Mechanisms associated with biogenesis of exosomes in cancer

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-016-0028-x · Cited by 15,947 · see citing works

Inflammation and cancer: back to Virchow?

Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746 · see citing works

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

Routes and mechanisms of extracellular vesicle uptake

Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832 · see citing works

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., Yu, Z., Yang, J., Wang, B., Sun, H., et al. (2018) · Nature · doi:10.1038/s41586-018-0392-8 · Cited by 2,813 · see citing works

Rab27a and Rab27b control different steps of the exosome secretion pathway

Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761 · see citing works

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692 · see citing works

Exosomes – vesicular carriers for intercellular communication

Simons, M., & Raposo, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.03.007 · Cited by 2,355 · see citing works

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266 · see citing works

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037 · see citing works

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943 · see citing works

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Perez-Hernandez, D., Vázquez, J., Martín-Cófreces, N., Martínez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,907 · see citing works

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899 · see citing works

The biology and function of exosomes in cancer

Kalluri, R. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81135 · Cited by 1,849 · see citing works

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730 · see citing works

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643 · see citing works

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

Thakur, B. K., Zhang, H., Becker, A., Matei, I. R., Huang, Y., Costa‐Silva, B., Zheng, Y., Hoshino, A., Brazier, H., Xiang, J., et al. (2014) · Cell Research · doi:10.1038/cr.2014.44 · Cited by 1,592 · see citing works

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

Parolini, I., Federici, C., Raggi, C., Lugini, L., Palleschi, S., Milito, A. D., Coscia, C., Iessi, E., Logozzi, M., Molinari, A., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041152 · Cited by 1,561 · see citing works

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,561 · see citing works

A century of trends in adult human height

NCD Risk Factor Collaboration (NCD-RisC) (2016) · eLife · doi:10.7554/elife.13410 · Cited by 1,558 · see citing works

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Colombo, M., Moita, C. F., van Niel, G., Kowal, J., Vigneron, J., Benaroch, P., Manel, N., Moita, L. F., Théry, C., & Raposo, G. (2013) · Journal of Cell Science · doi:10.1242/jcs.128868 · Cited by 1,472 · see citing works

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · see citing works

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

Balaj, L., Lessard, R., Dai, L., Cho, Y., Pomeroy, S. L., Breakefield, X. O., & Skog, J. (2011) · Nature Communications · doi:10.1038/ncomms1180 · Cited by 1,185 · see citing works

Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115 · see citing works

Hypoxic enhancement of exosome release by breast cancer cells

King, H. W., Michael, M. Z., & Gleadle, J. M. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-421 · Cited by 1,045 · see citing works

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

Hood, J. L., San, R. S., & Wickline, S. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4455 · Cited by 1,037 · see citing works

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

Chalmin, F., Ladoire, S., Mignot, G., Vincent, J., Bruchard, M., Rémy-Martin, J.-P., Boireau, W., Rouleau, A., Simon, B., Lanneau, D., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40483 · Cited by 999 · see citing works

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

van Niel, G., Charrin, S., Simoes, S., Romao, M., Rochin, L., Säftig, P., Marks, M. S., Rubinstein, E., & Raposo, G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.019 · Cited by 955 · see citing works

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringnér, M., Mörgelin, M., Bourseau-Guilmain, E., Bengzon, J., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220998110 · Cited by 939 · see citing works

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927 · see citing works

Correction: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

Douglas, A. D., Williams, A. R., Illingworth, J. J., Kamuyu, G., Biswas, S., Goodman, A. L., Wyllie, D. H., Crosnier, C., Miura, K., Wright, G. J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3355 · Cited by 925 · see citing works

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer*

Kahlert, C., Melo, S., Protopopov, A., Tang, J., Seth, S., Koch, M., Zhang, J.-H., Weitz, J., Chin, L., Futreal, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.532267 · Cited by 896 · see citing works

Exploration of pyrazine-embedded antiaromatic polycyclic hydrocarbons generated by solution and on-surface azomethine ylide homocoupling

