Circadian Rhythms: Mechanisms and Therapeutic Implications

A haplotype map of the human genome

The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858

Coordination of circadian timing in mammals

Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379

Can the pharmaceutical industry reduce attrition rates?

Kola, I., & Landis, J. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1470 · Cited by 4,167

Cellular processing of platinum anticancer drugs

Wang, D., & Lippard, S. J. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1691 · Cited by 3,801

A Map of Recent Positive Selection in the Human Genome

Voight, B. F., Kudaravalli, S., Wen, X., & Pritchard, J. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040072 · Cited by 2,925

Molecular Bases for Circadian Clocks

Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900

Life between Clocks: Daily Temporal Patterns of Human Chronotypes

Roenneberg, T., Wirz-Justice, A., & Merrow, M. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730402239679 · Cited by 2,662

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853

Entrainment of the circadian clock in the liver by feeding

Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800

Mop3 is an essential component of the master circadian pacemaker in mammals.

Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621

mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617

Extensive and divergent circadian gene expression in liver and heart

Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509

Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage

Dodd, A. N., Salathia, N. S., Hall, A. J. W., Kevei, É., Tóth, R., Nagy, F., Hibberd, J. M., Millar, A. J., & Webb, A. A. R. (2005) · Science · doi:10.1126/science.1115581 · Cited by 1,489

Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms

Welsh, D. K., Logothetis, D. E., Meister, M., & Reppert, S. M. (1995) · Neuron · doi:10.1016/0896-6273(95)90214-7 · Cited by 1,481

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

Chen, H., Lin, R. J., Schiltz, R. L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M. L., Nakatani, Y., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80516-4 · Cited by 1,480

Positional Cloning of the Mouse Circadian Gene

King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382

Induction of phase I, II and III drug metabolism/transport by xenobiotics

Xu, C., Li, C. Y.-T., & Kong, A. T. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977789 · Cited by 1,310

Drug Metabolism and Variability among Patients in Drug Response

Wilkinson, G. R. (2005) · New England Journal of Medicine · doi:10.1056/nejmra032424 · Cited by 1,185

Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21

Patil, N., Berno, A. J., Hinds, D. A., Barrett, W. A., Doshi, J. M., Hacker, C. R., Kautzer, C. R., Lee, D. H., Marjoribanks, C., McDonough, D. P., et al. (2001) · Science · doi:10.1126/science.1065573 · Cited by 1,145

Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo

Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., & Okamura, H. (2003) · Science · doi:10.1126/science.1086271 · Cited by 1,132

Reconstitution of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro

Nakajima, M., Imai, K., Ito, H., Nishiwaki, T., Murayama, Y., Iwasaki, H., Oyama, T., & Kondo, T. (2005) · Science · doi:10.1126/science.1108451 · Cited by 1,110

A Phase Response Curve to Single Bright Light Pulses in Human Subjects

Khalsa, S. B. S., Jewett, M. E., Cajochen, C., & Czeisler, C. A. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040477 · Cited by 1,040

Circadian Gene Expression in Individual Fibroblasts

Nagoshi, E., Saini, C., Bauer, C. R., Laroche, T., Naef, F., & Schibler, U. (2004) · Cell · doi:10.1016/j.cell.2004.11.015 · Cited by 1,031

Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

Pirkkala, L., NYKÄNEN, P., & Sistonen, L. (2001) · The FASEB Journal · doi:10.1096/fj00-0294rev · Cited by 996

Circadian Regulator CLOCK Is a Histone Acetyltransferase

Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 910

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 905

Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.

Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00380-4 · Cited by 900

A transcription factor response element for gene expression during circadian night

Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 865

A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms

Silver, R., LeSauter, J., Tresco, P. A., & Lehman, M. N. (1996) · Nature · doi:10.1038/382810a0 · Cited by 792

Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections

Abrahamson, E. E., & Moore, R. Y. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02890-6 · Cited by 788

Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777

Resonating circadian clocks enhance fitness in cyanobacteria

Ouyang, Y., Andersson, C. R., Kondo, T., Golden, S. S., & Johnson, C. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8660 · Cited by 772

A Web of Circadian Pacemakers

Schibler, U., & Sassone‐Corsi, P. (2002) · Cell · doi:10.1016/s0092-8674(02)01225-4 · Cited by 761

Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression

Welsh, D. K., Yoo, S.-H., Liu, A. C., Takahashi, J. S., & Kay, S. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.057 · Cited by 726

Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

Cheng, M. Y., Bullock, C. M., Li, C., Lee, A. G., Bermak, J. C., Belluzzi, J., Weaver, D. R., Leslie, F. M., & Zhou, Q.-Y. (2002) · Nature · doi:10.1038/417405a · Cited by 715

Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer

Lévi, F. A., Zidani, R., & Misset, J. L. (1997) · The Lancet · doi:10.1016/s0140-6736(97)03358-8 · Cited by 702

The circadian clock: pacemaker and tumour suppressor

Fu, L., & Lee, C. C. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1072 · Cited by 678

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

Ripperger, J. A., & Schibler, U. (2006) · Nature Genetics · doi:10.1038/ng1738 · Cited by 604

Light activates the adrenal gland: Timing of gene expression and glucocorticoid release

Ishida, A., Mutoh, T., Ueyama, T., Bando, H., Masubuchi, S., Nakahara, D., Tsujimoto, G., & Okamura, H. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.009 · Cited by 589

Rhythms of Mammalian Body Temperature Can Sustain Peripheral Circadian Clocks

Brown, S. A., Zumbrunn, G., Fleury-Olela, F., Preitner, N., & Schibler, U. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01145-4 · Cited by 589

NPAS2: an analog of clock operative in the mammalian forebrain

Reick, M., Garcia, J. A., Dudley, C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060699 · Cited by 572

Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock

Yin, L., Wang, J., Klein, P. S., & Lazar, M. A. (2006) · Science · doi:10.1126/science.1121613 · Cited by 563

The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei

Harmar, A. J., Marston, H. M., Shen, S., Spratt, C., West, K. M., Sheward, W. J., Morrison, C. F., Dorin, J. R., Piggins, H. D., Reubi, J.-C., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00736-5 · Cited by 549

Circadian orchestration of the hepatic proteome

Reddy, A. B., Karp, N. A., Maywood, E. S., Sage, E. A., Deery, M., O'Neill, J. S., Wong, G. K. Y., Chesham, J., Odell, M., Lilley, K. S., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.026 · Cited by 548

Peripheral Circadian Oscillators in Mammals: Time and Food

Schibler, U., Ripperger, J. A., & Brown, S. A. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403018003007 · Cited by 537

Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling

Kramer, A., Yang, F.-C., Snodgrass, P., Li, X., Scammell, T. E., Davis, F. C., & Weitz, C. J. (2001) · Science · doi:10.1126/science.1067716 · Cited by 536

The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification

Gachon, F., Fleury-Olela, F., Schaad, O., Descombes, P., & Schibler, U. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.015 · Cited by 513

Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil

Kuilenburg, A. B. P. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2003.12.004 · Cited by 498

Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation

Eide, E. J., Woolf, M. F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E. L., Giovanni, A., & Virshup, D. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2795-2807.2005 · Cited by 495

Glucocorticoid hormones inhibit food‐induced phase‐shifting of peripheral circadian oscillators

Minh, N. L., Damiola, F., Tronche, F., Schütz, G., & Schibler, U. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7128 · Cited by 480

Induction of Drug Metabolism: The Role of Nuclear Receptors

Handschin, C., & Meyer, U. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.2 · Cited by 473

Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts

Yagita, K., Tamanini, F., van der Horst, G. T. J., & Okamura, H. (2001) · Science · doi:10.1126/science.1059542 · Cited by 470

A clock shock: mouse CLOCK is not required for circadian oscillator function

DeBruyne, J. P., Noton, E., Lambert, C. M., Maywood, E. S., Weaver, D. R., & Reppert, S. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.041 · Cited by 430

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBPPreprint

Ripperger, J. A., Shearman, L. P., Reppert, S. M., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.14.6.679 · Cited by 429

Effects of Chronic Jet Lag on Tumor Progression in Mice

Filipski, E., Delaunay, F., King, V. M., Wu, M., Claustrat, B., Gréchez‐Cassiau, A., Guettier, C., Hastings, M. H., & Lévi, F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0674 · Cited by 424

Why Drugs Fail - A Study on Side Effects in New Chemical Entities

Schuster, D., Laggner, C., & Langer, T. (2005) · Current Pharmaceutical Design · doi:10.2174/138161205774414510 · Cited by 417

The mammalian circadian timing system: from gene expression to physiology

Gachon, F., Nagoshi, E., Brown, S., Ripperger, J. A., & Schibler, U. (2004) · Chromosoma · doi:10.1007/s00412-004-0296-2 · Cited by 398

Circadian Expression of Clock Genes in Human Oral Mucosa and Skin

Bjarnason, G. A., Jordan, R. C., Wood, P. A., Li, Q., Lincoln, D. W., Sothern, R. B., Hrushesky, W. J. M., & Ben‐David, Y. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64135-1 · Cited by 379

The Adaptive Value of Circadian Clocks

Woelfle, M. A., Ouyang, Y., Phanvijhitsiri, K., & Johnson, C. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.023 · Cited by 375

mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock

Albrecht, U., Zheng, B., Larkin, D., Sun, Z. S., & Lee, C. C. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129001791 · Cited by 375

Phase I study of oxaliplatin in patients with advanced cancer

Extra, J. M., Espié, M., Calvo, F. M., Fermé, C., Mignot, L., & Marty, M. E. (1990) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00684890 · Cited by 343

Changes in plasma levels of inflammatory cytokines in response to paclitaxel chemotherapy

Pusztai, L., Mendoza, T. R., Reuben, J. M., Martinez, M. M., Willey, J. S., Lara, J. M., Syed, A. R., Fritsche, H. A., Bruera, E. D., Booser, D. J., et al. (2003) · Cytokine · doi:10.1016/j.cyto.2003.10.004 · Cited by 319

The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals

Brown, S. A., Fleury-Olela, F., Nagoshi, E., Hauser, C., Juge-Aubry, C. E., Meier, C. A., Chicheportiche, R., Dayer, J., Albrecht, U., & Schibler, U. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030338 · Cited by 315

Temporal Coordination of Physiologic FunctionPreprint

Halberg, F. (1960) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1960.025.01.031 · Cited by 298

PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator

Brown, S. A., Ripperger, J. A., Kadener, S., Fleury-Olela, F., Vilbois, F., Rosbash, M., & Schibler, U. (2005) · Science · doi:10.1126/science.1107373 · Cited by 293

Chronotherapeutics (light and wake therapy) in affective disorders

WIRZ-JUSTICE, A., BENEDETTI, F., BERGER, M., LAM, R. W., MARTINY, K., TERMAN, M., & WU, J. C. (2005) · Psychological Medicine · doi:10.1017/s003329170500437x · Cited by 291

Come Together, Right…Now: Synchronization of Rhythms in a Mammalian Circadian Clock

Aton, S. J., & Herzog, E. D. (2005) · Neuron · doi:10.1016/j.neuron.2005.11.001 · Cited by 288

The loss of circadian PAR bZip transcription factors results in epilepsyPreprint

Gachon, F., Fonjallaz, P., Damiola, F., Gos, P., Kodama, T., Zákány, J., Duboule, D., Petit, B., Tafti, M., & Schibler, U. (2004) · Genes & Development · doi:10.1101/gad.301404 · Cited by 285

Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

Gorbacheva, V., Kondratov, R. V., Zhang, R., Cherukuri, S., Gudkov, A. V., Takahashi, J. S., & Antoch, M. P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409897102 · Cited by 275

Elevated Serum Cytokines Correlated with Altered Behavior, Serum Cortisol Rhythm, and Dampened 24-Hour Rest-Activity Patterns in Patients with Metastatic Colorectal Cancer

Rich, T. A., Innominato, P. F., Boerner, J. L., Mormont, M., Iacobelli, S., Baron, B., Jasmin, C., & Lévi, F. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2000 · Cited by 262

Pharmacokinetic variability of anticancer agents

Undevia, S. D., Gomez-Abuin, G., & Ratain, M. J. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1629 · Cited by 261

Circadian Rhythm of Glomerular Filtration Rate in Normal Individuals

Koopman, M. G., Koomen, G. C. M., Krediet, R. T., de Moor, E. A. M., Hoek, F. J., & Arisz, L. (1989) · Clinical Science · doi:10.1042/cs0770105 · Cited by 255

