Cited by 913Insect Pest Control StrategiesInsect Resistance and GeneticsInsect-Plant Interactions and Control

The DOI matches its Crossref record; 129 of the 131 references it cites were found in a registry or an index.

NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

Dhadialla, Tarlochan S., Carlson, Glenn R., Le, Dat P.·1998·Annual Review of Entomology

Open this paper in CoChat — free account

Abstract

Agrochemical research over the last two decades has resulted in the discovery of chemically novel insecticides that mimic the action of the two insect growth and developmental hormones, the steroidal 20-hydroxyecdysone (20E) and the sesquiterpenoid juvenile hormone (JH). Bisacylhydrazines are non-steroidal agonists of 20E and exhibit their insecticidal activity via interaction with the ecdysteroid receptor proteins. Interestingly, two of the bisacylhydrazine (tebufenozide and RH-2485) insecticides are very selectively toxic to lepidopteran pests. These insecticides are safe to beneficial insects and have a benign ecotoxicological profile. Aromatic non-terpenoidal insecticides (fenoxycarb and pyriproxyfen) mimic the action of JHs. However, like the JHs, their exact mode of action is not well understood. These insecticides are toxic to a broad spectrum of insects during their embryonic, last larval, or reproductive stages. The insecticidal, ecotoxicological properties and the mode of action of the two groups of insecticides are reviewed in this article.

Integrity signals

Registry

Crossref · 10.1146/annurev.ento.43.1.545

Cites

129 of 129 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Sustainability of Transgenic Insecticidal Cultivars: Integrating Pest Genetics and Ecology
Gould, F. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.701 · Cited by 1,392
Nutritional Interactions in Insect-Microbial Symbioses: Aphids and Their Symbiotic BacteriaBuchnera
Douglas, A. E. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.17 · Cited by 1,390
Identification of a nuclear receptor that is activated by farnesol metabolites
Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210
The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
Koelle, M. R., Talbot, W. S., Segraves, W. A., Bender, M. T., Cherbas, P. T., & Hogness, D. S. (1991) · Cell · doi:10.1016/0092-8674(91)90572-g · Cited by 966
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
Yao, T., FORMAN, B. M., Jiang, Z., Cherbas, L., Chen, J.-D., McKeown, M., Cherbas, P. T., & Evans, R. M. (1993) · Nature · doi:10.1038/366476a0 · Cited by 947
Temporal control of puffing activity in polytene chromosomes
Ashburner, M., Chihara, C., Meltzer, P., & Richards, G. (1974) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1974.038.01.070 · Cited by 641 · cited 1×
“Drosophila melanogaster , Ashburner and coworkers (3) proposed a model for ecdysteroid action.”
Background
Cellular and Molecular Actions of Juvenile Hormone I. General Considerations and Premetamorphic Actions
Riddiford, L. M. (1994) · Advances in insect physiology · doi:10.1016/s0065-2806(08)60084-3 · Cited by 610
Insect Hormones
Nijhout, H. F. (1994) · Princeton University Press eBooks · doi:10.1515/9780691225111 · Cited by 540
Cellular and Molecular Actions of Juvenile Hormone. II. Roles of Juvenile Hormone in Adult Insects
Wyatt, G. R., & Davey, K. G. (1996) · Advances in insect physiology · doi:10.1016/s0065-2806(08)60030-2 · Cited by 522

Flagged first, then by citations

Show all 131 references

2 of the 131 references couldn’t be matched to a known paper.

Research works printed but not linked: 31

Aller HE, 1988, Brighton Crop Prot. Conf. Pests Dis., 2, 511
Ashok M, 1991, Biochem. Int., 24, 69
Carlson GR, 1996, Crop Prot. Towards 2000: Int. Pestic. Conf. Kuala Lumpur, Malaysia,, 128
Charmillot PJ, 1994, Arboric. Hortic., 26, 123
Dorn S, 1981, Z. Pflanzenkrankh. Pflanzenschutz., 88, 269
Dubendorfer A, Liebig B. 1991. Primary culture of embryonic cells of the Colorado potato beetle,Leptinotarsa decemlineata(Coleoptera:Chrysomelidae): cell differentiation in vitro and establishment of permanent cell lines.Proc. Int. Conf. Invertebr. Tissue Cult., ed. MJ Fraser Jr, 8:7–15. Columbia: Tissue Cult. Assoc.
Estrada JG, 1986, J. Am. Mosq. Control Assoc., 2, 57
Giebultowicz JM, Blackburn MB, Thomas-Laemont PA, Raina AK. 1993.Sterilization of the gypsy moth by disruption of sperm release from testes.ACS Conf. Proc. Ser., Pest Manage.: Biol. Based Technol., ed. RD Lumsden, JL Vaughn, pp. 114–16. Washington, DC: Am. Chem. Soc.
Glancy MB, 1988, J. Econ. Entomol., 81, 642
Heller J, 1992, Brighton Crop Prot. Conf. Pests Dis., 1, 59
Heller P, 1996, Arthropod Manage. Tests, 21, 339
Jacas J, 1995, Med. Fac. Land. Toege. Biol. Wet. Gent., 60, 935
Le DP, 1996, Brighton Crop Prot. Conf. Pests Dis., 2, 481
Miller RW, 1989, J. Agric. Entomol., 6, 77
Miura T, 1987, J. Am. Mosq. Control Assoc., 3, 476
Natskova V, 1988, Plant Sci., 25, 87
Oaks L, 1994, Tech. Inf. Bull. Rohm & Haas Co.
Okazawa T, 1991, J. Am. Mosq. Control Assoc., 7, 604
Palli SR, 1995, Eur. J. Entomol., 92, 325
Quack S, 1995, Eur. J. Entomol., 92, 341
Regiroli G, 1997, Inf. Fitopetol., 5, 60
Retnakaran A, Granett G, Ennis T. 1985.Insect growth regulators.InComprehensive Insect Physiology, Biochemistry and Pharmacology, ed. GA Kerkut, LI Gilbert, 12:529–601. Oxford: Pergamon
10.1002/(SICI)1520-6327(1996)32:3/4<271::AID-ARCH2>3.0.CO;2-W · DOI
RohMid LLC, 1996, Tech. Info. Bull.
Sechser B, 1994, Brighton Crop Prot. Conf. Pests Dis., 3, 1193
Sevala VL, Davey KG. 1990. The action of juvenile hormone on the follicle cells ofRhodnius prolixusinvolves protein kinase C and calcium. InInsect Neurochemistry and Neurophysiology, ed. AB Borkovec, EP Masler, pp. 323–28. Clifton, NJ: Humana
Slama K, 1995, Eur. J. Entomol., 92, 317
Streibert HP, 1994, Brighton Crop Prot. Conf. Pests Dis., 1, 23
Watkinson IA, 1973, PANS, 14, 488
Wing KD, Aller HE. 1990.Ecdysteroid agonists as novel insect growth regulators.InPesticides and Alternatives: Innovative Chemical and Biological Approaches to Pest Control, ed. JE Casida, pp. 251–57. New York: Elsevier
Wing KD, 1989, BCPC Monogr., 43, 107

