The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Regulation of Endothelial Nitric Oxide Synthase: Location, Location, Location
Abstract
▪ Abstract Endothelial nitric oxide synthase (eNOS) is expressed in vascular endothelium, airway epithelium, and certain other cell types where it generates the key signaling molecule nitric oxide (NO). Diminished NO availability contributes to systemic and pulmonary hypertension, atherosclerosis, and airway dysfunction. Complex mechanisms underly the cell specificity of eNOS expression, and co- and post-translational processing leads to trafficking of the enzyme to plasma membrane caveolae. Within caveolae, eNOS is the downstream target member of a signaling complex in which it is functionally linked to both typical G protein-coupled receptors and less typical receptors such as estrogen receptor (ER) α and the high-density lipoprotein receptor SR-BI displaying novel actions. This compartmentalization facilitates dynamic protein-protein interactions and calcium- and phosphorylation-dependent signal transduction events that modify eNOS activity. Further understanding of these mechanisms will enable us to take preventive and therapeutic advantage of the powerful actions of NO in multiple cell types.
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Cites
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The L-Arginine-Nitric Oxide Pathway
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Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin
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Cited by
Kohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178
Nitric oxide in health and disease of the respiratory system
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
Mount, P. F., Kemp, B. E., & Power, D. A. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.05.023 · Cited by 498
Balligand, J.-L., Feron, O., & Dessy, C. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2007 · Cited by 477
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Metadata
- Authors
- Shaul, P. W.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2002-03
- Volume
- 64
- Issue
- 1
- Pages
- 749-774
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2106181213
- Cited by
- 541
- References
- 8
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shaul, P. W. (2002). Regulation of Endothelial Nitric Oxide Synthase: Location, Location, Location. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.64.081501.155952
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
