Cited by 913Insect Pest Control StrategiesInsect Resistance and GeneticsInsect-Plant Interactions and Control

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NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

Dhadialla, Tarlochan S., Carlson, Glenn R., Le, Dat P.·1998·Annual Review of Entomology

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Abstract

Agrochemical research over the last two decades has resulted in the discovery of chemically novel insecticides that mimic the action of the two insect growth and developmental hormones, the steroidal 20-hydroxyecdysone (20E) and the sesquiterpenoid juvenile hormone (JH). Bisacylhydrazines are non-steroidal agonists of 20E and exhibit their insecticidal activity via interaction with the ecdysteroid receptor proteins. Interestingly, two of the bisacylhydrazine (tebufenozide and RH-2485) insecticides are very selectively toxic to lepidopteran pests. These insecticides are safe to beneficial insects and have a benign ecotoxicological profile. Aromatic non-terpenoidal insecticides (fenoxycarb and pyriproxyfen) mimic the action of JHs. However, like the JHs, their exact mode of action is not well understood. These insecticides are toxic to a broad spectrum of insects during their embryonic, last larval, or reproductive stages. The insecticidal, ecotoxicological properties and the mode of action of the two groups of insecticides are reviewed in this article.

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Assessment of Sublethal Effects of Methoxyfenozide on Oriental Fruit Moth (Lepidoptera: Tortricidae)
Borchert, D. M., Walgenbach, J. F., & Kennedy, G. G. (2005) · Journal of Economic Entomology · doi:10.1603/0022-0493-98.3.765 · Cited by 16
“The bisacylhydrazine class of IGRs contains ecdysone agonists that mimic the steroid 20-hydroxyecdysone, the molting hormone in insects (Dhadialla et al. 1998).”
Background
Projecting Population-Level Responses of Mysids Exposed to an Endocrine Disrupting Chemical
Raimondo, S. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.1.151 · Cited by 16
“By disrupting the balance of hormones that facilitate molting, metamorphosis, and gametogenesis, methoprene has the potential to retard growth and reproduction of both target and nontarget invertebrates where applied (Dhadialla et al., 1998).”
Background
Sublethal Effects of Methoxyfenozide, in Comparison to Chlorfluazuron and Beta-Cypermethrin, on the Reproductive Characteristics of Common Cutworm Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae)
Shahout, H. A., Xu, J., Qiao, J., & QiaoDong, J. (2011) · Journal of entomological research society · Cited by 16
Developmental profiles and ecdysone regulation of the mRNAs for two ecdysone receptor isoforms in the Mediterranean fruit fly Ceratitis capitata
Verras, M., Gourzi, P., Zacharopoulou, A., & Mintzas, A. C. (2002) · Insect Molecular Biology · doi:10.1046/j.1365-2583.2002.00365.x · Cited by 16
“Such studies are particularly important in insect pests because they could lead to the development of novel species-specific control methods (Dhadialla et al ., 1998).”
Background
Ecdysteroid ligand-receptor selectivity–exploring trends to design orthogonal gene switches
Lapenna, S., Friz, J., Barlow, A., Palli, S. R., Dinan, L., & Hormann, R. E. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06687.x · Cited by 15
Ecdysteroids from Serratula wolffii Roots
Liktor-Busa, E., Simon, A., Tóth, G., Fekete, G., Kele, Z., & Báthori, M. (2007) · Journal of Natural Products · doi:10.1021/np070037y · Cited by 17
Sequencing and structural homology modeling of the ecdysone receptor in two chrysopids used in biological control of pest insects
Zotti, M. J., Christiaens, O., Rougé, P., Grützmacher, A. D., Zimmer, P. D., & Smagghe, G. J. (2012) · Ecotoxicology · doi:10.1007/s10646-012-0852-0 · Cited by 15
“These compounds exert their activity by binding to the 20E-binding site and activating EcRs permanently (Wing et al. 1988; Dhadialla et al. 1998; 2005; Nakagawa 2005).”
