., & Pasha, M. A. Q. (2012) · Clinical Science · doi:10.1042/cs20120371 · Cited by 56
Genetic engineering for heat tolerance in plants
Singh, A., & Grover, A. (2008) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-008-0014-2 · Cited by 56
Hsp90 in Cancer
Calderwood, S. K., & Neckers, L. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.08.002 · Cited by 58
Dual regulation of a heat shock promoter during embryogenesis: stage‐dependent role of heat shock elements
Almoguera, C., Prieto‐Dapena, P., & Jordano, J. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00044.x · Cited by 56
“The characteristics of eukaryotic HSF allowed us to perform such analysis using heterologous proteins expressed in bacteria, since the DNA binding of the different HSF is evolutionarily conserved (Wu, 1995), and E.”
Background
Heat Shock Factor 1 Contains Two Functional Domains That Mediate Transcriptional Repression of the c-fos and c-fms Genes
Xie, Y., Zhong, R., Chen, C., & Calderwood, S. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210189200 · Cited by 54
Geldanamycin Provides Posttreatment Protection Against Glutamate‐Induced Oxidative Toxicity in a Mouse Hippocampal Cell Line
Xiao, N., Callaway, C. W., Lipinski, C. A., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720095.x · Cited by 56
“Hsp90 has been found to associate with HSF-1 (Nair et al., 1996) and may be one component of a negative regulatory pathway that maintains HSF-1 in an inactive state in nonstressed cells (Morimoto, 1993).”
BackgroundInfluential
iTRAQ-based quantitative proteomic analysis of Takifugu fasciatus liver in response to low-temperature stress
Wen, X., Zhang, X., Hu, Y., Xu, J., Wang, T., & Yin, S. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.04.004 · Cited by 54
Sugar and Glycerol Transport in Saccharomyces cerevisiae
Bisson, L. F., Fan, Q., & Walker, G. A. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-25304-6_6 · Cited by 56
Anti-inflammatory properties of heat shock protein 70 and butyrate on Salmonella-induced interleukin-8 secretion in enterocyte-like Caco-2 cells
Malago, J. J., Koninkx, J. F. J. G., Tooten, P. C. J., van Liere, E. A., & van Dijk, J. E. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02810.x · Cited by 55
Anti-apoptotic Effects of L-Glutamine—Mediated Transcriptional Modulation of the Heat Shock Protein 72 During Heat Shock
Ropeleski, M. J., Riehm, J., Baer, K. A., Musch, M. W., & Chang, E. B. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.017 · Cited by 55
Developmentally regulated nuclear transport of transcription factors in Drosophila embryos enable the heat shock response
Wang, Z., & Lindquist, S. L. (1998) · Development · doi:10.1242/dev.125.23.4841 · Cited by 55
TaHsfA2-1, a new gene for thermotolerance in wheat seedlings: Characterization and functional roles
Liu, Z., Li, G., Zhang, H., et al. (2020) · Journal of Plant Physiology · doi:10.1016/j.jplph.2020.153135 · Cited by 54
“The expression of heat shock transcription factors (Hsfs) and their regulation of stress-related genes are a crucial component of the heat stress response (Wu, 1995).”
Background
Role of endotoxin and cytokines in the systemic inflammatory response to heat injury
Leon, L. R. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s111 · Cited by 54
“HSP gene expression is regulated by heat shock factors (HSF) interacting with the heat shock element (HSE) promoter (194,195).”
Background
Effect of Acute Heat Stress on Heat Shock Protein 70 and Its Corresponding mRNA Expression in the Heart, Liver, and Kidney of Broilers
Yu, J., & Bao, E. (2008) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2008.70703 · Cited by 54
“Many scientific researches have confirmed that the expression of HSPs is regulated mainly at the level of transcription by heat shock transcription factors (HSFs) (Morimoto, 1993; Wu, 1995; Morimoto, 1998).”
Background
Use of Heat Stress Responsive Gene Expression Levels for Early Selection of Heat Tolerant Cabbage (Brassica oleracea L.)
