Cited by 913Insect Pest Control StrategiesInsect Resistance and GeneticsInsect-Plant Interactions and Control

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NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

Dhadialla, Tarlochan S., Carlson, Glenn R., Le, Dat P.·1998·Annual Review of Entomology

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Abstract

Agrochemical research over the last two decades has resulted in the discovery of chemically novel insecticides that mimic the action of the two insect growth and developmental hormones, the steroidal 20-hydroxyecdysone (20E) and the sesquiterpenoid juvenile hormone (JH). Bisacylhydrazines are non-steroidal agonists of 20E and exhibit their insecticidal activity via interaction with the ecdysteroid receptor proteins. Interestingly, two of the bisacylhydrazine (tebufenozide and RH-2485) insecticides are very selectively toxic to lepidopteran pests. These insecticides are safe to beneficial insects and have a benign ecotoxicological profile. Aromatic non-terpenoidal insecticides (fenoxycarb and pyriproxyfen) mimic the action of JHs. However, like the JHs, their exact mode of action is not well understood. These insecticides are toxic to a broad spectrum of insects during their embryonic, last larval, or reproductive stages. The insecticidal, ecotoxicological properties and the mode of action of the two groups of insecticides are reviewed in this article.

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The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Sustainability of Transgenic Insecticidal Cultivars: Integrating Pest Genetics and Ecology
Gould, F. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.701 · Cited by 1,392
Nutritional Interactions in Insect-Microbial Symbioses: Aphids and Their Symbiotic BacteriaBuchnera
Douglas, A. E. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.17 · Cited by 1,390
Identification of a nuclear receptor that is activated by farnesol metabolites
Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210
The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
Koelle, M. R., Talbot, W. S., Segraves, W. A., Bender, M. T., Cherbas, P. T., & Hogness, D. S. (1991) · Cell · doi:10.1016/0092-8674(91)90572-g · Cited by 966
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
Yao, T., FORMAN, B. M., Jiang, Z., Cherbas, L., Chen, J.-D., McKeown, M., Cherbas, P. T., & Evans, R. M. (1993) · Nature · doi:10.1038/366476a0 · Cited by 947
Temporal control of puffing activity in polytene chromosomes
Ashburner, M., Chihara, C., Meltzer, P., & Richards, G. (1974) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1974.038.01.070 · Cited by 641 · cited 1×
“Drosophila melanogaster , Ashburner and coworkers (3) proposed a model for ecdysteroid action.”
Background
Cellular and Molecular Actions of Juvenile Hormone I. General Considerations and Premetamorphic Actions
Riddiford, L. M. (1994) · Advances in insect physiology · doi:10.1016/s0065-2806(08)60084-3 · Cited by 610
Insect Hormones
Nijhout, H. F. (1994) · Princeton University Press eBooks · doi:10.1515/9780691225111 · Cited by 540
Cellular and Molecular Actions of Juvenile Hormone. II. Roles of Juvenile Hormone in Adult Insects
Wyatt, G. R., & Davey, K. G. (1996) · Advances in insect physiology · doi:10.1016/s0065-2806(08)60030-2 · Cited by 522

Flagged first, then by citations

Show all 131 references

2 of the 131 references couldn’t be matched to a known paper.

