Ungvari, Zoltan

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 1,162

Mechanisms of Vascular Aging

Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research

Telomeres, Telomerase, and SenescenceCardiovascular Health and Disease Prevention

Cited by 919

Hypertension-induced cognitive impairment: From pathophysiology to public health

Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., & Csiszar, A. (2021) · Nature Reviews Nephrology

Neurological Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 544

Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging

Toth, P., Tarantini, S., Csiszar, A., & Ungvari, Z. (2017) · American Journal of Physiology-Heart and Circulatory Physiology

Neurological Disease Mechanisms and TreatmentsBarrier Structure and Function Studies

Cited by 522

Inflammation and endothelial dysfunction during aging: role of NF-κB

Csiszar, A., Wang, M., Lakatta, E. G., & Ungvari, Z. (2008) · Journal of Applied Physiology

Nitric Oxide and Endothelin EffectsNF-κB Signaling Pathways

Cited by 441

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

Tarantini, S., Tran, C. H. T., Gordon, G. R., Ungvari, Z., & Csiszar, A. (2017) · Experimental Gerontology

Barrier Structure and Function StudiesNeurological Disease Mechanisms and Treatments

Cited by 411

Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain

Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., DelFavero, J., Yabluchanskiy, A., Csipo, T., Farkas, E., Wiley, G., et al. (2020) · GeroScience

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 203

Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction, Neurovascular Uncoupling, and Cognitive Decline in Mice

Tucsek, Z., Toth, P., Tarantini, S., Sosnowska, D., Gautam, T., Warrington, J. P., Giles, C. B., Wren, J. D., Koller, A., Ballabh, P., et al. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Barrier Structure and Function StudiesNeurological Disease Mechanisms and Treatments

Cited by 191

Ionizing Radiation Promotes the Acquisition of a Senescence-Associated Secretory Phenotype and Impairs Angiogenic Capacity in Cerebromicrovascular Endothelial Cells: Role of Increased DNA Damage and Decreased DNA Repair Capacity in Microvascular Radiosensitivity

Ungvari, Z., Podlutsky, A., Sosnowska, D., Tucsek, Z., Toth, P., Deak, F., Gautam, T., Csiszar, A., & Sonntag, W. E. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Effects of Radiation ExposureTelomeres, Telomerase, and Senescence

Cited by 179

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection

Toth, P., Tarantini, S., Springo, Z., Tucsek, Z., Gautam, T., Giles, C. B., Wren, J. D., Koller, A., Sonntag, W. E., Csiszar, A., et al. (2015) · Aging Cell

Intracerebral and Subarachnoid Hemorrhage ResearchNeurological Disease Mechanisms and Treatments

Cited by 163

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., et al. (2020) · GeroScience

Sirtuins and Resveratrol in MedicineNeurological Disease Mechanisms and Treatments

Cited by 163

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies

Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., et al. (2017) · Aging and disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 118

Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression

Mitschelen, M., Yan, H., Farley, J. A., Warrington, J. P., Han, S., Hereñú, C. B., Csiszar, A., Ungvari, Z., Bailey-Downs, L. C., Bass, C. E., et al. (2011) · Neuroscience

Growth Hormone and Insulin-like Growth FactorsTreatment of Major Depression

Cited by 103

Mitochondria and aging in the vascular system

Ungvari, Z., Sonntag, W. E., & Csiszar, A. (2010) · Journal of Molecular Medicine

Mitochondrial Function and PathologyNitric Oxide and Endothelin Effects

Cited by 103

Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence

Ungvari, Z., Tarantini, S., Hertelendy, P., Valcarcel-Ares, M. N., Fülöp, G. A., Logan, S., Kiss, T., Farkas, E., Csiszar, A., & Yabluchanskiy, A. (2017) · GeroScience

Barrier Structure and Function StudiesNeurological Disease Mechanisms and Treatments

Cited by 101

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Tarantini, S., Tucsek, Z., Valcarcel-Ares, M. N., Toth, P., Gautam, T., Giles, C. B., Ballabh, P., Wei, J. Y., Wren, J. D., Ashpole, N. M., et al. (2016) · AGE

Neurological Disease Mechanisms and TreatmentsBarrier Structure and Function Studies

Cited by 98

Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease

Csiszar, A., Tarantini, S., Fülöp, G. A., Kiss, T., Valcarcel-Ares, M. N., Galvan, V., Ungvari, Z., & Yabluchanskiy, A. (2017) · GeroScience

Neurological Disease Mechanisms and TreatmentsBarrier Structure and Function Studies

Cited by 93

Intramyocardial VEGF-B 167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated Cardiomyopathy

Pepe, M., Mamdani, M., Zentilin, L., Csiszar, A., Qanud, K., Zacchigna, S., Ungvari, Z., Puligadda, U., Moimas, S., Xu, X., et al. (2010) · Circulation Research

Cardiomyopathy and Myosin StudiesCardiac Fibrosis and Remodeling

Cited by 93

Vascular Inflammation in Aging

Ungvari, Z., Csiszar, A., & Kaley, G. (2004) · Herz

Atherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin Effects

Cited by 75

Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain

Kiss, T., Nyúl-Tóth, Á., DelFavero, J., Balasubramanian, P., Tarantini, S., Faakye, J., Gulej, R., Ahire, C., Ungvari, A., Yabluchanskiy, A., et al. (2022) · GeroScience

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 66

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology

Cardiovascular Health and Disease PreventionTelomeres, Telomerase, and Senescence

Cited by 59

Association between red and processed meat consumption and colorectal cancer risk: a comprehensive meta-analysis of prospective studies

Ungvari, Z., Fekete, M., Varga, P., Lehoczki, A., Munkácsy, G., Fekete, J. T., Bianchini, G., Ocana, A., Buda, A., Ungvari, A., et al. (2025) · GeroScience

Nutritional Studies and DietColorectal Cancer Screening and Detection

Cited by 56

Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

Ungvari, Z., Krasnikov, B. F., Csiszar, A., Labinskyy, N., Mukhopadhyay, P., Pacher, P., Cooper, A. J. L., Podlutskaya, N., Austad, S. N., & Podlutsky, A. (2008) · AGE

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 56

Short-term weight loss reverses obesity-induced microvascular endothelial dysfunction

Csipo, T., Fulop, G. A., Lipecz, A., Tarantini, S., Kiss, T., Balasubramanian, P., Csiszar, A., Ungvari, Z., & Yabluchanskiy, A. (2018) · GeroScience

Cardiovascular and exercise physiologyNitric Oxide and Endothelin Effects

Cited by 50