Sorted by citations

Items 201–300 of 913

Lethal and sublethal effects of lufenuron on sugarcane borer Diatraea flavipennella and its parasitoid Cotesia flavipes
Fonseca, A. P. P., Marques, E. J., Torres, J. B., Silva, L. M. C. D., & Siqueira, H. A. A. (2015) · Ecotoxicology · doi:10.1007/s10646-015-1523-8 · Cited by 42
20-Hydroxyecdysone (20E) signaling as a promising target for the chemical control of malaria vectors
Ekoka, E., Maharaj, S., Nardini, L., Dahan-Moss, Y., & Koekemoer, L. L. (2021) · Parasites & Vectors · doi:10.1186/s13071-020-04558-5 · Cited by 43
Effect of ecdysone agonist RH-0345 on reproduction of mealworm, Tenebrio molitor
Taïbi, F. (2003) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(03)00112-1 · Cited by 42
Sublethal Effects of Spinosad (Tracer®) on the Cotton Leafworm (Lepidoptera: Noctuidae)
Abouelghar, G. E., Sakr, H. H., Ammar, H. A., Yousef, A. G., & Nassar, M. (2013) · Journal of Plant Protection Research · doi:10.2478/jppr-2013-0041 · Cited by 42
“In this scenario, using new types of insecticides, originated from natural agents or products that disrupt the physiological processes of the target pest, could be useful alternatives in the integrated management approach (Dhadialla et al. 1998; Thompson et al. 2000; Smagghe et al. 2003).”
Background
Quantitative structure-activity studies of insect growth regulators: XVI. Substituent effects of dibenzoylhydrazines on the insecticidal activity to Colorado potato beetleLeptinotarsa decemlineata
Nakagawa, Y., Smagghe, G. J., Kugimiya, S., Hattori, K., Ueno, T., Tirry, L., & Fujita, T. (1999) · Pesticide Science · doi:10.1002/(sici)1096-9063(199909)55:9 · Cited by 42
Effects of methoprene, nonylphenol, and estrone on the vitellogenesis of the mysid Neomysis integer
Ghekiere, A., Verslycke, T. A., & Janssen, C. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2005.12.021 · Cited by 41
Evaluation of mosquito repellent activity of isolated oleic acid, eicosyl ester from Thalictrum javanicum
Paulsamy, S., Gurunathan, A., & Jamuna, S. (2016) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.180259 · Cited by 41
“In that stage, digestion of the old cuticle is increasing with the increase in 20E titer[35].”
Background
The Marakkayar Muslims of Karikal, South India
More, J. B. P. (1991) · Journal of Islamic Studies · doi:10.1093/jis/2.1.25 · Cited by 41
Effect of RH-5992 on adult development in the spruce budworm, Choristoneura fumiferana
Sundaram, M., Palli, S. R., Smagghe, G. J., Ishaaya, I., Feng, Q., Primavera, M. J., Tomkins, W., Krell, P. J., & Retnakaran, A. (2002) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(01)00111-4 · Cited by 41
Effects of fenoxycarb exposure on complete larval development of the xanthid crab, Rhithropanopeus harrisii
Cripe, G. M., McKenney, C. L., Hoglund, M. D., & Harris, P. S. (2003) · Environmental Pollution · doi:10.1016/s0269-7491(02)00414-1 · Cited by 40
Regulation of queen development through worker aggression in a predatory ant
Penick, C. A., & Liebig, J. (2012) · Behavioral Ecology · doi:10.1093/beheco/ars062 · Cited by 40
“Previous trials revealed that JHA-treated larvae rarely eclosed from the pupal stage, a result consistent with the use of methoprene as an insecticide to disrupt pupal development (Dhadialla et al. 1998).”
Result
Inducible Control of Transgene Expression with Ecdysone Receptor: Gene Switches with High Sensitivity, Robust Expression, and Reduced Size
Karzenowski, D., Potter, D. W., & Padidam, M. (2005) · BioTechniques · doi:10.2144/05392st01 · Cited by 40
Toxicity and Residual Activity of Methoxyfenozide and Tebufenozide to Codling Moth (Lepidoptera: Tortricidae) and Oriental Fruit Moth (Lepidoptera: Tortricidae)
Borchert, D. M., Walgenbach, J. F., Kennedy, G. G., & Long, J. W. (2004) · Journal of Economic Entomology · doi:10.1093/jee/97.4.1342 · Cited by 40
Ecdysone differentially regulates metamorphic timing relative to 20-hydroxyecdysone by antagonizing juvenile hormone in Drosophila melanogaster
Ono, H. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.04.004 · Cited by 39
“20E agonists which show high affinity to lepidopteran EcR also trigger a 428 precocious larval molt (Dhadialla et al., 1998; Smagghe et al., 2012), indicating that a 429 mechanism for the acceleration of developmental timing by 20E in Lepidoptera is 430 regulated by EcR signaling.”
DAST-Mediated Cyclization of α,α-Disubstituted-α-acylaminoketones: Efficient and Divergent Synthesis of Unprecedented Heterocycles
Bigot, A., Blythe, J., Pandya, C., Wagner, T., & Loiseleur, O. (2010) · Organic Letters · doi:10.1021/ol102454e · Cited by 39
Toxicity of the insect growth regulators, buprofezin and pyriproxyfen, to the glassy-winged sharpshooter, Homalodisca coagulata say (Homoptera: Cicadellidae)
Prabhaker, N., & Toscano, N. C. (2006) · Crop Protection · doi:10.1016/j.cropro.2006.04.019 · Cited by 39
TOXICIDADE DE ACARICIDAS/INSETICIDAS EMPREGADOS NA CITRICULTURA PARA A ABELHA AFRICANIZADA APIS MELLIFERA L., 1758 (HYMENOPTERA: APIDAE)
Carvalho, S. M., Carvalho, G. A., Carvalho, C. F., Filho, J. S. D. S. B., & Baptista, A. P. M. (2009) · Arquivos do Instituto Biológico · doi:10.1590/1808-1657v76p5972009 · Cited by 39