Wang, X., Richter, M., He, Y., Björk, J., Riss, A., Rajesh, R., Garnica, M., Hennersdorf, F., Weigand, J. J., Narita, A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01934-1 · Cited by 893 · see citing works

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

Hsu, C., Morohashi, Y., Yoshimura, S., Manrique‐Hoyos, N., Jung, S., Lauterbach, M. A., Bakhti, M., Grønborg, M., Möbius, W., Rhee, J., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200911018 · Cited by 860 · see citing works

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

Webber, J. P., Steadman, R., Mason, M. D., Tabi, Z., & Clayton, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1722 · Cited by 850 · see citing works

Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis

Kahlert, C., & Kalluri, R. (2013) · Journal of molecular medicine · doi:10.1007/s00109-013-1020-6 · Cited by 842 · see citing works

Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells

Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835 · see citing works

Potential energy surface crossings in organic photochemistry

Bernardi, F., Olivucci, M., & Robb, M. A. (1996) · Chemical Society Reviews · doi:10.1039/cs9962500321 · Cited by 821 · see citing works

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

Zomer, A., Maynard, C., Verweij, F., Kamermans, A., Schäfer, R., Beerling, E., Schiffelers, R., de Wit, E., Berenguer, J., Ellenbroek, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.042 · Cited by 815 · see citing works

Generation and testing of clinical-grade exosomes for pancreatic cancer

Mendt, M. C., Kamerkar, S., Sugimoto, H., McAndrews, K. M., Wu, C.-C., Gagea, M., Yang, S., Blanko, E. V. R., Peng, Q., Ma, X., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99263 · Cited by 795 · see citing works

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

Kosaka, N., Iguchi, H., Hagiwara, K., Yoshioka, Y., Takeshita, F., & Ochiya, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.446831 · Cited by 772 · see citing works

Biogenesis and Function of Multivesicular Bodies

Piper, R. C., & Katzmann, D. J. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123319 · Cited by 771 · see citing works

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

Sansone, P., Savini, C., Kurelac, I., Chang, Q., Amato, L. B., Strillacci, A., Степанова, А., Iommarini, L., Mastroleo, C., Daly, L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704862114 · Cited by 732 · see citing works

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

Stuffers, S., Wegner, C. S., Stenmark, H., & Brech, A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00920.x · Cited by 731 · see citing works

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

Guescini, M., Genedani, S., Stocchi, V., & Agnati, L. F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0288-8 · Cited by 662 · see citing works

CANCER-ASSOCIATED FIBROBLAST EXOSOMES REGULATE SURVIVAL AND PROLIFERATION OF PANCREATIC CANCER CELLS

Richards, K. E., Zeleniak, A. E., Fishel, M., Wu, J.-M., Littlepage, L. E., & Hill, R. (2016) · Oncogene · doi:10.1038/onc.2016.353 · Cited by 656 · see citing works

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

Shurtleff, M. J., Karfilis, K. V., Temoche-Diaz, M. M., Ri, S., & Schekman, R. W. (2016) · eLife · doi:10.7554/elife.19276 · Cited by 648 · see citing works

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

Bobrie, A., Krumeich, S., Reyal, F., Recchi, C., Moita, L. F., Seabra, M. C., Ostrowski, M., & Théry, C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0925 · Cited by 647 · see citing works

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Ricklefs, F. L., Alayo, Q., Krenzlin, H., Mahmoud, A. B., Speranza, M. C., Nakashima, H., Hayes, J. L., Lee, K., Balaj, L., Passaro, C., et al. (2018) · Science Advances · doi:10.1126/sciadv.aar2766 · Cited by 610 · see citing works

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

Vojtech, L. N., Woo, S., Hughes, S. M., Levy, C., Ballweber, L., Sauteraud, R., Strobl, J., Westerberg, K., Gottardo, R., Tewari, M., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku347 · Cited by 572 · see citing works

