Cited by 913Insect Pest Control StrategiesInsect Resistance and GeneticsInsect-Plant Interactions and Control

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NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

Dhadialla, Tarlochan S., Carlson, Glenn R., Le, Dat P.·1998·Annual Review of Entomology

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Abstract

Agrochemical research over the last two decades has resulted in the discovery of chemically novel insecticides that mimic the action of the two insect growth and developmental hormones, the steroidal 20-hydroxyecdysone (20E) and the sesquiterpenoid juvenile hormone (JH). Bisacylhydrazines are non-steroidal agonists of 20E and exhibit their insecticidal activity via interaction with the ecdysteroid receptor proteins. Interestingly, two of the bisacylhydrazine (tebufenozide and RH-2485) insecticides are very selectively toxic to lepidopteran pests. These insecticides are safe to beneficial insects and have a benign ecotoxicological profile. Aromatic non-terpenoidal insecticides (fenoxycarb and pyriproxyfen) mimic the action of JHs. However, like the JHs, their exact mode of action is not well understood. These insecticides are toxic to a broad spectrum of insects during their embryonic, last larval, or reproductive stages. The insecticidal, ecotoxicological properties and the mode of action of the two groups of insecticides are reviewed in this article.

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The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Sustainability of Transgenic Insecticidal Cultivars: Integrating Pest Genetics and Ecology
Gould, F. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.701 · Cited by 1,392
Nutritional Interactions in Insect-Microbial Symbioses: Aphids and Their Symbiotic BacteriaBuchnera
Douglas, A. E. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.17 · Cited by 1,390
Identification of a nuclear receptor that is activated by farnesol metabolites
Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210
The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
Koelle, M. R., Talbot, W. S., Segraves, W. A., Bender, M. T., Cherbas, P. T., & Hogness, D. S. (1991) · Cell · doi:10.1016/0092-8674(91)90572-g · Cited by 966
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
Yao, T., FORMAN, B. M., Jiang, Z., Cherbas, L., Chen, J.-D., McKeown, M., Cherbas, P. T., & Evans, R. M. (1993) · Nature · doi:10.1038/366476a0 · Cited by 947
Temporal control of puffing activity in polytene chromosomes
Ashburner, M., Chihara, C., Meltzer, P., & Richards, G. (1974) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1974.038.01.070 · Cited by 641 · cited 1×
“Drosophila melanogaster , Ashburner and coworkers (3) proposed a model for ecdysteroid action.”
Background
Cellular and Molecular Actions of Juvenile Hormone I. General Considerations and Premetamorphic Actions
Riddiford, L. M. (1994) · Advances in insect physiology · doi:10.1016/s0065-2806(08)60084-3 · Cited by 610
Insect Hormones
Nijhout, H. F. (1994) · Princeton University Press eBooks · doi:10.1515/9780691225111 · Cited by 540
Cellular and Molecular Actions of Juvenile Hormone. II. Roles of Juvenile Hormone in Adult Insects
Wyatt, G. R., & Davey, K. G. (1996) · Advances in insect physiology · doi:10.1016/s0065-2806(08)60030-2 · Cited by 522

Flagged first, then by citations

Show all 131 references

2 of the 131 references couldn’t be matched to a known paper.