Chemically Regulated Expression Systems and their Applications in Transgenic Plants
Wang, R., Zhou, X., & Wang, X. (2003) · Transgenic Research · doi:10.1023/a:1025852307127 · Cited by 39
“The inducer used in this system is methoxyfenozide which is also a promising agrochemical (Dhadialla et al., 1998) and structurally similar to RH5992.”
Background
Influence of juvenile hormone and mating on oogenesis and oviposition in the codling moth, Cydia pomonella
Webb, T. J., Shu, S., Ramaswamy, S. B., & Dorn, S. (1999) · Archives of Insect Biochemistry and Physiology · doi:10.1002/(sici)1520-6327(1999)41:4 · Cited by 29
Biorational agents--mechanism and importance in IPM and IRM programs for controlling agricultural pests.
Ishaaya, I., Kontsedalov, S., Mazirov, D., & Ar, H. (2001) · PubMed · Cited by 39
Neuropeptide Physiology in Insects
Bendena, W. G. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6902-6_9 · Cited by 38
Ecdysteroid Agonists and Antagonists
Dinan, L. N., & Hormann, R. E. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00036-3 · Cited by 38
Impact of insect growth regulators on the predator Ceraeochrysa cincta (Schneider) (Neuroptera: Chrysopidae)
Rugno, G. R., Zanardi, O. Z., Cuervo, J. G. B., de Morais, M. R., & Yamamoto, P. T. (2016) · Ecotoxicology · doi:10.1007/s10646-016-1651-9 · Cited by 38
Ecdysteroid Responses of Estuarine Crustaceans Exposed Through Complete Larval Development to Juvenile Hormone Agonist Insecticides
Tuberty, S. R. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.1.106 · Cited by 38
“Methoprene, pyriproxyfen, and fenoxycarb are members of the juvenile hormone analogue (JHA) class of insecticides that gain their toxicity through modulation of the physiological processes in insects known to be regulated by endogenous juvenile hormones of insects (Downer and Laufer, 1983; Miyamoto et al., 1993; Dhadi…”
Background
Elimination of Transcriptional Interference between Tandem Genes in Plant Cells
Padidam, M., & Cao, Y. (2001) · BioTechniques · doi:10.2144/01312st04 · Cited by 38
Seasonal field efficacy of pyriproxyfen autodissemination stations against container‐inhabiting mosquito Aedes albopictus under different habitat conditions
Suman, D. S., Wang, Y., Faraji, A., Williams, G., Williges, E., & Gaugler, R. R. (2017) · Pest Management Science · doi:10.1002/ps.4780 · Cited by 36
Fitness Cost of Methoxyfenozide and the Effects of Its Sublethal Doses on Development, Reproduction, and Survival of Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae)
Rehan, A., & Freed, S. (2015) · Neotropical Entomology · doi:10.1007/s13744-015-0306-5 · Cited by 37
“Methoxyfenozide being highly effective against lepidopteran insect pests (Smagghe et al 2003) accelerates the larval molting by mimicking the molting hormone, resulting in premature molting (Dhadialla et al 1998).”
Background
New Building, Old Parasite: Mesostigmatid Mites--An Ever-Present Threat to Barrier Rodent Facilities
Watson, J. (2008) · ILAR Journal · doi:10.1093/ilar.49.3.303 · Cited by 37
“Insect growth regulators fall into two categories, nonsteroidal ecdysteroid agonists that mimic the action of molting hormones and cause accelerated and incomplete 306 ILAR Journal molting, and juvenile hormone chemical analogs that inhibit maturation (Dhadialla et al. 1998).”
Background
Synthesis and Insecticidal Evaluation of Novel N-Oxalyl Derivatives of Tebufenozide
Mao, C. H., Wang, Q., Huang, R. Q., Bi, F. C., Chen, L., Liu, Y. X., & Shang, J. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048834e · Cited by 37
Food Concentration Affects the Life History Response of Ceriodaphnia cf. dubia to Chemicals with Different Mechanisms of Action
Rose, R. M., Warne, M. S. J., & Lim, R. P. (2002) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.2001.2137 · Cited by 36
Juvenile Hormone Epoxide Hydrolase: a Promising Target for Hemipteran Pest Management
Tusun, A., Li, M., Liang, X., Yang, T., Yang, B., & Wang, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-00907-0 · Cited by 36
Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges
İyison, N. B., Shahraki, A., Kahveci, K., Düzgün, M. B., & Gün, G. (2021) · FEBS Journal · doi:10.1111/febs.15708 · Cited by 36
Susceptibility of Chrysoperla externa Eggs (Neuroptera: Chrisopidae) to Conventional and Biorational Insecticides
Rimoldi, F., Schneider, M. I., & Ronco, A. E. (2008) · Environmental Entomology · doi:10.1603/0046-225x(2008)37[1252:soceen]2.0.co;2 · Cited by 36
“MACs mimic the action of natural ecdysteroid hormones by binding to the same natural hormones receptors and causing an anticipated lethal molt (Dhadialla et al. 1998).”
Background
Ecdysteroid and Juvenile Hormone Receptors: Properties and Importance in Developing Novel Insecticides
Palli, S. R., & Retnakaran, A. (2001) · Springer eBooks · doi:10.1007/978-3-642-59549-3_5 · Cited by 36
Ecdysteroid Structure-Activity Relationships
(2003) · Studies in natural products chemistry · doi:10.1016/s1572-5995(03)80004-2 · Cited by 35
Biochemical Processes Related to Insecticide Action: an Overview
Ishaaya, I. (2001) · Springer eBooks · doi:10.1007/978-3-642-59549-3_1 · Cited by 35
