Cited by 1,231Heat shock proteins researchGenomics and Chromatin DynamicsBacterial Genetics and Biotechnology

The DOI matches its Crossref record.

Heat Shock Transcription Factors: Structure and Regulation

Wu, Carl·1995·Annual Review of Cell and Developmental Biology

Open this paper in CoChat — free account

Abstract

Organisms respond to elevated temperatures and to chemical and physiological stresses by an increase in the synthesis of heat shock proteins. The regulation of heat shock gene expression in eukaryotes is mediated by the conserved heat shock transcription factor (HSF). HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerization and high-affinity binding to DNA and by exposure of domains for transcriptional activity. Analysis of HSF cDNA clones from many species has defined structural and regulatory regions responsible for the inducible activities. The heat stress signal is thought to be transduced to HSF by changes in the physical environment, in the activity of HSF-modifying enzymes. or by changes in the intracellular level of heat shock proteins.

Integrity signals

Registry

Crossref · 10.1146/annurev.cb.11.110195.002301

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 201–300 of 1,000

An alternatively spliced heat shock transcription factor, Os HSFA 2dI, functions in the heat stress‐induced unfolded protein response in rice
Cheng, Q., Zhou, Y., Liu, Z., Zhang, L., Song, G., Guo, Z., Wang, W., Qu, X., Zhu, Y., & Yang, D. (2014) · Plant Biology · doi:10.1111/plb.12267 · Cited by 120
Pivotal Role of Reactive Oxygen Species as Intracellular Mediators of Hyperthermia-induced Apoptosis
Katschinski, D. M., Boos, K., Schindler, S., & Fandrey, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001629200 · Cited by 120
HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites
Jolly, C., Morimoto, R. I., Robert‐Nicoud, M., et al. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.23.2935 · Cited by 120
Encyclopedia of Signaling Molecules
Maroteaux, L., Roumier, A., Doly, S., et al. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4 · Cited by 120
Identification and characterization of a novel heat shock transcription factor gene, GmHsfA1, in soybeans (Glycine max)
Zhu, B., Ye, C., Lü, H., et al. (2006) · Journal of Plant Research · doi:10.1007/s10265-006-0267-1 · Cited by 119
“The DBD lies in the N-terminus of the HSF proteins, consisting of an antiparallel fourstranded β-sheet packed against a bundle of three α-helices, as found in HSFs from Kluyveromyces lactis, Drosophila melanogaster and tomato (for details see Mager and Krujiff 1995; Wu 1995; Nover et al. 1996).”
Background
Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity
Tan, K., Fujimoto, M., Takii, R., Takaki, E., Hayashida, N., & Nakai, A. (2015) · Nature Communications · doi:10.1038/ncomms7580 · Cited by 123
Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance
Tanabe, M., Kawazoe, Y., Takeda, S., Morimoto, R. I., Nagata, K., & Nakai, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1750 · Cited by 120
Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation
Min, J., Zhang, Y., Moskophidis, D., & Mivechi, N. F. (2004) · genesis · doi:10.1002/gene.20087 · Cited by 119
Disruption of Heat Shock Factor 1 Reveals an Essential Role in the Ubiquitin Proteolytic Pathway
Pirkkala, L., Alastalo, T., Zuo, X., Benjamin, I. J., & Sistonen, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2670-2675.2000 · Cited by 120
Effect of Hyaluronan Oligosaccharides on the Expression of Heat Shock Protein 72
Xu, H., Ito, T., Tawada, A., Maeda, H. A., Yamanokuchi, H., Isahara, K., Yoshida, K., Uchiyama, Y., & Asari, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112371200 · Cited by 118
Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders
Hashimoto‐Torii, K., Torii, M., Fujimoto, M., Nakai, A., Fatimy, R. E., Mezger, V., Ju, M. J., Ishii, S., Chao, S.-H., Brennand, K., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.002 · Cited by 124
“Transcription of HSPs is primarily regulated by the transcription factor heat shock factor 1 (HSF1) (Wu, 1995; Morimoto, 1998), which plays a dominant role in stress responses, whereas other HSFs function in normal cellular processes (Christians and Benjamin, 2006; Akerfelt et al.”
