CoChat
Sign Up
Cited by 151

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Roles of small regulatory RNAs in determining neuronal identity

Li, Xuekun, Jin, Peng·2010·Nature Reviews Neuroscience
DOI 10.1038/nrn2739
Open this paper in CoChat — free account

Abstract

Neurogenesis, the process of generating functional neurons from neural stem cells, is tightly controlled by many intrinsic and extrinsic mechanisms. Uncovering these regulatory mechanisms is crucial for understanding the functions and plasticity of the human brain. Recent studies in both invertebrates and vertebrates point to the importance of small regulatory RNAs in regulating lineage-specific gene expression and determining neuronal identity during neurogenesis. These new observations suggest that small regulatory RNAs could function at many levels to regulate self-renewal of neural stem cells and neuronal fate specification, implicating small regulatory RNAs in the complexity of neurogenesis.

Overview

Integrity signals

Registry

Crossref · 10.1038/nrn2739

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 19 references

Research works printed but not linked: 84

  1. Ming, G. L. & Song, H. Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci. 28, 223–250 (2005). · DOI
  2. Zhao, C., Deng, W. & Gage, F. H. Mechanisms and functional implications of adult neurogenesis. Cell 132, 645–660 (2008). · DOI · Paper page
  3. Mattick, J. S. The functional genomics of noncoding RNA. Science 309, 1527–1528 (2005). · DOI
  4. Gangaraju, V. K. & Lin, H. MicroRNAs: key regulators of stem cells. Nature Rev. Mol. Cell Biol. 10, 116–125 (2009). · DOI
  5. Stadler, B. M. & Ruohola-Baker, H. Small RNAs: keeping stem cells in line. Cell 132, 563–566 (2008). · DOI
  6. Lagos-Quintana, M. et al. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 12, 735–739 (2002). This is the first paper to report the tissue-specific expression of miRNAs in mammals. · DOI · Paper page
  7. Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & Tuschl, T. Identification of novel genes coding for small expressed RNAs. Science 294, 853–858 (2001). · DOI · Paper page
  8. Wulczyn, F. G. et al. Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J. 21, 415–426 (2007). · DOI
  9. Wienholds, E. & Plasterk, R. H. MicroRNA function in animal development. FEBS Lett. 579, 5911–5922 (2005). · DOI
  10. Wienholds, E. et al. MicroRNA expression in zebrafish embryonic development. Science 309, 310–311 (2005). · DOI · Paper page
  11. Krichevsky, A. M., Sonntag, K. C., Isacson, O. & Kosik, K. S. Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells 24, 857–864 (2006). · DOI · Paper page
  12. Giraldez, A. J. et al. MicroRNAs regulate brain morphogenesis in zebrafish. Science 308, 833–838 (2005). This study provides the first in vivo evidence that miRNAs are crucial for brain development. · DOI · Paper page
  13. Liu, J. et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437–1441 (2004). · DOI · Paper page
  14. Cuellar, T. L. et al. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc. Natl Acad. Sci. USA 105, 5614–5619 (2008). · DOI
  15. Davis, T. H. et al. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J. Neurosci. 28, 4322–4330 (2008). · DOI · Paper page
  16. De Pietri Tonelli, D. et al. miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development 135, 3911–3921 (2008). · DOI · Paper page
  17. Kawase-Koga, Y., Otaegi, G. & Sun, T. Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev. Dyn. 238, 2800–2812 (2009). · DOI
  18. Neumuller, R. A. & Knoblich, J. A. Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev. 23, 2675–2699 (2009). · DOI
  19. Zhong, W. & Chia, W. Neurogenesis and asymmetric cell division. Curr. Opin. Neurobiol. 18, 4–11 (2008). · DOI
  20. Schwamborn, J. C., Berezikov, E. & Knoblich, J. A. The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell 136, 913–925 (2009). This paper was the first to show that a miRNA-containing ribonucleoprotein complex could be unequally distributed and contribute to asymmetrical cell division. · DOI
  21. Loedige, I. & Filipowicz, W. TRIM-NHL proteins take on miRNA regulation. Cell 136, 818–820 (2009). · DOI
  22. Cao, X., Yeo, G., Muotri, A. R., Kuwabara, T. & Gage, F. H. Noncoding RNAs in the mammalian central nervous system. Annu. Rev. Neurosci. 29, 77–103 (2006). · DOI · Paper page