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

Hoshino, D., Kirkbride, K. C., Costello, K., Clark, E. S., Sinha, S., Grega‐Larson, N. E., Tyska, M. J., & Weaver, A. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.050 · Cited by 561 · see citing works

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

Yang, Y., Li, C., Chan, L.-C., Wei, Y., Hsu, J.-M., Xia, W., Cha, J., Hou, J., Hsu, J. L., Sun, L., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0060-4 · Cited by 515 · see citing works

Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium‐Dependent Manner

Savina, A., Fader, C. M., Damiani, M. T., & Colombo, M. I. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00257.x · Cited by 512 · see citing works

Murine Mammary Carcinoma Exosomes Promote Tumor Growth by Suppression of NK Cell Function

Liu, C., Yu, S., Zinn, K. R., Wang, J., Zhang, L., Jia, Y., Kappes, J. C., Barnes, S., Kimberly, R. P., Grizzle, W. E., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1375 · Cited by 499 · see citing works

The exosome pathway in K562 cells is regulated by Rab11

Savina, A., Vidal, M., & Colombo, M. I. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.12.2505 · Cited by 487 · see citing works

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

Lehmann, B. D., Paine, M. S., Brooks, A. M., McCubrey, J. A., Renegar, R. H., Wang, R., & Terrian, D. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6538 · Cited by 464 · see citing works

Endoplasmic Reticulum Stress in Malignancy

Clarke, H. J., Chambers, J. E., Liniker, E., & Marciniak, S. J. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.015 · Cited by 461 · see citing works

Author Correction: Cathelicidin-OA1, a novel antioxidant peptide identified from an amphibian, accelerates skin wound healing

Cao, X., Wang, Y., Wu, C., Li, X., Fu, Z., Yang, M., Bian, W., Wang, S., Song, Y., Tang, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33558-w · Cited by 459 · see citing works

Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis

Abusamra, A. J., Zhong, Z., Zheng, X., Li, M., Ichim, T. E., Chin, J. L., & Min, W. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.07.001 · Cited by 455 · see citing works

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

Melo, S. A., Sugimoto, H., O'Connell, J. T., Kato, N., Villanueva, A., Vidal, A., Qiu, L., Vitkin, E., Perelman, L., Melo, C., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.005 · Cited by 453 · see citing works

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

Heusermann, W., Hean, J., Trojer, D., Steib, E., von Bueren, S., Graff-Meyer, A., Genoud, C., Martin, K., Pizzato, N., Voshol, J., et al. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201506084 · Cited by 447 · see citing works

TGF-β1–Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

Borges, F. T., Melo, S. A., Özdemir, B. C., Kato, N., Revuelta, I., Miller, C. A., Gattone, V. H., LeBleu, V. S., & Kalluri, R. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012101031 · Cited by 420 · see citing works

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

Manca, S., Upadhyaya, B., Mutai, E., Desaulniers, A. T., Cederberg, R. A., White, B. R., & Zempleni, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-29780-1 · Cited by 402 · see citing works

Higher-Order Oligomerization Targets Plasma Membrane Proteins and HIV Gag to Exosomes

Fang, Y., Wu, N., Gan, X., Yan, W., Morrell, J. C., & Gould, S. J. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050158 · Cited by 382 · see citing works

Emerging roles of PKM2 in cell metabolism and cancer progression

Luo, W., & Semenza, G. L. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.06.010 · Cited by 380 · see citing works

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

Federici, C., Petrucci, F., Caimi, S., Cesolini, A., Logozzi, M., Borghi, M., D’Ilio, S., Lugini, L., Violante, N., Azzarito, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088193 · Cited by 356 · see citing works

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

Nanbo, A., Kawanishi, E., Yoshida, R., & Yoshiyama, H. (2013) · Journal of Virology · doi:10.1128/jvi.01310-13 · Cited by 356 · see citing works

Following a Long-Distance Classical Race the Whole-Body Kinematics of Double Poling by Elite Cross-Country Skiers Are Altered