Mobile phones, heat shock proteins and cancer
French, P. W., Penny, R., Laurence, J. A., & McKenzie, D. R. (2001) · Differentiation · doi:10.1046/j.1432-0436.2001.670401.x · Cited by 117
Advances and perspectives on the regulation and expression of piscine heat shock proteins
Deane, E. E., & Woo, N. Y. S. (2010) · Reviews in Fish Biology and Fisheries · doi:10.1007/s11160-010-9164-8 · Cited by 118
A Small Molecule Inhibitor of ATPase Activity of HSP70 Induces Apoptosis and Has Antitumor Activities
Ko, S., Kim, J., Na, D. C., Park, S., Park, S., Hyun, J. Y., Baek, K.-H., Kim, N. D., Kim, N.-K., Park, Y. N., et al. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.02.004 · Cited by 118
“Specifically, treatment of cancer cells with these inhibitors results in production of HSP70, thereby leading to a decrease in the cancer cell death effect of HSP90 inhibitors (Bagatell et al., 2000; Wu, 1995).”
Background
Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis
Batulan, Z., Taylor, D. M., Aarons, R. J., Minotti, S., Doroudchi, M. M., Nalbantoglu, J. N., & Durham, H. D. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.06.017 · Cited by 117
“The transcription factor Hsf1 is mainly responsible for transcriptional activation of Hsps in response to environmental stress (Wu, 1995; Morimoto, 1998; Voellmy, 2004).”
Background
Heat Shock Transcription Factor 1 Is Involved in Quality-Control Mechanisms in Male Germ Cells1
Izu, H., Inouye, S., Fujimoto, M., Shiraishi, K., Naito, K., & Nakai, A. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.020065 · Cited by 116
“The HSF1 is activated in response to stresses that induce protein denaturation [14, 15].”
Background
Cold stress induces antioxidants and Hsps in chicken immune organs
Zhao, F. Q., Zhang, Z. W., Qu, J. P., et al. (2014) · Cell Stress and Chaperones · doi:10.1007/s12192-013-0489-9 · Cited by 114
Facets of heat shock protein 70 show immunotherapeutic potential
Todryk, S. M., Gough, M. J., & Pockley, A. G. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01725.x · Cited by 117
Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?
Calderwood, S. K. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0524 · Cited by 114
Recent progress on hybrid fibrous electromagnetic shields: Key protectors of living species against electromagnetic radiation
Hashemi, S. A., Ghaffarkhah, A., Hosseini, E., Bahrani, S., Najmi, P., Omidifar, N., Mousavi, S. M., Amini, M., Ghaedi, M., Ramakrishna, S., et al. (2022) · Matter · doi:10.1016/j.matt.2022.09.012 · Cited by 112
Gene Regulation in Spermatogenesis
MacLean, J. A., & Wilkinson, M. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)71005-x · Cited by 112
Environmental Health and Long Non-coding RNAs
Karlsson, O., & Baccarelli, A. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0092-1 · Cited by 114
AtHsfA2 modulates expression of stress responsive genes and enhances tolerance to heat and oxidative stress in Arabidopsis
Li, C. (2005) · Science in China Series C Life Sciences · doi:10.1360/062005-119 · Cited by 111
Multiple Means to the Same End: The Genetic Basis of Acquired Stress Resistance in Yeast
Berry, D. B., Guan, Q., Hose, J., Haroon, S., Gebbia, M., Heisler, L. E., Nislow, C., Giaever, G. N., & Gasch, A. P. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002353 · Cited by 109
“The transcription factor Hsf1p , a critical regulator of the heat - shock response that plays an overlapping role with Msn2p [ 56 , 57 ] , was required for full acquisition of H 2 O 2 tolerance following heat , but not NaCl or DTT , pretreatments .”
Stress proteins in aging and life span
Murshid, A., Eguchi, T., & Calderwood, S. K. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.798873 · Cited by 111
“HSF1, the principal member of the HSF family of transcription factors is highly conserved and its activity is somewhat regulated through feedback by HSP [26].”