Cancer chronotherapy: Principles, applications, and perspectives

Mormont, M., & Lévi, F. (2002) · Cancer · doi:10.1002/cncr.11040 · Cited by 251

Optimal Therapeutic Level of Heparin Therapy in Patients With Venous Thrombosis

Hull, R. D. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400200027006 · Cited by 251

Phase III Trial Comparing 4-Day Chronomodulated Therapy Versus 2-Day Conventional Delivery of Fluorouracil, Leucovorin, and Oxaliplatin As First-Line Chemotherapy of Metastatic Colorectal Cancer: The European Organisation for Research and Treatment of Cancer Chronotherapy Group

Giacchetti, S., Bjarnason, G. A., Garufi, C., Genet, D., Iacobelli, S., Tampellini, M., Smaaland, R., Focan, C., Coudert, B. P., Humblet, Y., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.1440 · Cited by 237

Circadian Chronopharmacology

Reinberg, A., & Halberg, F. E. (1971) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.11.040171.002323 · Cited by 223

Changing the dosing schedule minimizes the disruptive effects of interferon on clock function

Ohdo, S., Koyanagi, S., Suyama, H., Higuchi, S., & Aramaki, H. (2001) · Nature Medicine · doi:10.1038/85507 · Cited by 205

Effects of light and food schedules on liver and tumor molecular clocks in mice

Filipski, E., Innominato, P. F., Wu, M., Li, X.-M., Iacobelli, S., Xian, L.-J., & Levi, F. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji083 · Cited by 200

Oxaliplatin

Lévi, F., Metzger, G., Massari, C., & Milano, G. A. (2000) · Clinical Pharmacokinetics · doi:10.2165/00003088-200038010-00001 · Cited by 193

Adenoma-carcinoma sequence or “de novo” Carcinogenesis?. A study of adenomatous remnants in a population-based series of large bowel cancers

Bedenne, L., Faivre, J., Boutron‐Ruault, M., Piard, F., Cauvin, J.-M., & Hillon, P. (1992) · Cancer · doi:10.1002/1097-0142(19920215)69:4 · Cited by 181

Circadian changes in anticoagulant effect of heparin infused at a constant rate.

Decousus, H., Croze, M., Lévi, F., Jaubert, J., Perpoint, B., Bonadona, J. F. D., Reinberg, A., & Queneau, P. (1985) · BMJ · doi:10.1136/bmj.290.6465.341 · Cited by 181

Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance

Pando, M. P., Morse, D., Cermakian, N., & Sassone‐Corsi, P. (2002) · Cell · doi:10.1016/s0092-8674(02)00803-6 · Cited by 180

Suprachiasmatic Regulation of Circadian Rhythms of Gene Expression in Hamster Peripheral Organs: Effects of Transplanting the Pacemaker

Guo, H., Brewer, J. M., Lehman, M. N., & Bittman, E. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4676-05.2006 · Cited by 180

Neural Circuitry in the Regulation of Adrenal Corticosterone Rhythmicity

Engeland, W. C., & Arnhold, M. M. (2005) · Endocrine · doi:10.1385/endo:28:3:325 · Cited by 178

A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity

Kraves, S., & Weitz, C. J. (2006) · Nature Neuroscience · doi:10.1038/nn1633 · Cited by 178

The neglected epidemic of chronic disease

Horton, R. C. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67454-5 · Cited by 168

Increased Tolerance of Leukemic Mice to Arabinosyl Cytosine with Schedule Adjusted to Circadian System

Haus, E. L., Franz Halberg, A., Scheving, L. E., Pauly, J. E., Cardoso, S., Jf, K., Sothern, R. B., Shiotsuka, R. N., & Hwang, D. S. (1972) · Science · doi:10.1126/science.177.4043.80 · Cited by 163

Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor

Granda, T. G., Liu, X., Smaaland, R., Cermakian, N., Filipski, E., Sassone‐Corsi, P., & Lévi, F. (2004) · The FASEB Journal · doi:10.1096/fj.04-2665fje · Cited by 163

Direct Association between Mouse PERIOD and CKIε Is Critical for a Functioning Circadian Clock

Lee, C., Weaver, D. R., & Reppert, S. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.584-594.2004 · Cited by 160

Suprachiasmatic Nucleus Grafts Restore Circadian Behavioral Rhythms of Genetically Arrhythmic Mice

Sujino, M., Masumoto, K., Yamaguchi, S., van der Horst, G. T. J., Okamura, H., & Inouye, S. T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00222-7 · Cited by 159

Circadian changes in estimated hepatic blood flow in healthy subjects.

Lemmer, B., & Nold, G. (1991) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1991.tb03964.x · Cited by 158

Chronopharmacokinetics

Bruguerolle, B. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199835020-00001 · Cited by 157

DNA synthesis in human bone marrow is circadian stage dependent

Smaaland, R., Od, L., Lote, K., Sletvold, O., Sothern, R., & Bjerknes, R. (1991) · Blood · doi:10.1182/blood.v77.12.2603.2603 · Cited by 153

Cellular oscillators: rhythmic gene expression and metabolism

Schibler, U., & Naef, F. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.01.007 · Cited by 139

Sustained-release theophylline for childhood asthma: Evidence for circadian variation of theophylline pharmacokinetics

Scott, P., Tabachnik, E., MacLeod, S. M., Correia, J., Newth, C. J. L., & Levison, H. (1981) · The Journal of Pediatrics · doi:10.1016/s0022-3476(81)80354-x · Cited by 139

Circadian variation in the propagation velocity of the migrating motor complex

Kumar, D., Wingate, D. L., & Ruckebusch, Y. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90696-7 · Cited by 135

The Coevolution of Blue-Light Photoreception and Circadian Rhythms

Gehring, W., & Rosbash, M. (2003) · Journal of Molecular Evolution · doi:10.1007/s00239-003-0038-8 · Cited by 132

The importance of circadian rhythms on drug response in hypertension and coronary heart disease—from mice and man

Lemmer, B. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.008 · Cited by 130

Putting its fingers on stressful situations: the heavy metal‐regulatory transcription factor MTF‐1

Lichtlen, P., & Schaffner, W. (2001) · BioEssays · doi:10.1002/bies.1146 · Cited by 126

Transcriptional Feedback Oscillators: Maybe, Maybe Not...

Lakin‐Thomas, P. L. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730405286102 · Cited by 125

Analysis of circadian liver gene expression by ADDER, a highly sensitive method for the display of differentially expressed mRNAs

Kornmann, B. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.e51 · Cited by 119

Circadian changes in the bioavailability and effects of indomethacin in healthy subjects

Clench, J., Reinberg, A., Dziewanowska, Z. E., Ghata, J., & Smolensky, M. H. (1981) · European Journal of Clinical Pharmacology · doi:10.1007/bf00615406 · Cited by 113

Timing optimizes sustained-release indomethacin treatment of osteoarthritis

Lévi, F. A., Louarn, C. L., & Reinberg, A. (1985) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1985.15 · Cited by 113

The influence of light on daily rhythm in hepatic drug metabolizing enzymes in rat

Nair, V., & Casper, R. C. (1969) · Life Sciences · doi:10.1016/0024-3205(69)90033-2 · Cited by 111

Role of Neural Cell Adhesion Molecule and Polysialic Acid in Mouse Circadian Clock Function

Shen, H., Watanabe, M., Tomasiewicz, H. G., Rutishauser, U. S., Magnuson, T., & Glass, J. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05221.1997 · Cited by 111

Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index

Wood, P. A., Du‐Quiton, J., You, S., & Hrushesky, W. J. M. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0177 · Cited by 109

Improved Tumor Control through Circadian Clock Induction by Seliciclib, a Cyclin-Dependent Kinase Inhibitor

Iurisci, I., Filipski, E., Reinhardt, J., Bach, S., Gianella-Borradori, A., Iacobelli, S., Meijer, L., & Lévi, F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2086 · Cited by 105

Aminoglycoside Nephrotoxicity: Modeling, Simulation, and Control

Rougier, F., Claude, D., Maurin, M., Sedoglavic, A., Ducher, M., Corvaisier, S., Jelliffe, R. W., & Maire, P. H. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.3.1010-1016.2003 · Cited by 105

The Role of Checkpoint Kinase 1 in Sensitivity to Topoisomerase I Poisons

Flatten, K. S., Dai, N. T., Vroman, B. T., Loegering, D. A., Erlichman, C., Karnitz, L. M., & Kaufmann, S. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411890200 · Cited by 104

