The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats
Abstract
We attempted to clarify whether leptin and uncoupling protein 1 (UCP1) are involved in the action of nicotine on the energy balance. Male Wistar rats were infused subcutaneously with nicotine (12 mg · kg−1 · day−1) for 4 or 14 days. At the end of the 4-day period, the plasma concentrations of leptin of the nicotine-treated and pair-fed rats were lower than those of the freely fed rats, although the levels of leptin mRNA expression in various white adipose tissues did not differ among the three groups. At the end of the 14-day nicotine infusion period, plasma concentrations of leptin were higher, and leptin mRNA expression in the omentum and epididymal and retroperitoneal adipose tissues was stronger in the nicotine-treated rats than in the pair-fed and freely fed rats. UCP1 mRNA expression in the brown adipose tissue of nicotine-treated was stronger than that of the pair-fed rats. These results suggest that continuous nicotine infusion differentially affects the synthesis and secretion of leptin according to the duration of infusion and stimulates UCP1 mRNA expression, probably in a manner independent of leptin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Fasting or chronic food restriction normally results in the downregulation of UCP1 expression in brown fat (Champigny and Ricquier, 1990) while nicotine induces UCP1 mRNA expression, which likely leads to enhanced energy expenditure (Yoshida et al., 1999; Arai et al., 2001).”
From Cigarette Smoking and Brain Regulation of Energy Homeostasis (2012) · cites this paper as Arai et al., 2001
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Cryer, P. E., Haymond, M. W., Santiago, J. V., & Shah, S. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609092951101 · Cited by 1,101 · cited 2×
“Nicotine increases the plasma concentrations of catecholamines in humans and rats (10, 19).”
BackgroundReceptor-mediated regional sympathetic nerve activation by leptin.
Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979
Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
Thornton, J. E., Cheung, C. C., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.11.5651 · Cited by 437 · cited 3×
“Nicotine is known to inhibit the expression of NPY mRNA in the arcuate nucleus of the hypothalamus (15) and to activate CRH-containing neurons in the paraventricular nucleus of the hypothalamus (25, 45).”
BackgroundBradley, R. L., & Cheatham, B. (1999) · Diabetes · doi:10.2337/diabetes.48.2.272 · Cited by 209
Research works printed but not linked: 47
- 10.1016/0306-4522(92)90262-Z · DOI
- 10.1038/29547 · DOI
- 10.1172/JCI485 · DOI
- 10.1006/bbrc.1999.0605 · DOI
- 10.2337/diabetes.49.4.532 · DOI
- 10.1126/science.7624778 · DOI · Paper page
- 10.1093/jn/120.12.1730 · DOI · Paper page
- 10.1016/0003-2697(87)90021-2 · DOI · Paper page
- 10.1111/j.1749-6632.1995.tb44724.x · DOI
- 10.1016/S0014-5793(99)00056-3 · DOI
- 10.1046/j.1365-2362.1999.00420.x · DOI
- 10.1152/ajpregu.1998.274.1.R204 · DOI
- 10.1016/0006-8993(95)00834-D · DOI
- 10.1038/27376 · DOI · Paper page
- 10.1006/bbrc.1997.7716 · DOI
- 10.1074/jbc.272.39.24129 · DOI
- 10.1016/0024-3205(88)90679-0 · DOI
- 10.1172/JCI118653 · DOI
- 10.1096/fasebj.4.11.2199286 · DOI
- Jin L, 1999, J Clin Endocrinol Metab, 84, 2903
- Klesges RC, 1993, Int J Obes, 17, 585
- 10.1210/endo.132.5.8386611 · DOI
- 10.2337/diab.44.7.855 · DOI
- 10.1038/nm0997-1029 · DOI · Paper page
- 10.1210/endo.140.2.6491 · DOI
- 10.1016/0026-0495(91)90225-L · DOI
- 10.1016/0014-5793(95)01030-I · DOI
- 10.2337/diab.46.3.342 · DOI
- 10.2337/diab.46.8.1360 · DOI
- 10.1126/science.7624776 · DOI · Paper page
- 10.1111/j.1360-0443.1992.tb02693.x · DOI
- 10.1056/NEJM198904063201404 · DOI
- 10.1210/endo.140.8.6890 · DOI
- 10.1152/ajpendo.1997.273.1.E226 · DOI
- 10.1172/JCI118891 · DOI
- 10.1530/eje.0.1430439 · DOI
- 10.1210/endo.140.4.6668 · DOI
- 10.1096/fasebj.13.10.1259 · DOI
- 10.1016/0092-8674(95)90151-5 · DOI · Paper page
- 10.1210/endo.137.2.8593811 · DOI
- 10.1093/ajcn/35.2.366 · DOI
- 10.1038/31474 · DOI · Paper page
- 10.1074/jbc.274.25.17541 · DOI
- 10.1038/sj.ijo.0800870 · DOI · Paper page
- 10.1038/372425a0 · DOI · Paper page
- 10.1073/pnas.94.12.6386 · DOI
- 10.1016/0092-8674(83)90544-5 · DOI
Cited by
Chen, H., Vlahos, R., Bozinovski, S., Jones, J., Anderson, G. P., & Morris, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300597 · Cited by 165
Cigarette Smoking and Brain Regulation of Energy Homeostasis
Chen, H., Saad, S., Sandow, S. L., & Bertrand, P. P. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00147 · Cited by 69
Metadata
- Authors
- Arai, K., Kim, K., Kaneko, K., Iketani, M., Otagiri, A., Yamauchi, N., & Shibasaki, T.
- Affiliations
- Department of Physiology, Nippon Medical School, Tokyo 113-8602, Japan
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2001-06-01
- Volume
- 280
- Issue
- 6
- Pages
- E867-E876
- ISSN
- 0193-1849
- 1522-1555
- Cited by
- 38
- References
- 5
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
