The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Bioavailability of the flavanone naringenin and its glycosides in rats
Abstract
Naringenin, the predominant flavanone in grapefruit, mainly occurs as glycosides such as naringenin-7- rhamnoglucoside or naringenin-7-glucoside. This study compared kinetics of absorption of naringenin and its glycosides in rats either after a single flavanone-containing meal or after adaptation to a diet for 14 days. Regardless of the diet, circulating metabolites were glucurono- and sulfoconjugated derivatives of naringenin. The kinetics of absorption of naringenin and naringenin-7-glucoside were similar, whereas naringenin-7-rhamnoglucoside exhibited a delay in its intestinal absorption, resulting in decreased bioavailability. After naringenin-7-glucoside feeding, no glucoside was found in the cecum. However, after feeding naringenin-7-rhamnoglucoside, some naringenin-7-rhamnoglucoside accumulated in cecum before being hydrolyzed by intestinal microflora. Adaptation to flavanone diets did not induce accumulation of plasma naringenin. Moreover, flavanone cecal content markedly decreased after adaptation, and almost no naringenin-7-rhamnoglucoside was recovered after naringenin-7-rhamnoglucoside feeding, suggesting that an adaptation of cecal microflora had occurred. Overall, these data indicate that flavanones are efficiently absorbed after feeding to rats and that their bioavailability is related to their glycosidic moiety.
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Self-citationMetabolic fate of polyphenols in the human superorganism
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Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products
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Metadata
- Authors
- Felgines, C., Texier, O., Morand, C., Manach, C., Scalbert, A., Régerat, F., & Rémésy, C.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2000-12-01
- Volume
- 279
- Issue
- 6
- Pages
- G1148-G1154
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2137461654
- Cited by
- 313
- References
- 26
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Felgines, C., Texier, O., Morand, C., Manach, C., Scalbert, A., Régerat, F., & Rémésy, C. (2000). Bioavailability of the flavanone naringenin and its glycosides in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.2000.279.6.g1148
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