CoChat
Sign Up
Cited by 41Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Behavioral and paired-pulse facilitation analyses of long-lasting depression at excitatory synapses in the medial prefrontal cortex in mice

Herry, Cyril, Garcia, René·2003·Behavioural Brain Research
DOI 10.1016/j.bbr.2003.09.017
Open this paper in CoChat — free account

Abstract

Accumulative evidence indicates that acute (before extinction) and long-lasting (during extinction) depression can occur at excitatory synapses in mouse medial prefrontal cortex (mPFC) during re-exposure to a tone (conditioned stimulus: CS), previously paired with footshock (unconditioned stimulus: US). As recently shown, the long-term depression (LTD)-like plasticity in the mPFC does not interfere with extinction of CS-evoked freezing but predicts spontaneous recovery of this fear response. Here, the objectives were to investigate: (i). whether a resistance to extinction without any prefrontal acute synaptic plasticity could produce LTD-like changes, and (ii). by the use of paired-pulse facilitation (PPF) analyses, whether pre- or post-synaptic mechanisms were involved in this LTD phenomenon. Preliminary analyses indicated that levels of acute depression did not correlate with the degree of fear acquisition (effects of number of CS-US pairings). As a consequence, mice conditioned with 2CS+ or 2CS+/2CS- (partial reinforcement of the CS known to induce resistance to extinction) exhibited CS-associated freezing without any acute synaptic depression in the mPFC. However, during further CS-alone presentations, the 2CS+/2CS- group developed LTD-like changes that accompanied their resistance to extinguish freezing to the CS. In contrast, the 2CS+ group normally extinguished their conditioned freezing with synaptic transmission remaining at baseline levels. PPF analyses revealed that facilitation was unchanged following prefrontal LTD. These data, combined with our previous findings, (i). support a critical involvement of prefrontal LTD-like changes in spontaneous recovery of fear responses, and (ii). suggest a post-synaptic site for these changes.

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2003.09.017

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The prefrontal cortex is critically involved in the retention of extinction of learned fear in adult humans and rodents.

    “Given that the PFC is critically involved in retention of extinction of learned fear in adult humans and rodents, the present study examined whether adolescent rats exhibit impaired extinction retention.”

    From Impaired Extinction Retention in Adolescent Rats: Effects of D-Cycloserine (2010) · cites this paper as Herry and Garcia, 2003

  • Depression of prefrontal cortex synaptic efficacy impairs extinction retention.

    “but it does impair extinction retention (Herry and Garcia, 2003).”

    From Impaired Extinction Retention in Adolescent Rats: Effects of D-Cycloserine (2010) · cites this paper as Herry and Garcia, 2003

  • The medial prefrontal cortex is critically involved in extinction of learned fear in postweaning and adult rats.

    “but is critically involved in postweaning and adult rats (Herry and Garcia, 2003;Kim et al, 2009).”

    From Impaired Extinction Retention in Adolescent Rats: Effects of D-Cycloserine (2010) · cites this paper as Herry and Garcia, 2003

  • The prefrontal cortex is critical for extinction retention.

    “This hypothesis was based on evidence that PFC (1) is critical for extinction retention (Herry and Garcia, 2003;Quirk et al, 2000;Milad and Quirk, 2002)”

    From Impaired Extinction Retention in Adolescent Rats: Effects of D-Cycloserine (2010) · cites this paper as Herry and Garcia, 2003

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Herry, C., & Garcia, R.
Affiliations
Centre National de la Recherche Scientifique (FR)
ORCID
Herry, Cyril
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2003-11
Volume
146
Issue
1-2
Pages
89-96
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2003.09.017
OpenAlex
W1972144339
Cited by
41
References
25
Citations by year
2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 4
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
long-term depression, medial prefrontal cortex, fear extinction, paired-pulse facilitation, excitatory synapses, synaptic plasticity, conditioned freezing, footshock, partial reinforcement, extinction resistance
MeSH terms
Animals, Behavior, Animal, Conditioning, Psychological, Electric Stimulation, Electrophysiology, Fear, Immobilization, Male, Mice, Inbred C57BL, Neural Inhibition, Reaction Time, Synapses, Time Factors, Prefrontal Cortex, Long-Term Synaptic Depression, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review