Research works printed but not linked: 31

Aller HE, 1988, Brighton Crop Prot. Conf. Pests Dis., 2, 511
Ashok M, 1991, Biochem. Int., 24, 69
Carlson GR, 1996, Crop Prot. Towards 2000: Int. Pestic. Conf. Kuala Lumpur, Malaysia,, 128
Charmillot PJ, 1994, Arboric. Hortic., 26, 123
Dorn S, 1981, Z. Pflanzenkrankh. Pflanzenschutz., 88, 269
Dubendorfer A, Liebig B. 1991. Primary culture of embryonic cells of the Colorado potato beetle,Leptinotarsa decemlineata(Coleoptera:Chrysomelidae): cell differentiation in vitro and establishment of permanent cell lines.Proc. Int. Conf. Invertebr. Tissue Cult., ed. MJ Fraser Jr, 8:7–15. Columbia: Tissue Cult. Assoc.
Estrada JG, 1986, J. Am. Mosq. Control Assoc., 2, 57
Giebultowicz JM, Blackburn MB, Thomas-Laemont PA, Raina AK. 1993.Sterilization of the gypsy moth by disruption of sperm release from testes.ACS Conf. Proc. Ser., Pest Manage.: Biol. Based Technol., ed. RD Lumsden, JL Vaughn, pp. 114–16. Washington, DC: Am. Chem. Soc.
Glancy MB, 1988, J. Econ. Entomol., 81, 642
Heller J, 1992, Brighton Crop Prot. Conf. Pests Dis., 1, 59
Heller P, 1996, Arthropod Manage. Tests, 21, 339
Jacas J, 1995, Med. Fac. Land. Toege. Biol. Wet. Gent., 60, 935
Le DP, 1996, Brighton Crop Prot. Conf. Pests Dis., 2, 481
Miller RW, 1989, J. Agric. Entomol., 6, 77
Miura T, 1987, J. Am. Mosq. Control Assoc., 3, 476
Natskova V, 1988, Plant Sci., 25, 87
Oaks L, 1994, Tech. Inf. Bull. Rohm & Haas Co.
Okazawa T, 1991, J. Am. Mosq. Control Assoc., 7, 604
Palli SR, 1995, Eur. J. Entomol., 92, 325
Quack S, 1995, Eur. J. Entomol., 92, 341
Regiroli G, 1997, Inf. Fitopetol., 5, 60
Retnakaran A, Granett G, Ennis T. 1985.Insect growth regulators.InComprehensive Insect Physiology, Biochemistry and Pharmacology, ed. GA Kerkut, LI Gilbert, 12:529–601. Oxford: Pergamon
10.1002/(SICI)1520-6327(1996)32:3/4<271::AID-ARCH2>3.0.CO;2-W · DOI
RohMid LLC, 1996, Tech. Info. Bull.
Sechser B, 1994, Brighton Crop Prot. Conf. Pests Dis., 3, 1193
Sevala VL, Davey KG. 1990. The action of juvenile hormone on the follicle cells ofRhodnius prolixusinvolves protein kinase C and calcium. InInsect Neurochemistry and Neurophysiology, ed. AB Borkovec, EP Masler, pp. 323–28. Clifton, NJ: Humana
Slama K, 1995, Eur. J. Entomol., 92, 317
Streibert HP, 1994, Brighton Crop Prot. Conf. Pests Dis., 1, 23
Watkinson IA, 1973, PANS, 14, 488
Wing KD, Aller HE. 1990.Ecdysteroid agonists as novel insect growth regulators.InPesticides and Alternatives: Innovative Chemical and Biological Approaches to Pest Control, ed. JE Casida, pp. 251–57. New York: Elsevier
Wing KD, 1989, BCPC Monogr., 43, 107