Park, H., Jung, W., Lee, S. Y., Song, J., Kwon, S., Kim, H., Kim, C., Ahn, J. C., & Cho, H. S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140611871 · Cited by 54
Structure and expression analysis of three subtypes of Arabidopsis MBF1 genes
Tsuda, K., & Yamazaki, K.-I. (2004) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2004.08.004 · Cited by 53
“Two putative heat shock elements (HSE, inverted repeat of 5V-nGAAn-3V; [20,21]), which are known to be necessary for heat induction and binding sites of trimeric transcription factor, heat shock factor (HSF; [22–24]), were found in the promoter of AtMBF1c (positions 316 to 304 bp and 99 to 87 bp relative to the transc…”
Background
Preheating Accelerates Mitogen-activated Protein (MAP) Kinase Inactivation Post-heat Shock via a Heat Shock Protein 70-mediated Increase in Phosphorylated MAP Kinase Phosphatase-1
Lee, K., Lee, C., Kim, Y. W., Han, S. K., Shim, Y., & Yoo, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410059200 · Cited by 54
Regulation of heat shock gene transcription in neuronal cells
Tonkiss, J., & Calderwood, S. K. (2005) · International Journal of Hyperthermia · doi:10.1080/02656730500165514 · Cited by 54
“This is the mammalian regulator of the response to protein stress (including heat, oxidative, ischemic stress) and activates the transcription of heat shock protein (HSP) genes [40, 41].”
BackgroundInfluential
Double-stranded RNA-dependent Protein Kinase (pkr) Is Essential for Thermotolerance, Accumulation of HSP70, and Stabilization of ARE-containing HSP70 mRNA during Stress
Zhao, M., Tang, D., Lechpammer, S., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208408200 · Cited by 53
Different Requirements of the SWI/SNF Complex for Robust Nucleosome Displacement at Promoters of Heat Shock Factor and Msn2- and Msn4-Regulated Heat Shock Genes
Erkina, T. Y., Tschetter, P. A., & Erkine, A. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01069-07 · Cited by 53
“The HSF system is highly conserved in its overall composition and function from yeast to humans (61).”
Background
A yeast heat shock transcription factor (Hsf1) mutant is defective in both Hsc82/Hsp82 synthesis and spindle pole body duplication
Zarzov, P., Boucherie, H., & Mann, C. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.16.1879 · Cited by 53
Plant responses to heat stress
Krishna, P. (2003) · Topics in current genetics · doi:10.1007/978-3-540-39402-0_4 · Cited by 56
“Studies from various organisms have led to the belief that Hsf is negatively regulated, at least in part, by hsp70 (reviewed in Wu 1995 ).”
Background
Activation of Heat Shock Transcription Factor 1 in Atherosclerosis
Metzler, B., Abia, R., Ahmad, M., Wernig, F., Pachinger, O. M., Hu, Y., & Xu, Q. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64301-5 · Cited by 53
“This activation process seems to involve the oligomerization of HSF from a monomeric to a trimeric state and is associated with HSF hyperphosphorylation.(25,26) Mouse HSF1”
Background
Tobacco Smoke Induces Coordinate Activation of HSF and Inhibition of NFκB in Human Monocytes: Effects on TNFα Release
Vayssier, M., Favatier, F., Pinot, F., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9586 · Cited by 53
Interaction between Heat Shock Transcription Factors (HSFs) and Divergent Binding Sequences
Sakurai, H., & Takemori, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611801200 · Cited by 52
Di (2-ethyl hexyl) phthalate (DEHP)-induced kidney injury in quail (Coturnix japonica) via inhibiting HSF1/HSF3-dependent heat shock response
Li, P.-C., Li, X., Du, Z., Wang, H., Yu, Z., & Li, J. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.06.158 · Cited by 52
Genome-wide identification, phylogenetic and expression analysis of the heat shock transcription factor family in bread wheat (Triticum aestivum L.)
Zhou, M., Zheng, S., Liu, R., et al. (2019) · BMC Genomics · doi:10.1186/s12864-019-5876-x · Cited by 52
Magnitude and Duration of Thermal Stress Determine Kinetics ofhspGene Regulation in the GobyGillichthys mirabilis
Buckley, B. A., & Hofmann, G. E. (2004) · Physiological and Biochemical Zoology · doi:10.1086/420944 · Cited by 53
“All inducible hsp genes are controlled by HSF1, a member of a general class of latent cytoplasmic transcription factors that become activated in response to stress (Morimoto 1993; Wu 1995; Pirkkala et al. 2001; Brivanlou and Darnell 2002).”