“…formation of compounds which affect the hormonal regulation of molting and developmental processes in insects such as ecdysone agonists (Wing 1988; Dhadialla et al. 1998), juvenile hormone mimics (Ishaaya and Horowitz 1992, 1995; Ishaaya et al. 1994) and chitin synthesis inhibitors (Cohen 1987;…”
BackgroundInfluential
Towards Coleoptera-specific high-throughput screening systems for compounds with ecdysone activity: development of EcR reporter assays using weevil (Anthonomus grandis)-derived cell lines and in silico analysis of ligand binding to A. grandis EcR ligand-binding pocket
Soin, T., Iga, M., Swevers, L., Rougé, P., Janssen, C., & Smagghe, G. J. (2009) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2009.06.003 · Cited by 36
“remains trapped in the molting process and dies slowly from starvation and desiccation (Dhadialla et al., 1998).”
BackgroundInfluential
EFFECTS OF THE INSECT GROWTH REGULATOR PYRIPROXYFEN ON IMMATURE STAGES OF SUNN PEST, EURYGASTER INTEGRICEPS PUTON (HETEROPTERA: SCUTELLERIDAE)
Mojaver, M., & Bandani, A. R. (2010) · Munis entomology & zoology · Cited by 35
Comparative susceptibility of two Neotropical predators, Eriopis connexa and Chrysoperla externa, to acetamiprid and pyriproxyfen: Short and long-term effects after egg exposure
Rimoldi, F., Fogel, M. N., Ronco, A. E., & Schneider, M. I. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.08.097 · Cited by 35
Sublethal effects of chlorantraniliprole on molting hormone levels and mRNA expressions of three Halloween genes in the rice stem borer, Chilo suppressalis
Meng, X., Zhang, N., Yang, X., Miao, L., Jiang, H., Ji, C., Xu, B., Qian, K., & Wang, J. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124676 · Cited by 35
Non-food bioactive products: Design and semisynthesis of novel (+)-nootkatone derivatives containing isoxazoline moiety as insecticide candidates
Guo, Y., Zhang, Q., Liu, Z., Bao, C., Fan, J., & Yang, R. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.111706 · Cited by 35
Molecular action of pyriproxyfen: Role of the Methoprene-tolerant protein in the pyriproxyfen-induced sterilization of adult female mosquitoes
Ahmed, T. H., Saunders, T. R., Mullins, D. E., Rahman, M. Z., & Zhu, J. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008669 · Cited by 37
“Juvenile hormone (JH), due to its exclusive presence in arthropods, has attracted a lot of attention in the development of environment-friendly insecticides [8–11].”
Controle de Anticarsia gemmatalis Hübner (Lepidoptera: Noctuidae) com reguladores de crescimento de insetos
da Silva, M. T. B., Costa, E. C., & Boss, A. (2003) · Ciência Rural · doi:10.1590/s0103-84782003000400002 · Cited by 35
“Esses compostos provocam uma aceleração no processo da ecdise, porém, seu exato modo de ação ainda é desconhecido (DHADIALLA et al., 1998).”
Toxicity risk of insecticides to the insect egg parasitoid Trichogramma evanescens Westwood (Hymenoptera: Trichogrammatidae)
Wang, Y., Wu, C., Cang, T., Yang, L., Yu, W., Zhao, X., Wang, Q., & Cai, L. (2013) · Pest Management Science · doi:10.1002/ps.3571 · Cited by 35
Sublethal Effects of Chronic Exposure to Tebufenozide on the Development, Survival, and Reproduction of the Tufted Apple Bud Moth (Lepidoptera: Tortricidae)
Biddinger, D. J., Hull, L. A., Huang, H., McPheron, B. A., & Loyer, M. (2006) · Journal of Economic Entomology · doi:10.1603/0022-0493-99.3.834 · Cited by 35
Synthesis of Haptens and Protein Conjugates for the Development of Immunoassays for the Insect Growth Regulator Fenoxycarb
Szurdoki, F., Székács, A., Le, H. M., & Hammock, B. D. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0107050 · Cited by 35
Identification and expression profile of a putative basement membrane protein gene in the midgut of Helicoverpa armigera
Wang, J., Jiang, X., Wang, Q., Hou, L., Xu, D., Wang, J., & Zhao, X. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-76 · Cited by 35
“The molecular mechanisms that cause premature, incomplete molting have been elucidated [ 23 ,24].”
Laboratory Evaluation of Selective Pesticides Against the Storage MiteTyrophagus putrescentiae(Acari: Acaridae)
Sánchez‐Ramos, I., & Castañera, P. (2003) · Journal of Medical Entomology · doi:10.1603/0022-2585-40.4.475 · Cited by 35
“These products have shown high efÞcacy and selectivity to target pests as well as low toxicity to nonarthropod organisms (Retnakaran et al. 1985, Dhadialla et al. 1998).”
Background
Ecdysteroids and a sucrose phenylpropanoid ester from Froelichia floridana
Wang, P., Li, S., Ownby, S., Zhang, Z., Yuan, W., Zhang, W., & Scott Beasley, R. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.01.017 · Cited by 34
Insect hormones: more than 50-years after the discovery of insect juvenile hormone analogues (JHA, juvenoids)
Sláma, K. (2013) · Terrestrial Arthropod Reviews · doi:10.1163/18749836-06041073 · Cited by 35
Characterization of brain acetylcholinesterase of bentonic fish Hoplosternum littorale: Perspectives of application in pesticides and metal ions biomonitoring
de Araújo, M. C., Assis, C. R. D., Silva, K. C. C., de Souza, K. S., de Azevedo, R. D. S., Alves, M. H. M. E., Silva, L. C., Silva, V. L., Adam, M. L., Carvalho, L. B., et al. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.10.017 · Cited by 34
