The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Genetics of RNA Silencing
Abstract
▪ Abstract Although initially recognized as a handy tool to reduce gene expression, RNA silencing, triggered by double-stranded RNA molecules, is now recognized as a mechanism for cellular protection and cleansing: It defends the genome against molecular parasites such as viruses and transposons, while removing abundant but aberrant nonfunctional messenger RNAs. The underlying mechanisms in distinct gene silencing phenomena in different genetic systems, such as cosuppression in plants and RNAi in animals, are very similar. There are common RNA intermediates, and similar genes are required in RNA silencing pathways in protozoa, plants, fungi, and animals, thus indicating an ancient pathway. This chapter gives an overview of both biochemical and genetic approaches leading to the current understanding of the molecular mechanism of RNA silencing and its probable biological function.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Ketting, R. F., Fischer, S. E. J., Bernstein, E., Sijen, T., Hannon, G. J., & Plasterk, R. H. A. (2001) · Genes & Development · doi:10.1101/gad.927801 · Cited by 1,852
Self-citationmiRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., & Dreyfuss, G. (2002) · Genes & Development · doi:10.1101/gad.974702 · Cited by 1,105
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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.007 · Cited by 2,052
Harborth, J., Elbashir, S. M., Vandenburgh, K., Manninga, H., Scaringe, S. A., Weber, K., & Tuschl, T. (2003) · Antisense and Nucleic Acid Drug Development · doi:10.1089/108729003321629638 · Cited by 474
Li, C. F., Pontes, O., El-Shami, M., Henderson, I. R., Bernatavichute, Y. V., Chan, S. W.-L., Lagrange, T., Pikaard, C. S., & Jacobsen, S. E. (2006) · Cell · doi:10.1016/j.cell.2006.05.032 · Cited by 373
The effect of stress on genome regulation and structure
MADLUNG, A. (2004) · Annals of Botany · doi:10.1093/aob/mch172 · Cited by 307
Roles of small regulatory RNAs in determining neuronal identity
Li, X., & Jin, P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2739 · Cited by 151
Metadata
- Authors
- Tijsterman, M., Ketting, R. F., & Plasterk, R. H. A.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2002-12
- Volume
- 36
- Issue
- 1
- Pages
- 489-519
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2102802740
- Cited by
- 298
- References
- 5
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
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