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Cited by 138Hormonal Regulation and HypertensionRenin-Angiotensin System StudiesSleep and Wakefulness Research

Aldosterone release during the sleep–wake cycle in humans

Charloux, Anne, Gronfier, Claude, Lonsdorfer-Wolf, Evelyne, Piquard, François, Brandenberger, Gabrielle·1999·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1999.276.1.e43
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Abstract

The aim of this study was to assess the relative influence on the 24-h aldosterone profile of the adrenocorticotropic system, primarily modulated by a circadian rhythmicity, and the renin-angiotensin system, which is influenced by sleep. Cortisol, plasma renin activity (PRA), and aldosterone were measured for 24 h in healthy subjects under basal conditions, once with nocturnal sleep and once with a night of sleep deprivation followed by 8 h of daytime sleep. The sleep period displayed high mean aldosterone levels, pulse amplitude, and frequency that were reduced during waking periods. During sleep, aldosterone pulses were mainly related to PRA oscillations, whereas they were mainly associated with cortisol pulses during waking periods. Cross-correlation analysis between sleep electroencephalographic activity in the delta band and aldosterone levels yielded significant results, aldosterone following delta waves by approximately 30 min. This study demonstrates that the 24-h aldosterone profile is strongly influenced by sleep processes. A dual influence, by the renin-angiotensin system during sleep and by the adrenocorticotropic system during wakefulness, is exerted on aldosterone pulses throughout the 24-h period.

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Crossref · 10.1152/ajpendo.1999.276.1.e43

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    From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [7]

  • A non-neuronal cholinergic system in T cells can locally provide acetylcholine release in the periphery.

    “yet a non-neuronal cholinergic system in T cells can locally provide acetylcholine release in the periphery (99, 203).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [99]

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Authors
Charloux, A., Gronfier, C., Lonsdorfer-Wolf, E., Piquard, F., & Brandenberger, G.
Affiliations
Laboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l’Homme, Institut de Physiologie, 67085 Strasbourg, France
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1999-01-01
Volume
276
Issue
1
Pages
E43-E49
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1999.276.1.e43
OpenAlex
W2287512653
Cited by
138
References
27
Citations by year
2026: 1 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 12 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 5
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
aldosterone, sleep-wake cycle, circadian rhythm, sleep deprivation, plasma renin activity, cortisol, ACTH, renin-angiotensin system, delta oscillations, EEG
MeSH terms
Adult, Aldosterone, Circadian Rhythm, Electroencephalography, Humans, Hydrocortisone, Male, Pulsatile Flow, Renin, Sleep, Sleep Stages, Wakefulness

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