Impact of sublethal and low lethal concentrations of flonicamid on key biological traits and population growth associated genes in melon aphid, Aphis gossypii Glover
Shi, D., Luo, C., Lv, H., Zhang, L., Desneux, N., You, H., Li, J., Ullah, F., & Ma, K. (2021) · Crop Protection · doi:10.1016/j.cropro.2021.105863 · Cited by 34
Activity of RH-0345 on Ecdysteroid Production and Cuticle Secretion in Tenebrio molitor Pupae In Vivo and In Vitro
Soltani, N., Aribi, N., Berghiche, H., Lakbar, S., & Smagghe, G. J. (2002) · Pesticide Biochemistry and Physiology · doi:10.1006/pest.2001.2586 · Cited by 34
Ecdysteroids and Ecdysteroid Signaling Pathways During Insect Oogenesis
Swevers, L., & Iatrou, K. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9112-4_5 · Cited by 35
“While the early stages of oogenesis and the initiation of vitellogenesis are dependent on the presence of active ecdysteroids in the hemolymph, experiments using dibenzoyl hydrazine ecdysone agonists such as tebufenozide (Dhadialla et al., 1998) have indicated that the completion of vitellogenesis and the process of e…”
Background
Field Efficacy and Application Timing of Methoxyfenozide, a Reduced-Risk Treatment for Control of Navel Orangeworm (Lepidoptera: Pyralidae) in Almond
Higbee, B. S., & Siegel, J. P. (2012) · Journal of Economic Entomology · doi:10.1603/ec11389 · Cited by 34
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
Yeoh, K. K., Chan, M. C., Thalhammer, A., Demetriades, M., Chowdhury, R., Tian, Y., Stolze, I. P., McNeill, L. A., Lee, M. K., Woon, E. C. Y., et al. (2012) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob26648b · Cited by 34
Structure-based analysis of the ultraspiracle protein and docking studies of putative ligands
Sasorith, S., Billas, I. M. L., Iwema, T., Moras, D., & Wurtz, J. (2002) · Journal of Insect Science · doi:10.1673/031.002.2501 · Cited by 34
“This peculiarity was exploited in the search for insecticides and numerous juvenile hormone mimics were derived, one of which is methoprene (Dhadialla et al., 1998).”
Background
Cytotoxic effects of two antimolting insecticides in mammalian CHO-K1 cells
Bayoumi, A. E., Pérez‐Pertejo, Y., Zidan, H. Z., Balaña‐Fouce, R., Ordóñez, C., & Ordóñez, D. (2003) · Ecotoxicology and Environmental Safety · doi:10.1016/s0147-6513(02)00068-4 · Cited by 34
Dynamic of ligand binding to Drosophila melanogaster ecdysteroid receptor
Grebe, M., Fauth, T., & Spindler‐Barth, M. (2004) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2004.06.007 · Cited by 34
BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES
Qu, M., Merzendorfer, H., Moussian, B., & Yang, Q. K. (2021) · Frontiers of Agricultural Science and Engineering · doi:10.15302/j-fase-2021404 · Cited by 33
A user-friendly software to easily count Anopheles egg batches
Mollahosseini, A., Rossignol, M., Pennetier, C., Cohuet, A., dos Anjos, A., Chandre, F., & Shahbazkia, H. R. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-122 · Cited by 33
Relationships between structure and molting hormonal activity of tebufenozide, methoxyfenozide, and their analogs in cultured integument system of Chilo suppressalis Walker☆
Nakagawa, Y., Hattori, K., Minakuchi, C., Kugimiya, S., & Ueno, T. (2000) · Steroids · doi:10.1016/s0039-128x(99)00091-4 · Cited by 33
Tebufenozide distorted codling moth larval growth and reproduction, and controlled field populations
Smagghe, G. J., Bylemans, D., Medina, P., Budia, F., Avilla, J., & Viñuela, E. (2004) · Annals of Applied Biology · doi:10.1111/j.1744-7348.2004.tb00386.x · Cited by 33
Synthesis and Insecticidal Activities of Novel N-Sulfenyl-N′-tert-butyl-N,N′-diacylhydrazines. 1. N-Alkoxysulfenate Derivatives
Zhao, Q., Shang, J., Liu, Y., Wang, K., Bi, F., Huang, R., & Wang, Q. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072390f · Cited by 33
Effects of Methoxyfenozide-treated Surfaces on the Attractiveness and Responsiveness of Adult Codling Moth (Lepidoptera: Tortricidae)
Hoelscher, J. A., & Barrett, B. A. (2003) · Journal of Economic Entomology · doi:10.1093/jee/96.3.623 · Cited by 33
Molecular characterization and functional analysis of the Halloween genes and CYP18A1 in Bemisia tabaci MED
Liu, S., He, C., Liang, J., Su, Q., Hua, D., Wang, S., Wu, Q., Xie, W., & Zhang, Y. (2020) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2020.104602 · Cited by 32
Toxicology of insecticides to mammals
Marrs, T. C. (2012) · Pest Management Science · doi:10.1002/ps.3362 · Cited by 32
Toxicity of Four Dibenzoylhydrazine Correlates with Evagination-Induction in the Cotton Leafworm
Smagghe, G. J., Carton, B., Heirman, A., & Tirry, L. (2000) · Pesticide Biochemistry and Physiology · doi:10.1006/pest.2000.2497 · Cited by 32
Molecular cloning and characterization of Hearm caspase-1 from Helicoverpa armigera
Yang, D., Chai, L., Wang, J., & Zhao, X. (2007) · Molecular Biology Reports · doi:10.1007/s11033-007-9100-8 · Cited by 32
“Hearm caspase-1 expression could be up-regulated by an ecdysone agonist RH-2485, which induces a similar effect on the larvae as that of 20-hydroxyecdysone [33], implying that it is correlative with the ecdysone release and may be up-regulated by ecdysone during development.”
Background