Background
Elevated Expression of Heat Shock Factor (HSF) 2A Stimulates HSF1-induced Transcription during Stress
He, H., Soncin, F., Grammatikakis, N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304663200 · Cited by 111
Transcriptome Analysis of Androgenic Gland for Discovery of Novel Genes from the Oriental River Prawn, Macrobrachium nipponense, Using Illumina Hiseq 2000
Jin, S., Fu, H., Zhou, Q., Sun, S., Jiang, S., Xiong, Y., Gong, Y., Qiao, H., & Zhang, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076840 · Cited by 109
“Heat shock proteins have several different families classified according to their molecular weight [70,71].”
Background
Cytosol-Localized Heat Shock Factor-Binding Protein, AtHSBP, Functions as a Negative Regulator of Heat Shock Response by Translocation to the Nucleus and Is Required for Seed Development in Arabidopsis
Hsu, S.-F., Lai, H.-C., & Jinn, T.-L. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.151225 · Cited by 110
“On the recovery of HS, HSBP1 and HSP70 bind directly to HSF1, which HSF1 dissociates into monomers and then returns to the cytoplasm (for review, see Wu, 1995; Morimoto, 1998; Satyal et al., 1998; Pirkkala et al., 2001).”
Background
Quercetin Inhibits Heat Shock Protein Induction but Not Heat Shock Factor DNA-Binding in Human Breast Carcinoma Cells
Hansen, R. K., Oesterreich, S., Lemieux, P., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7572 · Cited by 109
HSP expression in bivalves
Fabbri, E., VALBONESI, P., & Franzellitti, S. (2008) · Invertebrate survival journal · Cited by 109
Heat Shock Transcription Factor 1 Inhibits Expression of IL-6 through Activating Transcription Factor 3
Takii, R., Inouye, S., Fujimoto, M., Nakamura, T., Shinkawa, T., Prakasam, R., Tan, K., Hayashida, N., Ichikawa, H., Hai, T., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902579 · Cited by 111
Knockdown of Mitochondrial Heat Shock Protein 70 Promotes Progeria-like Phenotypes in Caenorhabditis elegans
Kimura, K., Tanaka, N., Nakamura, N., Takano, S., & Ohkuma, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609025200 · Cited by 108
Exercise, heat shock proteins, and myocardial protection from I-R injury
Powers, S. K., Locke, M., & Demirel, H. A. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200103000-00009 · Cited by 108
Differential Activation of p38 Mitogen-activated Protein Kinase and Extracellular Signal-regulated Protein Kinases Confers Cadmium-induced HSP70 Expression in 9L Rat Brain Tumor Cells
Hung, J., Cheng, T.-J. R., Lai, Y., & Chang, M. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.31924 · Cited by 105
Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs
Leach, M. D., Klipp, E., Cowen, L. E., & Brown, A. J. P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2875 · Cited by 107
Heat Shock Transcription Factor 1 Opens Chromatin Structure of Interleukin-6 Promoter to Facilitate Binding of an Activator or a Repressor
Inouye, S., Fujimoto, M., Nakamura, T., Takaki, E., Hayashida, N., Hai, T., & Nakai, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704471200 · Cited by 107
Comparative proteomic analysis of differentially expressed proteins in the early milky stage of rice grains during high temperature stress
Liao, J., Zhou, H., Zhang, H., Zhong, P.-A., & Huang, Y. (2013) · Journal of Experimental Botany · doi:10.1093/jxb/ert435 · Cited by 105
“The significant up-regulation of the Hsps is a key part of the heat shock response, and is induced primarily by heat shock factors (HSFs) such as drought, salinity, cold and hot temperatures, and chemicals (Wu, 1995; Scarpeci et al. , 2008; Al-Whaibi, 2011).”
Protein misfolding and temperature up-shift cause G 1 arrest via a common mechanism dependent on heat shock factor in Saccharomyces cerevisiae
Trotter, E. W., Berenfeld, L., Krause, S. A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121172998 · Cited by 105
Genome-Wide Identification and Function Analyses of Heat Shock Transcription Factors in Potato
Tang, R., Zhu, W., Song, X., Lin, X., Cai, J., Wang, M., & Yang, Q. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00490 · Cited by 106
“This domain consists of hydrophobic heptad repeats (HR-A and HR-B) which can form a curly structure to activate the formation of an Hsf trimer to combine with Hsp genes’ promoter efficiently (Sorger and Nelson, 1989; Wu, 1995; Lyck et al., 1997; Scharf et al., 2012).”