Background
Effects of chronic heat stress on the expressions of heat shock proteins 60, 70, 90, A2, and HSC70 in the rabbit testis
Pei, Y., Wu, Y., & Qin, Y. (2011) · Cell Stress and Chaperones · doi:10.1007/s12192-011-0287-1 · Cited by 51
“…to the molecular weights, mammalian HSPs are classified into different families including HSP105/110, HSP90, HSP70, HSP60, HSP40, and other small HSPs. HSPs act as molecular chaperones, assisting in the folding, assembly, and disassembly of other proteins (Wu 1995; Georgopoulos and Welch 1993).”
Background
A comparison of Hsp90α and Hsp90β interactions with cochaperones and substrates
Taherian, A., Krone, P. H., & Ovsenek, N. (2008) · Biochemistry and Cell Biology · doi:10.1139/o07-154 · Cited by 52
Over-expression of Arabidopsis thaliana heat shock factor gene (AtHsfA1b) enhances chilling tolerance in transgenic tomato
Li, H.-Y., Chang, C. J., Lu, L.-S., et al. (2005) · Cited by 51
Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases
Mishra, R., Upadhyay, A., Prajapati, V. K., & Mishra, A. (2018) · Medicinal Research Reviews · doi:10.1002/med.21502 · Cited by 51
Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response
Miles, J., Scherz‐Shouval, R., & van Oosten‐Hawle, P. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.06.009 · Cited by 53
Protein kinase and phosphatase control of plant temperature responses
Praat, M., Smet, I. D., & van Zanten, M. (2021) · Journal of Experimental Botany · doi:10.1093/jxb/erab345 · Cited by 50
“The dissociation of the HSP–HSF dimer releases the HSF, and subsequently the monomeric HSFs trimerize to form active homotrimers that can bind to cis elements in the promoters of HSP genes, known as Heat Shock Elements (HSEs) (Wu, 1995).”
Background
Heat shock factor-1 intertwines insulin/IGF-1, TGF-β and cGMP signaling to control development and aging
Barna, J., Princz, A., Kosztelnik, M., Hargitai, B., Takács‐Vellai, K., & Vellai, T. (2012) · BMC Developmental Biology · doi:10.1186/1471-213x-12-32 · Cited by 51
“Birnby DA, Link EM, Vowels JJ, Tian H, Colacurcio PL, Thomas JH: A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans.”
BackgroundInfluential
BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress
Jin, Y.-H., Ahn, S., & Kim, S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.006 · Cited by 50
Opposing roles for heat and heat shock proteins in macrophage functions during inflammation: a function of cell activation state?
Lee, C.-T., & Repasky, E. A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00140 · Cited by 51
“, fever, inflammation, and infection) as well as those induced by normal development stresses (Morimoto, 1993, 1998; Wu, 1995).”
Background
Heat shock proteins and the pancreas
Rakonczay, Z., Takács, T., Boros, I., et al. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10268 · Cited by 50
“Attenuation of the heat shock response additionally depends on the negative regulatory effects of HSF-binding protein 1, the dissociation of the trimers and refolding to the inert monomer state (Wu, 1995; Satyal et al., 1998).”
Background
Ethanol-induced small heat shock protein genes in the differentiation of mouse embryonic neural stem cells
Choi, M., Jung, K. H., Park, J. H., Das, N. D., Chung, M. K., Choi, I. G., Lee, B. C., Park, K. S., & Chai, Y. G. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0591-z · Cited by 48
“According to previous studies, the expression of HSPs, which are also known as molecular chaperones, is largely regulated by heat shock transcription factors (HSFs) that bind to the heat shock elements (HSE) of heat shock genes upon encountering stressful conditions that include but are not limited to heat stress ( Wu…”
Background
Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways
Rawat, P., & Mitra, D. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr198 · Cited by 48
Effect of heat stress on actin cytoskeleton and endoplasmic reticulum of tobacco BY-2 cultured cells and its inhibition by Co2+
Malerba, M., Crosti, P., & Cerana, R. (2009) · PROTOPLASMA · doi:10.1007/s00709-009-0078-z · Cited by 48
“1998) is induced by ethephon, an ethylene-releasing compound (Wu 1995).”
Background
Effect of dietary manganese on antioxidant status and expression levels of heat-shock proteins and factors in tissues of laying broiler breeders under normal and high environmental temperatures
Zhu, Y., Lü, L., Li, W.-X., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003803 · Cited by 48
“Some reports have confirmed that the expression levels of HSP are regulated mainly at the level of transcription by HSF((36,37)).”
