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Genetic Control of Bone Formation
Abstract
In the past few years, our molecular understanding of bone formation has continued to increase. This review aims to present a comprehensive view of the current state of knowledge in the field. Thus, it will cover our current knowledge of chondrogenesis and osteoblastogenesis. It will also cover the most salient aspects of osteoblast function.
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“There is evidence that osteocytes act as mechanosensors and orchestrators of this bone remodeling process [5–8].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [6]
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Metadata
- Authors
- Karsenty, G., Kronenberg, H. M., & Settembre, C.
- Affiliations
- Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032;
- Harvard University (US)
- Columbia University (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2009-11-01
- Volume
- 25
- Issue
- 1
- Pages
- 629-648
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2149193631
- Cited by
- 667
- References
- 116
- Citations by year
- 2026: 21 · 2025: 22 · 2024: 23 · 2023: 29 · 2022: 28 · 2021: 35 · 2020: 61 · 2019: 42 · 2018: 49 · 2017: 47 · 2016: 57 · 2015: 59 · 2014: 51 · 2013: 38 · 2012: 46
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067936)
- National Institute of Dental and Craniofacial Research (R01DE011290)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- bone formation, chondrogenesis, osteoblastogenesis, osteoblast activity, genetic control, skeletal development, osteogenic differentiation
- MeSH terms
- Animals, Humans, Osteoblasts, Osteogenesis, Transcription Factors, Gene Expression Regulation, Developmental, Chondrogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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