Cited by 142Estrogen and related hormone effectsMetabolism, Diabetes, and CancerAdipose Tissue and Metabolism

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Effect of the ovarian hormones on GLUT4 expression and contraction-stimulated glucose uptake

Campbell, S. E., Febbraio, M. A.·2002·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00184.2001

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Abstract

This study examined the roles of the female sex steroids, 17β-estradiol (E 2) and progesterone (Prog), on glucose uptake and GLUT4 protein expression. Female Sprague-Dawley rats were either sham operated (C) or ovariectomized and treated with placebo (O), E 2(E), Prog (P), or both hormones at physiological doses (P + E) or the same dose of Prog with a high dose of E 2(P + HiE) via timed-release pellets inserted at the time of surgery, 15 days before metabolic testing. On the morning of day 15, animals received a 300-μCi injection (ip) of 2-deoxy-[14 C]glucose and then either exercised on a motorized treadmill for 30 min at 0.35 m/s or remained sedentary in their cages for the same period. Basal glucose uptake was not different between the treatment groups in either the red or white quadriceps. However, glucose uptake was decreased ( P < 0.05) in O, P, and P + E rats during exercise in the red quadriceps compared with C rats, whereas E and P + HiE treatment restored glucose uptake. Glycogen content in skeletal muscle followed similar trends, with no differences seen in resting animals. Postexercise red quadriceps glycogen levels were higher ( P < 0.05) in the E and P + HiE rats compared with O and P. Treatment of ovariectomized rats with progesterone (P rats) decreased ( P < 0.05) GLUT4 content in the red quadriceps by 21% compared with C rats. These data demonstrate that estrogen-deficient animals have a decreased ability for contraction-stimulated glucose uptake and increased glycogen use during aerobic exercise. However, changes in contraction-stimulated glucose uptake could not be explained by altered transporter protein content, since the absence of E 2 had no effect on GLUT4 protein.

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Authors: Campbell, S. E., & Febbraio, M. A.
Affiliations: The University of Melbourne (AU)
ORCID: Febbraio, M. A.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2002-05-01
Volume: 282
Issue: 5
Pages: E1139-E1146
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00184.2001
OpenAlex: W2112665865
Semantic Scholar: 8786fa5da249859947f5bc875ed89357abc9e2b1
Cited by: 142
References: 42
Citations by year: 2026: 4 · 2025: 6 · 2024: 12 · 2023: 10 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 4
FWCI: 2.28
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: estradiol, progesterone, ovarian hormones, GLUT4, glucose uptake, skeletal muscle, physical activity, ovariectomy, glycogen, female sex hormones, skeletal muscle glucose transport
MeSH terms: Animals, Deoxyglucose, Estradiol, Physical Exertion, Female, Glucose, Glycogen, Insulin, Monosaccharide Transport Proteins, Muscle Contraction, Muscle Proteins, Ovariectomy, Progesterone, Rats, Sprague-Dawley, Muscle, Skeletal, Lactic Acid, Glucose Transporter Type 4, Rats

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Effect of the ovarian hormones on GLUT4 expression and contraction-stimulated glucose uptake

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