Background
Novel Insecticides and Their Application in the Management of Horticultural Crop Pests
Bhuvaneswari, K., Mani, M., Suganthi, A., & Manivannan, A. (2022) · Springer eBooks · doi:10.1007/978-981-19-0343-4_13 · Cited by 15
Spray‐induced and nanocarrier‐delivered gene silencing system targeting juvenile hormone receptor components: potential application as fertility inhibitors for Adelphocoris suturalis management
Zheng, W., Xu, X., Huang, X., Peng, J., Ma, W., Hull, J. J., Hua, H., & Chen, L. (2024) · Pest Management Science · doi:10.1002/ps.8077 · Cited by 15
“15 However, sporadic reports have suggested some of the mimics may impact vertebrate endocrine responses.”
Impact of Three Thiazolidinone Compounds with Piperine Skeletons on Trehalase Activity and Development of Spodoptera frugiperda Larvae
Tang, B., Hu, S., Luo, Y., Shi, D., Liu, X., Zhong, F., Jiang, X., Hu, G., Li, C., Duan, H., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c08898 · Cited by 15
Imaginal Discs and Tissue Cultures as Targets for Insecticide Action
Oberlander, H., & Smagghe, G. J. (2001) · Springer eBooks · doi:10.1007/978-3-642-59549-3_6 · Cited by 15
Resistance in the Post-Genomics Age
Pittendrigh, B. R., Margam, V. M., Sun, L., & Huesing, J. E. (2008) · Elsevier eBooks · doi:10.1016/b978-012373858-5.50005-8 · Cited by 15
The ecdysone receptor (EcR) is a major regulator of tissue development and growth in the marine salmonid ectoparasite, Lepeophtheirus salmonis (Copepoda, Caligidae)
Sandlund, L., Nilsen, F., Male, R., & Dalvin, S. T. (2016) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2016.06.007 · Cited by 15
Boosting the sterile insect technique with pyriproxyfen increases tsetse flies Glossina palpalis gambiensis sterilization in controlled conditions
Laroche, L., Ravel, S., Baldet, T., Lancelot, R., Chandre, F., Rossignol, M., Goff, V. L., Duhayon, M., Fafet, J.-F., Parker, A. G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66850-9 · Cited by 15
Residue degradation, transfer and risk assessment of pyriproxyfen and its metabolites from tea garden to cup by ultra performance liquid chromatography tandem mass spectrometry
Li, H., Zhong, Q., Wang, M., Luo, F., Wang, X., Zhou, L. L., & Zhang, X. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11746 · Cited by 15
Compounds Inhibiting Noppera-bo, a Glutathione S-transferase Involved in Insect Ecdysteroid Biosynthesis: Novel Insect Growth Regulators
Ebihara, K., & Niwa, R. (2023) · Biomolecules · doi:10.3390/biom13030461 · Cited by 15
“Some of these target insect-specific structural materials, such as chitins, which are essential for formation of the cuticular layer, and insect hormones, which are required for molting and metamorphosis [13,14].”
Background
Floating row covers and pyriproxyfen help control silverleaf whitefly Bemisia tabaci (Gennadius) Biotype B (Homoptera: Aleyrodidae) in zucchini
Qureshi, M. S., Midmore, D. J., Syeda, S. S., & Playford, C. L. (2007) · Australian Journal of Entomology · doi:10.1111/j.1440-6055.2007.00600.x · Cited by 15
20-Hydroxyecdysone regulation of H-fibroin gene in the stored grain pest Corcyra cephalonica, during the last instar larval development
Chaitanya, R. K., Sridevi, P., Senthilkumaran, B., & Gupta, A. D. (2010) · Steroids · doi:10.1016/j.steroids.2010.09.009 · Cited by 15
Validity Analysis of a Receptor Binding Assay for Ecdysone Agonists Using Cultured Intact Insect Cells
Minakuchi, C., Nakagawa, Y., & Miyagawa, H. (2003) · Journal of Pesticide Science · doi:10.1584/jpestics.28.55 · Cited by 15
Lethal and sublethal effects of cypermethrin and methoxyfenozide on the larvae ofRachiplusia nu(Guenee) (Lepidoptera: Noctuidae)
Rimoldi, F., Fogel, M. N., Schneider, M. I., & Ronco, A. E. (2011) · Invertebrate Reproduction & Development · doi:10.1080/07924259.2011.591177 · Cited by 15
“Its mode of action is to mimic the endogenous ecdysteroid hormone by binding to the natural hormone receptors and causing an anticipated lethal molt (Dhadialla et al. 1998).”
