Two-pore domain potassium channels in the adrenal cortex.
Open accessAbstract
The physiological control of steroid hormone secretion from the adrenal cortex depends on the function of potassium channels. The "two-pore domain K(+) channels" (K2P) TWIK-related acid sensitive K(+) channel 1 (TASK1), TASK3, and TWIK-related K(+) channel 1 (TREK1) are strongly expressed in adrenocortical cells. They confer a background K(+) conductance to these cells which is important for the K(+) sensitivity as well as for angiotensin II and adrenocorticotropic hormone-dependent stimulation of aldosterone and cortisol synthesis. Mice with single deletions of the Task1 or Task3 gene as well as Task1/Task3 double knockout mice display partially autonomous aldosterone synthesis. It appears that TASK1 and TASK3 serve different functions: TASK1 affects cell differentiation and prevents expression of aldosterone synthase in the zona fasciculata, while TASK3 controls aldosterone secretion in glomerulosa cells. TREK1 is involved in the regulation of cortisol secretion in fasciculata cells. These data suggest that a disturbed function of K2P channels could contribute to adrenocortical pathologies in humans.
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Angiotensin II stimulates aldosterone synthesis in adrenal zona glomerulosa cells via binding to the AT1 receptors.
“Angiotensin II stimulates aldosterone synthesis in adrenal zona glomerulosa cells via binding to the AT1 receptors (Bandulik et al., 2015).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Bandulik et al., 2015
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Aldosteron und Niere – eine komplexe Interaktion
Schwarz, C., & Lindner, G. (2024) · Journal für Endokrinologie Diabetologie und Stoffwechsel · doi:10.1007/s41969-024-00224-8 · Cited by 1 · see citing works
Research Progress of Two-Pore Potassium Channels
林, 千. (2023) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2023.132015
Jouen-Tachoire, T. R. H., Proks, P., Seiferth, D., Crowther, K. M., Biggin, P. C., Baukrowitz, T., Schewe, M., & Tucker, S. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.04.668454
- Authors
- Bandulik, S., Tauber, P., Lalli, E., Barhanin, J., & Warth, R.
- Affiliations
- University of Regensburg (DE)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Bandulik, Sascha
- Venue
- Pflügers Archiv - European Journal of Physiology
- Published
- 2014-10-23
- Volume
- 467
- Issue
- 5
- Pages
- 1027-1042
- ISSN
- 0031-6768 (ISSN-L)
- 1432-2013
- PMC
- PMC4428839
- OpenAlex
- W1983761633
- Cited by
- 38
- References
- 149
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 5
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Pflügers Archiv - European Journal of Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-LABX-0015)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- two-pore domain potassium channels, TASK-1, TASK-3, TREK-1, adrenal cortex, aldosterone biosynthesis, cortisol secretion, angiotensin II, ACTH, aldosterone synthase, zona fasciculata, glomerulosa cells
- MeSH terms
- Adrenal Cortex, Aldosterone, Angiotensin II, Animals, Cell Membrane, Humans, Nerve Tissue Proteins, Potassium Channels
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