Background
Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling
Merkle, T. (2003) · Current Genetics · doi:10.1007/s00294-003-0444-x · Cited by 102
“In contrast, Drosophila and yeast contain only one HSF gene and vertebrates have four (Wu 1995).”
Background
Induction of heat shock proteins by heregulin β1 leads to protection from apoptosis and anchorage-independent growth
Khaleque, A., Bharti, A. K., Sawyer, D. B., Gong, J., Benjamin, I. J., Stevenson, M. A., & Calderwood, S. K. (2005) · Oncogene · doi:10.1038/sj.onc.1208798 · Cited by 104
Toxicological and gene expression analysis of the impact of aflatoxin B1 on hepatic function of male broiler chicks
Yarru, L. P., Settivari, R. S., Antoniou, E., Ledoux, D. R., & Rottinghaus, G. E. (2009) · Poultry Science · doi:10.3382/ps.2008-00258 · Cited by 104
A Novel Mouse HSF3 Has the Potential to Activate Nonclassical Heat-Shock Genes during Heat Shock
Fujimoto, M., Hayashida, N., Katoh, T., Oshima, K., Shinkawa, T., Prakasam, R., Tan, K., Inouye, S., Takii, R., & Nakai, A. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-07-0639 · Cited by 111
“In mammals, the expression of classical Hsps is regulated by heat-shock transcription factor 1 (HSF1; Wu, 1995; Morimoto, 1998).”
Background
Different Thresholds in the Responses of Two Heat Shock Transcription Factors, HSF1 and HSF3
Tanabe, M., Nakai, A., Kawazoe, Y., & Nagata, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15389 · Cited by 100
Heat Shock Response - Pathophysiological Implications
Leppä, S., & Sistonen, L. (1997) · Annals of Medicine · doi:10.3109/07853899708998745 · Cited by 101
Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modifies its activity during acquired thermotholerance
Cohen-Peer, R., Schuster, S., Meiri, D., Breiman, A., & Avni, A. (2010) · Plant Molecular Biology · doi:10.1007/s11103-010-9652-1 · Cited by 103
“studied to date (Nover et al. 2001; Wu 1995).”
Background
Stress proteins in neural cells: functional roles in health and disease
Richter‐Landsberg, C., & Goldbaum, O. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300028 · Cited by 101
The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathwaysPreprint
Connolly, L. E., Peñas, A. D. L., Alba, B. M., et al. (1997) · Genes & Development · doi:10.1101/gad.11.15.2012 · Cited by 101
“For example, the cytoplasmic stress response in eukaryotes is coordinated by a family of transcriptional activators known as the heat shock transcription factors (HSFs) (Wu 1995; Morimoto et al. 1996).”
Background
Thermal acclimation changes DNA-binding activity of heat shock factor 1(HSF1) in the gobyGillichthys mirabilis: implications for plasticity in the heat-shock response in natural populations
Buckley, B. A., & Hofmann, G. E. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.20.3231 · Cited by 100
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
Csermely, P., & VÃgh, L. (2007) · Springer eBooks · doi:10.1007/978-0-387-39975-1 · Cited by 100
Heat shock proteins in health and disease: therapeutic targets or therapeutic agents?
Pockley, A. G. (2001) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399401003556 · Cited by 100
DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity
Boellmann, F., Guettouche, T., Guo, Y., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304768101 · Cited by 99
Regulation of the members of the mammalian heat shock factor family
Björk, J., & Sistonen, L. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07828.x · Cited by 98
A Seed-specific Heat-shock Transcription Factor Involved in Developmental Regulation during Embryogenesis in Sunflower
Almoguera, C., Rojas, A., Díaz‐Martín, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207330200 · Cited by 98
RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT
Fujimoto, M., Takaki, E., Takii, R., Tan, K., Prakasam, R., Hayashida, N., Iemura, S., Natsume, T., & Nakai, A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.026 · Cited by 99
Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced, and bind HSP90
Aviezer-Hagai, K., Skovorodnikova, J., Galigniana, M. D., Pisanty, O., Maayan, E., Bocovza, S., Efrat, Y., von Koskull‐Döring, P., Ohad, N., & Breiman, A. (2006) · Plant Molecular Biology · doi:10.1007/s11103-006-9085-z · Cited by 99
“For example both contain heatstress elements (HSEs, elements for binding heat shock transcription factor) (Wu 1995) at about -200 bp and CCAAT sequences essential for binding the C/EBP transcription factors (Akira et al.”
