Cited by 40Bacteriophages and microbial interactionsEvolution and Genetic DynamicsInvertebrate Immune Response Mechanisms

The DOI matches its Crossref record; 166 of the 167 references it cites were found in a registry or an index.

Interaction of phages, bacteria, and the human immune system: Evolutionary changes in phage therapy

Jariah, Rizka O.A., Hakim, Mohamad S.·2019·Reviews in Medical Virology

Abstract

Phages and bacteria are known to undergo dynamic and co-evolutionary arms race interactions in order to survive. Recent advances from in vitro and in vivo studies have improved our understanding of the complex interactions between phages, bacteria, and the human immune system. This insight is essential for the development of phage therapy to battle the growing problems of antibiotic resistance. It is also pivotal to prevent the development of phage-resistance during the implementation of phage therapy in the clinic. In this review, we discuss recent progress of the interactions between phages, bacteria, and the human immune system and its clinical application for phage therapy. Proper phage therapy design will ideally produce large burst sizes, short latent periods, broad host ranges, and a low tendency to select resistance.

Overview

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Crossref · 10.1002/rmv.2055

Cites

166 of 166 references verified0 citation errors · 0 not checkable

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  • Neutralizing antibodies can develop upon repeated phage exposure, potentially limiting long-term efficacy through enhanced clearance.

    “Neutralizing antibodies can develop upon repeated phage exposure, potentially limiting long-term efficacy through enhanced clearance.”
  • One significant challenge in clinical application is the complex interplay between administered phages and the human immune system.

    “One significant challenge in clinical application is the complex interplay between administered phages and the human immune system [140–142]”
  • Cytokine responses to phage administration, while potentially beneficial for tumor immunogenicity, could pose safety risks in immunosuppressed patients.

    “Cytokine responses to phage administration, while potentially beneficial for tumor immunogenicity, could pose safety risks in immunosuppressed patients.”

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1 of the 167 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Zimecki M, 2009, Immunosuppressed mice infected with Staphylococcus aureus, BMC Microbiol, 9, 1

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Metadata

Authors
Jariah, R. O. A., & Hakim, M. S.
Affiliations
  • Universitas Airlangga (ID)
  • Universitas Gadjah Mada (ID)
Corresponding author
Hakim, Mohamad S.
Venue
Reviews in Medical Virology
Publisher
Wiley
Published
2019-05-30
Volume
29
Issue
5
Pages
e2055-e2055
ISSN
  • 1052-9276 (ISSN-L)
  • 1099-1654
OpenAlex
W2947829184
Cited by
40
References
167
Citations by year
2026: 8 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 1
FWCI
0.23
Type
journal article
Language
en
Open access
closed
Locations
  • Reviews in Medical Virology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Keywords
bacteriophages, phage therapy, phage-bacteria coevolution, arms race, human immune system, antibiotic resistance, phage resistance, burst size, latency, host range
MeSH terms
Phage Therapy, Bacteria, Bacteriophages, Disease Susceptibility, Biological Evolution, Humans, Immune System, Bacterial Physiological Phenomena, Host-Pathogen Interactions

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