Research works printed but not linked: 31

Aller HE, 1988, Brighton Crop Prot. Conf. Pests Dis., 2, 511
Ashok M, 1991, Biochem. Int., 24, 69
Carlson GR, 1996, Crop Prot. Towards 2000: Int. Pestic. Conf. Kuala Lumpur, Malaysia,, 128
Charmillot PJ, 1994, Arboric. Hortic., 26, 123
Dorn S, 1981, Z. Pflanzenkrankh. Pflanzenschutz., 88, 269
Dubendorfer A, Liebig B. 1991. Primary culture of embryonic cells of the Colorado potato beetle,Leptinotarsa decemlineata(Coleoptera:Chrysomelidae): cell differentiation in vitro and establishment of permanent cell lines.Proc. Int. Conf. Invertebr. Tissue Cult., ed. MJ Fraser Jr, 8:7–15. Columbia: Tissue Cult. Assoc.
Estrada JG, 1986, J. Am. Mosq. Control Assoc., 2, 57
Giebultowicz JM, Blackburn MB, Thomas-Laemont PA, Raina AK. 1993.Sterilization of the gypsy moth by disruption of sperm release from testes.ACS Conf. Proc. Ser., Pest Manage.: Biol. Based Technol., ed. RD Lumsden, JL Vaughn, pp. 114–16. Washington, DC: Am. Chem. Soc.
Glancy MB, 1988, J. Econ. Entomol., 81, 642
Heller J, 1992, Brighton Crop Prot. Conf. Pests Dis., 1, 59
Heller P, 1996, Arthropod Manage. Tests, 21, 339
Jacas J, 1995, Med. Fac. Land. Toege. Biol. Wet. Gent., 60, 935
Le DP, 1996, Brighton Crop Prot. Conf. Pests Dis., 2, 481
Miller RW, 1989, J. Agric. Entomol., 6, 77
Miura T, 1987, J. Am. Mosq. Control Assoc., 3, 476
Natskova V, 1988, Plant Sci., 25, 87
Oaks L, 1994, Tech. Inf. Bull. Rohm & Haas Co.
Okazawa T, 1991, J. Am. Mosq. Control Assoc., 7, 604
Palli SR, 1995, Eur. J. Entomol., 92, 325
Quack S, 1995, Eur. J. Entomol., 92, 341
Regiroli G, 1997, Inf. Fitopetol., 5, 60
Retnakaran A, Granett G, Ennis T. 1985.Insect growth regulators.InComprehensive Insect Physiology, Biochemistry and Pharmacology, ed. GA Kerkut, LI Gilbert, 12:529–601. Oxford: Pergamon
10.1002/(SICI)1520-6327(1996)32:3/4<271::AID-ARCH2>3.0.CO;2-W · DOI
RohMid LLC, 1996, Tech. Info. Bull.
Sechser B, 1994, Brighton Crop Prot. Conf. Pests Dis., 3, 1193
Sevala VL, Davey KG. 1990. The action of juvenile hormone on the follicle cells ofRhodnius prolixusinvolves protein kinase C and calcium. InInsect Neurochemistry and Neurophysiology, ed. AB Borkovec, EP Masler, pp. 323–28. Clifton, NJ: Humana
Slama K, 1995, Eur. J. Entomol., 92, 317
Streibert HP, 1994, Brighton Crop Prot. Conf. Pests Dis., 1, 23
Watkinson IA, 1973, PANS, 14, 488
Wing KD, Aller HE. 1990.Ecdysteroid agonists as novel insect growth regulators.InPesticides and Alternatives: Innovative Chemical and Biological Approaches to Pest Control, ed. JE Casida, pp. 251–57. New York: Elsevier
Wing KD, 1989, BCPC Monogr., 43, 107