Zoppirolli, C., Bortolan, L., Stella, F., Boccia, G., Holmberg, H., Schena, F. F., & Pellegrini, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00978 · Cited by 347 · see citing works

Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma

Binenbaum, Y., Fridman, E., Yaari, Z. A., Milman, N., Schroeder, A., David, G. B., Shlomi, T., & Gil, Z. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0124 · Cited by 339 · see citing works

Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes

Cheng, Y., Zeng, Q., Han, Q., & Xia, W. (2019) · Protein & Cell · doi:10.1007/s13238-018-0529-4 · Cited by 336 · see citing works

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

Shurtleff, M. J., Yao, J., Qin, Y., Nottingham, R. M., Temoche-Diaz, M. M., Schekman, R. W., & Lambowitz, A. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712108114 · Cited by 333 · see citing works

Cortactin promotes exosome secretion by controlling branched actin dynamics

Sinha, S., Hoshino, D., Hong, N. H., Kirkbride, K. C., Grega‐Larson, N. E., Seiki, M., Tyska, M. J., & Weaver, A. M. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201601025 · Cited by 330 · see citing works

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

Hu, Y.-B., Yan, C., Mu, L., Huang, K., Li, X.-L., Tao, D., Wu, Y.-Q., & Qin, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125625 · Cited by 328 · see citing works

Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling

Goulet, C. R., Bernard, G., Tremblay, S., Chabaud, S., Bolduc, S., & Pouliot, F. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0784 · Cited by 322 · see citing works

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

Pavlyukov, M. S., Yu, H., Bastola, S., Minata, M., Shender, V. О., Lee, Y., Zhang, S., Wang, J., Komarova, S. V., Wang, J., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.05.012 · Cited by 321 · see citing works

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

Wei, Y., Wang, D., Jin, F., Bian, Z., Li, L., Liang, H., Li, M., Shi, L., Pan, C., Zhu, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms14041 · Cited by 316 · see citing works

Cancer exosomes induce tumor innervation

Madeo, M., Colbert, P. L., Vermeer, D. W., Lucido, C. T., Cain, J. T., Vichaya, E. G., Grossberg, A. J., Muirhead, D., Rickel, A. P., Hong, Z., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06640-0 · Cited by 313 · see citing works

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

Dorayappan, K. D. P., Wanner, R. A., Wallbillich, J. J., Saini, U., Zingarelli, R. A., Suarez, A. A., Cohn, D. E., & Selvendiran, K. (2018) · Oncogene · doi:10.1038/s41388-018-0189-0 · Cited by 309 · see citing works

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer

Datta, A., Kim, H., McGee, L. E., Johnson, A. E., Talwar, S., Marugán, J., Southall, N. T., Hu, X., Lal, M. A., Mondal, D., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26411-7 · Cited by 297 · see citing works

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

Kitai, Y., Kawasaki, T., Sueyoshi, T., Kobiyama, K., Ishii, K., Zou, J., Akira, S., Matsuda, T., & Kawai, T. (2017) · Journal of Immunology · doi:10.4049/jimmunol.1601694 · Cited by 296 · see citing works

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

Guescini, M., Guidolin, D., Vallorani, L., Casadei, L., Gioacchini, A. M., Tibollo, P., Battistelli, M., Falcieri, E., Battistin, L., Agnati, L. F., et al. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.006 · Cited by 294 · see citing works

Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties

Ostenfeld, M. S., Jeppesen, D. K., Laurberg, J. R., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3512 · Cited by 294 · see citing works

Analysis of exosome release and its prognostic value in human colorectal cancer

Silva, J., García‐Barberán, V., Rodríguez, M. E., Compte, M., Cisneros, E., Veguillas, P., Garcia, J. M., Domínguez, G., Campos‐Martín, Y., Cuevas, J., et al. (2011) · Genes Chromosomes and Cancer · doi:10.1002/gcc.21926 · Cited by 287 · see citing works

Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: A form of communication during injury, infection, and cell damage

Maio, A. D. (2010) · Cell Stress and Chaperones · doi:10.1007/s12192-010-0236-4 · Cited by 281 · see citing works

PIKfyve inhibition increases exosome release and induces secretory autophagy

Hessvik, N. P., Øverbye, A., Brech, A., Torgersen, M. L., Jakobsen, I. S., Sandvig, K., & Llorente, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2309-8 · Cited by 269 · see citing works

MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Mikamori, M., Yamada, D., Eguchi, H., Hasegawa, S., Kishimoto, T., Tomimaru, Y., Asaoka, T., Noda, T., Wada, H., Kawamoto, K., et al. (2017) · Scientific Reports · doi:10.1038/srep42339 · Cited by 269 · see citing works

Regulation of exosome release from mammary epithelial and breast cancer cells - a new regulatory pathway.

Riches, A., Campbell, E. C., Borger, E., & Powis, S. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2013.12.019 · Cited by 249 · see citing works

Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer

Yang, S., Che, S. P. Y., Kurywchak, P., Tavormina, J. L., Gansmo, L. B., Correa de Sampaio, P., Tachezy, M., Bockhorn, M., Gebauer, F., Haltom, A. R., et al. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1281499 · Cited by 248 · see citing works

Towards traceable size determination of extracellular vesicles

Varga, Z., Yuana, Y., Grootemaat, A. E., van der Pol, E., Gollwitzer, C., Krumrey, M. K., & Nieuwland, R. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.23298 · Cited by 243 · see citing works

A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

Messenger, S. W., Woo, S. S., Sun, Z., & Martin, T. F. J. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201710132 · Cited by 236 · see citing works

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells

Datta, A., Kim, H., Lal, M. A., McGee, L. E., Johnson, A. E., Moustafa, A. A., Jones, J. C., Mondal, D., Ferrer, M., & Abdel‐Mageed, A. B. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.08.020 · Cited by 226 · see citing works

Low pH increases the yield of exosome isolation

Ban, J.-J., Lee, M., Im, W., & Kim, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.172 · Cited by 225 · see citing works

Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing

Jenjaroenpun, P., Kremenska, Y., Nair, V. M., Kremenskoy, M., Joseph, B., & Kurochkin, I. V. (2013) · PeerJ · doi:10.7717/peerj.201 · Cited by 224 · see citing works

Neuronal networks provide rapid neuroprotection against spreading toxicity

Samson, A. J., Robertson, G. R., Zagnoni, M., & Connolly, C. N. (2016) · Scientific Reports · doi:10.1038/srep33746 · Cited by 218 · see citing works

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

Abrami, L., Brandi, L., Moayeri, M., Brown, M. J., Krantz, B. A., Leppla, S. H., & van der Goot, F. G. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.019 · Cited by 216 · see citing works

Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells

Lee, T. H., Chennakrishnaiah, S., Audemard, E. O., Montermini, L., Meehan, B., & Rak, J. W. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.07.109 · Cited by 210 · see citing works

Regulation of exosome release by glycosphingolipids and flotillins

Phuyal, S., Hessvik, N. P., Skotland, T., Sandvig, K., & Llorente, A. (2014) · The FEBS Journal · doi:10.1111/febs.12775 · Cited by 202 · see citing works

Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress

Kucharzewska, P., & Belting, M. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20304 · Cited by 183 · see citing works

Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect

Xu, S., Wang, J., Ding, N., et al. (2015) · RNA Biology · doi:10.1080/15476286.2015.1100795 · Cited by 168 · see citing works

Calcium wave signaling in cancer cells

Parkash, J., & Asotra, K. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.09.013 · Cited by 161 · see citing works

Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress

Kanemoto, S., Nitani, R., Murakami, T., Kaneko, M., Asada, R., Matsuhisa, K., Saito, A., & Imaizumi, K. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.019 · Cited by 158 · see citing works

