The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity
Abstract
Women in the modern era are challenged with facing menopausal symptoms as well as heightened disease risk associated with increasing adiposity and metabolic dysfunction for up to three decades of life. Treatment strategies to combat metabolic dysfunction and associated pathologies have been hampered by our lack of understanding regarding the biological causes of these clinical conditions and our incomplete understanding regarding the effects of estrogens and the tissue-specific functions and molecular actions of its receptors. In this chapter we provide evidence supporting a critical and protective role for skeletal muscle estrogen receptor α in the maintenance of metabolic homeostasis and insulin sensitivity. Studies identifying the critical ER-regulated pathways essential for disease prevention will lay the important foundation for the rational design of novel therapeutic strategies to improve the health of women while limiting secondary complications that have plagued traditional hormone replacement interventions.
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Significant sex differences and sex hormone influences on carbohydrate and lipid metabolism are apparent.
“Significant sex differences and sex hormone influences on carbohydrate and lipid metabolism are apparent”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [19]
Important sex differences exist in mitochondrial function, substrate utilization, insulin sensitivity, immune responses, muscle morphology and body composition, iron metabolism, thermoregulation, hydration, appetite control, and energy availability and endocrine function.
“important sex differences exist in mitochondrial function [14–16], substrate utilization, and insulin sensitivity [17–24], immune responses [25–28], muscle morphology and body composition [29–32], iron metabolism [33–40], thermoregulation [41–44], hydration [45,46]{Sims, 2008 #55, [47–53], appetite control [54–59], and energy availability and endocrine function [60–65].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [19]
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International society of sports nutrition position stand: nutritional concerns of the female athlete
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“sensitivity as well as prevention of lipid accumulation and inflammation [20,21,67,68].”
Background
- Authors
- Hevener, A. L., Zhou, Z., Drew, B. G., & Ribas, V.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Hevener, Andrea L.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer International Publishing
- Published
- 2017
- Volume
- 1043
- Pages
- 257-284
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W2772794054
- Cited by
- 23
- References
- 169
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 4.62
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK-063491)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089109, R01DK109724, U54DK120342, P30DK063491)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- estrogen receptor, metabolic homeostasis, insulin sensitivity, menopause, adiposity, metabolic dysfunction, women's health, hormone replacement therapy
- MeSH terms
- Animals, Energy Metabolism, Estrogens, Female, Homeostasis, Humans, Insulin Resistance, Male, Menopause, Metabolic Diseases, Receptors, Estrogen, Signal Transduction, Estrogen Replacement Therapy, Muscle, Skeletal
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