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“Methoxyfenozide binds to the ecdysone receptor protein and leads to ecdysis, starvation, dehydration, and ultimately death with difficulty in developing resistance and high selection [38,39].”
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Betz-Koch, S., Oehlmann, J., & Oetken, M. (2025) · Environmental Sciences Europe · doi:10.1186/s12302-025-01091-z · Cited by 5
“Moreover, the potential of pyre-throids to alter endocrine levels [2, 22] and the chemical stress on the invertebrates can lead to the delayed activation of ecdysteroid secretion [38, 63].”
Impact of insect growth regulators on beneficial insects: a comprehensive review
Ikram, M., Srinivasan, M., Suganthi, A., Saminathan, V. R., Auxcilia, J., Jayakanthan, M., Sahoo, B. K., Sivakumar, S., Kiruthika, K., Ramya, A. R., et al. (2026) · Journal of Plant Diseases and Protection · doi:10.1007/s41348-025-01214-x · Cited by 5
“Instead, they gradually interfere with an insect’s development, leading to disrupted moulting (Dhadialla et al. 1998), reproduction (Smagghe et al. 2019) and growth (Fansiri et al. 2022), which eventually results in mortality.”
RNA sequencing of Beauveria bassiana JEF-350-infected Thrips palmi reveals change of host defense and homeostasis
Jeong, Y. J., Kim, J., Song, G., Lee, M. R., & Kim, J. S. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-024-13345-6 · Cited by 5
“The insect hormone pathway plays a crucial role in regulating insect molting and development by controlling the transcription of genes involved in juvenile hormone and ecdysone biosynthesis (Dhadialla et al. 1998; Riddiford 2012).”
The plant-derived triterpenoid, cucurbitacin B, but not cucurbitacin E, inhibits the developmental transition associated with ecdysone biosynthesis in Drosophila melanogaster
Toyofuku, M., Fujinaga, D., Inaba, K., Funahashi, T., Fujikawa, Y., Inoue, H., Kataoka, H., Niwa, R., & Ono, H. (2021) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2021.104294 · Cited by 6
The potential of 20-hydroxyecdysone to accelerate termite baiting programs
Lee, S., & Su, N. (2025) · Journal of Economic Entomology · doi:10.1093/jee/toaf052 · Cited by 5
Effects of Hexaflumuron and Pyriproxyfen on the purified Phenoloxidase ofChilo suppressalisWalker (Lepidoptera: Crambidae)
Mirhaghparast, S. K., & Zibaee, A. (2013) · Archives of Phytopathology and Plant Protection · doi:10.1080/03235408.2013.777235 · Cited by 5
“Pyriproxyfen is a juvenile hormone analogue that mimics action of juvenile hormone (JH) in insects (Dhadialla et al. 1998).”
Background
Biological and Reproduction Activities of Mosquito Larvae of Culiseta morsitans (Theobald) after Treatment by Ecdysone Agonist Methoxyfenozide
Haouari-Abderrahim, J., & Rehimi, N. (2014) · Annual Research & Review in Biology · doi:10.9734/arrb/2014/11366 · Cited by 5
“So such, compounds tend to be selective and generally less toxic to non- target organisms than conventional insecticides [4,3].”
Background
Halofenozid ve metoksifenozidin önemli bir mantar meşesi yaprak zararlısı olan Lymantria dispar’ın farklı evrelerinde insektisidal etkisi
Ouakid, M. L., Adjami, Y., Habbachi, W., Ghanem, R., Daas, H., & Tahraoui, A. (2016) · Turkish Journal of Forestry | Türkiye Ormancılık Dergisi · doi:10.18182/tjf.97406 · Cited by 5
Green tea proanthocyanidins cause impairment of hormone-regulated larval development and reproductive fitness via repression of juvenile hormone acid methyltransferase, insulin-like peptide and cytochrome P450 genes in Anopheles gambiae sensu stricto
Muema, J. M., Nyanjom, S. G., Mutunga, J. M., Njeru, S. N., & Bargul, J. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173564 · Cited by 5
Disruptive Effects of Certain Chitin Synthesis Inhibitors on Adult Life Parameters and Reproductive Potential of the Pink Bollworm, Pectinophora gossypiella (Saunders)(Lepidoptera: Gelechidae).
Tanani, M., & Ghoneim, K. (2018) · Egyptian Academic Journal of Biological Sciences · doi:10.21608/eajbsa.2018.17743 · Cited by 5
Disruptive Effects of Some Novel Chitin Synthesis Inhibitors on the Transaminase Activity in Larval Tissues of Spodoptera littoralis (Lepidoptera: Noctuidae)
(2016) · International Journal of Research Studies in Zoology · doi:10.20431/2454-941x.0201001 · Cited by 5
Effect of a novel juvenoid fenoxycarb on the pupal-adult transformation in the blowfly, Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae)
Maddheshiya, R. (2021) · Parasitology Research · doi:10.1007/s00436-021-07205-9 · Cited by 5
Characterization of Qualitative and Quantitative Haemogram Parameters in Insects: Current Concepts and Future Prospects.
Ghoneim, K. (2019) · Egyptian Academic Journal of Biological Sciences · doi:10.21608/eajbsa.2019.25088 · Cited by 5