Background
Evaluation of Solution and Solid-Phase Approaches to the Synthesis of Libraries of α,α-Disubstituted-α-acylaminoketones
Garcia, J., Mata, E. G., Tice, C. M., Hormann, R. E., Nicolás, E., Alberício, F., & Michelotti, E. L. (2005) · Journal of Combinatorial Chemistry · doi:10.1021/cc0500396 · Cited by 15
Understanding Resistance and Induced Responses of Insects to Xenobiotics and Insecticides in the Age of “Omics” and Systems Biology
Pittendrigh, B. R., Margam, V. M., Walters, K. R., Steele, L. D., Olds, B. P., Sun, L., Huesing, J. E., Lee, S. H., & Clark, J. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396955-2.00003-5 · Cited by 16
Synergism of diacylhydrazine insecticides with metyrapone and diethylmaleate
Smagghe, G. J. (2004) · Journal of Applied Entomology · doi:10.1111/j.1439-0418.2004.00830.x · Cited by 15
“Over the last decades, the beet armyworm, Spodoptera exigua (Hübner) (BAW), has become a serious polyphagous pest that has developed resistance to various groups of chemical insecticide classes, including chlorinated hydrocarbons, organophosphates (OPs), carbamates, pyrethroids and IGRs such as benzoylphenylureas, an…”
BackgroundInfluential
Effect of dietary benzoxadiazole on larval development, cuticle enzyme and antioxidant defense system in housefly (Musca domestica L.)
Huang, Q., Liu, M., Feng, J. T., & Liu, Y. (2007) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2007.11.001 · Cited by 15
Effect of bisacylhydrazine ecdysteroid mimics (RH-5849 and RH-5992) on chromosomal puffing, imaginal disc proliferation and pupariation in larvae of Drosophila melanogaster
Farkas, R. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00077-6 · Cited by 15
Controle químico da lagarta-enroladeira (Bonagota cranaodes Meyrick) na cultura da macieira
Botton, M., Nakano, O., & Kovaleski, A. (2000) · Pesquisa Agropecuária Brasileira · doi:10.1590/s0100-204x2000001100003 · Cited by 15
Apple Damage, Pest Phenology, and Factors Influencing the Efficacy of Tebufenozide for Control of Obliquebanded Leafroller (Lepidoptera: Tortricidae)
Waldstein, D. E., & Reissig, W. H. (2001) · Journal of Economic Entomology · doi:10.1603/0022-0493-94.3.673 · Cited by 15
Resistant Target Sites and Insecticide Discovery
Salgado, V. L. (1999) · Elsevier eBooks · doi:10.1533/9781845698416.5.236 · Cited by 15
The ABC transporter Pdr5p mediates the efflux of nonsteroidal ecdysone agonists in Saccharomyces cerevisiae
Hu, W., Feng, Q., Palli, S. R., Krell, P. J., Arif, B. M., & Retnakaran, A. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02245.x · Cited by 15
“The inactivity of this compound on nonlepidopteran might be due to several reasons such as defects in the receptor levels [27], low affinity of hormone-receptor binding [1], or exclusion mechanism as indicated by our earlier studies using susceptible and resistant cell lines [6].”
BackgroundResult
Effects of different hormones as dietary supplements on biological characteristics of Coccinella septempunctata L.
Cheng, Y., Zhou, Y., Ran, H., & Li, F. (2023) · Journal of Applied Entomology · doi:10.1111/jen.13180 · Cited by 14
“Furthermore, the injection of JH or its analogues at the final larval stage can delay the larval- to-pupal transition (Bai et al., 2020; Dhadialla et al., 1998).”
Background
Molecular characterisation of the salmon louse, Lepeophtheirus salmonis salmonis (Krøyer, 1837), ecdysone receptor with emphasis on functional studies of female reproduction
Sandlund, L., Nilsen, F., Male, R., Grotmol, S., Kongshaug, H., & Dalvin, S. T. (2014) · International Journal for Parasitology · doi:10.1016/j.ijpara.2014.10.003 · Cited by 15
“Their selective specificity and their non-toxic effect on vertebrates have made these agonists important tools in integrated pest management as they have reduced the risk of affecting non-pest species and of causing negative environmental effects (Dhadialla et al., 1998; Hill et al., 2012).”
