Cited by 645Circadian rhythm and melatoninPharmacogenetics and Drug MetabolismSleep and Work-Related Fatigue

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Circadian Rhythms: Mechanisms and Therapeutic Implications

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Levi, Francis, Schibler, Ueli·2007·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev.pharmtox.47.120505.105208

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Abstract

The mammalian circadian system is organized in a hierarchical manner in that a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes cellular circadian oscillators in most peripheral body cells. Fasting-feeding cycles accompanying rest-activity rhythms are the major timing cues in the synchronization of many, if not most, peripheral clocks, suggesting that the temporal coordination of metabolism and proliferation is a major task of the mammalian timing system. The inactivation of noxious food components by hepatic, intestinal, and renal detoxification systems is among the metabolic processes regulated in a circadian manner, with the understanding of the involved clock output pathways emerging. The rhythmic control of xenobiotic detoxification provides the molecular basis for the dosing time-dependence of drug toxicities and efficacy. This knowledge can in turn be used in improving or designing chronotherapeutics for the patients who suffer from many of the major human diseases.

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Authors: Levi, F., & Schibler, U.
Affiliations: INSERM U776, Unité de Chronothérapie, Service de Cancérologie, Hôpital Paul Brousse et Université Paris XI, 94800 Villejuif, France;
University of Geneva (CH)
ORCID: Schibler, Ueli
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2007-02-01
Volume: 47
Issue: 1
Pages: 593-628
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev.pharmtox.47.120505.105208
OpenAlex: W2126157274
Cited by: 645
References: 156
Citations by year: 2026: 25 · 2025: 20 · 2024: 28 · 2023: 31 · 2022: 23 · 2021: 38 · 2020: 43 · 2019: 23 · 2018: 21 · 2017: 23 · 2016: 34 · 2015: 27 · 2014: 49 · 2013: 43 · 2012: 42
FWCI: 5.11
Type: journal article
Language: en
Open access: green
archive-ouverte.unige.ch
Licence: cc-by
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian rhythm, suprachiasmatic nucleus, circadian clock, peripheral oscillators, rest-activity rhythm, xenobiotic detoxification, drug toxicity, timing of drug administration, chronotherapy, metabolism, proliferation
MeSH terms: Animals, Biological Clocks, Circadian Rhythm, Humans, Inactivation, Metabolic, Suprachiasmatic Nucleus, Drug Design, Xenobiotics, Drug Delivery Systems, Chronotherapy

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Circadian Rhythms: Mechanisms and Therapeutic Implications

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