Background
Regulation of loquat fruit low temperature response and lignification involves interaction of heat shock factors and genes associated with lignin biosynthesis
Zeng, J., Li, X., Zhang, J., et al. (2016) · Plant Cell & Environment · doi:10.1111/pce.12741 · Cited by 97
HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes
Kovács, D., Sigmond, T., Hotzi, B., Bohár, B., Fazekas, D., Deák, V., Vellai, T., & Barna, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225815 · Cited by 97
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70Preprint
Maheswaran, S., Englert, C., Zheng, G., Lee, S. B., Wong, J. C., Harkin, D. P., Bean, J. M., Ezzell, R. M., Garvin, A. J., McCluskey, R. T., et al. (1998) · Genes & Development · doi:10.1101/gad.12.8.1108 · Cited by 97
“In contrast, both the heat shock response and the cell cycle regulation of Hsp70 expression are linked to activation of heat shock factor (HSF) family members binding the heat shock element (HSE) within the promoter (for review, see Sorger 1991; Wu 1995).”
Background
Cell-Nonautonomous Regulation of Proteostasis in Aging and DiseasePreprint
Morimoto, R. I. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a034074 · Cited by 98
“HSF1 is the founding member of the family of the HSF gene family (HSFs 1–4), which is conserved among eukaryotes (Sistonen et al. 1992; Wu 1995; McMillan et al. 1998;Morimoto 1998, 2008;Kallio et al. 2001; Fujimoto et al. 2004; Åkerfelt et al. 2010).”
Background
Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging
Janssens, G. E., Lin, X.-X., Millán-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., Stroustrup, N., Nollen, E. A. A., & Riedel, C. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.044 · Cited by 96
Natural and Genetic Engineering of the Heat-Shock Protein Hsp70 inDrosophila melanogaster: Consequences for Thermotolerance
Feder, M. E., & Krebs, R. A. (1998) · American Zoologist · doi:10.1093/icb/38.3.503 · Cited by 96
“cific, as expression of the principal human Hsp transcription factor, HSF1, in Drosophila cells causes its activation temperature to shift from that of human cells to that characteristic of Drosophila (Wu, 1995).”
Background
Clathrin self‐assembly is regulated by three light‐chain residues controlling the formation of critical salt bridges
Ybe, J. A., Greene, B., Liu, S., Pley, U., Parham, P., & Brodsky, F. M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1297 · Cited by 96
“Such self-assembly reactions include the polymerization of cytoskeletal elements (Egelman and Orlova, 1995), the oligomerization of transcription factors (Wu, 1995) and the assembly of membrane vesicle coats (Pearse and Crowther, 1987).”
Background
Role of Hsp17.4-CII as Coregulator and Cytoplasmic Retention Factor of Tomato Heat Stress Transcription Factor HsfA2
Port, M., Tripp, J., Zielinski, D., et al. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.042820 · Cited by 95
“They represent the recognition sites of the heat stress transcription factors (Hsf), which are the key regulators of the response conserved throughout the eukaryotic kingdom (Wu, 1995; Morimoto, 1998; Nover et al., 2001).”
Background
Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning
Miyabara, E. H., Martin, J. W., Griffin, T., Moriscot, A. S., & Mestril, R. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00399.2005 · Cited by 95
“The activated HSFs then form trimers (38) that bind to the promoters of HSP genes to stimulate transcription (27).”
Background
Herpes Simplex Virus Type 1 Suppresses the Interferon Signaling Pathway by Inhibiting Phosphorylation of STATs and Janus Kinases during an Early Infection Stage
Yokota, S., Yokosawa, N., Kubota, T., Suzutani, T., Yoshida, I., Miura, S., Jimbow, K., & Fujii, N. (2001) · Virology · doi:10.1006/viro.2001.0941 · Cited by 95
“Heat-shock-induced phosphorylation of heat shock factor 1, which is a transcription factor for stress-responsible genes such as heat shock protein genes (Wu, 1995), was not altered by HSV-1 infection until at least 6 h p.”