Characterization in relation to development of an ecdysteroid agonist-responsive cytochrome P450, CYP18A1, in Lepidoptera
Davies, L., Williams, D. R., Turner, P., & Rees, H. H. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.06.016 · Cited by 32
Sublethal effects of a juvenile hormone analog, Pyriproxyfen on demographic parameters of non-target predator, Hippodamia convergens Guerin-Meneville (Coleoptera: Coccinellidae)
Iftikhar, A., Hafeez, F., Hafeez, M., Farooq, M. A., Aziz, M. A., Sohaib, M., Naeem, A., & Lu, Y. (2020) · Ecotoxicology · doi:10.1007/s10646-020-02159-7 · Cited by 31
“Pyriproxyfen is an important juvenile hormone analogue that is used against variety of insects because it directly reduces the fecundity, affect the molting, metamorphosis and embryogenesis (Dhadialla et al. 1998; Richardson and Lagos 2007; Tunaz and Uygun 2004).”
Background
Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster
Davies, L., Williams, D. R., Aguiar-Santana, I. A., Pedersen, J., Turner, P., & Rees, H. H. (2006) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2006.08.001 · Cited by 31
Classical and three-dimensional QSAR for the inhibition of [3H]ponasterone A binding by diacylhydrazine-type ecdysone agonists to insect Sf-9 cells
Nakagawa, Y., Takahashi, K., Kishikawa, H., Ogura, T., Minakuchi, C., & Miyagawa, H. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.11.004 · Cited by 31
Synthesis, binding and bioactivity of γ-methylene γ-lactam ecdysone receptor ligands: Advantages of QSAR models for flexible receptors
Birru, W. A., Fernley, R. T., Graham, L. D., Grusovin, J., Hill, R. J., Hofmann, A., Howell, L., James, P., Jarvis, K. E., Johnson, W. M. P., et al. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.06.020 · Cited by 31
The Structure and Function of Ecdysone Receptors
Billas, I. M. L., Browning, C., Lawrence, M. C., Graham, L. D., Moras, D., & Hill, R. J. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9112-4_13 · Cited by 31
Potential of Camellia sinensis proanthocyanidins-rich fraction for controlling malaria mosquito populations through disruption of larval development
Muema, J. M., Bargul, J. L., Nyanjom, S. G., Mutunga, J. M., & Njeru, S. N. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1789-6 · Cited by 31
“Insect growth regulatory (IGR) compounds act by adversely interfering with physiologically and hormonally-regulated developmental events resulting into immature deaths and non-viable reproductive adults [52, 54].”
Background
Efficacy of biorational insecticides against Bemisia tabaci (Genn.) and their selectivity for its parasitoid Encarsia formosa Gahan on Bt cotton
Gogi, M. D., Syed, A. H., Atta, B., Sufyan, M., Arif, M. J., Arshad, M., Nawaz, A., Khan, M. A., Mukhtar, A., & Liburd, O. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-81585-x · Cited by 30
Effects of methoxyfenozide on Lobesia botrana Den & Schiff (Lepidoptera: Tortricidae) egg, larval and adult stages
Irigaray, F. J. S. D. C., Mancebón, V. S. M., Zalom, F. G., & Moreno, I. P. (2005) · Pest Management Science · doi:10.1002/ps.1082 · Cited by 30
Field assessment of novaluron for sugarcane borer, Diatraea saccharalis (F.) (Lepidoptera: Crambidae), management in Louisiana sugarcane
Beuzelin, J. M., Akbar, W., Mészáros, A., Reay‐Jones, F. P. F., & Reagan, T. E. (2010) · Crop Protection · doi:10.1016/j.cropro.2010.06.004 · Cited by 30
Insecticide use: context and ecological consequences
Devine, G. J., Eza, D., Ogusuku, E., & Furlong, M. J. (2008) · Americanae (AECID Library) · doi:10.17843/rpmesp.2008.251.1241 · Cited by 30
Wide mutational spectrum of a gene involved in hormone action and insecticide resistance in Drosophila melanogaster
Wilson, T. G., Wang, S., Beňo, M., & Farkas, R. (2006) · Molecular Genetics and Genomics · doi:10.1007/s00438-006-0138-4 · Cited by 30
Effect of ecdysone agonists on vitellogenesis and the expression of EcR and USP in codling moth (Cydia pomonella)
Sun, X., Song, Q., & Barrett, B. A. (2003) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.10073 · Cited by 30
Role of phytoecdysteroids in insect pest management: a review
Chaubey, M. K. (2017) · Journal of Agronomy · doi:10.3923/ja.2018.1.10 · Cited by 30
Susceptibility of the predatory stinkbug Picromerus bidens to selected insecticides
Mahdian, K., Leeuwen, T. V., Tirry, L., & CLERCQ, P. D. (2007) · BioControl · doi:10.1007/s10526-007-9075-3 · Cited by 29
“Methoxyfenozide is an agonist of 20-hydroxyecdysone, a key hormone in the moulting process, with specificity against its lepidopteran target pests and little impact on beneficial arthropods (Wing 1988; Dhadialla et al. 1998).”
Sublethal Effects of Fenoxycarb on thePlutella xylostella(Lepidoptera: Plutellidae)
Mahmoudvand, M., & Moharramipour, S. (2015) · Journal of Insect Science · doi:10.1093/jisesa/iev064 · Cited by 29
“Juvenile Hormone Analogues (JHAs) can alter the endocrine balance and therefore cause to abnormal development in some insects especially after metamorphosis (Retnakaran et al. 1985, Dhadialla et al. 1998).”
Background
Impact of Insecticides Used in Soybean Crops to the Egg Parasitoid Telenomus podisi (Hymenoptera: Platygastridae)
