Regulation of placental amino acid transporter activity by mammalian target of rapamycin

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Purification, Characterization, andin vitroDifferentiation of Cytotrophoblasts from Human Term Placentae*

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Birth Weight and Adult Hypertension, Diabetes Mellitus, and Obesity in US Men

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

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Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

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hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

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Pregnancy Outcomes in Women With Gestational Diabetes Compared With the General Obstetric Population

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Placental Origins of Chronic Disease

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Developmental origins of metabolic diseases

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Maternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta

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Regulation of Nutrient Transport across the Placenta

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Physiological role of taurine – from organism to organelle

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Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies

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Leucine and mTORC1: a complex relationship

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Placental Adaptation: What Can We Learn from Birthweight:Placental Weight Ratio?

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Placental Responses to Changes in the Maternal Environment Determine Fetal Growth

Dimasuay, K. G., Boeuf, P., Powell, T. L., & Jansson, T. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00012 · Cited by 258

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

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Placental Function in Maternal Obesity

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Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

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Placental adaptations to the maternal–fetal environment: implications for fetal growth and developmental programming

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Role of amino acid transporters in amino acid sensing

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Early-life glucocorticoid exposure: the hypothalamic-pituitary-adrenal axis, placental function, and long-term disease risk

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Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight

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Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells

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Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters

Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2011) · Endocrinology · doi:10.1210/en.2010-1153 · Cited by 176

IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2

Jones, H. N., Jansson, T., & Powell, T. L. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2009 · Cited by 168

Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling

Roos, S., Lagerlöf, O., Wennergren, M., Powell, T. L., & Jansson, T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2009 · Cited by 168

The emerging role of mTORC1 signaling in placental nutrient-sensing

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Placental Dysfunction and Fetal Programming: The Importance of Placental Size, Shape, Histopathology, and Molecular Composition

Longtine, M. S., & Nelson, D. M. (2011) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1275515 · Cited by 169

The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1

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Placental mTOR links maternal nutrient availability to fetal growth

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Placental energy metabolism in health and disease—significance of development and implications for preeclampsia

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The role of LAT1 in 18F-DOPA uptake in malignant gliomas

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Placental regulation of fetal nutrient supply

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Down‐regulation of placental mTOR, insulin/IGF‐I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

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Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast Cells

Jones, H. N., Jansson, T., & Powell, T. L. (2010) · Diabetes · doi:10.2337/db09-0824 · Cited by 136

Regulation of Placental Amino Acid Transport and Fetal Growth

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Placental transport in response to altered maternal nutrition

Gaccioli, F., Lager, S., Powell, T. L., & Jansson, T. (2013) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000529 · Cited by 129

Molecular pathways disrupted by gestational diabetes mellitus

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Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise

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Intrauterine Growth Restriction: Hungry for an Answer

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Effect of IL-6 and TNF-α on fatty acid uptake in cultured human primary trophoblast cells

Lager, S., Jansson, N., Olsson, A., Wennergren, M., Jansson, T., & Powell, T. L. (2010) · Placenta · doi:10.1016/j.placenta.2010.10.012 · Cited by 106

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2

Rosario, F. J., Dimasuay, K. G., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Clinical Science · doi:10.1042/cs20150554 · Cited by 104

Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction

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Chronic maternal infusion of full‐length adiponectin in pregnant mice down‐regulates placental amino acid transporter activity and expression and decreases fetal growth

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Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

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Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review)

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Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

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Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With ^|^alpha;-Alkyl Moieties

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Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice

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Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats1

Gaccioli, F., White, V., Capobianco, E., Powell, T. L., Jawerbaum, A., & Jansson, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109702 · Cited by 76

Hypoxia Induces Autophagy in Primary Human Trophoblasts

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Role of Insulin in Placental Transport of Nutrients in Gestational Diabetes Mellitus

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Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth†

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Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR

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Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight

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Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4

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Transplacental Nutrient Transport Mechanisms of Intrauterine Growth Restriction in Rodent Models and Humans

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Insulin Stimulates GLUT4 Trafficking to the Syncytiotrophoblast Basal Plasma Membrane in the Human Placenta

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Gossypol reduced the intestinal amino acid absorption capacity of young grass carp (Ctenopharyngodon idella)

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Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta

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The uniformity and stability of cellular mass density in mammalian cell culture

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Differential levels of amino acid transporters System L and ASCT2, and the mTOR protein in placenta of preeclampsia and IUGR

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mTOR folate sensing links folate availability to trophoblast cell function

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Weekly Intra-Amniotic IGF-1 Treatment Increases Growth of Growth-Restricted Ovine Fetuses and Up-Regulates Placental Amino Acid Transporters

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Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC

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Fetal undernutrition, placental insufficiency, and pancreatic β-cell development programming in utero

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The effects of L-type amino acid transporter 1 on milk protein synthesis in mammary glands of dairy cows

Lin, Y., Duan, X., Lv, H., Yang, Y., Liu, Y., Gao, X., & Hou, X. (2017) · Journal of Dairy Science · doi:10.3168/jds.2017-13201 · Cited by 46

Prenatal high‐fat diet alters placental morphology, nutrient transporter expression, and mtorc1 signaling in rat

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Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling

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Survival by self-destruction: A role for autophagy in the placenta?

Bildirici, İ., Longtine, M. S., Chen, B., & Nelson, D. M. (2012) · Placenta · doi:10.1016/j.placenta.2012.04.011 · Cited by 44

Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids

Lager, S., Jansson, T., & Powell, T. L. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00196.2014 · Cited by 42

Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells

He, B., Zhang, N., & Zhao, R. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25076 · Cited by 42

Expression of Mammalian Target of Rapamycin and Downstream Targets in Normal and Gestational Diabetic Human Term Placenta

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Exposure of pregnant mice to triclosan impairs placental development and nutrient transport

Cao, X., Xu, H., Wang, X., & Chen, L. (2017) · Scientific Reports · doi:10.1038/srep44803 · Cited by 41

Maternal L-proline supplementation enhances fetal survival, placental development, and nutrient transport in mice†

Liu, N., Dai, Z., Zhang, Y., Chen, J., Yang, Y., Wu, G., Tso, P., & Wu, Z. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy240 · Cited by 41

Regulation of placental amino acid transport in health and disease

Shimada, H., Powell, T. L., & Jansson, T. (2024) · Acta Physiologica · doi:10.1111/apha.14157 · Cited by 46

Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women

Lager, S., Ramirez, V. I., Acosta, O. M., Meireles, C. L., Miller, E., Gaccioli, F., Rosario, F. J., Gelfond, J. A. L., Hakala, K. W., Weintraub, S. T., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01384 · Cited by 39

Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport

Day, P. E., Ntani, G., Crozier, S., Mahon, P. A., Inskip, H. M., Cooper, C. C., Harvey, N. C., Godfrey, K. M., Hanson, M. A., Lewis, R. M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143653 · Cited by 38

Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon

Pantham, P., Rosario, F. J., Nijland, M. J., Cheung, A., Nathanielsz, P. W., Powell, T. L., Galan, H. L., Li, C., & Jansson, T. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00161.2015 · Cited by 37

Mechanisms of Transfer Across the Human Placenta

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Syncytiotrophoblast Functions and Fetal Growth Restriction during Placental Malaria: Updates and Implication for Future Interventions

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Metabolic Consequences of Glucocorticoid Exposure before Birth

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Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction

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Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells

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The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health

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Amino Acids and Developmental Origins of Hypertension

Hsu, C., & Tain, Y. (2020) · Nutrients · doi:10.3390/nu12061763 · Cited by 30

System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts

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1,25(OH)2D3 Protects Trophoblasts Against Insulin Resistance and Inflammation Via Suppressing mTOR Signaling

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Immune Response Gene Profiles in the Term Placenta Depend Upon Maternal Muscle Mass

O’Tierney, P. F., Lewis, R. M., McWeeney, S. K., Hanson, M. A., Inskip, H. M., Morgan, T. K., Barker, D. J., Bagby, G., Cooper, C., Godfrey, K. M., et al. (2012) · Reproductive Sciences · doi:10.1177/1933719112440051 · Cited by 24

Role of the l-amino Acid Transporter-1 (LAT-1) in Mouse Trophoblast Cell Invasion

Chrostowski, M. K., McGonnigal, B., Stabila, J. P., & Padbury, J. F. (2010) · Placenta · doi:10.1016/j.placenta.2009.12.010 · Cited by 23

Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring

Beetch, M., & Alejandro, E. U. (2021) · Children · doi:10.3390/children8110970 · Cited by 22

LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle

Mazzulla, M., Hodson, N. W., Lees, M. J., Scaife, P. J., Smith, K., Atherton, P. J., Kumbhare, D. A., & Moore, D. R. (2021) · Nutrients · doi:10.3390/nu13113906 · Cited by 23

