Cited by 438Bacterial Genetics and BiotechnologyEvolution and Genetic DynamicsEscherichia coli research studies

Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptation

Moxon, Richard, Bayliss, Chris, Hood, Derek·2006·Annual Review of Genetics

Abstract

Bacterial pathogens face stringent challenges to their survival because of the many unpredictable, often precipitate, and dynamic changes that occur in the host environment or in the process of transmission from one host to another. Bacterial adaptation to their hosts involves either a mechanism for sensing and responding to external changes or the selection of variants that arise through mutation. Here we review how bacterial pathogens exploit localized hypermutation, through polymerase slippage of simple sequence repeats (SSRs), to generate phenotypic variation and enhanced fitness. These SSRs are located within the reading frame or in the promoter of a subset of genes, often termed contingency loci, whose functions are usually involved in direct interactions with host structures.

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Crossref · 10.1146/annurev.genet.40.110405.090442

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Authors
Moxon, R., Bayliss, C., & Hood, D.
Affiliations
  • University of Oxford (GB)
  • Oxford University Department of Paediatrics, Molecular Infectious Diseases Group, Weatherall Institute of Molecular Medicine Oxford, United Kingdom;
Venue
Annual Review of Genetics
Published
2006-12-01
Volume
40
Issue
1
Pages
307-333
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
OpenAlex
W2163255170
Cited by
438
References
108
Citations by year
2026: 13 · 2025: 16 · 2024: 20 · 2023: 11 · 2022: 24 · 2021: 33 · 2020: 25 · 2019: 23 · 2018: 26 · 2017: 25 · 2016: 35 · 2015: 19 · 2014: 27 · 2013: 25 · 2012: 30
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords
microsatellite markers, bacterial adaptation, hypermutation, polymerase slippage, pathogenic bacteria, host-pathogen interaction, phenotypic variability, promoter
MeSH terms
Adaptation, Physiological, Base Sequence, DNA, Bacterial, Genes, Bacterial, Haemophilus influenzae, Molecular Sequence Data, Mutation, Phenotype, Genetic Variation, Open Reading Frames, Microsatellite Repeats

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