The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
White Matter Damage in Alzheimer Disease and Its Relationship to Gray Matter Atrophy
Abstract
PURPOSE: To explore the regional patterns of white matter (WM) tract damage in (a) patients with probable Alzheimer disease (AD) and (b) patients with amnestic mild cognitive impairment (aMCI) and at least one abnormal biomarker and to investigate whether WM damage is related to gray matter (GM) atrophy. MATERIALS AND METHODS: This study was approved by the institutional review board, and written informed consent was obtained from each participant. Twenty-three patients with AD, 15 patients with aMCI, and 15 healthy control subjects underwent diffusion tensor magnetic resonance imaging. WM tract damage was investigated by using tract-based spatial statistics, and GM atrophy was measured by using voxel-based morphometry. RESULTS: Compared with control subjects, patients with AD had an increase in mean diffusivity in all major WM tracts studied, including the limbic, cortico-cortical, interhemispheric, and corticospinal tracts. Conversely, fractional anisotropy decreased only in the parahippocampal tract, fornix, and small, inferior parietal regions. In addition, patients with AD showed a widespread increase in axial and radial diffusivity compared with control subjects. Patients with aMCI showed an increase in axial diffusivity only in tracts projecting to the frontal cortex and splenium of the corpus callosum. Significant and anatomically congruent correlations between WM changes and regional GM atrophy were found in patients with AD. Conversely, damage to most WM tracts in patients with aMCI did not correlate with GM atrophy. CONCLUSION: In AD, the observed patterns of WM abnormalities may reflect the advanced phase of a secondary degenerative process and an association, especially in the early phases of the disease, with primary WM tract damage over and above GM abnormalities.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Such white matter alterations cannot be fully accounted for as degenerative processes secondary to grey matter damage (Brun and Englund, 1986; Englund, 1998; Agosta et al., 2011), but may stem from vascular amyloid deposition and microvascular damage (Weller et al., 2009).”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Agosta et al., 2011
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 8,167
A fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122
Ashburner, J., & Friston, K. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.018 · Cited by 7,507
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen‐Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,598
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411
Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo
Basser, P. J., Mattiello, J., & Bihan, D. L. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1037 · Cited by 3,656
Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582
THE TOKEN TEST: A SENSITIVE TEST TO DETECT RECEPTIVE DISTURBANCES IN APHASICS
Renzi, E. D., & Vignolo, L. A. (1962) · Brain · doi:10.1093/brain/85.4.665 · Cited by 1,868
A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT
Wahlund, L., Barkhof, F., Fazekas, F., Bronge, L., Augustin, M., Sjögren, M., Wallin, A., Adèr, H., Leys, D., Pantoni, L., et al. (2001) · Stroke · doi:10.1161/01.str.32.6.1318 · Cited by 1,838
Carlesimo, G. A., Caltagirone, C., Gainotti, G., Fadda, L., Gallassi, R., Lorusso, S., Marfia, G. A., Marra, C., Nocentini, U., & Parnetti, L. (2008) · European Neurology · doi:10.1159/000117297 · Cited by 1,234
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.8.7.271-276 · Cited by 1,088
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014
Water diffusion changes in wallerian degeneration and their dependence on white matter architecture
Pierpaoli, C., Barnett, A., Pajevic, S., Chen, R., Penix, L., Virta, A., & Basser, P. (2001) · NeuroImage · doi:10.1006/nimg.2001.0765 · Cited by 938
Rey-Osterrieth complex figure: normative values in an Italian population sample
Caffarra, P., Vezzadini, G., Dieci, F., Zonato, F., & Venneri, A. (2002) · Neurological Sciences · doi:10.1007/s100720200003 · Cited by 726
Whitwell, J. L., Przybelski, S. A., Weigand, S. D., Knopman, D. S., Boeve, B. F., Petersen, R. C., & Jack, C. R. (2007) · Brain · doi:10.1093/brain/awm112 · Cited by 607
Bozzali, M. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.742 · Cited by 568
White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study
