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Cited by 23Sleep and Wakefulness ResearchStress Responses and CortisolCircadian rhythm and melatonin

Blockade of mineralocorticoid receptors enhances naïve T-helper cell counts during early sleep in humans

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Besedovsky, Luciana, Born, Jan, Lange, Tanja·2012·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2012.07.016
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Abstract

Sleep supports the formation of immunological memory as evidenced by a stronger immune response to vaccination if subjects sleep during the subsequent night than if they stay awake. One mechanism underlying this adjuvant-like action of sleep might be an enhanced homing of circulating naïve T cells to lymph nodes. Indeed, compared to nocturnal wakefulness, sleep acutely lowers T cell counts in peripheral blood during the early night, with the efflux of these cells to lymphoid tissues possibly mediated by sleep-associated release of the mineralocorticoid aldosterone. We show here that blocking mineralocorticoid receptors by spironolactone (200mg, orally at 23:00 h and again at 4:00 h) in 11 healthy men enhances naïve T-helper cell counts in blood during early nocturnal sleep. Effects in the same direction on naïve cytotoxic T cells and central memory T-helper cells were less consistent. Spironolactone did not influence T cell subsets not migrating to lymph nodes (i.e., CD62L(-) effector memory and effector T cells), or expression of CD62L and CXCR4. The typical circadian decrease in T cell numbers in the morning hours was not affected by the blockade of mineralocorticoid receptors, in line with the view that this decrease is mainly due to activation of glucocorticoid receptors during the circadian morning rise in cortisol. We assume that sleep-associated activation of mineralocorticoid receptors at a time of low cortisol levels contributes to an enhanced redistribution of circulating naïve T-helper cells to lymph nodes, as a mechanism that eventually promotes immunological memory formation.

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  • Blocking of mineralocorticoid receptors during early SWS-rich sleep produces an enhancement in naive T-helper cell counts.

    “In fact, blocking of mineralocorticoid receptors during early SWS-rich sleep produces an enhancement in naive T-helper cell counts (89).”

    From About Sleep's Role in Memory (2013) · cites this paper as [89]

  • Total monocyte counts, lymphocyte counts, and major lymphocyte subsets (B cells, CD4 and CD8 T cells, NK cells) have been found either reduced by sleep or unchanged compared with acute or prolonged sleep reduction in humans.

    “Similarly, total monocyte counts, lymphocyte counts, and the major lymphocyte subsets (i.e., B cells, CD4 and CD8 T cells, NK cells), have been found to be either reduced by sleep (46, 67, 148, 251, 254, 480, 556, 580) or unchanged (3, 69, 103, 122, 152, 178, 224, 234, 263, 338, 418, 463, 469) when compared with acute or prolonged sleep reduction in humans.”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [46]

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Authors
Besedovsky, L., Born, J., & Lange, T.
Affiliations
University of Tübingen (DE)
Corresponding author
Lange, Tanja
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2012-10
Volume
26
Issue
7
Pages
1116-1121
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2012.07.016
OpenAlex
W2008275044
Cited by
23
References
41
Citations by year
2024: 5 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3
FWCI
0.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinde (DFG) (SFB 654)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
mineralocorticoid receptor blockade, spironolactone, aldosterone, sleep, immunological memory, circadian rhythm, glucocorticoid receptor, cortisol, L-selectin, CXCR4, central memory T cells, cytotoxic T lymphocytes
MeSH terms
Adolescent, Adult, Aldosterone, Mineralocorticoid Receptor Antagonists, Blood Pressure, Cell Movement, Double-Blind Method, T-Lymphocytes, Helper-Inducer, Hormones, Humans, Hydrocortisone, Male, Sleep, Sleep Stages, Spironolactone, Polysomnography, Receptors, Mineralocorticoid, Lymphocyte Count, L-Selectin, Receptors, CXCR4, Young Adult

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