“Hemocyte Population and Endocrine Control in Insects: Growth and development in insects are regulated by a number of hormones, such as the steroid 20-hydroxyecdysone (20E; molting hormone; ecdysone or ecdysterone), the sesquiterpenoid JHs, eclosion hormone and other neurohormones (Dhadialla et al., 1998). The cyclical…”
BackgroundInfluential
Insecticide Susceptibility of Three Species of Cutworm (Lepidoptera: Noctuidae) Pests of Grapes
Smirle, M. J., Zurowski, C. L., Lowery, D. T., & Mostafa, A. (2013) · Journal of Economic Entomology · doi:10.1603/ec13110 · Cited by 5
Efeitos de três análogos do hormônio juvenil aplicados em bicho-da-seda, Bombyx mori L. (Lepidoptera: Bombycidae)
Miranda, J. E., Bortoli, S. A. D., & Takahashi, R. (2002) · Neotropical Entomology · doi:10.1590/s1519-566x2002000100003 · Cited by 5
Effects of Tebufenozide on the Biological Characteristics of Beet Armyworm (Spodoptera exigua Hübner) and Its Resistance Selection
Liu, W., Mu, W., Bing-yu, Z. H. U., & Liu, F. (2008) · Agricultural Sciences in China · doi:10.1016/s1671-2927(08)60168-6 · Cited by 5
New insect control agents: modes of action and selectivity
Sparks, T. C., Endersby, N. M., & Ridland, P. M. (2001) · Cited by 5
Synthesis and insecticidal evaluation of novel N-oxalyl derivatives of diacylhydrazines containing methylcarbamate moieties
Mao, C., Wang, Q., Huang, R., Chen, L., Shang, J., & Bi, F. (2005) · Heteroatom Chemistry · doi:10.1002/hc.20135 · Cited by 5
TOXICITY OF SOME CONVENTIONAL AND NONCONVENTIONAL INSECTICIDES AGAINST COTTON LEFWORM, Spodoptera littoralis (BOISD.)
Saleh, A., Elgohary, L., Watson, W., & Elabasy, A. S. S. (2015) · Journal of Plant Protection and Pathology /Journal of Plant Protection and Pathology · doi:10.21608/jppp.2015.74493 · Cited by 5
Aversion for bitter taste reveals sexual differences in alimentation strategies in a praying mantis
Carle, T., Yamashita, T., & Yamawaki, Y. (2015) · Animal Behaviour · doi:10.1016/j.anbehav.2015.05.010 · Cited by 5
Ecdysone-regulated chromosome puffing in the salivary glands of the Mediterranean fruit fly, Ceratitis capitata
Gariou-Papalexiou, A., Mintzas, A. C., & Zacharopoulou, A. (2001) · Genome · doi:10.1139/g01-068 · Cited by 5
Developing IPM Packages in the Caribbean
Lawrence, J., Tolin, S. A., Edwards, C., Fleischer, S. J., Jackson, D. M., Clarke-Harris, D., McDonald, S. A. M., Dalip, K., & Chung, P. E. (2005) · doi:10.1002/9780470290163.ch6 · Cited by 5
Comparative effects of a non-steroidal ecdysone agonist RH-5992 and 20-hydroxyecdysone in a lepidopteran cell line (IAL-PID2)
Auzoux-Bordenave, S., Solvar, M., Quéguiner, I., Bozzolan, F., Mottier, V., Siaussat, D., Porcheron, P., & Debernard, S. (2005) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2005.04.004 · Cited by 5
“Like 20E, RH-5992 manifested its biological effects by binding to the EcR/USP complex with a higher affinity than 20E (Dhadialla et al., 1998; Nakagawa et al., 2000; Smagghe et al., 2002).”
Background
Functionalized carbon quantum dots for efficient dsRNA translocation in rice plant and delivery to phloem-feeding insects
Tang, X., Chen, Q., & Lin, X. (2025) · Carbon · doi:10.1016/j.carbon.2025.120955 · Cited by 4
Feeding cessation after feeding on 20‐hydroxyecdysone in the Formosan subterranean termite
Lee, S., Carnohan, L., Gazdick, K., Chouvenc, T., & Su, N. (2023) · Pest Management Science · doi:10.1002/ps.7844 · Cited by 4
A new binding mode for ecdysteroid analog tebufenozide as a multitargeted IGR with chitinase
Cui, J., Feng, Y., Li, X., Wang, H., He, Q., Zhang, L., & Yang, Q. K. (2023) · Advanced Agrochem · doi:10.1016/j.aac.2023.11.006 · Cited by 4
Unexpected soundscape response to insecticide application in oak forests
Mitesser, O., Hochrein, S. M., Buřivalová, Z., Müeller, S., Strätz, C., Liebhold, A. M., Leroy, B. M. L., Hilmers, T., Georgiev, K. B., Bae, S., et al. (2024) · Conservation Biology · doi:10.1111/cobi.14422 · Cited by 5
“However, it is highly selective to Lepidoptera (Dhadialla et al., 1998).”
Influential
Engineering of insect juvenile hormone III biosynthesis in the plant Nicotiana benthamiana
Stathaki, A., Alam, R. M., Köllner, T. G., & O'Connor, S. E. (2024) · Metabolic Engineering · doi:10.1016/j.ymben.2024.12.005 · Cited by 4
“For example, fenoxycarb, a synthetic JH analog, causes prolonged instar duration, deformed pupae and larval-pupal intermediates, sterility, inhibited egg production, and abnormal caste differentiation in a number of different insects (Dhadialla et al., 1998; Wilson, 2004).”
Life expectancy (ex) and stable age distribution (Cx) ofPlutella xylostella(L.) (Lep.: Yponomeutidae), exposed to sublethal doses of hexaflumuron
Mahmoudvand, M., Abbasipour, H., Garjan, A. S., & Bandani, A. R. (2011) · Archives of Phytopathology and Plant Protection · doi:10.1080/03235408.2011.587250 · Cited by 4
“Insect growth regulators (IGRs), diverse groups of chemical compounds, interrupt moulting (juvenile hormone or ecdysone mimics) and cuticle formation (chitin synthesis inhibitors) of insects (Dhadialla et al. 1998).”