Proteomic changes in the liver of Channa striatus in response to high temperature stress
Mahanty, A., Purohit, G. K., Banerjee, S., et al. (2016) · Electrophoresis · doi:10.1002/elps.201500393 · Cited by 48
Induction of HSF1 expression is associated with sporadic colorectal cancer
Cen, H. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i21.3122 · Cited by 48
“HSF1 could be induced by heat, chemicals and hypoxia [ 17-19 ] and usually exists as a monomer in the cytoplasm.”
Background
Stress and the cell nucleus: dynamics of gene expression and structural reorganization.
Jolly, C., & Morimoto, R. I. (1999) · Europe PMC (PubMed Central) · Cited by 48
Heat shock factor 2 is activated during mouse heart development
Eriksson, M. R., Jokinen, E., Sistonen, L., et al. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11032181 · Cited by 48
“JEDLICKA, P., MORTIN, M.A. and WU, C. (1997).”
Influential
EFFECTS ON PROTEIN KINASE C AND GENE EXPRESSION IN A HUMAN MAST CELL LINE, HMC‐1, FOLLOWING MICROWAVE EXPOSURE
Harvey, C., & French, P. W. (1999) · Cell Biology International · doi:10.1006/cbir.1999.0436 · Cited by 48
Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration
Ali, Y., Kitay, B. M., & Zhai, R. G. (2010) · Molecules · doi:10.3390/molecules15106859 · Cited by 49
“Reduced stress level will trigger a negative feedback loop where excess chaperones will sequester monomeric HSF1, thus attenuating HSF1-mediated transcription [68,69,71].”
Background
Expression Profiles of Class A Rice Heat Shock Transcription Factor Genes Under Abiotic Stresses
Liu, A., Zou, J., Zhang, X., et al. (2010) · Journal of Plant Biology · doi:10.1007/s12374-010-9099-6 · Cited by 47
“The central regulators of the expression of such heat-responsive genes are the heat stress transcription factors (Hsfs; Wu 1995).”
Background
PI3K-mTORC1 Attenuates Stress Response by Inhibiting Cap-independent Hsp70 Translation
Sun, J., Conn, C. S., Han, Y. Y., Yeung, V., & Qian, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.172882 · Cited by 50
NF-IL6 and HSF1 Have Mutually Antagonistic Effects on Transcription in Monocytic Cells
Xie, Y., Chen, C., Stevenson, M. A., Hume, D. A., Auron, P. E., & Calderwood, S. K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6562 · Cited by 46
Two Distinct Disulfide Bonds Formed in Human Heat Shock Transcription Factor 1 Act in Opposition To Regulate Its DNA Binding Activity
Lu, M., Kim, H.-E., Li, C.-R., Kim, S., Kwak, I.-J., Lee, Y., Kim, S., Moon, J., Kim, C. H., Kim, D., et al. (2008) · Biochemistry · doi:10.1021/bi702185u · Cited by 47
Essential role of the first intron in the transcription of hsp90β gene
Shen, Y., Liu, J.-H., Wang, X.-Z., Cheng, X.-K., Wang, Y., & Wu, N. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00883-1 · Cited by 47
Function of Heat-Shock Proteins in Drought Tolerance Regulation of Plants
Augustine, S. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-28899-4_7 · Cited by 47
Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
Goldstein, M. G., & Li, Z. (2009) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-2-5 · Cited by 46
“In cancer, however, hsf1 in particular has been found to be overexpressed and to contribute to invasion and metastasis by permitting increased cell proliferation and by decreasing cell death [44-47].”
Background
Molecular mechanisms underlying thermal adaptation of xeric animals
Evgen’ev, M. B., Garbuz, D. G., Shilova, V. Y., et al. (2007) · Journal of Biosciences · doi:10.1007/s12038-007-0048-6 · Cited by 46
“…(HSF), that is normally present in a monomeric state, but after an increase in temperature or action of some other stress agents the factor enters the nucleus, trimerizes and thereby becomes active to bind with the special promoter elements located in the regulatory regions of Hsp genes (Wu 1995).”