Stecca, C. D. S., Bueno, A. F., Pasini, A., da Silva, D. M., de Andrade, K. S., & Filho, D. M. (2017) · Neotropical Entomology · doi:10.1007/s13744-017-0552-9 · Cited by 29
Comparative bio-efficacy of nuclear polyhedrosis virus (NPV) and Spinosad against American bollwormm, Helicoverpa armigera (Hubner)
Nawaz, A., Ali, H., Sufyan, M., Gogi, M. D., Arif, M. J., Ranjha, M. H., Arshid, M., Waseem, M., Mustafa, T., Qasim, M. U., et al. (2019) · Revista Brasileira de Entomologia · doi:10.1016/j.rbe.2019.09.001 · Cited by 29
“Furthermore, new chemistry insecticides have been established from natural sources, disturb the normal physiological functions of the targeted species in pest management programs (Qasim et al., 2018a; Schneider et al., 2003; Thompson et al., 2000; Dhadialla et al., 1998) by targeting insect development mechanism like…”
Background
Development of a methoxyfenozide‐responsive gene switch for applications in plants
Tavva, V. S., Dinkins, R. D., Palli, S. R., & Collins, G. B. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02628.x · Cited by 29
“The EcR-based gene switch is one of the best gene regulation systems available, because the chemical ligand required for its regulation is already registered for field use (Dhadialla et al., 1998).”
Background
Exposure to sublethal concentrations of methoxyfenozide disrupts honey bee colony activity and thermoregulation
Meikle, W. G., Corby‐Harris, V., Carroll, M. J., Weiss, M., Snyder, L. A., Meador, C., Beren, E., & Brown, N. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0204635 · Cited by 28
Effects of a methanolic extract of the plant Haplophyllum tuberculatum and of teflubenzuron on female reproduction in the migratory locust, Locusta migratoria (Orthoptera: Oedipodinae)
Acheuk, F., Cusson, M., & DOUMANDJI-MITICHE, B. (2011) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2011.12.004 · Cited by 28
Western Flower Thrips (Thysanoptera: Thripidae) and Insecticide Resistance: An Overview and Strategies to Mitigate Insecticide Resistance Development
Cloyd, R. A. (2016) · Journal of Entomological Science · doi:10.18474/jes16-15.1 · Cited by 28
“The main reason for the minimal use of insect growth regulators against western flower thrips is that most insect growth regulators are only directly active on the larval stage, not on the adults (Dhadialla et al. 1998, Ware 2005).”
Background
Controle químico da Grapholita molesta (Busck) (Lepidoptera: Tortricidae) na cultura do pessegueiro
Arioli, C. J., Botton, M., & Carvalho, G. A. (2004) · Ciência Rural · doi:10.1590/s0103-84782004000600005 · Cited by 28
“A diferença na mortalidade das lagartas entre 48 e 96 HAA, observada com o metoxyfenozide (regulador de crescimento), deve-se ao modo de ação desse inseticida, que é mais lento que os produtos neurotóxicos (DHADIALLA et al., 1998).”
Background
Baseline Monitoring of Codling Moth (Lepidoptera: Tortricidae) Larval Response to Benzoylhydrazine Insecticides
Knight, A. L., Dunley, J. E., & Jansson, R. K. (2001) · Journal of Economic Entomology · doi:10.1603/0022-0493-94.1.264 · Cited by 28
Sterilization Effects of Adult-targeted Baits Containing Insect Growth Regulators on Delia antiqua
Zhou, F., Zhu, G., Zhao, H., Wang, Z., Xue, M., Li, X., Hua-qiang, X., Ma, X., & Liu, Y. (2016) · Scientific Reports · doi:10.1038/srep32855 · Cited by 27
Susceptibility ofChrysoperla externaEggs (Neuroptera: Chrisopidae) to Conventional and Biorational Insecticides
Rimoldi, F., Schneider, M. I., & Ronco, A. E. (2008) · Environmental Entomology · doi:10.1093/ee/37.5.1252 · Cited by 27
Compatibility of reduced‐risk insecticides with the non‐target predatory mite Iphiseius degenerans (Acari: Phytoseiidae)
Döker, İ., Pappas, M. L., Σαμαράς, Κ., Triantafyllou, A., Kazak, C., & Broufas, G. D. (2014) · Pest Management Science · doi:10.1002/ps.3921 · Cited by 27
Activity of Selected Formulated Biorational and Synthetic Insecticides Against Larvae ofHelicoverpa armigera(Lepidoptera: Noctuidae)
Vivan, L. M., Torres, J. B., & Fernandes, P. L. S. (2016) · Journal of Economic Entomology · doi:10.1093/jee/tow244 · Cited by 27
Non-target effects of the insecticide methoprene on molting in the estuarine crustacean Neomysis integer (Crustacea: Mysidacea)
Ghekiere, A., Verslycke, T. A., Fockedey, N., & Janssen, C. (2006) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2005.11.021 · Cited by 27
“Methoprene can enter estuarine environments by either direct application for controlling aquatic-borne pests (such as mosquitoes) or indirectly through land-drainage or erosion from adjacent pesticide-treated agricultural lands (Dhadialla et al., 1998; Retnakaran et al., 1985).”
Background
Biochemical mode of action and differential activity of new ecdysone agonists against mosquitoes and moths
Palli, S. R., Tice, C. M., Margam, V. M., & Clark, A. M. (2005) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20046 · Cited by 27
Genome-wide Identification of Tebufenozide Resistant Genes in the smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae)
Uchibori‐Asano, M., Jouraku, A., Uchiyama, T., Yokoi, K., Akiduki, G., Suetsugu, Y., Kobayashi, T., Ozawa, A., Minami, S., Ishizuka, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40863-5 · Cited by 26

Authors: Dhadialla, T. S., Carlson, G. R., & Le, D. P.
Affiliations: Insecticide Research Laboratories, Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania 19477;
Venue: Annual Review of Entomology
Publisher: Annual Reviews
Published: 1998-01
Volume: 43
Issue: 1
Pages: 545-569
ISSN: 0066-4170 (ISSN-L)
1545-4487
DOI: 10.1146/annurev.ento.43.1.545
OpenAlex: W2149662691
Cited by: 912
References: 131
Citations by year: 2026: 12 · 2025: 29 · 2024: 29 · 2023: 22 · 2022: 23 · 2021: 44 · 2020: 22 · 2019: 30 · 2018: 23 · 2017: 34 · 2016: 32 · 2015: 28 · 2014: 21 · 2013: 32 · 2012: 49
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Entomology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
Keywords: insect growth regulators, ecdysteroid agonists, juvenile hormone agonists, tebufenozide, fenoxycarb, pyriproxyfen, 20-hydroxyecdysone, ecdysteroid receptor, insecticide mode of action, ecotoxicology, lepidopteran pests
MeSH terms: Animals, Forecasting, Hydrazines, Insecticides, Insecta, Juvenile Hormones, Steroids, Molecular Structure, Molecular Mimicry, Ecdysteroids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks