The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Methods to Detect Selection in Populations with Applications to the Human
Abstract
The development of statistical tests of natural selection at the DNA level in population samples has been ongoing for the past 13 years. The current state of the field is reviewed, and the available tests of selection are described. All tests use predictions from the theory of neutrally evolving sites as a null hypothesis. Departures from equilibrium-neutral expectations can indicate the presence of natural selection acting either at one or more of the sites under investigation or at a sufficiently tightly linked site. Complications can arise in the interpretation of departures from neutrality if populations are not at equilibrium for mutation and genetic drift or if populations are subdivided, both of which are likely scenarios for humans. Attempts to understand the nonequilibrium configuration of silent polymorphism in human mitochondrial DNA illustrate the difficulty of distinguishing between selection and alternative demographic hypotheses. The range of plausible alternatives to selection will become better defined, however, as additional population genetic data sets become available, allowing better null models to be constructed.
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Citations
Cites
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“The nuclear genome shows little evidence for a skew towards rare alleles (18, 37, 38, 42, 83, 106), and thus towards a negative Tajima’s D, as predicted under the population expansion hypothesis.”
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Cited by
Positive Natural Selection in the Human Lineage
Sabeti, P. C., Schaffner, S. F., Fry, B., Lohmueller, J., Varilly, P., Shamovsky, O., Palma, A., Mikkelsen, T. S., Altshuler, D., & Lander, E. S. (2006) · Science · doi:10.1126/science.1124309 · Cited by 1,157
Genealogical trees, coalescent theory and the analysis of genetic polymorphisms
Rosenberg, N. A., & Nordborg, M. (2002) · Nature Reviews Genetics · doi:10.1038/nrg795 · Cited by 750
Patterns of Positive Selection in Six Mammalian Genomes
Kosiol, C., Vinař, T., da Fonseca, R. R., Hubisz, M. J., Bustamante, C. D., Nielsen, R., & Siepel, A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000144 · Cited by 576
Forces shaping the fastest evolving regions in the human genome
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A new approach for using genome scans to detect recent positive selection in the human genome
Tang, K., Thornton, K. R., & Stoneking, M. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050171 · Cited by 489
Conservation and the Genomics of Populations
Allendorf, F. W., Funk, W. C., Aitken, S. N., Byrne, M., Luikart, G., & Antunes, A. (2022) · doi:10.1093/oso/9780198856566.001.0001 · Cited by 207
Evolutionary genetic dissection of human interferons
Manry, J., Laval, G., Patin, E., Fornarino, S., Itan, Y., Fumagalli, M., Sironi, M., Tichit, M., Bouchier, C., Casanova, J.-L., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20111680 · Cited by 176
Comparative Genomics Search for Losses of Long-Established Genes on the Human Lineage
Zhu, J., Sanborn, J. Z., Diekhans, M., Lowe, C. B., Pringle, T. H., & Haussler, D. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030247 · Cited by 129
Veilleux, C. C., Louis, E. E., & Bolnick, D. A. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst058 · Cited by 103
Signatures of Purifying and Local Positive Selection in Human miRNAs
Quach, H., Barreiro, L. B., Laval, G., Zidane, N., Patin, E., Kidd, K. K., Kidd, J. R., Bouchier, C., Veuille, M., Antoniewski, C., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.01.022 · Cited by 85
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Metadata
- Authors
- Kreitman, M.
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2000-09
- Volume
- 1
- Issue
- 1
- Pages
- 539-559
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2096866954
- Cited by
- 422
- References
- 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
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