Background
The maize heat shock factor-binding protein paralogs EMP2 and HSBP2 interact non-redundantly with specific heat shock factors
Fu, S., Rogowsky, P., Nover, L., et al. (2005) · Planta · doi:10.1007/s00425-005-0191-y · Cited by 46
“The heat shock transcription factor (HSF) activates the transcription of hsps in response to heat stress (Nover et al. 2001; Wu 1995 and references therein).”
Background
An RNA aptamer that interferes with the DNA binding of the HSF transcription activator
Zhao, X. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl470 · Cited by 47
Cellular localization of the heat shock transcription factors HSF1 and HSF2 in the rat brain during postnatal development and following hyperthermia
Brown, I. R., & Rush, S. J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01087-2 · Cited by 46
Transcriptional activation of a heat shock gene promoter in sunflower embryos: synergism between ABI3 and heat shock factors
Rojas, A., Almoguera, C., & Jordano, J. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00635.x · Cited by 46
Overexpression of HSF2-β Inhibits Hemin-induced Heat Shock Gene Expression and Erythroid Differentiation in K562 Cells
Leppä, S., Pirkkala, L., Saarento, H., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15293 · Cited by 46
Glutamine-mediated Dual Regulation of Heat Shock Transcription Factor-1 Activation and Expression
Xue, H., Slavov, D. B., & Wischmeyer, P. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410712 · Cited by 45
“It has long been believed that HSF1 is constitutively expressed in most tissues and cell types and that HSF1-regulated increases inHsp expression occur primarily via posttranslational mechanisms (7).”
Background
Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes
Kalo, D., & Roth, Z. (2011) · Reproduction Fertility and Development · doi:10.1071/rd10330 · Cited by 45
“The intracellular response to heat shock is associated with activation of heat-shock transcription factor 1 (Hsf1), which mediates the transcription of heat-shock genes (Wu 1995; Morimoto 1998).”
Background
Heat shock protein induction in the freshwater prawn Macrobrachium malcolmsonii: Acclimation-influenced variations in the induction temperatures for Hsp70
Selvakumar, S., & Geraldine, P. (2005) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2005.01.008 · Cited by 45
Canonical Heat Shock Element in the αB-crystallinGene Shows Tissue-specific and Developmentally Controlled Interactions with Heat Shock Factor
Somasundaram, T., & Bhat, S. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000304200 · Cited by 45
Regulation of Protein Phosphatase 2A Activity by Heat Shock Transcription Factor 2
Hong, Y., & Sarge, K. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.12967 · Cited by 46
Expression of Heat Shock and Other Stress Response Proteins in Ticks and Cultured Tick Cells in Response toAnaplasmaspp. Infection and Heat Shock
Villar, M., Ayllón, N., Busby, A. T., et al. (2010) · International Journal of Proteomics · doi:10.1155/2010/657261 · Cited by 45
“HSEs are the binding sites for the transactive heat shock factor (HSF), and efficient binding requires at least three units, resulting in 5′nGAAnnTTCnnGAAn-3 [20].”
BackgroundInfluential
Phylogeny Disambiguates the Evolution of Heat-Shock cis-Regulatory Elements in Drosophila
Tian, S., Haney, R. A., & Feder, M. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010669 · Cited by 43
“response in eukaryotes [11,12] in combination with numerous co-”
Background
The Role of Heat Shock Factors in Stress-Induced Transcription
Zhang, Y., Chou, S., Murshid, A., Prince, T. L., Schreiner, S., Stevenson, M. A., & Calderwood, S. K. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-295-3_2 · Cited by 45
“(5) Measuring HSF1 binding to HSP promoters in vivo by the chromatin”
Mutated Yeast Heat Shock Transcription Factor Activates Transcription Independently of Hyperphosphorylation
Hashikawa, N., Mizukami, Y., Imazu, H., & Sakurai, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510827200 · Cited by 42
Effects of vitamin E and vitamin A supplementation on performance, thyroid status and serum concentrations of some metabolites and minerals in broilers reared under heat stress (32 degrees C)
Şahin, N., Şahin, K., & Küçük, O. (2001) · Veterinární Medicína · doi:10.17221/7894-vetmed · Cited by 44
Effect of 50 Hz Electromagnetic Fields on the Induction of Heat-Shock Protein Gene Expression in Human Leukocytes
Coulton, L. A., Harris, P. A., Barker, A. T., & Pockley, A. G. (2004) · Radiation Research · doi:10.1667/rr3145 · Cited by 44
“The consequences of HSF1 binding to its target, and the events that result in the ensuing transcription of heat-shock protein genes, have been reviewed extensively (9, 10).”
Background
Inhibiting Heat Shock Factor 1 in Human Cancer Cells with a Potent RNA Aptamer
Salamanca, H. H., Antonyak, M. A., Cerione, R. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096330 · Cited by 43
“The Heat Shock Factor 1 (HSF1) is a transcription factor that responds to a variety of environmental stressors to activate the heat shock response in eukaryotes, a protective mechanism conserved among different kingdoms [1].”
Background
Exposure of the gilthead seabream ( Sparus aurata ) to sediments contaminated with heavy metals down-regulates the gene expression of stress biomarkers
Hamed, S. B., Guardiola, F. A., Martínez, S., et al. (2016) · Toxicology Reports · doi:10.1016/j.toxrep.2016.02.006 · Cited by 43
Differential activation of heat shock and nuclear factor κB transcription factors in postischemic reperfused rat liver
Tacchini, L., Radice, L., Pogliaghi, G., et al. (1997) · Hepatology · doi:10.1002/hep.510260124 · Cited by 43
“4), increases genes induced by heat shock or other environmental further during the first 30 minutes of reperfusion, and then stresses.(15) The proteins coded by these genes, particularly declines 1 hour after the re-establishment of the blood flow.”
Background
Nanomaterial-mediated low-temperature photothermal therapy via heat shock protein inhibition
Yu, X., Sun, Z., Liu, J., Li, W., Wang, M., Chu, Y., Sun, Z., & Deng, G. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1027468 · Cited by 43
“Meanwhile, tumor cells stimulated by high temperature easily acquire tolerance to hyperthermia, which will further enhance the viability of tumor cells, a phenomenon known as thermotolerance (Kampinga, 1993; Wu, 1995).”
Background
HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression
Dai, Y., & Hu, L. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00306.2022 · Cited by 45
HSFs, Stress Sensors and Sculptors of Transcription Compartments and Epigenetic Landscapes
Miozzo, F., Sabéran‐Djoneidi, D., & Mezger, V. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.10.007 · Cited by 49
Regulations of essential amino acids and proteomics of bacterial endophytes S phingomonas sp. L k11 during cadmium uptake
Khan, A. L., Ullah, I., Hussain, J., et al. (2014) · Environmental Toxicology · doi:10.1002/tox.22100 · Cited by 42
Functional characterization of four metallothionein genes in Daphnia pulex exposed to environmental stressors
Asselman, J., Glaholt, S., Smith, Z., Smagghe, G. J., Janssen, C., Colbourne, J. K., Shaw, J. R., & Schamphelaere, K. D. (2011) · Aquatic Toxicology · doi:10.1016/j.aquatox.2011.12.010 · Cited by 42
“The heat shock transcription factors targeting to these binding sites (HSF1, HSF2 and HSTF) were characterized in Drosophila melanogaster (Westwood and Wu, 1993; Wiederracht et al., 1987; Wu, 1995), Homo sapiens (Rabindran et al.”
Background

Authors: Wu, C.
Affiliations: National Institutes of Health (US)
Corresponding author: Wu, Carl
ORCID: Wu, Carl
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1995-11
Volume: 11
Issue: 1
Pages: 441-469
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cb.11.110195.002301
OpenAlex: W2145760315
Cited by: 1,231
References: 0
Citations by year: 2026: 13 · 2025: 23 · 2024: 29 · 2023: 20 · 2022: 32 · 2021: 33 · 2020: 23 · 2019: 35 · 2018: 35 · 2017: 31 · 2016: 40 · 2015: 48 · 2014: 44 · 2013: 49 · 2012: 57
FWCI: 11.93
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: heat shock transcription factor, heat shock proteins, heat shock gene expression, DNA binding, transcriptional activation
MeSH terms: Heat Shock Transcription Factors, Amino Acid Sequence, Animals, Bacteria, Binding Sites, Cloning, Molecular, DNA-Binding Proteins, Heat-Shock Proteins, Humans, Models, Structural, Molecular Sequence Data, Transcription Factors, Conserved Sequence, Sequence Homology, Amino Acid, Protein Structure, Secondary, Helix-Turn-Helix Motifs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Heat Shock Transcription Factors: Structure and Regulation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks