Cited by 288Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsAlzheimer's disease research and treatments

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

White Matter Damage in Alzheimer Disease and Its Relationship to Gray Matter Atrophy

Abstract

PURPOSE: To explore the regional patterns of white matter (WM) tract damage in (a) patients with probable Alzheimer disease (AD) and (b) patients with amnestic mild cognitive impairment (aMCI) and at least one abnormal biomarker and to investigate whether WM damage is related to gray matter (GM) atrophy. MATERIALS AND METHODS: This study was approved by the institutional review board, and written informed consent was obtained from each participant. Twenty-three patients with AD, 15 patients with aMCI, and 15 healthy control subjects underwent diffusion tensor magnetic resonance imaging. WM tract damage was investigated by using tract-based spatial statistics, and GM atrophy was measured by using voxel-based morphometry. RESULTS: Compared with control subjects, patients with AD had an increase in mean diffusivity in all major WM tracts studied, including the limbic, cortico-cortical, interhemispheric, and corticospinal tracts. Conversely, fractional anisotropy decreased only in the parahippocampal tract, fornix, and small, inferior parietal regions. In addition, patients with AD showed a widespread increase in axial and radial diffusivity compared with control subjects. Patients with aMCI showed an increase in axial diffusivity only in tracts projecting to the frontal cortex and splenium of the corpus callosum. Significant and anatomically congruent correlations between WM changes and regional GM atrophy were found in patients with AD. Conversely, damage to most WM tracts in patients with aMCI did not correlate with GM atrophy. CONCLUSION: In AD, the observed patterns of WM abnormalities may reflect the advanced phase of a secondary degenerative process and an association, especially in the early phases of the disease, with primary WM tract damage over and above GM abnormalities.

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Crossref · 10.1148/radiol.10101284

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Research works printed but not linked: 7

  1. Salat DH, Neurobiol Aging
  2. Stenset V, Neurobiol Aging
  3. Barigazzi R, 1987, Ric Psicol, 1, 50
  4. Novelli G, 1986, Arch Psicol Neurol Psichiatr, 47, 477
  5. Spinnler H, 1987, Ital J Neurol Sci, 6, 1
  6. Ferreira LK, Neurobiol Aging
  7. Pievani M, Hum Brain Mapp

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Metadata

Authors
Agosta, F., Pievani, M., Sala, S., Geroldi, C., Galluzzi, S., Frisoni, G. B., & Filippi, M.
Affiliations
  • IRCCS Ospedale San Raffaele (IT)
  • Centro San Giovanni di Dio Fatebenefratelli (IT)
  • Vita-Salute San Raffaele University (IT)
Venue
Radiology
Published
2011-03
Volume
258
Issue
3
Pages
853-863
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
OpenAlex
W2168463796
Cited by
288
References
53
Citations by year
2026: 8 · 2025: 13 · 2024: 12 · 2023: 21 · 2022: 11 · 2021: 17 · 2020: 24 · 2019: 14 · 2018: 17 · 2017: 11 · 2016: 27 · 2015: 25 · 2014: 19 · 2013: 26 · 2012: 26
FWCI
14.96
Type
journal article
Language
en
Open access
closed
Locations
  • Radiology (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, white matter injury, gray matter atrophy, amnestic mild cognitive impairment, diffusion tensor imaging, mean diffusivity, fractional anisotropy, axial and radial diffusivity, white matter tracts, corticospinal tract, fornix, corpus callosum, tract-based spatial statistics, voxel-based morphometry
MeSH terms
Aged, Alzheimer Disease, Atrophy, Cognition Disorders, Female, Humans, Male, Nerve Fibers, Myelinated, Neuropsychological Tests, Prospective Studies, Biomarkers, Case-Control Studies, Statistics, Nonparametric, Diffusion Magnetic Resonance Imaging

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