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Background
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Toxicity and biochemical study of two insect growth regulators, buprofezin and pyriproxyfen, on cotton leafworm Spodoptera littoralis
Nasr, H. M., Badawy, M. E. I., & Rabea, E. I. (2010) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2010.06.007 · Cited by 101
“Most compounds that belong to the IGR class are not stomach or neurotoxic poisons, but have a unique mode of action that disrupts the molting process or cuticle formation in insects [12] or interferes with the hormonal balance of insects [9].”
Background
Insect growth regulatory effects of some extracts and sterols from Myrtillocactus geometrizans (Cactaceae) against Spodoptera frugiperda and Tenebrio molitor
Céspedes, C. L., Salazar, J. R., Martínez‐Vázquez, M., & Aranda, E. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.07.010 · Cited by 101
“geometrizans; these data are important for insect control studies (Klocke and Kubo, 1982; Kubo and Klocke, 1982a; Berenbaum, 1988; Hedin et al., 1991; Dhadialla et al., 1998; Agarwal et al., 2000; Kessler and Baldwin, 2002).”
Background
The genus Sida L. – A traditional medicine: Its ethnopharmacological, phytochemical and pharmacological data for commercial exploitation in herbal drugs industry
Dinda, B., Das, N., Dinda, S., Dinda, M., & SilSarma, I. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.10.027 · Cited by 101
“These ecdysteroids may be useful candidates for successful insect control agents (Dhadialla et al., 1998).”
Background
An Overview of Insect Growth Disruptors; Applied Aspects
Pener, M. P., & Dhadialla, T. S. (2012) · Advances in insect physiology · doi:10.1016/b978-0-12-391500-9.00001-2 · Cited by 101
Genomic and proteomic studies on the effects of the insect growth regulator diflubenzuron in the model beetle species Tribolium castaneum
Merzendorfer, H., Kim, H. S., Chaudhari, S. S., Kumari, M., Specht, C. A., Butcher, S. C., Brown, S. J., Manak, J. R., Beeman, R. W., Kramer, K. J., et al. (2011) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2011.12.008 · Cited by 100
“Ecdysone agonists such as tebufenozide or methoxyfenozide, and juvenile hormone mimics such as fenoxycarb, methoprene or pyriproxyfen interfere with the hormonal control of molting and metamorphosis (Dhadialla et al., 1998).”
Background
Effects of endocrine-active chemicals on the development of sex characteristics of Daphnia magna
Olmstead, A. W., & LeBlanc, G. A. (2000) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620190821 · Cited by 100
“icking juvenile hormones in insects [18].”
Pro-active Management of Beet Armyworm (Lepidoptera: Noctuidae) Resistance to Tebufenozide and Methoxyfenozide: Baseline Monitoring, Risk Assessment, and Isolation of Resistance
Moulton, J. K., Pepper, D. A., Jansson, R. K., & Dennehy, T. J. (2002) · Journal of Economic Entomology · doi:10.1603/0022-0493-95.2.414 · Cited by 99
“An analog, tebufenozide (RH-5992), proved to be extremely potent against and selective toward larval Lepidoptera (Carlson et al. 1994, Dhadialla et al. 1998) and is now widely used against lepidopteranpestson several crops throughout the world.”
Background
Chemical-Inducible, Ecdysone Receptor-Based Gene Expression System for Plants
Padidam, M., Gore, M. A., Lu, D., & Смирнова, О. Г. (2003) · Transgenic Research · doi:10.1023/a:1022113817892 · Cited by 99
“Methoxyfenozide, a non-steroidal agonist of EcR, binds to EcR with nanomolar affinity and is safe to many organisms (Dhadialla et al., 1998).”
Background
Impact of Halofenozide, Imidacloprid, and Bendiocarb on Beneficial Invertebrates and Predatory Activity in Turfgrass
Kunkel, B., Held, D. W., & Potter, D. (1999) · Journal of Economic Entomology · doi:10.1093/jee/92.4.922 · Cited by 98
Cloning and characterization of the ecdysone receptor and ultraspiracle protein from the water flea Daphnia magna
Kato, Y., Kobayashi, K., Oda, S., Tatarazako, N., Watanabe, H., & Iguchi, T. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0228 · Cited by 98
“Some insecticides have been developed to target the growth of pests by disturbing hormonal systems (Dhadialla et al. 1998); however, their effects on nontarget arthropods have not been evaluated fully.”
Background
Recent advances in hormones in insect pest control
Hoffmann, K. H., & Lorenz, M. W. (1998) · Phytoparasitica · doi:10.1007/bf02981447 · Cited by 98
“The search for ecdysteroid agonists has been very successful (38) and the ecdysteroid mimic, RH 5992 (tebufenozide), is currently marketed under the trade names Mimic, | Confirm ~ and Romdan | ( 7 ).”
BackgroundInfluential
Organization and repression by juvenile hormone of a vitellogenin gene cluster in the crustacean, Daphnia magna