Epidemiology and Therapeutic Strategies for Women With Preexisting Diabetes in Pregnancy: How Far Have We Come? The 2021 Norbert Freinkel Award Lecture

Feig, D. S. (2022) · Diabetes Care · doi:10.2337/dci21-0027 · Cited by 24

Amino Acids during Pregnancy and Offspring Cardiovascular–Kidney–Metabolic Health

Tain, Y., & Hsu, C. (2024) · Nutrients · doi:10.3390/nu16091263 · Cited by 21

Reduced uterine perfusion pressure causes loss of pancreatic β-cell area but normal function in fetal rat offspring

Akhaphong, B., Lockridge, A. D., Jo, S., Mohan, R., Wilcox, J. A., Wing, C. R., Regal, J. F., & Alejandro, E. U. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00458.2017 · Cited by 21

Vasoactive Intestinal Peptide induces glucose and neutral amino acid uptake through mTOR signalling in human cytotrophoblast cells

Merech, F., Soczewski, E., Hauk, V. C., Paparini, D., Ramhorst, R., Vota, D., & Leirós, C. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-53676-3 · Cited by 20

Disrupted Prenatal Metabolism May Explain the Etiology of Suboptimal Neurodevelopment: A Focus on Phthalates and Micronutrients and their Relationship to Autism Spectrum Disorder

Parenti, M., & Slupsky, C. M. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100279 · Cited by 19

Analysis of amino acid and acyl carnitine profiles in maternal and fetal serum from preeclampsia patients

Liu, G., Deng, W., Cui, W., Xie, Q., Zhao, G., Wu, X., Lijuan, D., Chen, D., & Yu, B. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1560407 · Cited by 19

mTOR ensures increased release and reduced uptake of the organic osmolyte taurine under hypoosmotic conditions in mouse fibroblasts

Lambert, I. H., Jensen, J. V., & Pedersen, P. A. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00005.2014 · Cited by 19

Effect of light-load resistance exercise on postprandial amino acid transporter expression in elderly men

Agergaard, J., Bülow, J., Jensen, J. K., Reitelseder, S., Bornø, A., Drummond, M. J., Schjerling, P., & Holm, L. (2017) · Physiological Reports · doi:10.14814/phy2.13444 · Cited by 17

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Diniz, M. S., Grilo, L. F., Tocantins, C., Falcão‐Pires, I., & Pereira, S. P. (2023) · Metabolites · doi:10.3390/metabo13070845 · Cited by 17

Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition

Sedlmeier, E., Meyer, D. M., Stecher, L., Sailer, M., Daniel, H., Hauner, H., & Bader, B. (2021) · BMC Molecular and Cell Biology · doi:10.1186/s12860-021-00345-x · Cited by 18

Lipopolysaccharide and double stranded viral RNA mediate insulin resistance and increase system a amino acid transport in human trophoblast cells in vitro

Liong, S., & Lappas, M. (2017) · Placenta · doi:10.1016/j.placenta.2017.01.124 · Cited by 17

Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Kelly, A. C., Kramer, A. W., Rosario, F. J., Powell, T. L., & Jansson, T. (2020) · Clinical Science · doi:10.1042/cs20201050 · Cited by 15

Prenatal exercise reverses high-fat-diet-induced placental alterations and alters male fetal hypothalamus during late gestation in rats†

Song, L., Yan, J., Wang, N., Wei, X., Luo, X. M., Meng, K., & Sun, B. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz213 · Cited by 15

Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling

Roos, S., Lagerlöf, O., Wennergren, M., Powell, T. L., & Jansson, T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2009 · Cited by 168

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2

Rosario, F. J., Dimasuay, K. G., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Clinical Science · doi:10.1042/cs20150554 · Cited by 104

Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction

Jansson, T., Castillo‐Castrejón, M., Gupta, M. B., Powell, T. L., & Rosario, F. J. (2020) · Clinical Science · doi:10.1042/cs20190794 · Cited by 30

Regulation of placental amino acid transporter activity by mammalian target

Roos, S., Kanai, Y., Pd, P., Tl, P., & Regulation, J. T. (2008)

Lentivirus-Mediated Trophoblast-Specific Deptor Knockdown Increases Transplacental System A and System L Amino Acid Transport and Fetal Growth in Mice

Kramer, A. C., Vaughan, O. R., Barentsen, K., Urschitz, J., Powell, T. L., Jansson, T., & Rosario, F. J. (2025) · Function · doi:10.1093/function/zqaf018 · Cited by 4