Circadian rhythm of gastric acid secretion in men with active duodenal ulcer

Moore, J. G., & Halberg, F. (1986) · Digestive Diseases and Sciences · doi:10.1007/bf01296516 · Cited by 98

Chronobiology and Anesthesia

Warltier, D. C., CHASSARD, D., & Bruguerolle, B. (2004) · Anesthesiology · doi:10.1097/00000542-200402000-00034 · Cited by 97

A Network of (Autonomic) Clock Outputs

Kalsbeek, A., Perreau‐Lenz, S., & Buijs, R. M. (2006) · Chronobiology International · doi:10.1080/07420520600651073 · Cited by 95

Chronic Treatment with Prednisolone Represses the Circadian Oscillation of Clock Gene Expression in Mouse Peripheral Tissues

Koyanagi, S., Okazawa, S., Kuramoto, Y., Ushijima, K., Shimeno, H., Soeda, S., Okamura, H., & Ohdo, S. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0165 · Cited by 93

Daily coordination of cancer growth and circadian clock gene expression

You, S., Wood, P. A., Xiong, Y., Kobayashi, M., Du‐Quiton, J., & Hrushesky, W. J. M. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-6603-z · Cited by 85

Circadian rhythm of 5-fluorouracil population pharmacokinetics in patients with metastatic colorectal cancer

Bressolle, F., Joulia, J. M., Pinguet, F., Ychou, M., Astre, C., Duffour, J., & Goméni, R. (1999) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050980 · Cited by 79

The Effects of Standard Anthracycline-Based Chemotherapy on Soluble ICAM-1 and Vascular Endothelial Growth Factor Levels in Breast Cancer

Mills, P. J., Parker, B. A., Jones, V. E., Adler, K. A., Perez, C. J., Johnson, S., Cohen‐Zion, M., Marler, M., Sadler, G. R., Dimsdale, J. E., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0734-04 · Cited by 76

The Human PER1 Gene is Inducible by Interleukin-6

Motzkus, D., Albrecht, U., & Maronde, E. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:18:1-2:105 · Cited by 71

Spontaneous or imposed circadian changes in plasma concentrations of 5-fluorouracil coadministered with folinic acid and oxaliplatin: Relationship with mucosal toxicity in patients with cancer

Metzger, G., Massari, C., Étienne-Grimaldi, M.-C., Comisso, M., Touitou, Y., Milano, G. A., Bastian, G., Misset, J. L., & Lévi, F. (1994) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1994.123 · Cited by 69

Electron transfer in human cytochrome P450 reductase

Gutiérrez, A., Grunau, A., Paine, M. J. I., Munro, A. W., Wolf, C. R., Roberts, G. C. K., & Scrutton, N. S. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310497 · Cited by 68

Circadian Changes in the Pharmacokinetics of Oral Ketoprofen

Ollagnier, M., Decousus, H., Cherrah, Y., Lévi, F., Mechkouri, M., Queneau, P., & Reinberg, A. (1987) · Clinical Pharmacokinetics · doi:10.2165/00003088-198712050-00003 · Cited by 65

Daily Cycle of bHLH-PAS Proteins, Ah Receptor and Arnt, in Multiple Tissues of Female Sprague–Dawley Rats

Richardson, V. M., Santostefano, M. J., & Birnbaum, L. S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9634 · Cited by 65

Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice

Filipski, E., King, V. M., Étienne-Grimaldi, M.-C., Li, X., Claustrat, B., Granda, T. G., Milano, G. A., Hastings, M. H., & Lévi, F. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00085.2004 · Cited by 64

Circadian variations in serum levels and the renal toxicity of aminoglycosides in patients

Prins, J. M., Weverling, G. J., Ketel, R. J. V., & Speelman, P. (1997) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(97)90156-9 · Cited by 61

Continuous intravenous infusions of famotidine maintain high intragastric pH in duodenal ulcer.