Background
Incorporating Organophosphate Alternative Insecticides Into Codling Moth Management Programs in Washington Apple Orchards
Doerr, M. D., Brunner, J. F., & Granger, K. R. (2012) · Journal of Integrated Pest Management · doi:10.1603/ipm09001 · Cited by 14
Toxicity assessment of two IGR insecticides on eggs and larvae of the ladybird Eriopis connexa
Fogel, M. N., Scorsetti, A. C., Minardi, G., & Schneider, M. I. (2022) · Pest Management Science · doi:10.1002/ps.7293 · Cited by 14
Comparative toxicity of three ecdysone agonist insecticides against the Mediterranean flour moth.
Hami, M., Taïbi, F., Smagghe, G. J., & Soltani-Mazouni, N. (2005) · PubMed · Cited by 14
Predicting Scenarios for Successful Autodissemination of Pyriproxyfen by Malaria Vectors from Their Resting Sites to Aquatic Habitats; Description and Simulation Analysis of a Field-Parameterizable Model
Kiware, S. S., Corliss, G. F., Merrill, S. J., Lwetoijera, D. W., Devine, G. J., Majambere, S., & Killeen, G. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131835 · Cited by 12
Cell Cycle Quiescence can Suppress Transcription from an Ecdysone Receptor–Based Inducible Promoter in Mammalian Cells
Wallbaum, S., Grau, N., Schmid, A., Frick, K., Neeb, A., & Sleeman, J. P. (2009) · BioTechniques · doi:10.2144/000113121 · Cited by 14
Non-target toxicity of synthetic insecticides on the biological performance and population growth of Bracon hebetor Say
Muslim, M., Ansari, M. S., & Hasan, F. (2018) · Ecotoxicology · doi:10.1007/s10646-018-1947-z · Cited by 14
Toxicity effects and biomarkers of tebufenozide exposure in Yuukianura szeptyckii (Collembola: Neanuridae)
Lee, Y., Lee, S., Son, J., Kim, Y., Wee, J., & Cho, K. (2018) · Environmental Geochemistry and Health · doi:10.1007/s10653-018-0143-7 · Cited by 14
“This insect growth regulator appears to be specific to lepidopterans, with inconsistent effects on insects of other orders, including Coleoptera, Diptera, Heteroptera, and Orthoptera (Hsu et al. 1991; Dhadialla et al. 1998; Oberlander et al. 1995; Retnakaran et al. 1995).”
Background
Growth Regulator Insecticides for the Control of the Lesser Mealworm Beetle Alphitobius Diaperinus (Coleoptera: Tenebrionidae)
Zorzetti, J., Constanski, K. C., Santoro, P. H., Fonseca, I. C. B., & Neves, P. M. O. J. (2015) · Revista Colombiana de Entomología · doi:10.1177/012004881504100105 · Cited by 14
“The diacyl hydrazines act as ecdysone antagonists, promoting acceleration in the ecdysis process (Dhadialla et al. 1998; Omoto 2000).”
Applications of EcR gene switch technology in functional genomics
Tavva, V. S., Palli, S. R., Dinkins, R. D., & Collins, G. B. (2007) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20193 · Cited by 14
“These agonists bind EcR with nanomolar affinity, are non-phytotoxic, safe to many organisms, and, therefore, suitable for both laboratory and field applications (Dhadialla et al. 1998).”
Background
Enhancement of 20-hydroxyecdysone production in cell suspension cultures of Vitex glabrata R.Br. by precursors feeding
Sinlaparaya, D., Duanghaklang, P., & Panichajakul, S. (2007) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v6i14.57734 · Cited by 14
“Ecdysteroids and analogues could be use as insecticides (Dhadialla and Tzertzinis, 1998).”
Background
Ovicidal effect of some insecticides on the diamondback moth, Plutella xylostella (L.) (Lepidoptera: Yponomeutidae)
Mahmoudvand, M., Garjan, A. S., & Abbasipour, H. (2011) · Chilean journal of agricultural research · doi:10.4067/s0718-58392011000200007 · Cited by 14
“They interrupt molting (juvenile hormone or ecdysone mimics) and cuticle formation (chitin synthesis inhibitors) and affect the insect endocrine system (Dhadialla et al., 1998; Hoffmann and Lorenz, 1998).”
Background
Fecundity, Fertility and Longevity Reductions in Adult Oriental Fruit Moth (Lepidoptera: Tortricidae) Exposed to Surfaces Treated with the Ecdysteroid Agonists Tebufenozide and Methoxyfenozide
Reinke, M. D., & Barrett, B. A. (2007) · Journal of Entomological Science · doi:10.18474/0749-8004-42.4.457 · Cited by 14
Insect Cell Lines as Tools in Insecticide Mode of Action Research
Smagghe, G. J. (2007) · Springer eBooks · doi:10.1007/978-3-540-46907-0_12 · Cited by 14
Pesticides for Arthropod Control in Vineyards
Bostanian, N. J., Wise, J. C., & Isaacs, R. (2012) · Springer eBooks · doi:10.1007/978-94-007-4032-7_4 · Cited by 14
Evaluation of toxicity of pesticides and their biodegradation products using human cells
Forman, S., Novák, J., Tykva, R., Káš, J., Wimmer, Z., & Ruml, T. (2002) · Chemosphere · doi:10.1016/s0045-6535(01)00066-2 · Cited by 14
Insect Growth Regulators
Pener, M. P. (2002) · CRC Press eBooks · doi:10.1201/noe0824706326.ch168 · Cited by 14
Isoforms of the heteropteran Nezara viridula ecdysone receptor: protein characterisation, RH5992 insecticide binding and homology modelling
Tohidi‐Esfahani, D., Lawrence, M. C., Graham, L. D., Hannan, G. N., Simpson, A. M., & Hill, R. J. (2011) · Pest Management Science · doi:10.1002/ps.2200 · Cited by 13
Transcription‐inducing activity of natural and synthetic juvenile hormone agonists through the Drosophila Methoprene‐tolerant protein
Yokoi, T., Nabe, T., Ishizuka, C., Hayashi, K., Ito‐Harashima, S., Yagi, T., Nakagawa, Y., & Miyagawa, H. (2020) · Pest Management Science · doi:10.1002/ps.5766 · Cited by 13
Persistence, leaching and associated toxicity risks of insecticide pyriproxyfen in soil ecosystem
Kumari, P., Duhan, A., Rani, N., & Beniwal, R. K. (2022) · Ecotoxicology · doi:10.1007/s10646-022-02600-z · Cited by 13
“It is synthesized and commercialized by Sumitomo Chemicals Limited with trade name of ‘Lano® 10EC’ (Dhadialla et al. 1998; Paya et al. 2013; Kumari et al. 2021).”
Method

Authors: Dhadialla, T. S., Carlson, G. R., & Le, D. P.
Affiliations: Insecticide Research Laboratories, Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania 19477;
Venue: Annual Review of Entomology
Publisher: Annual Reviews
Published: 1998-01
Volume: 43
Issue: 1
Pages: 545-569
ISSN: 0066-4170 (ISSN-L)
1545-4487
DOI: 10.1146/annurev.ento.43.1.545
OpenAlex: W2149662691
Cited by: 912
References: 131
Citations by year: 2026: 12 · 2025: 29 · 2024: 29 · 2023: 22 · 2022: 23 · 2021: 44 · 2020: 22 · 2019: 30 · 2018: 23 · 2017: 34 · 2016: 32 · 2015: 28 · 2014: 21 · 2013: 32 · 2012: 49
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Entomology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
Keywords: insect growth regulators, ecdysteroid agonists, juvenile hormone agonists, tebufenozide, fenoxycarb, pyriproxyfen, 20-hydroxyecdysone, ecdysteroid receptor, insecticide mode of action, ecotoxicology, lepidopteran pests
MeSH terms: Animals, Forecasting, Hydrazines, Insecticides, Insecta, Juvenile Hormones, Steroids, Molecular Structure, Molecular Mimicry, Ecdysteroids

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NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

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