  23. Fineberg, S. K., Kosik, K. S. & Davidson, B. L. MicroRNAs potentiate neural development. Neuron 64, 303–309 (2009). · DOI
  24. Kosik, K. S. The neuronal microRNA system. Nature Rev. Neurosci. 7, 911–920 (2006). · DOI
  25. Schratt, G. microRNAs at the synapse. Nature Rev. Neurosci. 10, 842–849 (2009). · DOI · Paper page
  26. Coolen, M. & Bally-Cuif, L. MicroRNAs in brain development and physiology. Curr. Opin. Neurobiol. 19, 461–470 (2009). · DOI
  27. Chang, S., Johnston, R. J. Jr, Frokjaer-Jensen, C., Lockery, S. & Hobert, O. MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode. Nature 430, 785–789 (2004). · DOI
  28. Johnston, R. J. & Hobert, O. A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature 426, 845–849 (2003). References 33 and 34 provide the first evidence that miRNAs regulate neuronal fate determination. · DOI
  29. Lim, L. P. et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433, 769–773 (2005). · DOI · Paper page
  30. Makeyev, E. V., Zhang, J., Carrasco, M. A. & Maniatis, T. The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol. Cell 27, 435–448 (2007). · DOI · Paper page
  31. Ballas, N., Grunseich, C., Lu, D. D., Speh, J. C. & Mandel, G. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121, 645–657 (2005). · DOI · Paper page
  32. Visvanathan, J., Lee, S., Lee, B., Lee, J. W. & Lee, S. K. The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev. 21, 744–749 (2007). · DOI · Paper page
  33. Conaco, C., Otto, S., Han, J. J. & Mandel, G. Reciprocal actions of REST and a microRNA promote neuronal identity. Proc. Natl Acad. Sci. USA 103, 2422–2427 (2006). · DOI · Paper page
  34. Cheng, L. C., Pastrana, E., Tavazoie, M. & Doetsch, F. miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nature Neurosci. 12, 399–408 (2009). · DOI · Paper page
  35. Kloosterman, W. P. et al. Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res. 34, 2558–2569 (2006). · DOI
  36. Li, Y., Wang, F., Lee, J. A. & Gao, F. B. MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev. 20, 2793–2805 (2006). · DOI · Paper page
  37. Leucht, C. et al. MicroRNA-9 directs late organizer activity of the midbrain–hindbrain boundary. Nature Neurosci. 11, 641–648 (2008). · DOI · Paper page
  38. Shibata, M., Kurokawa, D., Nakao, H., Ohmura, T. & Aizawa, S. MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium. J. Neurosci. 28, 10415–10421 (2008). · DOI · Paper page
  39. Sun, G., Yu, R. T., Evans, R. M. & Shi, Y. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc. Natl Acad. Sci. USA 104, 15282–15287 (2007). · DOI
  40. Zhao, C., Sun, G., Li, S. & Shi, Y. A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nature Struct. Mol. Biol. 16, 365–371 (2009). · DOI · Paper page
  41. Decembrini, S. et al. MicroRNAs couple cell fate and developmental timing in retina. Proc. Natl Acad. Sci. USA 106, 21179–21184 (2009). · DOI
  42. Ferretti, E. et al. Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J. 27, 2616–2627 (2008). · DOI
  43. Northcott, P. A. et al. The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res. 69, 3249–3255 (2009). · DOI
  44. Li, X. & Carthew, R. W. A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell 123, 1267–1277 (2005). This paper was the first to show that miRNAs regulate neuronal fate through EGF receptor signalling. · DOI · Paper page
  45. Li, X. & Zhao, X. Epigenetic regulation of mammalian stem cells. Stem Cells Dev. 17, 1043–1052 (2008). · DOI
  46. Mehler, M. F. Epigenetics and the nervous system. Ann. Neurol. 64, 602–617 (2008). · DOI
  47. Lim, D. A. et al. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature 458, 529–533 (2009). · DOI
  48. Ma, D. K. et al. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323, 1074–1077 (2009). · DOI
  49. Zhao, X. et al. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl Acad. Sci. USA 100, 6777–6782 (2003). References 56–58 show the key role of epigenetic regulation in neurogenesis. · DOI
  50. Cheng, L. C., Tavazoie, M. & Doetsch, F. Stem cells: from epigenetics to microRNAs. Neuron 46, 363–367 (2005). · DOI
  51. Hsieh, J. & Gage, F. H. Epigenetic control of neural stem cell fate. Curr. Opin. Genet. Dev. 14, 461–469 (2004). · DOI
  52. Abel, T. & Zukin, R. S. Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr. Opin. Pharmacol. 8, 57–64 (2008). · DOI
  53. Tijsterman, M., Ketting, R. F. & Plasterk, R. H. A. The genetics of RNA silencing. Annu. Rev. Genet. 36, 489–519 (2002). · DOI
  54. Morris, K. V., Chan, S. W., Jacobsen, S. E. & Looney, D. J. Small interfering RNA-induced transcriptional gene silencing in human cells. Science 305, 1289–1292 (2004). · DOI
  55. Kawasaki, H. & Taira, K. Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 431, 211–217 (2004). · DOI
  56. Nomura, T. et al. MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Hum. Mol. Genet. 17, 1192–1199 (2008). · DOI
  57. Chahrour, M. & Zoghbi, H. Y. The story of Rett syndrome: from clinic to neurobiology. Neuron 56, 422–437 (2007). · DOI · Paper page
  58. Godlewski, J. et al. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 68, 9125–9130 (2008). · DOI · Paper page
  59. Yoo, A. S., Staahl, B. T., Chen, L. & Crabtree, G. R. MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature 460, 642–646 (2009). · DOI · Paper page
  60. Kawamura, Y. et al. Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells. Nature 453, 793–797 (2008). · DOI
  61. Czech, B. et al. An endogenous small interfering RNA pathway in Drosophila. Nature 453, 798–802 (2008). · DOI
  62. Okamura, K. & Lai, E. C. Endogenous small interfering RNAs in animals. Nature Rev. Mol. Cell Biol. 9, 673–678 (2008). · DOI
  63. Kuwabara, T. et al. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nature Neurosci. 12, 1097–1105 (2009). · DOI · Paper page
  64. Muotri, A. R. & Gage, F. H. Generation of neuronal variability and complexity. Nature 441, 1087–1093 (2006). · DOI
  65. Yang, N. & Kazazian, H. H. Jr. L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells. Nature Struct. Mol. Biol. 13, 763–771 (2006). · DOI
  66. Kapranov, P. et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316, 1484–1488 (2007). · DOI
  67. Taft, R. J. et al. Tiny RNAs associated with transcription start sites in animals. Nature Genet. 41, 572–578 (2009). · DOI
  68. Kuwabara, T., Hsieh, J., Nakashima, K., Taira, K. & Gage, F. H. A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell 116, 779–793 (2004). · DOI · Paper page
  69. Bushati, N. & Cohen, S. M. microRNA functions. Annu. Rev. Cell Dev. Biol. 23, 175–205 (2007). · DOI · Paper page
  70. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215–233 (2009). · DOI · Paper page
  71. Rybak, A. et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nature Cell Biol. 10, 987–993 (2008). · DOI
  72. Sawamoto, K. et al. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 311, 629–632 (2006). · DOI
  73. Ghildiyal, M. & Zamore, P. D. Small silencing RNAs: an expanding universe. Nature Rev. Genet. 10, 94–108 (2009). · DOI
  74. Kim, V. N., Han, J. & Siomi, M. C. Biogenesis of small RNAs in animals. Nature Rev. Mol. Cell Biol. 10, 126–139 (2009). · DOI · Paper page
  75. Mardis, E. R. Next-generation DNA sequencing methods. Annu. Rev. Genomics Hum. Genet. 9, 387–402 (2008). · DOI
  76. Rusk, N. & Kiermer, V. Primer: Sequencing — the next generation. Nature Methods 5, 15 (2008). · DOI
  77. Maller Schulman, B. R. et al. The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle 7, 3935–3942 (2008). · DOI
  78. Beveridge, N. J., Tooney, P. A., Carroll, A. P., Tran, N. & Cairns, M. J. Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation. Cell Signal. 21, 1837–1845 (2009). · DOI
  79. Kawasaki, H. & Taira, K. Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature 423, 838–842 (2003). · DOI
  80. Le, M. T. et al. MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol. Cell. Biol. 29, 5290–5305 (2009). · DOI · Paper page
  81. Choi, P. S. et al. Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron 57, 41–55 (2008). · DOI
  82. Cayirlioglu, P. et al. Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science 319, 1256–1260 (2008). · DOI
  83. Dugas, J. C. et al. Dicer1 and miR-219 are required for normal oligodendrocyte differentiation and myelination. Neuron 65, 597–611 (2010). · DOI · Paper page
  84. Zhao, X. et al. MicroRNA-mediated control of oligodendrocyte differentiation. Neuron 65, 612–626 (2010). · DOI · Paper page

Cited by

Sorted by citations

See all 151

Metadata

Authors
Li, X., & Jin, P.
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2010-03-31
Volume
11
Issue
5
Pages
329-338
ISSN
  • 1471-003X
  • 1471-0048
DOI
10.1038/nrn2739
Cited by
151
References
19
Language
en
Update notices
erratum (2010-06-01)
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review