The DOI matches its Crossref record; 315 of the 315 references it cites were found in a registry or an index.
Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging
Open accessAbstract
Increasing evidence from epidemiological, clinical and experimental studies indicate that age-related cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including Alzheimer’s disease. Understanding and targeting the age-related pathophysiological mechanisms that underlie vascular contributions to cognitive impairment and dementia (VCID) are expected to have a major role in preserving brain health in older individuals. Maintenance of cerebral perfusion, protecting the microcirculation from high pressure-induced damage and moment-to-moment adjustment of regional oxygen and nutrient supply to changes in demand are prerequisites for the prevention of cerebral ischemia and neuronal dysfunction. This overview discusses age-related alterations in three main regulatory paradigms involved in the regulation of cerebral blood flow (CBF): cerebral autoregulation/myogenic constriction, endothelium-dependent vasomotor function, and neurovascular coupling responses responsible for functional hyperemia. The pathophysiological consequences of cerebral microvascular dysregulation in aging are explored, including blood-brain barrier disruption, neuroinflammation, exacerbation of neurodegeneration, development of cerebral microhemorrhages, microvascular rarefaction, and ischemic neuronal dysfunction and damage. Due to the widespread attention that VCID has captured in recent years, the evidence for the causal role of cerebral microvascular dysregulation in cognitive decline is critically examined.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In addition, microvascular endothelial aging also disrupts the blood-brain barrier, which promotes neuroinflammation, exacerbating cognitive decline”
From Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain (2020) · cites this paper as Toth et al. 2017
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice
Sagare, A. P., Bell, R. D., Zhao, Z., Ma, Q., Winkler, E. A., Ramanathan, A., & Zlokovic, B. V. (2013) · Nature Communications · doi:10.1038/ncomms3932 · Cited by 589
RetractedKeleshian, V. L., Modi, H. R., Rapoport, S. I., & Rao, J. S. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12153 · Cited by 53
RetractedGorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244
Blood-brain barrier breakdown in the aging human hippocampus
Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102
Research works printed but not linked: 13
- Bergsneider M, 1998, Acta Neurochir Suppl, 71, 266
- Faraci FM, 1989, J Hypertens Suppl, 7, S61
- Hertelendy P, 2016, J Cereb Blood Flow, 0271678X1664373
- Jessen SB, 2015, Cereb Cortex, bhv261
- Lassen NA, 1964, Circ Res, 15, 201
- Longden T, 2011, Proc Br Pharmacol Soc, 9, 062P
- Mayhan WG, 1987, Circulation, 75, I107
- Mellander S., 1989, J Hypertens Suppl, 7, S21
- Paulson OB, 1990, Cerebrovasc Brain Metab Rev, 2, 161
- Rombouts SA, 2000, AJNR Am J Neuroradiol, 21, 1869
- Schubert R, 2008, Cardiovasc Res, 77, 8
- Tarantini S, 2014, Aging Cell, 28, 1079.1076
- Zaletel M, 2005, Funct Neurol, 20, 115
Cited by
Sorted by citations
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
Claassen, J. A. H. R., Thijssen, D. H. J., Panerai, R. B., & Faraci, F. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00022.2020 · Cited by 1,005
Vascular Cognitive Impairment and Dementia
Iadecola, C., Duering, M., Hachinski, V., Joutel, A., Pendlebury, S. T., Schneider, J. A., & Dichgans, M. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.034 · Cited by 865
Hypertension-induced cognitive impairment: From pathophysiology to public health
Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., & Csiszar, A. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00430-6 · Cited by 544
Self-citationHypoxia and brain aging: Neurodegeneration or neuroprotection?
Burtscher, J., Mallet, R. T., Burtscher, M., & Millet, G. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101343 · Cited by 359
Vascular Cognitive Impairment (VCI)
Rundek, T., Tolea, M. I., Ariko, T., Fagerli, E. A., & Camargo, C. J. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01170-y · Cited by 347
Metadata
- Authors
- Toth, P., Tarantini, S., Csiszar, A., & Ungvari, Z.
- Affiliations
- Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;
- University of Oklahoma Health Sciences Center (US)
- University of Szeged (HU)
- Corresponding author
- Ungvari, Zoltan
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2017-01-01
- Volume
- 312
- Issue
- 1
- Pages
- H1-H20
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC5283909
- OpenAlex
- W2543174917
- Cited by
- 522
- References
- 315
- Citations by year
- 2026: 41 · 2025: 65 · 2024: 51 · 2023: 56 · 2022: 61 · 2021: 62 · 2020: 65 · 2019: 53 · 2018: 41 · 2017: 26
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Center for Complementary and Alternative Medicine (NCCAM) (R01-AT006526)
- HHS | NIH | National Institute on Aging (U.S. National Institute on Aging) (R01-AG047879, R01-AG038747)
- HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) (R01-NS056218)
- American Heart Association (AHA)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Keywords
- cerebral autoregulation, myogenic constriction, endothelial dysfunction, neurovascular uncoupling, cerebral microvascular dysfunction, aging, Alzheimer's disease, blood-brain barrier disruption, neuroinflammation, cerebral microhemorrhages, microvascular rarefaction, cerebral ischemia, functional hyperemia, cognitive decline
- MeSH terms
- Neurovascular Coupling, Aging, Cerebrovascular Circulation, Dementia, Endothelium, Vascular, Homeostasis, Humans, Microcirculation, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
