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Cited by 645Circadian rhythm and melatoninPharmacogenetics and Drug MetabolismSleep and Work-Related Fatigue

The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.

Circadian Rhythms: Mechanisms and Therapeutic Implications

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Levi, Francis, Schibler, Ueli·2007·Annual Review of Pharmacology and Toxicology
DOI 10.1146/annurev.pharmtox.47.120505.105208
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Abstract

The mammalian circadian system is organized in a hierarchical manner in that a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes cellular circadian oscillators in most peripheral body cells. Fasting-feeding cycles accompanying rest-activity rhythms are the major timing cues in the synchronization of many, if not most, peripheral clocks, suggesting that the temporal coordination of metabolism and proliferation is a major task of the mammalian timing system. The inactivation of noxious food components by hepatic, intestinal, and renal detoxification systems is among the metabolic processes regulated in a circadian manner, with the understanding of the involved clock output pathways emerging. The rhythmic control of xenobiotic detoxification provides the molecular basis for the dosing time-dependence of drug toxicities and efficacy. This knowledge can in turn be used in improving or designing chronotherapeutics for the patients who suffer from many of the major human diseases.

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Crossref · 10.1146/annurev.pharmtox.47.120505.105208

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Metadata

Authors
Levi, F., & Schibler, U.
Affiliations
  • INSERM U776, Unité de Chronothérapie, Service de Cancérologie, Hôpital Paul Brousse et Université Paris XI, 94800 Villejuif, France;
  • University of Geneva (CH)
ORCID
Schibler, Ueli
Venue
Annual Review of Pharmacology and Toxicology
Publisher
Annual Reviews
Published
2007-02-01
Volume
47
Issue
1
Pages
593-628
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
DOI
10.1146/annurev.pharmtox.47.120505.105208
OpenAlex
W2126157274
Cited by
645
References
156
Citations by year
2026: 25 · 2025: 20 · 2024: 28 · 2023: 31 · 2022: 23 · 2021: 38 · 2020: 43 · 2019: 23 · 2018: 21 · 2017: 23 · 2016: 34 · 2015: 27 · 2014: 49 · 2013: 43 · 2012: 42
FWCI
5.11
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • The Annual Review of Pharmacology and Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian rhythm, suprachiasmatic nucleus, circadian clock, peripheral oscillators, rest-activity rhythm, xenobiotic detoxification, drug toxicity, timing of drug administration, chronotherapy, metabolism, proliferation
MeSH terms
Animals, Biological Clocks, Circadian Rhythm, Humans, Inactivation, Metabolic, Suprachiasmatic Nucleus, Drug Design, Xenobiotics, Drug Delivery Systems, Chronotherapy

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