Cited by 62Memory and Neural MechanismsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology Studies

Methods for developmental studies of fear conditioning circuitry

Pine, Daniel S, Fyer, Abby, Grun, Joseph, Phelps, Elizabeth A, Szeszko, Philip R, Koda, Vivian, Li, Wei, Ardekani, Babak +3 more·2001·Biological Psychiatry

Abstract

Psychophysiologic studies use air puff as an aversive stimulus to document abnormal fear conditioning in children of parents with anxiety disorders. This study used functional magnetic resonance imaging (fMRI) to examine changes in amygdala activity during air-puff conditioning among adults. Blood oxygen level-dependent (BOLD) signal was monitored in seven adults during 16 alternating presentations of two different colored lights (CS+ vs. CS-), one of which was consistently paired with an aversive air puff. A region-of-interest analysis demonstrated differential change in BOLD signal in the right but not left amygdala across CS+ versus CS- viewing. The amygdala is engaged by pairing of a light with an air puff. Given that prior studies relate air-puff conditioning to risk for anxiety in children, these methods may provide an avenue for directly studying the developmental neurobiology of fear conditioning.

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Crossref · 10.1016/s0006-3223(01)01159-3

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Authors
Pine, D. S., Fyer, A., Grun, J., Phelps, E. A., Szeszko, P. R., Koda, V., Li, W., Ardekani, B., Maguire, E. A., Burgess, N., & Bilder, R. M.
Affiliations
  • National Institute of Mental Health (US)
  • New York State Psychiatric Institute (US)
  • New York University (US)
  • Northwell Health (US)
  • UCL Queen Square Institute of Neurology (GB)
  • University College London (GB)
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2001-08
Volume
50
Issue
3
Pages
225-228
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2125038211
Cited by
62
References
25
Citations by year
2025: 1 · 2023: 1 · 2020: 2 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
2.10
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
National Institute of Mental Health (MH01391, K08MH001391)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
fear conditioning, amygdala, air puff, aversive conditioning, BOLD signal, right amygdala, anxiety risk, developmental neuroscience, functional MRI
MeSH terms
Adult, Amygdala, Anxiety Disorders, Conditioning, Classical, Fear, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen

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