Medina, D., deToledo-Morrell, L., Urresta, F., Gabrieli, J. D. E., Moseley, M., Fleischman, D., Bennett, D. A., Leurgans, S., Turner, D. A., & Stebbins, G. T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.026 · Cited by 492
Evans, D. A., Hebert, L. E., Beckett, L. A., Scherr, P. A., Albert, M. S., Chown, M. J., Pilgrim, D. M., & Taylor, J. O. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550230066019 · Cited by 435
The role of diffusion tensor imaging in the evaluation of ischemic brain injury – a review
Sotak, C. H. (2002) · NMR in Biomedicine · doi:10.1002/nbm.786 · Cited by 433
Absolute diffusivities define the landscape of white matter degeneration in Alzheimer’s disease
Acosta-Cabronero, J., Williams, G. B., Pengas, G., & Nestor, P. J. (2010) · Brain · doi:10.1093/brain/awp257 · Cited by 393
Villain, N., Desgranges, B., Viader, F., de la Sayette, V., Mezenge, F., Landeau, B., Baron, J.-C., Eustache, F., & Chetelat, G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1392-08.2008 · Cited by 366
White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
Zhang, Y., Schuff, N., Du, A.-T., Rosen, H. J., Kramer, J. H., Gorno-Tempini, M. L., Miller, B. L., & Weiner, M. W. (2009) · Brain · doi:10.1093/brain/awp071 · Cited by 356
Stricker, N. H., Schweinsburg, B. C., Delano‐Wood, L., Wierenga, C. E., Bangen, K. J., Haaland, K. Y., Frank, L. R., Salmon, D. P., & Bondi, M. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.027 · Cited by 318
White matter pathology isolates the hippocampal formation in Alzheimer's disease
Salat, D. H., Tuch, D. S., van der Kouwe, A. J. W., Greve, D. N., Pappu, V., Lee, S. Y., Hevelone, N. D., Zaleta, A. K., Growdon, J. H., Corkin, S., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.013 · Cited by 279
Fellgiebel, A., Müller, M. J., Wille, P. R., Dellani, P. R., Scheurich, A., Schmidt, L., & Stoeter, P. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.11.006 · Cited by 266
Thompson, P. M., Hayashi, K. M., Dutton, R. A., Chiang, M., Leow, A., Sowell, E. R., de Zubicaray, G. I., Becker, J. T., López, O. L., Aizenstein, H. J., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.017 · Cited by 259
White matter tract integrity in aging and Alzheimer's disease
Damoiseaux, J. S., Smith, S. M., Witter, M. P., Sanz‐Arigita, E., Barkhof, F., Scheltens, P., Stam, C. J., Zarei, M., & Rombouts, S. A. R. B. (2008) · Human Brain Mapping · doi:10.1002/hbm.20563 · Cited by 259
Neurostructural predictors of Alzheimer's disease: A meta-analysis of VBM studies
Ferreira, L. K., Diniz, B. S., Forlenza, O. V., Busatto, G. F., & Zanetti, M. V. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.008 · Cited by 241
Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes
Xu, J., Chen, S., Ahmed, S. H., Chen, H., Ku, G., Goldberg, M. P., & Hsu, C. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0001.2001 · Cited by 230
Huang, J., Friedland, R. P., & Auchus, A. P. (2007) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0700 · Cited by 220
Neuropathology of white matter changes in Alzheimer’s disease and vascular dementia
Englund, E. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051183 · Cited by 213
Amodio, P., Wenin, H., Piccolo, F. D., Mapelli, D., Montagnese, S., Pellegrini, A., Musto, C., Gatta, A., & Umiltà, C. A. (2002) · Aging Clinical and Experimental Research · doi:10.1007/bf03324425 · Cited by 189
The contribution of voxel-based morphometry in staging patients with mild cognitive impairment
Bozzali, M., Filippi, M., Magnani, G., Cercignani, M., Franceschi, M., Schiatti, E., Castiglioni, S., Mossini, R., Falautano, M., Scotti, G., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000228243.56665.c2 · Cited by 180
Self-citationMultivariate network analysis of fiber tract integrity in Alzheimer’s disease
Teipel, S. J., Stahl, R., Dietrich, O., Schoenberg, S. O., Perneczky, R., Bokde, A. L. W., Reiser, M. F., Möller, H., & Hampel, H. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.07.047 · Cited by 169
Motor dysfunction in mildly demented AD individuals without extrapyramidal signs
Goldman, W. P., Baty, J., Buckles, V., Sahrmann, S. A., & Morris, J. C. (1999) · Neurology · doi:10.1212/wnl.53.5.956 · Cited by 163
Postmortem MRI and Histopathology of White Matter Changes in Alzheimer Brains
Bronge, L., Bogdanović, N., & Wahlund, L. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000057698 · Cited by 157
Choi, S. J., Lim, K. O., Monteiro, I. M., & Reisberg, . (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704271763 · Cited by 156
Assessment of white matter tract damage in mild cognitive impairment and Alzheimer's disease
