Cited by 66Lipid metabolism and biosynthesisLipid metabolism and disordersAdipose Tissue and Metabolism

Triacylglycerol lipases and metabolic control: implications for health and disease

Watt, Matthew J., Spriet, Lawrence L.·2010·American Journal of Physiology-Endocrinology and Metabolism

Abstract

Fatty acids derived from the hydrolysis of adipose tissue and skeletal muscle triacylglycerol (TG) are an important energy substrate at rest and during physical activity. This review outlines the identification of the new TG lipase, adipose triglyceride lipase, the current understanding of how cellular TG lipases are regulated, and the implications for understanding the integrated control of TG lipolysis. Furthermore, this review outlines recent advances that propose a "revised" role for TG lipases in cellular function, metabolic homeostasis, and disease prevention.

Integrity signals

Registry

Crossref · 10.1152/ajpendo.00698.2009

Cites

86 of 86 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lipolytic enzymes lipoprotein lipase (LPL) and HSL are necessary to mobilize FAs from the intracellular glycerol molecule.

    “However, the lipolytic enzymes lipoprotein lipase (LPL) and HSL are necessary to mobilize FAs (lipolysis) from the intracellular glycerol molecule [9].”
  • Lipolysis is under a hierarchal regulation by ATGL and hormone sensitive lipase (HSL).

    “Recent findings indicate that lipolysis is under a hierarchal regulation by ATGL and hormone sensitive lipase (HSL) [8, 9, 17].”
  • The overall IMTG concentration and energy contribution is still under debate due to tissue variabilities.

    “Despite the known presence of IMTG within muscle (primarily with endurance trained subjects and type II diabetic subjects) [20], the overall IMTG concentration and energy contribution is still under debate due to tissue variabilities [9, 18, 22].”

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Authors
Watt, M. J., & Spriet, L. L.
Affiliations
  • Monash University (AU)
  • University of Guelph (CA)
Corresponding author
Watt, Matthew J.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
2010-08
Volume
299
Issue
2
Pages
E162-E168
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W2127656325
Cited by
66
References
88
Citations by year
2026: 4 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 11 · 2012: 7
FWCI
0.83
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
triacylglycerol lipase, adipose triglyceride lipase, triacylglycerol lipolysis, fatty acid mobilization, adipose tissue, skeletal muscle, metabolic homeostasis, energy metabolism, disease prevention
MeSH terms
Animals, Disease, Fatty Acids, Health, Humans, Lipase, Lipolysis, Metabolism, Mitochondria, Substrate Specificity, Gene Expression Regulation, Enzymologic

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