Tokishita, S., Kato, Y., Kobayashi, T., Nakamura, S., Ohta, T., & Yamagata, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.04.102 · Cited by 97
Biochemical mechanisms conferring cross-resistance between tebufenozide and abamectin in Plutella xylostella
Lu, Q., Cao, G., Song, J., Yin, Q., & Han, Z. (2008) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2008.03.011 · Cited by 97
Field Efficacy of New Larvicide Products for Control of Multi-Resistant Aedes aegypti Populations in Martinique (French West Indies)
Marcombe, S., Darriet, F., Agnew, P., Étienne, M., Yp‐Tcha, M., Yébakima, A., & Corbel, V. (2011) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2011.10-0335 · Cited by 97
Improved ecdysone receptor‐based inducible gene regulation system
Palli, S. R., Kapitskaya, M. Z., Kumar, M. B., & Cress, D. E. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03501.x · Cited by 95
Ecdysteroid Receptors and their Applications in Agriculture and Medicine
Palli, S. R., Hormann, R. E., Schlattner, U., & Lezzi, M. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)73003-x · Cited by 92
Ecdysone agonists: Mechanism and importance in controlling insect pests of agriculture and forestry
Retnakaran, A., Krell, P. J., Feng, Q., & Arif, B. M. (2003) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.10116 · Cited by 93
Biological Control and Integrated Pest Management
Orr, D. B. (2009) · Springer eBooks · doi:10.1007/978-1-4020-8992-3_9 · Cited by 92
Adenovirus-mediated inducible gene expression in vivo by a hybrid ecdysone receptor.
Hoppe, U. C., Marbán, E., & Johns, D. (2000) · Molecular Therapy · doi:10.1006/mthe.1999.0023 · Cited by 92
Effects of insect growth regulators on the nontarget soil arthropod Folsomia candida (Collembola)
Campiche, S., Slooten, K. B., Ridreau, C., & Tarradellas, J. (2005) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2005.07.004 · Cited by 87
The retinoid‐X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand
Jones, G., Jones, D., Teal, P. E. A., Sapa, A., & Woźniak, M. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05498.x · Cited by 85
Olyset Duo® (a Pyriproxyfen and Permethrin Mixture Net): An Experimental Hut Trial against Pyrethroid Resistant Anopheles gambiae and Culex quinquefasciatus in Southern Benin
Ngufor, C., N’Guessan, R., Fagbohoun, J., Odjo, A., Malone, D. J., Akogbeto, M. C., & Rowland, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093603 · Cited by 84
“The primary use of pyriproxyfen is as an insect growth regulator to inhibit adult emergence hence its use for mosquito control has been limited to larval stages [12,15,16].”
Background
Dynamics of insecticide resistance in Bemisia tabaci: a case study with the insect growth regulator pyriproxyfen
Horowitz, A. R., Kontsedalov, S., Denholm, I., & Ishaaya, I. (2002) · Pest Management Science · doi:10.1002/ps.545 · Cited by 84
Molecular cloning, expression analysis and functional confirmation of ecdysone receptor and ultraspiracle from the Colorado potato beetle Leptinotarsa decemlineata
Ogura, T., Minakuchi, C., Nakagawa, Y., Smagghe, G. J., & Miyagawa, H. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04823.x · Cited by 83
Critical Role of Desolvation in the Binding of 20-Hydroxyecdysone to the Ecdysone Receptor
Browning, C., Martin, E., Loch, C., Wurtz, J., Moras, D., Stote, R. H., Dejaegere, A. P., & Billas, I. M. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705559200 · Cited by 86
Toxicity and sublethal effects of seven insecticides to eggs of the flower bug Orius insidiosus (Say) (Hemiptera: Anthocoridae)
Moscardini, V. F., Gontijo, P. D. C., Carvalho, G. A., de Oliveira, R. L., Maia, J. B., & Silva, F. F. E. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.01.111 · Cited by 82
“Insecticides of this group are responsible for the regulation of molting, metamorphosis, caste determination, and yolk synthesis (Hartfelder, 2000), as well as extending the development period and affecting the reproductive stages (Dhadialla et al., 1998).”
Background
Comparative toxicity and sublethal effects of emamectin benzoate, lufenuron and spinosad on Spodoptera littoralis Boisd. (Lepidoptera: Noctuidae)
El-Sheikh, E.-S. A. (2014) · Crop Protection · doi:10.1016/j.cropro.2014.10.022 · Cited by 82
The Ecdysteroid Receptor
Henrich, V. C. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384749-2.10005-6 · Cited by 83
Disruption of mating in codling moth (Lepidoptera: Tortricidae) by chlorantranilipole, an anthranilic diamide insecticide
Knight, A. L., & Flexner, L. (2006) · Pest Management Science · doi:10.1002/ps.1318 · Cited by 81
Efficacy of Royal Guard, a new alpha-cypermethrin and pyriproxyfen treated mosquito net, against pyrethroid-resistant malaria vectors
Ngufor, C., Agbevo, A., Fagbohoun, J., Fongnikin, A., & Rowland, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69109-5 · Cited by 80
A juvenile hormone analog, pyriproxifen, affects some biochemical components in the hemolymph and fat bodies of Eurygaster integriceps Puton (Hemiptera: Scutelleridae)
Zibaee, A., Zibaee, I., & Sendi, J. J. (2011) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2011.05.002 · Cited by 80
“In fact, these insecticides, such as chitin inhibitors, juvenile hormone analogs (JHA) and ecdysteroid agonists, affect the hormonal regulation of both molting and developmental processes as well as disrupt the regular physiological processes of insects [3–5].”
Background
Impact of pesticides on non-target invertebrates in agricultural ecosystems
Elhamalawy, O. H., Bakr, A., & Eissa, F. (2024) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2024.105974 · Cited by 85
Toxicity and Pharmacokinetics of Insect Growth Regulators and Other Novel Insecticides on Pupae of Hyposoter didymator (Hymenoptera: Ichneumonidae), a Parasitoid of Early Larval Instars of Lepidopteran Pests
Schneider, M. I., Smagghe, G. J., Gobbi, A., & Viñuela, E. (2003) · Journal of Economic Entomology · doi:10.1093/jee/96.4.1054 · Cited by 76
Insect juvenile hormone action as a potential target of pest management
Minakuchi, C., & Riddiford, L. M. (2006) · Journal of Pesticide Science · doi:10.1584/jpestics.31.77 · Cited by 78
Endocrine modulation of a pheromone-responsive gene in the honey bee brain
Grozinger, C. M., & Robinson, G. E. (2006) · Journal of Comparative Physiology A · doi:10.1007/s00359-006-0202-x · Cited by 75
“Bees were fed sucrose solution containing methoprene, a well known JH agonist (4 mg/ml, Wellmark International, reviewed in Dhadialla et al. 1998) or octopamine (2 mg/ml, Sigma).”
Method
Covert signal disruption: Anti-ecdysteroidal activity of bisphenol a involves cross talk between signaling pathways
Mu, X., Rider, C. V., Hwang, G. S., Hoy, H., & LeBlanc, G. A. (2004) · Environmental Toxicology and Chemistry · doi:10.1897/04-063r.1 · Cited by 75
“ability to bind the EcR as agonists [10].”
Background
Significance of penetration, excretion, and transovarial uptake to toxicity of three insect growth regulators in predatory lacewing adults
Medina, P., Smagghe, G. J., Budia, F., del Estal, P., Tirry, L., & Viñuela, E. (2002) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.10053 · Cited by 75
Synthesis and SAR of cis-1-Benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems
Smith, H. C., Cavanaugh, C. K., Friz, J. L., Thompson, C. S., Saggers, J. A., Michelotti, E. L., Garcia, J., & Tice, C. M. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00317-2 · Cited by 75
Effect of pyriproxyfen, a juvenile hormone mimic, on egg hatch, nymph development, adult emergence and reproduction of the Asian citrus psyllid, Diaphorina citri Kuwayama
Boina, D. R., Rogers, M. E., Wang, N., & Stelinski, L. L. (2009) · Pest Management Science · doi:10.1002/ps.1880 · Cited by 75
Mode of action of the ecdysone agonist tebufenozide (RH‐5992), and an exclusion mechanism to explain resistance to it
Retnakaran, A., Gelbič, I., Sundaram, M., Tomkins, W., Ladd, T. R., Primavera, M. J., Feng, Q., Arif, B. M., Palli, S. R., & Krell, P. J. (2001) · Pest Management Science · doi:10.1002/ps.377 · Cited by 74
Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene transfer
Hoppe, U. C., Marbán, E., & Johns, D. C. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8757 · Cited by 74
“GS-E is a member of the bisacylhydrazine chemical family that have been shown to have no adverse effects over a broad dosage range in mammals (21).”
Background
Efficacy of Pyriproxyfen-Treated Nets in Sterilizing and Shortening the Longevity of Anopheles gambiae (Diptera: Culicidae)
Ohashi, K., Nakada, K., Ishiwatari, T., 宮口純一, Shono, Y., Lucas, J., & Mito, N. (2012) · Journal of Medical Entomology · doi:10.1603/me12006 · Cited by 72
A cell‐based high‐throughput screening system for detecting ecdysteroid agonists and antagonists in plant extracts and libraries of synthetic compounds
Swevers, L., Kravariti, L., Ciolfi, S., Xenou‐Kokoletsi, M., Ragoussis, N., Smagghe, G. J., Nakagawa, Y., Mazomenos, B., & Iatrou, K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0627fje · Cited by 74
Various novel insecticides are less toxic to humans, more specific to key pests
Grafton‐Cardwell, E. E., Godfrey, L. D., Chaney, W. E., & Bentley, W. J. (2005) · California Agriculture · doi:10.3733/ca.v059n01p29 · Cited by 72
“It is nontoxic to honeybees and is selective, not affecting most natural enemies (Dhadialla et al. 1998).”
Background

