Methods for developmental studies of fear conditioning circuitry
Abstract
Psychophysiologic studies use air puff as an aversive stimulus to document abnormal fear conditioning in children of parents with anxiety disorders. This study used functional magnetic resonance imaging (fMRI) to examine changes in amygdala activity during air-puff conditioning among adults. Blood oxygen level-dependent (BOLD) signal was monitored in seven adults during 16 alternating presentations of two different colored lights (CS+ vs. CS-), one of which was consistently paired with an aversive air puff. A region-of-interest analysis demonstrated differential change in BOLD signal in the right but not left amygdala across CS+ versus CS- viewing. The amygdala is engaged by pairing of a light with an air puff. Given that prior studies relate air-puff conditioning to risk for anxiety in children, these methods may provide an avenue for directly studying the developmental neurobiology of fear conditioning.
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Findings of greater adolescent amygdala activation to fearful faces are not ubiquitous.
“These findings, however, are not ubiquitous”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Pine et al, 2001
These findings are not ubiquitous.
“These findings, however, are not ubiquitous (see Pine et al, 2001; Thomas et al, 2001b; McClure et al, 2004; Deeley et al, 2008)”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Pine et al, 2001
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- Authors
- Pine, D. S., Fyer, A., Grun, J., Phelps, E. A., Szeszko, P. R., Koda, V., Li, W., Ardekani, B., Maguire, E. A., Burgess, N., & Bilder, R. M.
- Affiliations
- National Institute of Mental Health (US)
- New York State Psychiatric Institute (US)
- New York University (US)
- Northwell Health (US)
- UCL Queen Square Institute of Neurology (GB)
- University College London (GB)
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 50
- Issue
- 3
- Pages
- 225-228
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2125038211
- Cited by
- 62
- References
- 25
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 2 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute of Mental Health (MH01391, K08MH001391)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- fear conditioning, amygdala, air puff, aversive conditioning, BOLD signal, right amygdala, anxiety risk, developmental neuroscience, functional MRI
- MeSH terms
- Adult, Amygdala, Anxiety Disorders, Conditioning, Classical, Fear, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen
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