Merki, H. S., Witzel, L., Kaufman, D., Kempf, M., Neumann, J., Röhmel, J., & Walt, R. P. (1988) · Gut · doi:10.1136/gut.29.4.453 · Cited by 60

Casein Kinase I in the Mammalian Circadian Clock

Eide, E. J., Kang, H., Crapo, S., Gallego, M., & Virshup, D. M. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93019-x · Cited by 59

Chronopharmacology and controlled drug release

Lemmer, B. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2.4.667 · Cited by 57

Circadian variations in the renal toxicity of gentamicin in rats

Pariat, C., Courtois, P., Cambar, J., Piriou, A., & Bouquet, S. (1988) · Toxicology Letters · doi:10.1016/0378-4274(88)90159-2 · Cited by 50

Pharmacologic Modulation of Reduced Glutathione Circadian Rhythms with Buthionine Sulfoximine: Relationship with Cisplatin Toxicity in Mice

Li, X., Metzger, G., Filipski, E., Boughattas, N. A., Lemaigre, G., Hecquet, B., Filipski, J., & Lévi, F. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.8088 · Cited by 50

Light-Induced Phase Shifts in Mice Lacking mPER1 or mPER2

Bae, K., & Weaver, D. R. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403252248 · Cited by 47

Chronopharmacokinetic study of a prolonged release form of indomethacin

Guissou, P. I., Cuisinaud, G., Llorca, G., Lejeune, E., & Sassard, J. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00542219 · Cited by 45

Administration-Time-Dependency of the Pharmacokinetic Behavior and Therapeutic Effect of a Once-A-Day Theophylline in Asthmatic Children

Smolensky, M. H., Scott, P., Harrist, R. B., Hiatt, P., Wong, T., Baenziger, J. C., Klank, B., Marbella, A. M., & Meltzer, A. A. (1987) · Chronobiology International · doi:10.3109/07420528709083532 · Cited by 42

Glutathione Content in Human Bone Marrow and Circadian Stage Relation to DNA Synthesis

Smaaland, R., Svardal, A. M., Lote, K., Ueland, P. M., & Lærum, O. D. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.15.1092 · Cited by 38

Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver

Porsin, B., Formento, J. L., Filipski, E., Etienne, M. C., Francoual, M., Renée, N., Magné, N., Lévi, F., & Milano, G. A. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00598-1 · Cited by 37

Optimal therapeutic level of heparin therapy in patients with venous thrombosis

Hull, R. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.152.8.1589 · Cited by 33

Circadian Rhythm in Dihydropyrimidine Dehydrogenase Activity and Reduced Glutathione Content in Peripheral Blood of Nasopharyngeal Carcinoma Patients

Zeng, Z.-L., Sun, J., Guo, L., Li, S., Wu, M., Qiu, F., Jiang, W., Lévi, F., & Xian, L.-J. (2005) · Chronobiology International · doi:10.1080/07420520500179969 · Cited by 30

Pyrimidine and Purine Analogues, Effects on Cell Cycle Regulation and the Role of Cell Cycle Inhibitors to Enhance Their Cytotoxicity

Sigmond, J., & Peters, G. J. (2005) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770500269556 · Cited by 30

In-vitro circadian rhythm of murine bone marrow progenitor production

Bourin, P., Ledain, A. F., Beau, J., Mille, D., & Lévi, F. (2002) · Chronobiology International · doi:10.1081/cbi-120002677 · Cited by 29

Optimizing the Dosing Schedule of TNP-470 [O-(Chloroacetyl-carbamoyl) Fumagillol] Enhances Its Antitumor and Antiangiogenic Efficacies

Koyanagi, S., Nakagawa, H., Kuramoto, Y., Ohdo, S., Soeda, S., & Shimeno, H. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.043562 · Cited by 29

Relationship Between Circadian Rhythm of Vinorelbine Toxicity and Efficacy in P388-Bearing Mice

Filipski, E., Amat, S., Lemaigre, G., Vincenti, M., Breillout, F., & Lévi, F. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38128-5 · Cited by 28

Circadian rhythm in tolerance of mice for the new anthracycline analog 4′-O-tetrahydropyranyl-adriamycin (THP)

Lévi, F., Mechkouri, M., Roulon, A., Bailleul, F., Lemaigre, G., Reinberg, A., & Mathé, G. (1985) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(85)90022-7 · Cited by 27

Pharmacological effects of vinorelbine on body temperature and locomotor activity circadian rhythms in mice