Authors: Dhadialla, T. S., Carlson, G. R., & Le, D. P.
Affiliations: Insecticide Research Laboratories, Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania 19477;
Venue: Annual Review of Entomology
Publisher: Annual Reviews
Published: 1998-01
Volume: 43
Issue: 1
Pages: 545-569
ISSN: 0066-4170 (ISSN-L)
1545-4487
DOI: 10.1146/annurev.ento.43.1.545
OpenAlex: W2149662691
Cited by: 912
References: 131
Citations by year: 2026: 12 · 2025: 29 · 2024: 29 · 2023: 22 · 2022: 23 · 2021: 44 · 2020: 22 · 2019: 30 · 2018: 23 · 2017: 34 · 2016: 32 · 2015: 28 · 2014: 21 · 2013: 32 · 2012: 49
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Entomology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
Keywords: insect growth regulators, ecdysteroid agonists, juvenile hormone agonists, tebufenozide, fenoxycarb, pyriproxyfen, 20-hydroxyecdysone, ecdysteroid receptor, insecticide mode of action, ecotoxicology, lepidopteran pests
MeSH terms: Animals, Forecasting, Hydrazines, Insecticides, Insecta, Juvenile Hormones, Steroids, Molecular Structure, Molecular Mimicry, Ecdysteroids

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NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

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