The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Open accessAbstract
The psychology of extinction has been studied for decades. Approximately 10 years ago, however, there began a concerted effort to understand the neural circuits of extinction of fear conditioning, in both animals and humans. Progress during this period has been facilitated by a high degree of coordination between rodent and human researchers examining fear extinction. Here we review the major advances and highlight new approaches to understanding and exploiting fear extinction. Research in fear extinction could serve as a model for translational research in other areas of behavioral neuroscience.
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In the citing paper
“A closely related domain of research on conditioning and extinction in both rodents and humans also suggests that ventromedial PFC (vmPFC), an area neighboring rACC, supports extinction while cACC supports increased aversive processing (Milad and Quirk, 2012; see Figure 7).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Milad and Quirk, 2012
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In the citing paper
“The vmPFC is proposed to be the homologue for the IL in rodents [87] and serves to inhibit threat responses produced by the amygdala.”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [87]
The cited source says what the claim attributes to it.
In the citing paper
“The vmPFC is thought to modulate amygdala processing of conditioned fear by suppressing fear responses through a set of amygdala neurons in the intercalated region between the basolateral and central amygdala nucleus (Milad and Quirk, 2012).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Milad and Quirk, 2012
In the citing paper
“The vmPFC is activated during retrieval of extinction learning and down-regulates the amygdala”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as Milad and Quirk, 2012
In the citing paper
“Therefore, in PTSD, there is both hyperactivation of the fear expression and hypoactivation of the extinction memory networks [59, 60].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“However, rather than erasing the CS-US association, extinction represents formation of a new memory, an “extinction memory,” signifying “CS-no US,” that competitively inhibits the memory of the CS-US contingency and expression of its associated CR when the CS is again encountered [51–59].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“A deficit in the ability to encode, consolidate, or retrieve extinction memory is believed to play a role in the development and perpetuation of such disorders [6, 59, 61, 87].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“Neuroimaging research using de novo fear-conditioning and extinction paradigms has revealed areas in the brain associated with experiencing conditioned fear (a “fear expression network”) in the amygdala and dorsal anterior cingulate cortex (dACC) and other areas associated with memory for the extinction (inhibition) of this fear (an “extinction memory network”) that includes the hippocampus and”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“Brain circuitry at the core of threat discrimination learning includes areas within the amygdala and medial prefrontal cortex (mPFC)1.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
In the citing paper
“During threat extinction training, the CS is presented without the aversive outcome, which results in reduced amygdala responses to the CS over time3, with the mPFC playing a critical role1,4,5.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
In the citing paper
“During threat extinction training, the CS is presented without the aversive outcome, which results in reduced amygdala responses to the CS over time3, with the mPFC playing a critical role1,4,5.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
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Citations
Cites
Items 201–230 of 230
Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice
Goddyn, H., Callaerts‐Vegh, Z., Stroobants, S., Dirikx, T., Vansteenwegen, D., Hermans, D., van der Putten, H., & D’Hooge, R. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.01.001 · Cited by 70
Teich, A. H., McCabe, P. M., Gentile, C. G., Schneiderman, L. S., Winters, R. W., Liskowsky, D. R., & Schneiderman, N. (1989) · Brain Research · doi:10.1016/0006-8993(89)91584-9 · Cited by 69
Augmentation of Cognitive Behavioral Therapy with Pharmacotherapy
Ganasen, K. A., Ipser, J., & Stein, D. J. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.04.008 · Cited by 68
Maeng, L. Y., Waddell, J., & Shors, T. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2265-10.2010 · Cited by 65
Learning-related diminution of unconditioned SCR and fMRI signal responses
Knight, D. C., Waters, N. S., King, M. K., & Bandettini, P. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.07.012 · Cited by 65
Methods for developmental studies of fear conditioning circuitry
Pine, D. S., Fyer, A., Grun, J., Phelps, E. A., Szeszko, P. R., Koda, V., Li, W., Ardekani, B., Maguire, E. A., Burgess, N., et al. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01159-3 · Cited by 62
Contextual fear conditioning differs for infant, adolescent, and adult rats
Esmorís-Arranz, F. J., Méndez, C., & Spear, N. E. (2008) · Behavioural Processes · doi:10.1016/j.beproc.2008.01.010 · Cited by 58
Kaczorowski, C. C., Davis, S. J., & Moyer, J. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.020 · Cited by 58
Angenstein, F., Kammerer, E., & Scheich, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5015-08.2009 · Cited by 58
