Genetic Control of Bone Formation

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336

Hedgehog signaling in animal development: paradigms and principlesPreprint

Ingham, P. W., & McMahon, A. P. (2001) · Genes & Development · doi:10.1101/gad.938601 · Cited by 3,025

AP-1 function and regulation

Karin, M., Liu, Z.-G., & Zandi, E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80068-3 · Cited by 2,904

Developmental regulation of the growth plate

Kronenberg, H. M. (2003) · Nature · doi:10.1038/nature01657 · Cited by 2,859

Endocrine regulation of energy metabolism by the skeleton

Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

Gerber, H. P., Vu, T. H., Ryan, A. M., Kowalski, J., Werb, Z., & Ferrara, N. (1999) · Nature Medicine · doi:10.1038/9467 · Cited by 2,107

Leptin Inhibits Bone Formation through a Hypothalamic Relay

Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M., & Tabin, C. J. (1996) · Science · doi:10.1126/science.273.5275.613 · Cited by 1,999

Receptor Specificity of the Fibroblast Growth Factor Family

Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871

WNT and β-catenin signalling: diseases and therapies

Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763

Sox9 is required for cartilage formation

Bi, W., Deng, J. M., Zhang, Z., Behringer, R. R., & Crombrugghe, B. D. (1999) · Nature Genetics · doi:10.1038/8792 · Cited by 1,760

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationPreprint

St‐Jacques, B., Hammerschmidt, M., & McMahon, A. P. (1999) · Genes & Development · doi:10.1101/gad.13.16.2072 · Cited by 1,742

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

Vu, T. H., Shipley, J. M., Bergers, G., Berger, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M., & Werb, Z. (1998) · Cell · doi:10.1016/s0092-8674(00)81169-1 · Cited by 1,737

Leptin Regulates Bone Formation via the Sympathetic Nervous System

Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01049-8 · Cited by 1,735

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Schroeter, E. H., Kisslinger, J. A., & Kopan, R. (1998) · Nature · doi:10.1038/30756 · Cited by 1,624

Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis

Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616

Reaching a Genetic and Molecular Understanding of Skeletal Development

Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,611

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

Foster, J. W., Dominguez-Steglich, M., Guioli, S., Kwok, C., Weller, P., Stevanović, M., Weissenbach, J., Mansour, S., Young, I., Goodfellow, P., et al. (1994) · Nature · doi:10.1038/372525a0 · Cited by 1,602

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.

Wagner, T., Wirth, J., Meyer, J., Zabel, B., Held, M., Zimmer, J., Pasantes, J., Bricarelli, F. D., Keutel, J., Hustert, E., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90041-8 · Cited by 1,592

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591

The serotonin signaling system: from basic understanding to drug development for functional GI disorders

Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563

Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558

A new member of the frizzled family from Drosophila functions as a Wingless receptor

Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S. G., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,502

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

Shiang, R., Thompson, L. M., Zhu, Y., Church, D. M., Fielder, T. J., Bocian, M. E., Winokur, S. T., & Wasmuth, J. J. (1994) · Cell · doi:10.1016/0092-8674(94)90302-6 · Cited by 1,329

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

Lanske, B., Karaplis, A. C., Lee, K., Luz, A., Vortkamp, A., Pirro, A. E., Karperien, M., Defize, L. H. K., Ho, C., Mulligan, R. C., et al. (1996) · Science · doi:10.1126/science.273.5275.663 · Cited by 1,325

Leptin regulation of bone resorption by the sympathetic nervous system and CART

Elefteriou, F., Ahn, J. D., Takeda, S., Starbuck, M., Yang, X., Liu, X., Kondo, H., Richards, W. G., Bannon, T. W., Noda, M., et al. (2005) · Nature · doi:10.1038/nature03398 · Cited by 1,311

Structural and Functional Diversity in the FGf Receptor Multigene Family

Johnson, D. E., & Williams, L. T. (1992) · Advances in cancer research · doi:10.1016/s0065-230x(08)60821-0 · Cited by 1,254

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

Shore, E. M., Xu, M., Feldman, G. J., Fenstermacher, D., Cho, T., Choi, I. H., Connor, J. M., Delai, P. L. R., Glaser, D. L., Merrer, M. F. L., et al. (2006) · Nature Genetics · doi:10.1038/ng1783 · Cited by 1,215

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint

Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151

Fibroblast growth factor receptor 3 is a negative regulator of bone growth.