Background
Enzyme immunoassay measurements of the molting hormone in different post-embryonic stages of two mosquito species, Culex pipiens and Culiseta longiareolata
Tine-Djebbar (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb11.2085 · Cited by 4
“The phenomena of molting and metamorphosis of insects are controlled by different hormones that are essentially the moulting hormone (ecdysteroids) secreted by the prothoracic glands, and juvenile hormone (JH), produced by the corpora allata (Dhadialla et al., 1998).”
Background
Effects of Tebufenozide on Eggs, Larvae and Adults of Chrysoperla carnea (Neuroptera: Chrysopidae)
Suárez-López, Y. A., Hatem, A. E., Aldebis, H. K., & Osuna, E. V. (2023) · Insects · doi:10.3390/insects14060521 · Cited by 4
“Tebufenozide is a nonsteroidal ecdysone antagonist that stimulates the moulting hormone receptor of target insect pests, especially Lepidoptera, thereby inducing premature and lethal moulting [6,7].”
Background
Insect Sterols and Steroids
Lafont, R., & Dinan, L. N. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_823 · Cited by 7
Lipid Metabolism as a Target Site in Pest Control
Toprak, U., İnak, E., & Nauen, R. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_822 · Cited by 4
Chemosterilant Potential of Insect Growth Regulators for Management of Bactrocera cucurbitae (Diptera: Tephritidae)
Kainat, I., Saeed, S., Farooq, M. A., Alkherb, W. A. H., Abbasi, A., Baig, F., Liaqat, U., Khan, F. Z. A., Akram, M. I., Hasnain, M., et al. (2025) · Insects · doi:10.3390/insects16020137 · Cited by 4
“We also included Buprofezin, which delays chitin formation [32], and Pyriprox-yfen, which acts as a juvenile hormone mimic, i.e., it disrupts the progression of immature stages and also effects reproductive potential [15].”
Tebufenozide disrupts ovarian development and function in silkmoths
Sridhara, S., & Lee, V. H. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.09.002 · Cited by 4
Exposure to Methoxyfenozide-Treated Surfaces Reduces the Responsiveness of Adult Male Codling Moth (Lepidoptera: Tortricidae) to Codlemone and Pear Ester Lures in a Wind Tunnel
Barrett, B. A. (2010) · Journal of Economic Entomology · doi:10.1603/ec09433 · Cited by 4
MATING BEHAVIOR OF THE PREDATOR Podisus nigrispinus (HETEROPTERA:PENTATOMIDAE) UNDER EXPOSURE TO NEEM
de Oliveira, S. O. D., Barbosa, W. F., Mallqui, K. S. V., & Guedes, R. N. C. (2013) · TSpace (University of Toronto) · Cited by 4
RNAi-Mediated Control of Lepidopteran Pests of Important Crop Plants
Saxena, S., Yogindran, S., Arya, M., Sharma, Y., & Singh, C. P. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96429 · Cited by 4
Juvenile Hormones and Juvenoids
(2013) · QSAR in environmental and health sciences · doi:10.1201/b14899-2 · Cited by 4
Unraveling the Role of Cuticular Protein 3-like (HvCP3L) in the Chitin Pathway through RNAi and Methoxyfenozide Stress Response in Heortia vitessoides Moore
Wang, H., Sun, M., Liu, N., Yin, M., & Lin, T. (2024) · Insects · doi:10.3390/insects15050362 · Cited by 4
“It accelerates the molting process in larvae, leading to premature molting, and exhibits high insecticidal activity against Lepidopteran pests [27,28].”
Background
Insect endocrinology and hormone-based pest control products in IPM
Doucet, D. S., Cusson, M., & Retnakaran, A. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511626463.023 · Cited by 4
Identification of two juvenile hormone inducible transcription factors from the silkworm, Bombyx mori
Matsumoto, H., Ueno, C., Nakamura, Y., Kinjoh, T., Ito, Y., Shimura, S., Noda, H., Imanishi, S., Mita, K., Fujiwara, H., et al. (2015) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2015.02.011 · Cited by 4
“Thus, JH I had greater induction activity than methoprene for E75 and E(spl)mb expression, although synthetic JH agonists including methoprene generally show higher pharmacological JH activity than natural JHs (Dhadialla et al., 1998).”
Background
Toxicological, biological and biochemical impacts of Indoxacarb and Methoxyfenozoid on the larvae of the Cotton leafworm, Spodoptera littoralis (Boisd.). (Lepidoptera: Noctuidae)
Khaled, A., & Farag, S. (2015) · Egyptian Academic Journal of Biological Sciences F Toxicology & Pest Control · doi:10.21608/eajbsf.2015.17144 · Cited by 4
Comparison in the response of three European Gammarid species exposed to the growth regulator insecticide fenoxycarb
Arambourou, H., Vulliet, E., Danièle, G., Noury, P., Delorme, N., Abbaci, K. T., Forcellini, M., Tutundjian, R., & Barata, C. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-04631-2 · Cited by 4
20-hydroxyecdysone receptor ligand binding domain: 1. A semiempirical study of dibenzoylhydrazines selectivity
dos Santos, A. C. S., & Sant’Anna, C. M. R. (2002) · Journal of Molecular Structure THEOCHEM · doi:10.1016/s0166-1280(02)00031-3 · Cited by 4

Authors: Dhadialla, T. S., Carlson, G. R., & Le, D. P.
Affiliations: Insecticide Research Laboratories, Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania 19477;
Venue: Annual Review of Entomology
Publisher: Annual Reviews
Published: 1998-01
Volume: 43
Issue: 1
Pages: 545-569
ISSN: 0066-4170 (ISSN-L)
1545-4487
DOI: 10.1146/annurev.ento.43.1.545
OpenAlex: W2149662691
Cited by: 912
References: 131
Citations by year: 2026: 12 · 2025: 29 · 2024: 29 · 2023: 22 · 2022: 23 · 2021: 44 · 2020: 22 · 2019: 30 · 2018: 23 · 2017: 34 · 2016: 32 · 2015: 28 · 2014: 21 · 2013: 32 · 2012: 49
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Entomology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
Keywords: insect growth regulators, ecdysteroid agonists, juvenile hormone agonists, tebufenozide, fenoxycarb, pyriproxyfen, 20-hydroxyecdysone, ecdysteroid receptor, insecticide mode of action, ecotoxicology, lepidopteran pests
MeSH terms: Animals, Forecasting, Hydrazines, Insecticides, Insecta, Juvenile Hormones, Steroids, Molecular Structure, Molecular Mimicry, Ecdysteroids

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NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

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