Central injections of arginine vasopressin prolong extinction of active avoidance
Koob, G. F., Dantzer, R., Bluthé, R.-M., Lebrun‐Frénay, C., Bloom, F. E., & Moal, M. L. (1986) · Peptides · doi:10.1016/0196-9781(86)90215-9 · Cited by 57
Modulation of auditory neural responses by a visual context in human fear conditioning
Armony, J. L., & Dolan, R. J. (2001) · Neuroreport · doi:10.1097/00001756-200110290-00051 · Cited by 56
Avoidance, operant and locomotor behavior in rats with neostriatal injections of kainic acid
Sanberg, P. R., Pisa, M., & Fibiger, H. C. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90179-5 · Cited by 54
Histamine facilitates consolidation of fear extinction
Bonini, J. S., da Silva, W. C. F. N., da Silveira, C. K. B., Köhler, C. A., Izquierdo, I., & Cammarota, M. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001501 · Cited by 49
Impact of predatory threat on fear extinction in Lewis ratsPreprint
Goswami, S., Cascardi, M. A., Rodríguez-Sierra, O. E., Duvarci, S., & Paré, D. (2010) · Learning & Memory · doi:10.1101/lm.1948910 · Cited by 43
Herry, C., & Garcia, R. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.017 · Cited by 41
Memory of fearful events: the role of fibroblast growth factor-2 in fear acquisition and extinction
Graham, B. M., & Richardson, R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.041 · Cited by 39
Falls, W. A., & Davis, M. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90504-b · Cited by 37
Protein synthesis inhibition and memory for pole jump active avoidance and extinction
Flood, J. F., Jarvik, M. E., Bennett, E. L., Orme, A. E., & Rosenweig, M. R. (1977) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(77)90013-2 · Cited by 33
Linnman, C., Zeidan, M. A., Pitman, R. K., & Milad, M. R. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.12.012 · Cited by 33
Self-citationOntogeny of active avoidance in the rat: Learning and memory
Mysliveček, J., & Hassmannová, J. (1979) · Developmental Psychobiology · doi:10.1002/dev.420120209 · Cited by 29
Interaction of brain noradrenaline and the pituitary-adrenal axis in learning and extinction
Mason, S. T., Roberts, D. C. S., & Fibiger, H. C. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90161-8 · Cited by 28
Human Fear Conditioning Conducted in Full Immersion 3-Dimensional Virtual Reality
Huff, N. C., Zeilinski, D. J., Fecteau, M. E., Brady, R. B., & LaBar, K. S. (2010) · Journal of Visualized Experiments · doi:10.3791/1993 · Cited by 25
Impaired fear extinction in mice lacking protease nexin‐1
Meins, M., Herry, C., Müller, C., Ciocchi, S., Moreno, E., Lüthi, A., & Monard, D. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07221.x · Cited by 25
Disinhibition of Inhibitory Conditioned Responses following Selective Brain Lesions in Dogs
Brutkowski, S., & Mempel, E. (1961) · Science · doi:10.1126/science.134.3495.2040 · Cited by 22
Hormonal dissociation of limbic lesion effects on shuttle box avoidance in rats.
Lovely, R. H. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0076807 · Cited by 19
Deschaux, O., Thevenet, A., Spennato, G., Arnaud, C., Moreau, J., & Garcia, R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.067 · Cited by 17
Kokkinidis, L. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90333-7 · Cited by 12
Brennan, J. F., & Wisniewski, C. (1982) · Behavioural Brain Research · doi:10.1016/0166-4328(82)90068-7 · Cited by 8
Rezai, A. R., Gabriëls, L., Greenberg, B. D., Malone, D. A., Friehs, G. M., Foote, K. D., Machado, A. G., Okun, M. S., Shapira, N. A., Cosyns, P. R., et al. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/108/04/a621 · Cited by 5
Gralewicz, K., & Gralewicz, S. (1984) · PubMed · Cited by 1
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The Neuroscience of Mindfulness Meditation
Tang, Y.-Y., Hölzel, B. K., & Posner, M. I. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3916 · Cited by 2,889
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547
Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529
Self-citationMcLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.012 · Cited by 1,389
“, 2004), and increased vmPFC activity during such recall is associated with dampened amygdala activity (Milad et al., 2007, 2009; Milad and Quirk, 2012).”
BackgroundUsing Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework
LeDoux, J. E., & Pine, D. S. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16030353 · Cited by 1,035
Metadata
- Authors
- Milad, M. R., & Quirk, G. J.
- Affiliations
- Harvard University (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Venue
- Annual Review of Psychology
- Publisher
- Annual Reviews
- Published
- 2012-01-10
- Volume
- 63
- Issue
- 1
- Pages
- 129-151
- ISSN
- 0066-4308 (ISSN-L)
- 1545-2085
- PMC
- PMC4942586
- OpenAlex
- W2160253364
- Semantic Scholar
- 3e1b47b5a0d8ab9823c918aa6f6ce64eb2eba033
- Cited by
- 1,466
- References
- 228
- Citations by year
- 2026: 105 · 2025: 96 · 2024: 80 · 2023: 96 · 2022: 110 · 2021: 114 · 2020: 131 · 2019: 120 · 2018: 109 · 2017: 102 · 2016: 100 · 2015: 105 · 2014: 88 · 2013: 73 · 2012: 36
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50mh086400-05, 5r01mh081975-05)
- National Institute of Mental Health (P-50-MH-086400, K01-MH08036, R01-MH081975, R01MH058883, K01MH080346)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fear extinction, fear conditioning, neural circuits, translational neuroscience, psychobiology, anxiety disorders
- MeSH terms
- Brain, Conditioning, Psychological, Extinction, Psychological, Fear, Humans, Magnetic Resonance Imaging, Neurosciences
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