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Cited by 407Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

The DOI matches its Crossref record.

Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones

Rosenbaum, Michael, Murphy, Ellen M., Heymsfield, Steven B., Matthews, Dwight E., Leibel, Rudolph L.·2002·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.87.5.2391
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Abstract

Maintenance of a reduced body weight is associated with decreased 24-hour energy expenditure, and decreased circulating concentrations of leptin and thyroid hormones. To determine whether these adaptive metabolic and endocrine changes are partly leptin-mediated, we measured body composition, aspects of energy expenditure, and circulating concentrations of leptin and thyroid hormones in 4 subjects at 3 time points: 1.) Usual body weight; 2.) While stable at 10% reduced body weight; and 3.) During a 5-week period at 10% reduced body weight while receiving twice per day leptin injections that restored 8 AM circulating leptin concentrations to those seen at usual body weight. During maintenance of a 10% reduced body weight, circulating T3, T4, and leptin concentrations were decreased. All of these endocrine changes were reversed by administration of “replacement” doses of leptin (r-metHuLeptin). Indirect calorimetry, and subtle changes in body composition associated with leptin administration, were used to calculate the net change in stored calories and in 24-hour energy expenditure. Total energy expenditure increased in all subjects during r-metHuLeptin administration. These data indicate that decrease leptin concentrations resulting from loss of fat mass account for some aspects of the endocrine/metabolic phenotype associated with the weight-reduced state.

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Crossref · 10.1210/jcem.87.5.8628

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  • r-metHuLeptin administration has been found to increase FT4 and FT3 levels in leptin-deficient children and to reverse the decreased T3 and T4 levels in four subjects on a long-term hypocaloric diet.

    “Although r-metHuLeptin administration has been found to increase FT4 and FT3 levels in leptin-deficient children (34) and to reverse the decreased T3 and T4 levels in four subjects on a long-term hypocaloric diet (42)”

    From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [42]

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Metadata

Authors
Rosenbaum, M., Murphy, E. M., Heymsfield, S. B., Matthews, D. E., & Leibel, R. L.
Affiliations
  • Columbia University (US)
  • University of Vermont Medical Center (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2002-05-01
Volume
87
Issue
5
Pages
2391-2394
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.87.5.2391
OpenAlex
W2044939881
Cited by
407
References
0
Citations by year
2026: 5 · 2025: 16 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 16 · 2017: 25 · 2016: 11 · 2015: 22 · 2014: 19 · 2013: 13 · 2012: 13
FWCI
9.38
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dk030583-18)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064773, DK-30583)
  • National Center for Research Resources (RR 00645, M01RR000645)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
leptin, leptin replacement, weight loss, energy expenditure, thyroid hormones, T3, thyroxine, body composition, fat mass, metabolic adaptation, obesity, leptin deficiency
MeSH terms
Adult, Body Composition, Calorimetry, Indirect, Dose-Response Relationship, Drug, Energy Metabolism, Female, Humans, Male, Osmolar Concentration, Thyroid Hormones, Weight Loss, Leptin

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