Li, X., Vincenti, M., & Lévi, F. (2002) · Chronobiology International · doi:10.1081/cbi-120002591 · Cited by 25

Detection of telomerase activity and correlation with mitotic and apoptotic indices, Ki-67 and expression of cyclins D1 and A in cutaneous melanoma

Miracco, C., Pacenti, L., Santopietro, R., BIAGIOLI, M., Fimiani, M., Perotti, R., Rubegni, P., Pirtoli, L., & Luzi, P. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20001101)88:3 · Cited by 23

Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones

Kuramoto, Y., Hata, K., Koyanagi, S., Ohdo, S., Shimeno, H., & Soeda, S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.034 · Cited by 20

Circadian pharmacology of l -alanosine (SDX-102) in mice

Li, X., Kanekal, S., Crépin, D., Guettier, C., Carrière, J., Elliott, G., & Lévi, F. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0332 · Cited by 18

Temporal variations in the erythrocyte permeability to bupivacaine,etidocaine and mepivacaine in mice

Bruguerolle, B., & Prat, M. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90243-9 · Cited by 16

Introduction

(2006) · Springer eBooks · doi:10.1007/3-540-27789-7_1 · Cited by 16

Phosphorylation of mCRY2 at Ser557 in the Hypothalamic Suprachiasmatic Nucleus of the Mouse

Kurabayashi, N., Hirota, T., Harada, Y., Sakai, M., & Fukada, Y. (2006) · Chronobiology International · doi:10.1080/07420520500464478 · Cited by 15

Statin response and pharmacokinetics variants

Kajinami, K., Masuya, H., Hoshiba, Y., Takeda, K., Sato, R., Okabayashi, M., & Schaefer, E. J. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.8.1291 · Cited by 14

Circadian clocks go in vitro: purely post‐translational oscillators in cyanobacteria

Naef, F. (2005) · Molecular Systems Biology · doi:10.1038/msb4100027 · Cited by 14

Japanese single nucleotide polymorphism database for 267 possible drug‐related genes

Iida, A., Saito, S., Sekine, A., Takahashi, A., Kamatani, N., & Nakamura, Y. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2006.00142.x · Cited by 11

Circadian Rhythm in the Membrane of Circulating Human Blood Cells: Microviscosity and Number of Benzodiazepine Binding Sites. A Search for Regulation by Plasma Ions, Nucleosides, Proteins or Hormones

Lévi, F., Reinberg, A., Fur, G. L., Gueremy, C., Uzan, A., Bénavidès, J., Quarteronet, D., Canton, T., Touitou, Y., Auzéby, A., et al. (1987) · Chronobiology International · doi:10.3109/07420528709078530 · Cited by 9

Chronopharmacologic Effects of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) on Hematopoiesis in Mice

Li, X., & Lévi, F. A. (1999) · Biological Rhythm Research · doi:10.1076/brhm.30.3.339.3049 · Cited by 2

A circadian gene expression atlas in mammals: Implications for biology and medicine

Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304

The genetics of mammalian circadian order and disorder: implications for physiology and disease

Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611

Haematopoietic stem cell release is regulated by circadian oscillations

Méndez‐Ferrer, S., Lucas, D., Battista, M., & Frenette, P. S. (2008) · Nature · doi:10.1038/nature06685 · Cited by 1,310

Circadian control of the immune system

Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135

Physiology of Circadian Entrainment

Golombek, D. A., & Rosenstein, R. E. (2010) · Physiological Reviews · doi:10.1152/physrev.00009.2009 · Cited by 1,169

Crosstalk between xenobiotics metabolism and circadian clock

Claudel, T., Cretenet, G., Saumet, A., & Gachon, F. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.009 · Cited by 76

187 REVIEW Circadian clocks: regulators of endocrine and metabolic rhythms

Hastings, M. H., O'Neill, J. S., & Maywood, E. S. (2013)

Circadian Regulation of the Hepatic Endobiotic and Xenobitoic Detoxification Pathways: The Time Matters

Zmrzljak, U. P., & Rozman, D. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200538r · Cited by 97

Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action☆

Sukumaran, S., Almon, R. R., DuBois, D. C., & Jusko, W. J. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.009 · Cited by 163

Circadian clocks: regulators of endocrine and metabolic rhythms

Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426