Deng, C.-X., Wynshaw-Boris, A., Zhou, F., Kuo, A., & Leder, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81069-7 · Cited by 1,095

Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,086

SOX9 Is a Potent Activator of the Chondrocyte-Specific Enhancer of the Proα1(II) Collagen Gene

Lefebvre, V., Huang, W., Harley, V. R., Goodfellow, P. N., & Crombrugghe, B. D. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2336 · Cited by 1,077

FGF signaling pathways in endochondral and intramembranous bone development and human genetic diseasePreprint

Ornitz, D. M., & Marie, P. J. (2002) · Genes & Development · doi:10.1101/gad.990702 · Cited by 924

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

Rousseau, F., Bonaventure, J., Legeai-Mallet, L., Pelet, A., Rozet, J., Maroteaux, P., Merrer, M. L., & Munnich, A. (1994) · Nature · doi:10.1038/371252a0 · Cited by 920

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

Colvin, J. S., Bohne, B. A., Harding, G. W., McEwen, D. G., & Ornitz, D. M. (1996) · Nature Genetics · doi:10.1038/ng0496-390 · Cited by 868

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

Yadav, V. K., Ryu, J.-H., Suda, N., Tanaka, K. F., Gingrich, J. A., Schütz, G., Glorieux, F. H., Chiang, C. Y., Zajac, J. D., Insogna, K. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.059 · Cited by 839

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone‐Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 822

A new long form of Sox5 (L‐Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

Lefebvre, V., Li, P., & de Crombrugghe, B. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5718 · Cited by 811

Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survivalPreprint

Schipani, E., Ryan, H. E., Didrickson, S., Kobayashi, T., Knight, M. C., & Johnson, R. S. (2001) · Genes & Development · doi:10.1101/gad.934301 · Cited by 807

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

Vega, R. B., Matsuda, K., Oh, J., Barbosa, A. C. C., Yang, X., Meadows, E., McAnally, J., Pomajzl, C., Shelton, J. M., Richardson, J. A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.024 · Cited by 805

Interactions between Sox9 and β-catenin control chondrocyte differentiationPreprint

Akiyama, H., Lyons, J. P., Mori–Akiyama, Y., Yang, X., Zhang, R., Zhang, Z., Deng, J. M., Taketo, M. M., Nakamura, T., Behringer, R. R., et al. (2004) · Genes & Development · doi:10.1101/gad.1171104 · Cited by 755

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., et al. (2000) · Nature Genetics · doi:10.1038/74231 · Cited by 737

A Constitutively Active Mutant PTH-PTHrP Receptor in Jansen-Type Metaphyseal Chondrodysplasia

Schipani, E., Kruse, K., & Jüppner, H. (1995) · Science · doi:10.1126/science.7701349 · Cited by 677

A Twist Code Determines the Onset of Osteoblast Differentiation

Bialek, P., Kern, B., Yang, X., Schrock, M., Šošić, D., Hong, N. A., Wu, H., Yu, K., Ornitz, D. M., Olson, E. N., et al. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00058-9 · Cited by 674

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

Long, F., Zhang, X. M., Karp, S. J., Yang, Y., & McMahon, A. P. (2001) · Development · doi:10.1242/dev.128.24.5099 · Cited by 654

