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Genetic Control of Bone Formation
Abstract
In the past few years, our molecular understanding of bone formation has continued to increase. This review aims to present a comprehensive view of the current state of knowledge in the field. Thus, it will cover our current knowledge of chondrogenesis and osteoblastogenesis. It will also cover the most salient aspects of osteoblast function.
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“There is evidence that osteocytes act as mechanosensors and orchestrators of this bone remodeling process [5–8].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [6]
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Metadata
- Authors
- Karsenty, G., Kronenberg, H. M., & Settembre, C.
- Affiliations
- Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032;
- Harvard University (US)
- Columbia University (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2009-11-01
- Volume
- 25
- Issue
- 1
- Pages
- 629-648
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2149193631
- Cited by
- 667
- References
- 116
- Citations by year
- 2026: 21 · 2025: 22 · 2024: 23 · 2023: 29 · 2022: 28 · 2021: 35 · 2020: 61 · 2019: 42 · 2018: 49 · 2017: 47 · 2016: 57 · 2015: 59 · 2014: 51 · 2013: 38 · 2012: 46
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067936)
- National Institute of Dental and Craniofacial Research (R01DE011290)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- bone formation, chondrogenesis, osteoblastogenesis, osteoblast activity, genetic control, skeletal development, osteogenic differentiation
- MeSH terms
- Animals, Humans, Osteoblasts, Osteogenesis, Transcription Factors, Gene Expression Regulation, Developmental, Chondrogenesis
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