Cited by 300Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsAlzheimer's disease research and treatments

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Mild Cognitive Impairment and Alzheimer Disease: Regional Diffusivity of Water

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Kantarci, Kejal, Jack, Clifford R., Xu, Yue Cheng, Campeau, Norberg G., O’Brien, Peter C., Smith, Glenn E., Ivnik, Robert J., Boeve, Bradley F., Kokmen, Emre, Tangalos, Eric G., Petersen, Ronald C.·2001·Radiology

DOI 10.1148/radiology.219.1.r01ap14101PMC PMC2771587

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Abstract

PURPOSE: To compare the regional diffusivity of water in the brains of normally aging elderly people and patients with mild cognitive impairment (MCI) or Alzheimer disease. MATERIALS AND METHODS: Magnetic resonance images were obtained in 21 patients with Alzheimer disease, 19 patients with MCI, and 55 normally aging elderly control subjects without evidence of cognitive impairment. Regions of interest were drawn to compare the apparent diffusion coefficient (ADC) and the anisotropy index (AI) in frontal, parietal, temporal, occipital, anterior, and posterior cingulate white matter (WM), and the thalami and hippocampi. RESULTS: Hippocampal ADC was higher in MCI and Alzheimer disease patients than in control subjects. ADC of the temporal stem and posterior cingulate, occipital, and parietal WM was higher in Alzheimer disease patients than in control subjects. Except for occipital AI, which was lower in MCI patients than in control subjects, there were no differences in AI among the three groups for any of the regions. CONCLUSION: Hippocampal ADC was significantly different between control subjects and MCI patients, many of whom likely have preclinical Alzheimer disease. Elevation in hippocampal ADC may reflect early ultrastructural changes in the progression of Alzheimer disease.

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Authors: Kantarci, K., Jack, C. R., Xu, Y. C., Campeau, N. G., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Kokmen, E., Tangalos, E. G., & Petersen, R. C.
Affiliations: Mayo Clinic (US)
ORCID: Kantarci, Kejal
Jack, Clifford R.
Xu, Yue Cheng
O’Brien, Peter C.
Smith, Glenn E.
Boeve, Bradley F.
Petersen, Ronald C.
Venue: Radiology
Publisher: Radiological Society of North America (RSNA)
Published: 2001-04
Volume: 219
Issue: 1
Pages: 101-107
ISSN: 0033-8419 (ISSN-L)
1527-1315
DOI: 10.1148/radiology.219.1.r01ap14101
PMC: PMC2771587
OpenAlex: W2128776571
Cited by: 300
References: 36
Citations by year: 2026: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 4 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 22 · 2012: 9
FWCI: 9.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Radiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG-06786, AG 16574, U01AG006786, R01AG011378, AG-11378, R37AG011378, P50AG016574)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: mild cognitive impairment, Alzheimer's disease, apparent diffusion coefficient, anisotropy index, water diffusion, white matter, hippocampus, posterior cingulate cortex, preclinical Alzheimer's disease, brain aging, ultrastructural changes
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Amnesia, Brain, Cerebral Cortex, Diffusion, Female, Gyrus Cinguli, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Reference Values, Sensitivity and Specificity, Thalamus, Anisotropy

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Mild Cognitive Impairment and Alzheimer Disease: Regional Diffusivity of Water

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