Mutations in TWIST, a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome

Howard, T. D., Paznekas, W. A., Green, E. D., Chiang, L. C., Ma, N. S. F., Luna, R. I. O. D., Delgado, C. G., Gonzalez-Ramos, M., Kline, A. D., & Jabs, E. W. (1997) · Nature Genetics · doi:10.1038/ng0197-36 · Cited by 645

Mutations of the TWIST gene in the Saethre-Chotzene syndrome

Ghouzzi, V. E., Merrer, M. F. L., Perrin‐Schmitt, F., Lajeunie, E., Bénit, P., Rénier, D., Bourgeois, P., Bolcato‐Bellemin, A., Münnich, A., & Bonaventure, J. (1997) · Nature Genetics · doi:10.1038/ng0197-42 · Cited by 644

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Hilton, M. J., Tu, X., Wu, X., Bai, S., Zhao, H., Kobayashi, T., Kronenberg, H. M., Teitelbaum, S. L., Ross, F. P., Kopan, R., et al. (2008) · Nature Medicine · doi:10.1038/nm1716 · Cited by 604

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

Tavormina, P. L., Shiang, R., Thompson, L. M., Zhu, Y., Wilkin, D. J., Lachman, R. S., Wilcox, W. R., Rimoin, D. L., Cohn, D. H., & Wasmuth, J. J. (1995) · Nature Genetics · doi:10.1038/ng0395-321 · Cited by 602

The Transcription Factors L-Sox5 and Sox6 Are Essential for Cartilage Formation

Smits, P. J., Li, P., Mandel, J., Zhang, Z., Deng, J. M., Behringer, R. R., Crombrugghe, B. D., & Lefèbvre, V. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00003-x · Cited by 600

The Molecular Clock Mediates Leptin-Regulated Bone Formation

Fu, L., Patel, M. S., Bradley, A., Wagner, E. F., & Karsenty, G. (2005) · Cell · doi:10.1016/j.cell.2005.06.028 · Cited by 590

Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehogPreprint

Yoshida, C. A., Yamamoto, H., Fujita, T., Furuichi, T., Ito, K., Inoue, K., Yamana, K., Zanma, A., Takada, K., Ito, Y., et al. (2004) · Genes & Development · doi:10.1101/gad.1174704 · Cited by 588

Bone and Mineral Research/4

Premakumari, S. (1986) · The Indian Journal of Nutrition and Dietetics · Cited by 577

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia

Lee, B., Thirunavukkarasu, K., Zhou, L., Pastore, L., Baldini, A., Hecht, J. T., Geoffrey, V., Ducy, P. F., & Karsenty, G. (1997) · Nature Genetics · doi:10.1038/ng0797-307 · Cited by 567

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

Peters, K. G., Werner, S., Chen, G., & Williams, L. T. (1992) · Development · doi:10.1242/dev.114.1.233 · Cited by 543

Fos/AP‐1 proteins in bone and the immune system

Wagner, E. F., & Eferl, R. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00332.x · Cited by 537

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

Naski, M., Wang, Q., Xu, J.-S., & Ornitz, D. (1996) · Nature Genetics · doi:10.1038/ng0696-233 · Cited by 525

SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation

Dobreva, G. D., Chahrour, M. H., Dautzenberg, M., Chirivella, L., Kanzler, B., Fariñas, I., Karsenty, G., & Grosschedl, R. (2006) · Cell · doi:10.1016/j.cell.2006.05.012 · Cited by 522

Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient micePreprint

Takeda, S., Bonnamy, J.-P., Owen, M. J., Ducy, P. F., & Karsenty, G. (2001) · Genes & Development · doi:10.1101/gad.845101 · Cited by 518

Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.Preprint

Liu, Z.-H., Xu, J.-S., Colvin, J. S., & Ornitz, D. (2002) · Genes & Development · doi:10.1101/gad.965602 · Cited by 501

NFAT and Osterix cooperatively regulate bone formation

Koga, T., Matsui, Y., Asagiri, M., Kodama, T., Crombrugghe, B. D., Nakashima, K., & Takayanagi, H. (2005) · Nature Medicine · doi:10.1038/nm1270 · Cited by 497