Background
JNK phosphorylates the HSF1 transcriptional activation domain: Role of JNK in the regulation of the heat shock response
Park, J. H., & Liu, A. Y. ‐. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1163 · Cited by 94
“…of monomers to trimers, translocation of HSF1 from the cytosol to the nucleus, additional post-translational modi®cations including phosphorylation of serine residues, and transcriptional competence with enhanced heat shock gene expression [Wu, 1995; Morimoto, 1998; Morimoto and Santoro, 1998].”
Background
Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment
Yih, L. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.867 · Cited by 95
“Elevated expression of HSTF2 also activates the genes involved in differentiation and embryogenesis ( 61 ).”
Background
Activation of Heat Shock Genes Is Not Necessary for Protection by Heat Shock Transcription Factor 1 against Cell Death Due to a Single Exposure to High Temperatures
Inouye, S., Katsuki, K., Izu, H., Fujimoto, M., Sugahara, K., Yamada, S., Shinkai, Y., Oka, Y., Katoh, Y., & Nakai, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5882-5895.2003 · Cited by 96
“The heat shock response is regulated mainly at the level of transcription by heat shock transcription factors (HSFs) in eukaryotes, which bind to heat shock elements on upstream sequences of heat shock genes (45).”
Background
Ca2+ and Calmodulin Modulate DNA-Binding Activity of Maize Heat Shock Transcription Factor in Vitro
Li, B., Liu, H., Sun, D., et al. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch074 · Cited by 94
“During heat shock (HS), the HSF is converted from a transcriptional inactive monomer to active trimmer that is capable of binding to conservative promoter elements (heat shock elements, HSEs) and exhibits transcriptional activity (Craig et al. 1994, Wu 1995).”
Background
Heat shock transcription factor A1b regulates heat tolerance in wheat and Arabidopsis through OPR 3 and jasmonate signalling pathway
Tian, X., Wang, F., Zhao, Y., et al. (2019) · Plant Biotechnology Journal · doi:10.1111/pbi.13268 · Cited by 93
“HSEs are usually bound by HSFs to regulate gene expression (Wu, 1995).”
Background
Mathematical Modeling of the Eukaryotic Heat-Shock Response: Dynamics of the hsp70 Promoter
Rieger, T. R., Morimoto, R. I., & Vassily Hatzimanikatis, A. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.055301 · Cited by 93
“HSF1 is constitutively expressed in human cells in an inert monomeric state, which homotrimerizes immediately upon exposure to stress conditions to achieve a DNA-binding competent state (Baler et al., 1993; Mosser et al., 1988; Pirkkala et al., 2001; Wu, 1995), and binds to a promoter site known as the heat-shock elem…”
Background
Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock
Chowdhary, S., Kainth, A. S., Pincus, D., & Gross, D. S. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.034 · Cited by 94
HSP25 protects skeletal muscle cells against oxidative stress
Escobedo, J., Pucci, A. M., & Koh, T. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.07.024 · Cited by 92
Cell cycle transition under stress conditions controlled by vertebrate heat shock factors
Nakai, A., & Ishikawa, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2885 · Cited by 92
Signal Transduction Pathways Leading to Heat Shock Transcription
Calderwood, S. K., Wang, Y. E., Xie, X. S., Khaleque, M. A., Chou, S. D., Murshid, A., Prince, T. L., & Zhang, Y. (2010) · Signal Transduction Insights · doi:10.4137/sti.s3994 · Cited by 92
Polo-like Kinase 1 Phosphorylates Heat Shock Transcription Factor 1 and Mediates Its Nuclear Translocation during Heat Stress
Kim, S., Yoon, J., Lee, S.-H., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411908200 · Cited by 91
Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2
Soncin, F., Zhang, X., Chu, B., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00398-x · Cited by 91
A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol
Ikeyama, S., Kusumoto, K., Miyake, H., et al. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00053-8 · Cited by 91
Proteomics of rice in response to heat stress and advances in genetic engineering for heat tolerance in rice
Zou, J., Liu, C., & Chen, X. (2011) · Plant Cell Reports · doi:10.1007/s00299-011-1122-y · Cited by 90
“HSFs participate in regulating the expression of HSP genes by recognizing the conserved binding motifs (heat stress element, HSE) that exist in their promoters (Baniwal et al. 2004; Wu 1995).”