Pievani, M., Agosta, F., Pagani, E., Canu, E., Sala, S., Absinta, M., Geroldi, C., Ganzola, R., Frisoni, G. B., & Filippi, M. (2010) · Human Brain Mapping · doi:10.1002/hbm.20978 · Cited by 152
Self-citationWang, L., Goldstein, F. C., Veledar, E., Levey, A. I., Lah, J. J., MELTZER, C. C., Holder, C. A., & Mao, H. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1484 · Cited by 148
Fellgiebel, A., Dellani, P. R., Greverus, D., Scheurich, A., Stoeter, P., & Müller, M. J. (2006) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2006.01.006 · Cited by 118
Firbank, M., Blamire, A. M., Krishnan, M. S., Teodorczuk, A., English, P. T., Gholkar, A. R., Harrison, R. M., & O'Brien, J. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.027 · Cited by 88
Sydykova, D., Stahl, R., Dietrich, O., Ewers, M., Reiser, M. F., Schoenberg, S. O., Möller, H. ‐., Hampel, H. J., & Teipel, S. J. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl136 · Cited by 84
Evaluation of bilateral cingulum with tractography in patients with Alzheimer’s disease
Xie, S., Xiao, J. X., Wang, Y. H., Wu, H. K., Gong, G. L., & Jiang, X. X. (2005) · NeuroReport · doi:10.1097/01.wnr.0000174061.41897.ee · Cited by 68
Cingulum fiber diffusivity and CSF T-tau in patients with subjective and mild cognitive impairment
Stenset, V. T. V., Bjørnerud, A., Fjell, A. M., Walhovd, K. B., Hofoss, D., Due‐Tønnessen, P., Gjerstad, L., & Fladby, T. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.014 · Cited by 61
Medina, D. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s3381 · Cited by 48
Galluzzi, S., Testa, C., Boccardi, M., Bresciani, L. C., Benussi, L., Ghidoni, R., Beltramello, A., Bonetti, M., Bono, G. G., Falini, A., et al. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03324915 · Cited by 32
Self-citation
Flagged first, then by citations
Research works printed but not linked: 7
- Salat DH, Neurobiol Aging
- Stenset V, Neurobiol Aging
- Barigazzi R, 1987, Ric Psicol, 1, 50
- Novelli G, 1986, Arch Psicol Neurol Psichiatr, 47, 477
- Spinnler H, 1987, Ital J Neurol Sci, 6, 1
- Ferreira LK, Neurobiol Aging
- Pievani M, Hum Brain Mapp
Cited by
Sorted by citations
Brain atrophy in Alzheimer’s Disease and aging
Pini, L., Pievani, M., Bocchetta, M., Altomare, D., Bosco, P., Cavedo, E., Galluzzi, S., Marizzoni, M., & Frisoni, G. B. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.002 · Cited by 836
Self-citationEffectiveness of regional DTI measures in distinguishing Alzheimer’s disease, MCI, and normal aging
Nir, T. M., Jahanshad, N., Villalon-Reina, J. E., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.07.006 · Cited by 348
Skrobot, O. A., Attems, J., Esiri, M. M., Hortobágyi, T., Ironside, J. W., Kalaria, R. N., King, A., Lammie, G. A., Mann, D. M. A., Neal, J., et al. (2016) · Brain · doi:10.1093/brain/aww214 · Cited by 331
How and how not to correct for CSF-contamination in diffusion MRI
Metzler-Baddeley, C., O'Sullivan, M. J., Bells, S., Pasternak, O., & Jones, D. K. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.043 · Cited by 291
McAleese, K. E., Walker, L., Graham, S., Moya, E. L. J., Johnson, M. A., Erskine, D., Colloby, S. J., Dey, M., Martin-Ruiz, C. M., Taylor, J., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1738-2 · Cited by 280
Metadata
- Authors
- Agosta, F., Pievani, M., Sala, S., Geroldi, C., Galluzzi, S., Frisoni, G. B., & Filippi, M.
- Affiliations
- IRCCS Ospedale San Raffaele (IT)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Vita-Salute San Raffaele University (IT)
- ORCID
- Venue
- Radiology
- Published
- 2011-03
- Volume
- 258
- Issue
- 3
- Pages
- 853-863
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2168463796
- Cited by
- 288
- References
- 53
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 12 · 2023: 21 · 2022: 11 · 2021: 17 · 2020: 24 · 2019: 14 · 2018: 17 · 2017: 11 · 2016: 27 · 2015: 25 · 2014: 19 · 2013: 26 · 2012: 26
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, white matter injury, gray matter atrophy, amnestic mild cognitive impairment, diffusion tensor imaging, mean diffusivity, fractional anisotropy, axial and radial diffusivity, white matter tracts, corticospinal tract, fornix, corpus callosum, tract-based spatial statistics, voxel-based morphometry
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Cognition Disorders, Female, Humans, Male, Nerve Fibers, Myelinated, Neuropsychological Tests, Prospective Studies, Biomarkers, Case-Control Studies, Statistics, Nonparametric, Diffusion Magnetic Resonance Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