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.Preprint

Ohbayashi, N., Shibayama, M., Kurotaki, Y., Imanishi, M., Fujimori, T., Itoh, N., & Takada, S. (2002) · Genes & Development · doi:10.1101/gad.965702 · Cited by 487

Dual roles of Wnt signaling during chondrogenesis in the chicken limb

Hartmann, C., & Tabin, C. J. (2000) · Development · doi:10.1242/dev.127.14.3141 · Cited by 472

MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone Development

Arnold, M., Kim, Y., Czubryt, M. P., Phan, D., McAnally, J., Qi, X., Shelton, J. M., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.02.004 · Cited by 456

Bone morphogenetic protein-3 is a negative regulator of bone density

Daluiski, A., Engstrand, T., Bahamonde, M. E., Gamer, L. W., Agius, E., Stevenson, S., Cox, K. A., Rosen, V., & Lyons, K. M. (2001) · Nature Genetics · doi:10.1038/83810 · Cited by 427

Dimorphic effects of Notch signaling in bone homeostasis

Engin, F., Yao, Z., Yang, T., Zhou, G. D., Bertin, T., Jiang, M. M., Chen, Y., Wang, L. E., Zheng, H., Sutton, R. E., et al. (2008) · Nature Medicine · doi:10.1038/nm1712 · Cited by 425

Convergence between bone and energy homeostases: Leptin regulation of bone mass

Karsenty, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.008 · Cited by 423

Patterning Mechanisms Controlling Vertebrate Limb Development

Capdevila, J., & Belmonte, J. C. I. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.87 · Cited by 404

Wnt5aandWnt5bexhibit distinct activities in coordinating chondrocyte proliferation and differentiation

Yang, Y., Topol, L. Z., Lee, H., & Wu, J. (2003) · Development · doi:10.1242/dev.00324 · Cited by 398

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway.Preprint

Sahni, M., Ambrosetti, D., Mansukhani, A., Gertner, R., Levy, D., & Basilico, C. (1999) · Genes & Development · doi:10.1101/gad.13.11.1361 · Cited by 391

Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway

Murakami, S., Kan, M., McKeehan, W. L., & Crombrugghe, B. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1113 · Cited by 377

Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis

Sabatakos, G., Sims, N. A., Chen, J., Aoki, K., Kelz, M. B., Amling, M., Bouali, Y., Mukhopadhyay, K., Ford, K.-K., Nestler, E. J., et al. (2000) · Nature Medicine · doi:10.1038/79683 · Cited by 339

Activation of Statl by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

Su, W.-C., Kitagawa, M., Xue, N., Xie, B., Garofalo, S., Cho, J., Deng, C., Horton, W., & Fu, X.-Y. (1997) · Nature · doi:10.1038/386288a0 · Cited by 316

Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

Jochum, W., David, J., Elliott, C., Wutz, A., Plenk, H., Jr., Matsuo, K., & Wagner, E. F. (2000) · Nature Medicine · doi:10.1038/79676 · Cited by 311

BMPs Are Required at Two Steps of Limb Chondrogenesis: Formation of Prechondrogenic Condensations and Their Differentiation into Chondrocytes

Pizette, S., & Niswander, L. A. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9610 · Cited by 296

Ext1-Dependent Heparan Sulfate Regulates the Range of Ihh Signaling during Endochondral Ossification

Koziel, L., Kunath, M., Kelly, O., & Vortkamp, A. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.05.009 · Cited by 286

Core-binding factor β interacts with Runx2 and is required for skeletal development

Yoshida, C. A., Furuichi, T., Fujita, T., Fukuyama, R., Kanatani, N., Kobayashi, S., Satake, M., Takada, K., & Komori, T. (2002) · Nature Genetics · doi:10.1038/ng1015 · Cited by 283