Background
Expression Characterization of Stress Genes Under High and Low Temperature Stresses in the Pacific Oyster, Crassostrea gigas
Zhu, Q., Zhang, L., Li, L., Que, H., & Zhang, G. (2016) · Marine Biotechnology · doi:10.1007/s10126-015-9678-0 · Cited by 90
“It has been proposed that the transcription of HSP genes is induced by the release of HSF1, a transcription factor, from Hsp70, in the presence of denatured proteins (Wu 1995).”
Background
An artificial promoter construct for heat-inducible misexpression during fish embryogenesis
Bajoghli, B., Aghaallaei, N., Heimbucher, T., & Czerny, T. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.04.006 · Cited by 91
“In response to heat shock and other chemical, environmental, or physiological stresses, HSF1 undergoes trimerization, binds to the HSE, and exhibits transcriptional activity (Wu, 1995).”
Regulation of Drosophila Heat Shock Factor Trimerization: Global Sequence Requirements and Independence of Nuclear Localization
Orosz, A., Wiśniewski, J., & Wu, C. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.7018 · Cited by 88
“In addition, there are local regions of HSF which have an important role in suppressing the activities of the trimerization and transactivation domains under normal conditions (55).”
BackgroundSelf-citation
A Specialized Nucleosome Modulates Transcription Factor Access to a C. glabrata Metal Responsive Promoter
Zhu, Z., & Thiele, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81366-5 · Cited by 90
Genome-wide cloning, identification, classification and functional analysis of cotton heat shock transcription factors in cotton (Gossypium hirsutum)
Wang, J., Sun, N., Deng, T., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-961 · Cited by 89
“WRKY [2], MYB [3], AP2/ERF [4], NAC [5], bZip [6] and heat shock transcription factors (Hsfs) [7,8] participate in these complex and overlapping processes.”
Background
Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress
Shehata, A. M., Saadeldin, I. M., Tukur, H. A., & Habashy, W. S. (2020) · Animals · doi:10.3390/ani10122407 · Cited by 94
“, they decrease the possibility that proteins interact with each other in an undesirable way via their involvement in protein folding, translocation, higher-order assembly, and degradation [44].”
Background
Modulation of tolerance by mutant heat shock transcription factors
Xia, W., Vilaboa, N. E., Martin, J. W., Mestril, R., Guo, Y., & Voellmy, R. W. (1999) · Cell Stress and Chaperones · doi:10.1379/1466-1268(1999)004 · Cited by 45
Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond
Lang, B. J., Guerrero-Gimenez, M. E., Prince, T. L., Ackerman, A., Bonorino, C., & Calderwood, S. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184507 · Cited by 93
Genome-wide Analysis Reveals New Roles for the Activation Domains of the Saccharomyces cerevisiae Heat Shock Transcription Factor (Hsf1) during the Transient Heat Shock Response
Eastmond, D. L., & Nelson, H. C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602454200 · Cited by 90
A trans-Activation Domain in Yeast Heat Shock Transcription Factor Is Essential for Cell Cycle Progression during Stress
Morano, K. A., Santoro, N., Koch, K. A., & Thiele, D. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.402 · Cited by 87
“HSF(1-583) cells were found to be severely deficient in expression of both Hsp90 genes as judged by immunoblot analysis, and depletion of Hsp90 from wild-type yeast cells partially recapitulated the cell cycle arrest phenotype, demonstrating an essential role for the HSF CTA and Hsp90 in cell cycle progression during…”
BackgroundInfluential
Over-expression of OsHsfA7 enhanced salt and drought tolerance in transgenic rice
Liu, A.-L., Zou, J., Liu, C.-F., et al. (2013) · BMB Reports · doi:10.5483/bmbrep.2013.46.1.090 · Cited by 87
“Under abiotic stresses, different Hsfs can specifically bind to heat shock elements of some Hsps and subsequently activate their transcription (3-6).”
