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Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects
Abstract
Maintenance of reduced or elevated body weight results in respective decreases or increases in energy expended in physical activity, defined as 24-h energy expenditure excluding resting energy expenditure and the thermic effect of feeding, beyond those attributable to weight change. We examined skeletal muscle work efficiency by graded cycle ergometry and, in some subjects, rates of gastrocnemius muscle ATP flux during exercise by magnetic resonance spectroscopy (MRS), in 30 subjects (15 males, 15 females) at initial weight and 10% below initial weight and in 8 subjects (7 males, 1 female) at initial weight and 10% above initial weight to determine whether changes in skeletal muscle work efficiency at altered body weight were correlated with changes in the energy expended in physical activity. At reduced weight, muscle work efficiency was increased in both cycle ergometry [mean (SD) change = +26.5 (26.7)%, P < 0.001] and MRS [ATP flux change = -15.2 (23.2)%, P = 0.044] studies. Weight gain resulted in decreased muscle work efficiency by ergometry [mean (SD) change = -17.8 (20.5)%, P = 0.043]. Changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity.
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“reductions in skeletal muscle mass and increased work efficiency are reported to contribute directly to this phenomenon [12].”
From Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism (2024) · cites this paper as [12]
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Metadata
- Authors
- Rosenbaum, M., Vandenborne, K., Goldsmith, R., Simoneau, J.-A., Heymsfield, S., Joanisse, D. R., Hirsch, J., Murphy, E., Matthews, D., Segal, K. R., & Leibel, R. L.
- Affiliations
- Columbia University (US)
- ORCID
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-07
- Volume
- 285
- Issue
- 1
- Pages
- R183-R192
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2169216660
- Cited by
- 255
- References
- 47
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 8 · 2023: 15 · 2022: 9 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 8 · 2015: 12 · 2014: 11 · 2013: 10 · 2012: 16
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2m01rr000102-41, 5r01dk030583-18)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK37948, DK-30583, R01DK037948, DK 26687, P30DK026687)
- National Center for Research Resources (RR00102, RR 00645, M01RR000645)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- weight change, weight loss, weight gain, energy expenditure, physical activity energy expenditure, gastrocnemius, physical activity, cycle ergometry, magnetic resonance spectroscopy
- MeSH terms
- Body Composition, Energy Metabolism, Exercise Test, Female, Humans, Male, Muscle Contraction, Magnetic Resonance Spectroscopy, Obesity, Reproducibility of Results, Weight Gain, Weight Loss, Exercise, Muscle, Skeletal
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