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiationPreprint

Kim, S., Koga, T., Isobe, M., Kern, B., Yokochi, T., Chin, Y. E., Karsenty, G., Taniguchi, T., & Takayanagi, H. (2003) · Genes & Development · doi:10.1101/gad.1119303 · Cited by 283

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotypePreprint

Murakami, S., Balmes, G. C., McKinney, S., Zhang, Z., Givol, D., & Crombrugghe, B. D. (2004) · Genes & Development · doi:10.1101/gad.1179104 · Cited by 279

Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone

MAEDA, Y. Y., Nakamura, E., Nguyen, M., Suva, L. J., Swain, F. L., Razzaque, M. S., Mackem, S., & Lanske, B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608449104 · Cited by 267

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP

Kobayashi, T. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24397 · Cited by 267

Cartilage Molecular Aspects

Hall, B. K., & Newman, S. A. (1991) · Medical Entomology and Zoology · Cited by 259

Two Domains Unique to Osteoblast-Specific Transcription Factor Osf2/Cbfa1 Contribute to Its Transactivation Function and Its Inability To Heterodimerize with Cbfβ

Thirunavukkarasu, K., Mahajan, M., McLarren, K. W., Stifani, S., & Karsenty, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4197 · Cited by 252

Regulation of Adult Bone Mass by the Zinc Finger Adapter Protein Schnurri-3

Jones, D. C., Wein, M. N., Oukka, M., Hofstaetter, J. G., Glimcher, M. J., & Glimcher, L. H. (2006) · Science · doi:10.1126/science.1126313 · Cited by 246

The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen

Tribioli, C., & Lufkin, T. (1999) · Development · doi:10.1242/dev.126.24.5699 · Cited by 244

The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones

Huang, W., Chung, U., Kronenberg, H. M., & Crombrugghe, B. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.160 · Cited by 243

ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae

Elefteriou, F., Benson, M. D., Sowa, H., Starbuck, M. W., Liu, X., Ron, D., Parada, L. F., & Karsenty, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.010 · Cited by 234

Cbfβ interacts with Runx2 and has a critical role in bone development

Kundu, M., Javed, A., Jeon, J., Horner, A. A., Shum, L., Eckhaus, M., Muenke, M., Lian, J. B., Yang, Y., Nuckolls, G. H., et al. (2002) · Nature Genetics · doi:10.1038/ng1050 · Cited by 222

Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesisPreprint

Zeng, L., Kempf, H., Murtaugh, L. C., Sato, M. E., & Lassar, A. B. (2002) · Genes & Development · doi:10.1101/gad.1008002 · Cited by 219

Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects

Kenner, L., Hoebertz, A., Beil, F. T., Keon, N., Karreth, F. A., Eferl, R., Scheuch, H., Szremska, A., Amling, M., Schorpp‐Kistner, M., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200308155 · Cited by 212

The Fos‐related antigen Fra‐1 is an activator of bone matrix formation

Eferl, R., Hoebertz, A., Schilling, A. F., Rath, M., Karreth, F. A., Kenner, L., Amling, M., & Wagner, E. F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600282 · Cited by 199

Stop codon FGFR3 mutations in thanatophoric dwarfism type 1

Rousseau, F., Saugier-Véber, P., Merrer, M. F. L., Münnich, A., Delezoide, A., MAROTEAUX, P., Bonaventure, J., Narcy, F., & Sanak, M. (1995) · Nature Genetics · doi:10.1038/ng0595-11 · Cited by 199

Reciprocal regulation of bone and energy metabolism

Lee, N. K., & Karsenty, G. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.02.006 · Cited by 190

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

Hilton, M. J., Tu, X., Cook, J., Hu, H., & Long, F. (2005) · Development · doi:10.1242/dev.02025 · Cited by 186

Visualization of Cartilage Formation: Insight into Cellular Properties of Skeletal Progenitors and Chondrodysplasia Syndromes

Barna, M., & Niswander, L. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.016 · Cited by 178

Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondriumPreprint

Hinoi, E., Bialek, P., Chen, Y., Rached, M.-T., Groner, Y., Behringer, R. R., Ornitz, D. M., & Karsenty, G. (2006) · Genes & Development · doi:10.1101/gad.1482906 · Cited by 163

FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod

Hung, I. H., Yu, K., Lavine, K. J., & Ornitz, D. M. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.04.048 · Cited by 160

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

Koziel, L., Wuelling, M., Schneider, S., & Vortkamp, A. (2005) · Development · doi:10.1242/dev.02097 · Cited by 151

The Chick Transcriptional Repressor Nkx3.2 Acts Downstream of Shh to Promote BMP-Dependent Axial Chondrogenesis

Murtaugh, L. C., Zeng, L., Chyung, J. H., & Lassar, A. B. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00039-9 · Cited by 139

Multiplicity of BMP Signaling in Skeletal Development

Wu, X., Shi, W., & Cao, X. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.053 · Cited by 122

Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains

Wang, Q., Green, R. P., Zhao, G., & Ornitz, D. M. (2001) · Development · doi:10.1242/dev.128.19.3867 · Cited by 120

Collagen types IX and X in the developing chick tibiotarsus: analyses of mRNAs and proteins

Linsenmayer, T. F., Chen, Q., Gibney, E. P., Gordon, M. K., Marchant, J. K., Mayne, R., & Schmid, T. M. (1991) · Development · doi:10.1242/dev.111.1.191 · Cited by 115

Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossificationPreprint

Settembre, C., Arteaga‐Solis, E., McKee, M. D., de Pablo, R., Al‐Awqati, Q., Ballabio, A., & Karsenty, G. (2008) · Genes & Development · doi:10.1101/gad.1711308 · Cited by 96

β-blockers Increase Bone Mineral Density

Türker, S., Karatosun, V., & Günal, İ. (2006) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000200242.52802.6d · Cited by 63

Skeletal Development - Wnts Are in Control

Hartmann, C. (2007) · Molecules and Cells · doi:10.1016/s1016-8478(23)07326-0 · Cited by 57

Serotonin Receptors: Genetic insights into serotonin function

Heath, M. J., & Hen, R. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00199-0 · Cited by 38

Biologists abandon Popper at their peril

(2000) · doi:10.1002/(sici)1521-1878(200002)22:2

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044

Osteoblast-Osteoclast Communication and Bone Homeostasis

Kim, J., Lin, C., Stavre, Z., Greenblatt, M. B., & Shim, J. (2020) · Cells · doi:10.3390/cells9092073 · Cited by 1,266

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

Schett, G., & Gravallese, E. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.153 · Cited by 947

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

Yang, L., Tsang, K. Y., Tang, H. C., Chan, D. T.-M., & Cheah, K. S. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302703111 · Cited by 755

Endocrine Regulation of Male Fertility by the Skeleton

Oury, F., Sumara, G., Sumara, O., Ferron, M., Chang, H., Smith, C. E., Hermo, L., Suarez, S., Roth, B. L., Ducy, P., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.004 · Cited by 628

[Molecular mechanisms of the regulation of osteoblast and chondrocyte differentiation and bone formation].

Komori, T. (2006) · PubMed · Cited by 2

Biology of Bone and Cartilage

Boyce, B. F., Zuscik, M. J., & Xing, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804182-6.00011-3 · Cited by 14

The Molecular Genetics of Bone Formation

Marie, P. J. (2001) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200101030-00003 · Cited by 25

Osteoblast biology: developmental origin and interactive nature of osteoblasts

van der Eerden, B. C. J., & van Wijnen, A. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00006-x · Cited by 1

Molecular control of osteo-chondroprogenitors formation

Lu, L. (2009) · doi:10.5353/th_b4467396