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Mild Cognitive Impairment and Alzheimer Disease: Regional Diffusivity of Water
Open accessAbstract
PURPOSE: To compare the regional diffusivity of water in the brains of normally aging elderly people and patients with mild cognitive impairment (MCI) or Alzheimer disease. MATERIALS AND METHODS: Magnetic resonance images were obtained in 21 patients with Alzheimer disease, 19 patients with MCI, and 55 normally aging elderly control subjects without evidence of cognitive impairment. Regions of interest were drawn to compare the apparent diffusion coefficient (ADC) and the anisotropy index (AI) in frontal, parietal, temporal, occipital, anterior, and posterior cingulate white matter (WM), and the thalami and hippocampi. RESULTS: Hippocampal ADC was higher in MCI and Alzheimer disease patients than in control subjects. ADC of the temporal stem and posterior cingulate, occipital, and parietal WM was higher in Alzheimer disease patients than in control subjects. Except for occipital AI, which was lower in MCI patients than in control subjects, there were no differences in AI among the three groups for any of the regions. CONCLUSION: Hippocampal ADC was significantly different between control subjects and MCI patients, many of whom likely have preclinical Alzheimer disease. Elevation in hippocampal ADC may reflect early ultrastructural changes in the progression of Alzheimer disease.
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“The MD measurements in grey matter regions are in good agreement with previous studies that have detected elevated values in the brains of AD patients (Fellgiebel et al., 2004, Kantarci et al., 2001, Rose et al., 2008) and in mouse models exhibiting amyloid pathology at late stages of progression (Sun et al., 2005).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Kantarci et al., 2001
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980
Self-citationSpin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient
Stejskal, E. O., & Tanner, J. E. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1695690 · Cited by 8,239
Le Bihan, D., Breton, E., Lallemand, D., Grenier, P., Cabanis, E., & Laval-Jeantet, M. (1986) · Radiology · doi:10.1148/radiology.161.2.3763909 · Cited by 3,912
Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O'Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997) · Neurology · doi:10.1212/wnl.49.3.786 · Cited by 1,128
Self-citationThe biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.
Delacourte, A., David, J. P., Sergeant, N., Buée, L., Wattez, A., Vermersch, P., Ghozali, F., Fallet-Bianco, C., Pasquier, F., Lebert, F., et al. (1999) · Neurology · doi:10.1212/wnl.52.6.1158 · Cited by 828
Petersen, R. C. (1995) · JAMA · doi:10.1001/jama.1995.03520400044042 · Cited by 783
Self-citationThe Pathogenesis of Senile Plaques
DICKSON, D. W. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199704000-00001 · Cited by 753
Duvernoy, H. M., Cattin, F., & Risold, P. (2013) · Springer eBooks · doi:10.1007/978-3-642-33603-4 · Cited by 569
Preclinical prediction of Alzheimer's disease using SPECT
Johnson, K. A., Jones, K., Holman, B. L., Becker, J. A., Spiers, P. A., Satlin, A., & Albert, M. S. (1998) · Neurology · doi:10.1212/wnl.50.6.1563 · Cited by 471
Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease
Kantarci, K., Jack, C. R., Xu, Y., Campeau, N. G., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Kokmen, E., Tangalos, E. G., et al. (2000) · Neurology · doi:10.1212/wnl.55.2.210 · Cited by 461
Self-citationHistopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal aging
Scheltens, P., Barkhof, F., Leys, D., Wolters, E. C., Ravid, R., & Kamphorst, W. (1995) · Neurology · doi:10.1212/wnl.45.5.883 · Cited by 344
Brunberg, J. A., Chenevert, T. L., McKeever, P. E., Ross, D. A., Junck, L., Muraszko, K. M., Dauser, R., Pipe, J. G., & Betley, A. T. (1995) · PubMed Central · Cited by 269
Memory and mental status correlates of modified Braak staging
Grober, E. H., Dickson, D. W., Sliwinski, M. J., Herman Buschke, L., Katz, M., Crystal, H., & Lipton, R. B. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00063-9 · Cited by 235
Neuropathology of white matter changes in Alzheimer’s disease and vascular dementia
Englund, E. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051183 · Cited by 213
Definition, course, and outcome of mild cognitive impairment
Smith, G. E., Petersen, R. C., Parisi, J. E., Ivnik, R. J., Kokmen, E., Tangalos, E. G., & Waring, S. (1996) · Aging, Neuropsychology, and Cognition · doi:10.1080/13825589608256619 · Cited by 186
Self-citationDiffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease
Hanyu, H., Sakurai, H., Iwamoto, T., Takasaki, M., Shindo, H., & Abe, K. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00043-4 · Cited by 175
White matter volumes and periventricular white matter hyperintensities in aging and dementia
Smith, C. D., Snowdon, D. A., Wang, H., & Markesbery, W. R. (2000) · Neurology · doi:10.1212/wnl.54.4.838 · Cited by 137
Diffusion-weighted MR imaging in acute stroke: theoretic considerations and clinical applications.
Provenzale, J. M., & Sorensen, A. G. (1999) · American Journal of Roentgenology · doi:10.2214/ajr.173.6.10584783 · Cited by 131
CSF‐suppressed quantitative single‐shot diffusion imaging
Kwong, K. K., McKinstry, R. C., Chien, D., Crawley, A. P., Pearlman, J. D., & Rosen, B. R. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910210120 · Cited by 118
Diffusion-Weighted Magnetic Resonance Imaging in Alzheimer’s Disease
Sandson, T. A., Félician, O., Edelman, R. R., & Warach, S. J. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017099 · Cited by 112
Increased Water Diffusion in Cerebral White Matter in Alzheimer’s Disease
Hanyu, H., Shindo, H., Kakizaki, D., Abe, K., Iwamoto, T., & Takasaki, M. (2009) · Gerontology · doi:10.1159/000213874 · Cited by 83
Mayo Clinic Alzheimer’s Disease Patient Registry
Petersen, R. C., Kokmen, E., Tangalos, E. G., Ivnik, R. J., & Kurland, L. T. (1990) · Aging Clinical and Experimental Research · doi:10.1007/bf03323961 · Cited by 79
Self-citationGower, E. C. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902800303 · Cited by 69
Duvernoy, H. M. (1998) · Springer eBooks · doi:10.1007/978-3-662-03628-0_5 · Cited by 14
Price (1999) · doi:10.1002/1531-8249(199903)45:3
Cited by
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Mueller, S. G., Weiner, M. W., Thal, L. J., Petersen, R. C., Jack, C. R., Jagust, W., Trojanowski, J. Q., Toga, A. W., & Beckett, L. (2005) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2005.06.003 · Cited by 1,233
Self-citationHead, D. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh003 · Cited by 645
Rathore, S., Habes, M., Iftikhar, M. A., Shacklett, A., & Davatzikos, C. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.03.057 · Cited by 622
Bozzali, M. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.742 · Cited by 568
White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study
Medina, D., deToledo-Morrell, L., Urresta, F., Gabrieli, J. D. E., Moseley, M., Fleischman, D., Bennett, D. A., Leurgans, S., Turner, D. A., & Stebbins, G. T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.026 · Cited by 492
Metadata
- Authors
- Kantarci, K., Jack, C. R., Xu, Y. C., Campeau, N. G., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Kokmen, E., Tangalos, E. G., & Petersen, R. C.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Venue
- Radiology
- Published
- 2001-04
- Volume
- 219
- Issue
- 1
- Pages
- 101-107
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- PMC
- PMC2771587
- OpenAlex
- W2128776571
- Cited by
- 300
- References
- 36
- Citations by year
- 2026: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 4 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 22 · 2012: 9
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG-06786, AG 16574, U01AG006786, R01AG011378, AG-11378, R37AG011378, P50AG016574)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- mild cognitive impairment, Alzheimer's disease, apparent diffusion coefficient, anisotropy index, water diffusion, white matter, hippocampus, posterior cingulate cortex, preclinical Alzheimer's disease, brain aging, ultrastructural changes
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amnesia, Brain, Cerebral Cortex, Diffusion, Female, Gyrus Cinguli, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Reference Values, Sensitivity and Specificity, Thalamus, Anisotropy
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