Background
Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy
Franke, J., Eichner, S., Zeilinger, C., & Kirschning, A. (2013) · Natural Product Reports · doi:10.1039/c3np70012g · Cited by 89
Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1
Calderwood, S. K., & Murshid, A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00192 · Cited by 91
“The key effector of HSP gene transcription is heat shock factor 1 (HSF1), a sequence specific factor that binds upstream of all HSP genes at the onset of stress (Wu, 1995).”
Background
Progress toward improving ethanol production through decreased glycerol generation in Saccharomyces cerevisiae by metabolic and genetic engineering approaches
Naghshbandi, M. P., Tabatabaei, M., Aghbashlo, M., Gupta, V. K., Sulaiman, A., Karimi, K., Moghimi, H., & Maleki, M. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.109353 · Cited by 86
Demyelination, Astrogliosis, and Accumulation of Ubiquitinated Proteins, Hallmarks of CNS Disease in hsf1 -Deficient Mice
Homma, S. T., Jin, X., Wang, G., Tu, N., Min, J., Yanasak, N. E., & Mivechi, N. F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0006-07.2007 · Cited by 92
“Hsfs bind to heat shock elements present on the promoters of Hsps and other genes, but the mechanisms responsible for Hsf transcriptional activation are diverse (Wu, 1995; Morimoto, 1998).”
Influential
Inhibition of the Ubiquitin-Proteasome Pathway Induces Differential Heat-Shock Protein Response in Cardiomyocytes and Renders Early Cardiac Protection
Stangl, K., Günther, C., Frank, T. M., Lorenz, M., Meiners, S., Röpke, T., Stelter, L., Moobed, M., Baumann, G., Kloetzel, P., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6476 · Cited by 87
Sublethal concentrations of imidacloprid increase reproduction, alter expression of detoxification genes, and prime Myzus persicae for subsequent stress
Rix, R. R., Ayyanath, M., & Cutler, G. C. (2015) · Journal of Pest Science · doi:10.1007/s10340-015-0716-5 · Cited by 87
“persicae (Stanley and Fenton 2000), which are important in response to temperature, chemical, or physiological stress (Wu 1995).”
Background
Crystallins, genes and cataract
Bhat, S. P. (2003) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8012-1_7 · Cited by 86
The Role of Inducible Hsp70, and Other Heat Shock Proteins, in Adaptive Complex of Cold Tolerance of the Fruit Fly (Drosophila melanogaster)
Štětina, T., Košťál, V., & Korbelová, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128976 · Cited by 86
STRESS PROTEIN EXPRESSION KINETICS
Diller, K. R. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.7.060804.100449 · Cited by 86
“The inducible elevated synthesis of stress proteins is known to be facilitated directly by activity of heat shock factors (HSFs) on targeted genes (39).”
Background

Authors: Wu, C.
Affiliations: National Institutes of Health (US)
Corresponding author: Wu, Carl
ORCID: Wu, Carl
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1995-11
Volume: 11
Issue: 1
Pages: 441-469
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cb.11.110195.002301
OpenAlex: W2145760315
Cited by: 1,231
References: 0
Citations by year: 2026: 13 · 2025: 23 · 2024: 29 · 2023: 20 · 2022: 32 · 2021: 33 · 2020: 23 · 2019: 35 · 2018: 35 · 2017: 31 · 2016: 40 · 2015: 48 · 2014: 44 · 2013: 49 · 2012: 57
FWCI: 11.93
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: heat shock transcription factor, heat shock proteins, heat shock gene expression, DNA binding, transcriptional activation
MeSH terms: Heat Shock Transcription Factors, Amino Acid Sequence, Animals, Bacteria, Binding Sites, Cloning, Molecular, DNA-Binding Proteins, Heat-Shock Proteins, Humans, Models, Structural, Molecular Sequence Data, Transcription Factors, Conserved Sequence, Sequence Homology, Amino Acid, Protein Structure, Secondary, Helix-Turn-Helix Motifs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Heat Shock Transcription Factors: Structure and Regulation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks