The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The Bittersweet Interface of Parasite and Host: Lectin-Carbohydrate Interactions During Human Invasion by the Parasite Entamoeba histolytica
Abstract
▪ Abstract Entamoeba histolytica, as its name suggests, is an enteric parasite with a remarkable ability to lyse host tissues. However, the interaction of the parasite with the host is more complex than solely destruction and invasion. It is at the host-parasite interface that cell-signaling events commit the parasite to (a) commensal, noninvasive infection, (b) developmental change from trophozoite to cyst, or (c) invasion and potential death of the human host. The molecule central to these processes is an amebic cell surface protein that recognizes the sugars galactose (Gal) and N-acetylgalactosamine (GalNAc) on the surface of host cells. Engagement of the Gal/GalNAc lectin to the host results in cytoskeletal reorganization in the parasite. The parasite cytoskeleton regulates the extracellular adhesive activity of the lectin and recruits to the host-parasite interface factors required for parasite survival within its host. If the parasite lectin attaches to the host mucin glycoproteins lining the intestine, the result is commensal infection. In contrast, attachment of the lectin to a host cell surface glycoprotein leads to lectin-induced host cell calcium transients, caspase activation, and destruction via apoptosis. Finally, trophozoite quorum sensing via the lectin initiates the developmental pathway resulting in encystment. The structure and function of the lectin that controls these divergent cell biologic processes are the subject of this review.
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Cites
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Role of Adherence in Cytopathogenic Mechanisms of Entamoeba Histolytica
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Rat and human colonic mucins bind to and inhibit adherence lectin of Entamoeba histolytica.
Chadee, K., Petri, W. A., Innes, D. J., & Ravdin, J. I. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113199 · Cited by 286
Self-citationPetri, W. A., Smith, R. D., Schlesinger, P. H., Murphy, C. F., & Ravdin, J. I. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113198 · Cited by 281
Self-citationPore-forming peptide of pathogenic Entamoeba histolytica.
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Self-citationGenomic DNA differences between pathogenic and nonpathogenic Entamoeba histolytica.
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Adherence and cytotoxicity of Entamoeba histolytica or how lectins let parasites stick around
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Self-citation
Cited by
The gastrointestinal mucus system in health and disease
Johansson, M. E. V., Sjövall, H., & Hansson, G. C. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.35 · Cited by 1,438
Role of mucus layers in gut infection and inflammation
Hansson, G. C. (2012) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.11.002 · Cited by 473
Glycan microarray analysis of Candida glabrata adhesin ligand specificity
Zupancic, M. L., Frieman, M., Smith, D., Alvarez, R. A., Cummings, R. D., & Cormack, B. P. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06184.x · Cited by 143
Martínez-Ocaña, J., Maravilla, P., & Olivo-Díaz, A. (2020) · Revista do Instituto de Medicina Tropical de São Paulo · doi:10.1590/s1678-9946202062064 · Cited by 16
Editorial: Insights into glyco-parasitology
Kato, K., & Heimburg-Molinaro, J. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1422955 · Cited by 2
Metadata
- Authors
- Petri, W. A., Haque, R., & Mann, B. J.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2002-10
- Volume
- 56
- Issue
- 1
- Pages
- 39-64
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2059905961
- Cited by
- 326
- References
- 35
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
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