Endoplasmic reticulum stress stimulates the release of extracellular vesicles carrying danger-associated molecular pattern (DAMP) molecules

Collett, G. P., Redman, C. W. G., Sargent, I. L., & Vatish, M. (2018) · Oncotarget · doi:10.18632/oncotarget.24158 · Cited by 145 · see citing works

Massive release of extracellular vesicles from cancer cells after photodynamic treatment or chemotherapy

Aubertin, K., Silva, A., Luciani, N., Espinosa, A., Djemat, A., Charue, D., Gallet, F., Blanc‐Brude, O., & Wilhelm, C. (2016) · Scientific Reports · doi:10.1038/srep35376 · Cited by 144 · see citing works

Accelerated growth of B16 BL 6 tumor in mice through efficient uptake of their own exosomes by B16 BL 6 cells

Matsumoto, A., Takahashi, Y., Nishikawa, M., Sano, K., Morishita, M., Charoenviriyakul, C., Saji, H., & Takakura, Y. (2017) · Cancer Science · doi:10.1111/cas.13310 · Cited by 133 · see citing works

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis

Vulpis, E., Cecere, F., Molfetta, R., Soriani, A., Fionda, C., Peruzzi, G., Caracciolo, G., Palchetti, S., Masuelli, L., Simonelli, L., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1279372 · Cited by 121 · see citing works

Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content*

Montermini, L., Meehan, B., Garnier, D., Lee, W.-J., Lee, T., Guha, A., Al-Nedawi, K., & Rak, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.679217 · Cited by 121 · see citing works

Going to sleep in the supine position is a modifiable risk factor for late pregnancy stillbirth; Findings from the New Zealand multicentre stillbirth case-control study

McCowan, L. M. E., Thompson, J., Cronin, R. S., Li, M., Stacey, T., STONE, P. R., LAWTON, B. A., Ekeroma, A. J., & Mitchell, E. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179396 · Cited by 105 · see citing works

CD44v6-competent tumor exosomes promote motility, invasion and cancer-initiating cell marker expression in pancreatic and colorectal cancer cells

Wang, Z., von Au, A., Schnölzer, M., Hackert, T., & Zöller, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10580 · Cited by 104 · see citing works

The ceramide pathway is involved in the survival, apoptosis and exosome functions of human multiple myeloma cells in vitro

Cheng, Q., Li, X., Wang, Y., Dong, M., Zhan, F., & Liu, J. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.118 · Cited by 104 · see citing works

Biogenesis of the Posterior Pole Is Mediated by the Exosome/Microvesicle Protein-sorting Pathway

Shen, B., Fang, Y., Wu, N., & Gould, S. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274803 · Cited by 95 · see citing works

Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H-ras

Lee, T. H., Chennakrishnaiah, S., Meehan, B., Montermini, L., Garnier, D., D’Asti, E., Hou, W., Magnus, N., Gayden, T., Jabado, N., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10627 · Cited by 94 · see citing works

Exosomes are released by bystander cells exposed to radiation-induced biophoton signals: Reconciling the mechanisms mediating the bystander effect

Le, M., Fernández-Palomo, C., McNeill, F. E., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173685 · Cited by 87 · see citing works

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

Zheng, Y. H., Campbell, E. C., Lucocq, J. M., Riches, A., & Powis, S. J. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.10.006 · Cited by 82 · see citing works

Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy

Facciabene, A., Sanctis, F. D., Pierini, S., Reis, E. S., Balint, K., Facciponte, J. G., Rueter, J., Kagabu, M., Magotti, P., Lanitis, E., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1326442 · Cited by 69 · see citing works

The function and clinical significance of eIF3 in cancer

Yin, Y., Long, J., Sun, Y., et al. (2018) · Gene · doi:10.1016/j.gene.2018.06.034 · Cited by 63 · see citing works

EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma

Lee, H., Chen, C., Ho, C., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24149 · Cited by 59 · see citing works

Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis

Okon, I. S., Coughlan, K. A., Zhang, C., Moriasi, C., Ding, Y., Song, P., Zhang, W., Li, G., & Zou, M.-H. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75371 · Cited by 52 · see citing works

Generation of a novel transgenic rat model for tracing extracellular vesicles in body fluids

Yoshimura, A., Kawamata, M., Yoshioka, Y., Katsuda, T., Kikuchi, H., Nagai, Y., Adachi, N., Numakawa, T., Kunugi, H., Ochiya, T., et al. (2016) · Scientific Reports · doi:10.1038/srep31172 · Cited by 47 · see citing works

Stimulation of exosome release by extracellular DNA is conserved across multiple cell types

Iliev, D. B., Strandskog, G., Nepal, A., Aspar, A., Olsen, R. F., Jørgensen, J. B., Wolfson, D. L., Ahluwalia, B. S., Handzhiyski, J., & Mironova, R. (2018) · FEBS Journal · doi:10.1111/febs.14601 · Cited by 41 · see citing works

The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles

Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., Odaka, H., Numakawa, T., Kunugi, H., Ochiya, T., et al. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.028779 · Cited by 34 · see citing works

Jian-Kang Liu: A pioneer of sex determination studies in vertebrates

Zhou, L., & Gui, J. (2015) · Protein & Cell · doi:10.1007/s13238-015-0232-7 · Cited by 29 · see citing works

Liver kinase�B1 restoration promotes exosome secretion and motility of lung cancer cells

Zhang, C., Xiao, X., Chen, M., Aldharee, H., Chen, Y., & Long, W. (2017) · Oncology Reports · doi:10.3892/or.2017.6085 · Cited by 29 · see citing works

Incorporation of the Endoplasmic Reticulum Stress-Induced Spliced Form of XBP1 mRNA in the Exosomes

Hosoi, T., Nakashima, M., & Ozawa, K. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01357 · Cited by 27 · see citing works

Untitled work

Squadrito (2014) · doi:10.1016/j.celrep.2014.07.035

The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Extracellular vesicle PD‐L1 in reshaping tumor immune microenvironment: biological function and potential therapy strategies

Liu, J., Peng, X., Yang, S., Li, X., Huang, M., Wei, S., Zhang, S., He, G., Zheng, H., Fan, Q., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-021-00816-w · Cited by 75 · see citing works

Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challenges

Ubanako, P., Mirza, S., Ruff, P., & Penny, C. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1447953 · Cited by 68 · see citing works

Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry

Liguori, G. L. (2024) · Cells · doi:10.3390/cells13040336 · Cited by 24 · see citing works

miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells

Xu, Y., Zhang, Y.-F., Wang, L., Zhao, R., Qiao, Y., Han, D., Sun, Q., Dong, N., Liu, Y.-C., Wu, D.-T., et al. (2017) · Oncology Report · doi:10.3892/or.2017.5506 · Cited by 25 · see citing works

Inhibitory effect of microvesicles collected from stored blood on platelet aggregation

Daveloose, D., Wolf, C., Jeanguillaume, C., et al. (1981) · Thrombosis Research · doi:10.1016/0049-3848(81)90321-2 · Cited by 5 · see citing works

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles

Clancy, J. W., Sedgwick, A., Rossé, C., Muralidharan-Chari, V., Raposo, G., Method, M., Chavrier, P., & D’Souza‐Schorey, C. (2015) · Nature Communications · doi:10.1038/ncomms7919 · Cited by 189 · see citing works

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

Bastos-Amador, P., Royo, F., González, E., Conde‐Vancells, J., Palomo-Diez, L., Borràs, F. E., & Falcón‐Pérez, J. M. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.03.054 · Cited by 97 · see citing works

The bioactive content of CTCL cell line-derived exosomes and small microvesicles: First study in CTCL

Moyal, L., Gorovitz, B., Arkin, C., et al. (2018) · European Journal of Cancer · doi:10.1016/j.ejca.2018.07.151