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Cited by 255Cardiovascular and exercise physiologyMuscle metabolism and nutritionMuscle activation and electromyography studies

The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.

Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects

Rosenbaum, Michael, Vandenborne, Krista, Goldsmith, Rochelle, Simoneau, Jean-Aime, Heymsfield, Steven, Joanisse, Denis R., Hirsch, Jules, Murphy, Ellen, Matthews, Dwight, Segal, Karen R., Leibel, Rudolph L.·2003·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00474.2002
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Abstract

Maintenance of reduced or elevated body weight results in respective decreases or increases in energy expended in physical activity, defined as 24-h energy expenditure excluding resting energy expenditure and the thermic effect of feeding, beyond those attributable to weight change. We examined skeletal muscle work efficiency by graded cycle ergometry and, in some subjects, rates of gastrocnemius muscle ATP flux during exercise by magnetic resonance spectroscopy (MRS), in 30 subjects (15 males, 15 females) at initial weight and 10% below initial weight and in 8 subjects (7 males, 1 female) at initial weight and 10% above initial weight to determine whether changes in skeletal muscle work efficiency at altered body weight were correlated with changes in the energy expended in physical activity. At reduced weight, muscle work efficiency was increased in both cycle ergometry [mean (SD) change = +26.5 (26.7)%, P < 0.001] and MRS [ATP flux change = -15.2 (23.2)%, P = 0.044] studies. Weight gain resulted in decreased muscle work efficiency by ergometry [mean (SD) change = -17.8 (20.5)%, P = 0.043]. Changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity.

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Crossref · 10.1152/ajpregu.00474.2002

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  1. 10.1210/jcem.87.5.8628 · DOI · Paper page

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Metadata

Authors
Rosenbaum, M., Vandenborne, K., Goldsmith, R., Simoneau, J.-A., Heymsfield, S., Joanisse, D. R., Hirsch, J., Murphy, E., Matthews, D., Segal, K. R., & Leibel, R. L.
Affiliations
Columbia University (US)
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2003-07
Volume
285
Issue
1
Pages
R183-R192
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00474.2002
OpenAlex
W2169216660
Cited by
255
References
47
Citations by year
2026: 3 · 2025: 12 · 2024: 8 · 2023: 15 · 2022: 9 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 8 · 2015: 12 · 2014: 11 · 2013: 10 · 2012: 16
FWCI
19.48
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2m01rr000102-41, 5r01dk030583-18)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK37948, DK-30583, R01DK037948, DK 26687, P30DK026687)
  • National Center for Research Resources (RR00102, RR 00645, M01RR000645)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
Keywords
weight change, weight loss, weight gain, energy expenditure, physical activity energy expenditure, gastrocnemius, physical activity, cycle ergometry, magnetic resonance spectroscopy
MeSH terms
Body Composition, Energy Metabolism, Exercise Test, Female, Humans, Male, Muscle Contraction, Magnetic Resonance Spectroscopy, Obesity, Reproducibility of Results, Weight Gain, Weight Loss, Exercise, Muscle, Skeletal

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