The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Regulation of Receptor Trafficking by GRKs and Arrestins
Abstract
To ensure that extracellular stimuli are translated into intracellular signals of appropriate magnitude and specificity, most signaling cascades are tightly regulated. One of the major mechanisms involved in the regulation of G protein–coupled receptors (GPCRs) involves their endocytic trafficking. GPCR endocytic trafficking entails the targeting of receptors to discrete endocytic sites at the plasma membrane, followed by receptor internalization and intracellular sorting. This regulates the level of cell surface receptors, the sorting of receptors to degradative or recycling pathways, and in some cases the specific signaling pathways. In this chapter we discuss the mechanisms that regulate receptor endocytic trafficking, emphasizing the role of GPCR kinases (GRKs) and arrestins in this process.
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Cites
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Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
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Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor
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ARH Is a Modular Adaptor Protein That Interacts with the LDL Receptor, Clathrin, and AP-2
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Irannejad, R., Tomshine, J. C., Tomshine, J. R., Chevalier, M., Mahoney, J. P., Steyaert, J., Rasmussen, S. G. F., Sunahara, R. K., El-Samad, H., Huang, B., et al. (2013) · Nature · doi:10.1038/nature12000 · Cited by 819
An atlas of substrate specificities for the human serine/threonine kinome
Johnson, J. L., Yaron, T. M., Huntsman, E. M., Kerelsky, A., Song, J., Regev, A., Lin, T.-Y., Liberatore, K., Cizin, D. M., Cohen, B. M., et al. (2023) · Nature · doi:10.1038/s41586-022-05575-3 · Cited by 728
Regulation of Clathrin-Mediated Endocytosis
Mettlen, M., Chen, P.-H., Srinivasan, S., Danuser, G., & Schmid, S. L. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012644 · Cited by 614
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Labeling and Single-Molecule Methods To Monitor G Protein-Coupled Receptor Dynamics
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Evidence for the role of corticotropin-releasing factor in major depressive disorder
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Huang, M., Celniker, A. F., Chitsazi, R., Dyer, D. P., Jansma, A. L., Kufareva, I., Salanga, C. L., & Handel, T. M. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110736 · Cited by 1
Metadata
- Authors
- Moore, C. A. C., Milano, S. K., & Benovic, J. L.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2007-03-01
- Volume
- 69
- Issue
- 1
- Pages
- 451-482
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2119398013
- Cited by
- 676
- References
- 5
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
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